LOCUS X14758 1504 bp mRNA linear HUM 18-APR-2005
DEFINITION Human mRNA for adenocarcinoma-associated antigen (KSA).
ACCESSION X14758
VERSION X14758.1
KEYWORDS antigen; cell surface glycoprotein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1504)
AUTHORS Strnad J., Hamilton A.E., Beavers L.S., Gamboa G.C., Apelgren L.D.,
Taber L.D., Sportsman J.R., Bumol T.F., Sharp J.D., Gadski R.A.
TITLE Molecular cloning and characterization of a human
adenocarcinoma/epithelial cell surface antigen complementary DNA
JOURNAL Cancer Res. 49(2), 314-317(1989).
PUBMED 2463074
FEATURES Location/Qualifiers
source 1..1504
/db_xref="H-InvDB:HIT000321458"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="lambda gt11."
/cell_line="UCLA-P3"
/db_xref="taxon:9606"
CDS 155..1099
/note="KSA preproantigen peptide"
/db_xref="GOA:P16422"
/db_xref="H-InvDB:HIT000321458.12"
/db_xref="HGNC:HGNC:11529"
/db_xref="InterPro:IPR000716"
/db_xref="InterPro:IPR036857"
/db_xref="InterPro:IPR041630"
/db_xref="PDB:4MZV"
/db_xref="PDB:6I07"
/db_xref="UniProtKB/Swiss-Prot:P16422"
/protein_id="CAA32870.1"
/translation="MAPPQVLAFGLLLAAATATFAAAQEECVCENYKLAVNCFVNNNR
QCQCTSVGAQNTVICSKLAAKCLVMKAEMNGSKLGRRAKPEGALQNNDGLYDPDCDES
GLFKAKQCNGTSTCWCVNTAGVRRTDKDTEITCSERVRTYWIIIELKHKAREKPYDSK
SLRTALQKEITTRYQLDPKFITSILYENNVITIDLVQNSSQKTQNDVDIADVAYYFEK
DVKGESLFHSKKMDLTVNGEQLDLDPGQTLIYYVDEKAPEFSMQGLKAGVIAVIVVVV
MAVVAGIVVLVISRKKRMAKYEKAEIKEMGEMHRELNA"
sig_peptide 155..223
/note="put. signal peptide (most likely cleavage site) (AA
-23 to -1)"
misc_feature 224..1096
/note="KSA proantigen (AA 1-291)"
mat_peptide 398..1096
/note="mature KSA antigen (AA 59-291)"
polyA_site 1504..1504
/note="polyA site"
BASE COUNT 442 a 302 c 356 g 404 t
ORIGIN
1 gagcgagcac cttcgacgcg gtccggggac cccctcgtcg ctgtcctccc gacgcggacc
61 cgcgtgcccc aggcctcgcg ctgcccggcc ggctcctcgt gtcccactcc cggcgcacgc
121 cctcccgcgc ccctcttctc ggcgcgcgcg cagcatggcg cccccgcagg tcctcgcgtt
181 cgggcttctg cttgccgcgg cgacggcgac ttttgccgca gctcaggaag aatgtgtctg
241 tgaaaactac aagctggccg taaactgctt tgtgaataat aatcgtcaat gccagtgtac
301 ttcagttggt gcacaaaata ctgtcatttg ctcaaagctg gctgccaaat gtttggtgat
361 gaaggcagaa atgaatggct caaaacttgg gagaagagca aaacctgaag gggccctcca
421 gaacaatgat gggctttatg atcctgactg cgatgagagc gggctcttta aggccaagca
481 gtgcaacggc acctccacgt gctggtgtgt gaacactgct ggggtcagaa gaacagacaa
541 ggacactgaa ataacctgct ctgagcgagt gagaacctac tggatcatca ttgaactaaa
601 acacaaagca agagaaaaac cttatgatag taaaagtttg cggactgcac ttcagaagga
661 gatcacaacg cgttatcaac tggatccaaa atttatcacg agtattttgt atgagaataa
721 tgttatcact attgatctgg ttcaaaattc ttctcaaaaa actcagaatg atgtggacat
781 agctgatgtg gcttattatt ttgaaaaaga tgttaaaggt gaatccttgt ttcattctaa
841 gaaaatggac ctgacagtaa atggggaaca actggatctg gatcctggtc aaactttaat
901 ttattatgtt gatgaaaaag cacctgaatt ctcaatgcag ggtctaaaag ctggtgttat
961 tgctgttatt gtggttgtgg tgatggcagt tgttgctgga attgttgtgc tggttatttc
1021 cagaaagaag agaatggcaa agtatgagaa ggctgagata aaggagatgg gtgagatgca
1081 tagggaactc aatgcataac tatataattt gaagattata gaagaaggga aatagcaaat
1141 ggacacaaat tacaaatgtg tgtgcgtggg acgaagacat ctttgaaggt catgagtttg
1201 ttagtttaac atcatatatt tgtaatagtg aaacctgtac tcaaaatata agcagcttga
1261 aactggcttt accaatcttg aaatttgacc acaagtgtct tatatatgca gatctaatgt
1321 aaaatccaga acttggactc catcgttaaa attatttatg tgtaacattc aaatgtgtgc
1381 attaaatatg cttccacagt aaaatctgaa aaactgattt gtgattgaaa gctgcctttc
1441 tatttacttg agtcttgtac atacatactt ttttatgagc tatgaaataa aacattttaa
1501 actg
//