LOCUS X14329 1702 bp mRNA linear HUM 07-OCT-2008
DEFINITION Human mRNA for carboxypeptidase N small subunit (EC 3.4.17.3).
ACCESSION X14329
VERSION X14329.1
KEYWORDS carboxypeptidase; metalloproteinase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1702)
AUTHORS Gebhard W., Schube M., Eulitz M.
TITLE cDNA cloning and complete primary structure of the small, active
subunit of human carboxypeptidase N (kininase 1)
JOURNAL Eur. J. Biochem. 178(3), 603-607(1989).
PUBMED 2912725
FEATURES Location/Qualifiers
source 1..1702
/db_xref="H-InvDB:HIT000321418"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="lambda gt11"
/db_xref="taxon:9606"
CDS 214..1590
/note="carboxypeptidase N precursor (AA -20 to 438)"
/db_xref="GOA:P15169"
/db_xref="H-InvDB:HIT000321418.12"
/db_xref="HGNC:HGNC:2312"
/db_xref="InterPro:IPR000834"
/db_xref="InterPro:IPR008969"
/db_xref="PDB:2NSM"
/db_xref="UniProtKB/Swiss-Prot:P15169"
/protein_id="CAA32507.1"
/translation="MSDLLSVFLHLLLLFKLVAPVTFRHHRYDDLVRTLYKVQNECPG
ITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVGNMHGNEALGRELMLQLSEF
LCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQGPNKPGYLVGRNNANGVDLN
RNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRAVIRWMHSFNFVLSANLHGG
AVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLAKVYSYAHGWMFQGWNCGDYFP
DGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCDKFPPEEELQREWLGNREALIQF
LEQVHQGIKGMVLDENYNNLANAVISVSGINHDVTSGDHGDYFRLLLPGIYTVSATAP
GYDPETVTVTVGPAEPTLVNFHLKRSIPQVSPVRRAPSRRHGVRAKVQPQARKKEMEM
RQLQRGPA"
sig_peptide 214..273
/note="signal peptide (AA -20 to -1)"
mat_peptide 274..1587
/note="mature carboxypeptidase N (AA 1-438)"
polyA_site 1702..1702
/note="polyA site"
BASE COUNT 422 a 452 c 461 g 367 t
ORIGIN
1 tgaaagggag tgagggagga gagatgagtg gctattccag aacgacataa agaatttcca
61 gccttggacg gacagctggg aacgtcttcc aatttggact ggtgtttaca agcgggaagc
121 taggtggacc ttggattttg gcgggtgaag aggctaggtt gtttaaggag gtggggcgcg
181 tttcagtggc tctctttgaa aaagcccagc aagatgtcag acctgctctc agtcttcctc
241 cacctcctcc ttctcttcaa gttggttgcc ccggtgacct ttcgccacca ccgctatgat
301 gatcttgtgc ggacgctgta caaggtgcaa aacgaatgcc ccggcatcac gcgggtctac
361 agcattgggc gcagcgtgga ggggagacac ctctacgtgc tggagttcag cgaccaccct
421 ggaatccacg agcccttgga accagaggtc aagtatgtgg ggaacatgca cggcaacgaa
481 gcgttgggcc gcgagctgat gctgcagctg tcggagtttc tgtgcgagga gttccggaac
541 aggaaccagc gcatcgtcca gctcatccag gacacgcgca ttcacatcct gccatccatg
601 aaccccgacg gctacgaggt ggctgctgcc cagggcccaa acaagcctgg gtatctagtt
661 ggcaggaaca atgcaaatgg agtggacctg aaccgcaact tccctgatct caatacctat
721 atctