LOCUS X14346 2558 bp mRNA linear HUM 24-SEP-2008
DEFINITION Human mRNA for eosinophil peroxidase.
ACCESSION X14346
VERSION X14346.1
KEYWORDS eosinophil peroxidase; peroxidase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2558)
AUTHORS Rosa M.T.
JOURNAL Submitted (08-FEB-1989) to the INSDC. Rosa M.T., Mayo Clinic and
Foundation, 406 Guggenheim Building, Rochester, MN 55905.
REFERENCE 2 (bases 1 to 2558)
AUTHORS Ten R.M., Pease L.R., McKean D.J., Bell M.P., Gleich G.J.
TITLE Molecular cloning of a human eosinophil perioxidase
JOURNAL J. Exp. Med. 169(5), 1757-1769(1989).
PUBMED 2541222
COMMENT Data kindly reviewed (23-aug-1989) by Gleich G.J.
FEATURES Location/Qualifiers
source 1..2558
/db_xref="H-InvDB:HIT000321420"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="lambda ZAP"
/tissue_type="blood"
/db_xref="taxon:9606"
CDS <1..2109
/codon_start=1
/product="eosinophil preperoxidase (AA -127 to 575)"
/db_xref="GOA:P11678"
/db_xref="H-InvDB:HIT000321420.14"
/db_xref="HGNC:HGNC:3423"
/db_xref="InterPro:IPR010255"
/db_xref="InterPro:IPR019791"
/db_xref="InterPro:IPR029599"
/db_xref="InterPro:IPR037120"
/db_xref="UniProtKB/Swiss-Prot:P11678"
/protein_id="CAA32530.1"
/translation="EFRGQDPCQGTDPASPGAVETSVLRDCIAEAKLLVDAAYNWTQK
SIKQRLRSGSASPMDLLSYFKQPVAATRTVVRAADYMHVALGLLEEKLQPQRSGPFIV
TDVLTEPQLRLLSQASGCALRDQAERCSDKYRTITGRCNNKRRPLLGASNQALARWLP
AEYEDGLSLPFGWTPSRRRNGFLLPLVRAVSNQIVRFPNERLTSDRGRALMFMQWGQF
IDHDLDFSPESPARVAFTAGVDCERTCAQLPPCFPIKIPPNDPRIKNQRDCIPFFRSA
PSCPQNKNRVRNQINALTSFVDASMVYGSEVSLSLRLRNRTNYLGLLAINQRFQDNGR
ALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSTETPKLAAMHTLFMREHNRLATELRR
LNPRWNGDKLYNEARKIMGAMVQIITYRDFLPLVLGKARARRTLGHYRGYCSNVDPRV
ANVFTLAFRFGHTMLQPFMFRLDSQYRASAPNSHVPLSSAFFASWRIVYEGGIDPILR
GLMATPAKLNRQDAMLVDELRDRLFRQVRRIGLDLAALNMQRSRDHGLPGYNAWRRFC
GLSQPRNLAQLSRVLKNQDLARKFLNLYGTPDNIDIWIGAIAEPLLPGARVGPLLACL
FENQFRRAETETGSGGRTRCFHQRQRKALSRISLSRIICDNTGITTVSRDIFRANIYP
RGFVNCSRIPRLNLSAWRGT"
sig_peptide <1..381
/codon_start=1
/note="signal peptide (AA -127 to -1)"
mat_peptide 382..2106
/product="eosinophil peroxidase (AA 1 - 575)"
misc_feature 382..714
/note="light chain (AA 1 - 111)"
misc_feature 715..2106
/note="heavy chain (AA 112 - 575)"
regulatory 2538..2543
/note="pot. polyA signal"
/regulatory_class="polyA_signal_sequence"
BASE COUNT 527 a 820 c 698 g 513 t
ORIGIN
1 gaattccgtg gccaggaccc ctgccagggc actgacccag cctcccctgg ggcagtggag
61 acctcggtcc tgcgagactg catagcagag gccaagttgc tggtggatgc tgcctacaat
121 tggacccaga agagcatcaa gcagcggctt cgcagcggtt cagccagccc catggacctc
181 ctgtcctact tcaaacaacc ggtagcagcc accaggacag ttgttcgggc cgcagattat
241 atgcatgtgg ctttggggct gcttgaagag aagttacaac cccagcggtc cggacccttc
301 attgtcactg atgtgctaac agaaccacag ctgcggctgc tgtcccaggc cagtggctgt
361 gctctccggg accaggccga gcgctgcagc gacaagtacc gcaccatcac tggacggtgc
421 aacaacaaga ggagaccctt gctaggggcc tccaaccagg ctctggctcg ctggctgccc
481 gccgagtatg aggatgggct gtcgctcccc ttcggctgga cccccagcag gaggcgcaat
541 ggcttccttc tccctcttgt ccgggctgtc tccaaccaga ttgtgcgctt ccccaatgag
601 agactgacct ccgaccgtgg ccgagccctc atgttcatgc agtggggcca gttcattgac
661 catgacctgg acttctcccc ggagtccccg gccagagtgg ccttcactgc aggcgttgac
721 tgtgagagga cctgcgccca gctgcccccc tgctttccca tcaagatccc acccaatgac
781 ccccgcatca agaaccagcg tgactgcatc cctttcttcc gctcggcacc ctcatgcccc
841 caaaacaaga acagagtccg caaccagatc aacgcgctca cctcctttgt ggacgccagc
901 atggtgtatg gcagtgaggt ctccctctcg ctgcggctcc gcaaccggac caactacctg
961 gggctgctgg ccatcaacca gcgctttcaa gacaacggcc gggccctgct gcccttcgac
1021 aacctgcacg atgacccctg tctcctcacc aaccgctcgg cgcgcatccc ctgcttcctg
1081 gcaggtgaca cccgatcaac ggaaaccccc aaactggcag ccatgcacac cctctttatg
1141 cgagagcaca accggctggc caccgagctg agacgcctga atccccggtg gaatggagac
1201 aaactgtaca atgaggctcg gaagatcatg ggggccatgg tccagatcat cacctaccga
1261 gactttctgc ccctggttct gggcaaggcc cgggccagga gaaccctggg gcactacagg
1321 gggtactgct ccaatgtgga cccacgggtg gccaatgtct tcaccctggc cttccgcttt
1381 ggccacacaa tgctccagcc cttcatgttc cgcttggaca gtcagtaccg ggcctccgca
1441 cccaactcgc atgtcccact tagctctgcc ttctttgcca gctggcggat cgtgtatgaa
1501 gggggcatcg accccatcct ccggggcctc atggccaccc ctgccaagct gaaccgtcag
1561 gatgccatgt tagtggatga gctccgggac cggctgtttc ggcaagtgag gaggattggg
1621 ctggacctgg cagctctcaa catgcaacga agccgggacc acggccttcc agggtacaat
1681 gcttggaggc gcttctgtgg gctctcccag ccccggaatt tggcacagct tagccgggtg
1741 ctgaaaaacc aggacttggc aaggaagttc ctgaatttgt atggaacacc tgacaacatt
1801 gacatctgga ttggggccat cgctgagcct cttttgccgg gggctcgagt ggggcctctt
1861 ctggcttgtc tgttcgagaa ccagttcaga agagccgaga cggagacagg ttctggtggc
1921 agaacgaggt gttttcacca aagacagcgc aaggccctga gcagaatttc cttgtctcga
1981 attatatgtg acaataccgg tatcaccacg gtttcaaggg acatcttcag agccaacatc
2041 taccctcggg gctttgtgaa ctgcagccgt atccccaggt tgaacctatc agcctggcga
2101 gggacatgag gcttctgcag gagtctatcc caagtctcca acttttggag acaaggggaa
2161 ggggaggacc atgaggctgc cttgtctccc tggagcaagt gcaggctcgt gacgcttctg
2221 ctggctacag ctcagagctg ggttccccag ccaggagtga aggctggggg ctcctatcag
2281 caatggacct tccgccttgg gagcctctta ggtattaggc tatgaatcag cgccacgtgc
2341 aaaggcttgg gagccaagcc atgtggtctt gcaccccagg caagaaaagt cagctggagg
2401 gtttacagca ctttctactg tttcccagcc ctccctcccc tccctcacca tgactaagag
2461 accactcggt cctagcctcc agacacccca caatactcct ctgagcctga ggccaggcag
2521 catgctctgc ttctaccaat aaagcactgc cggaattc
//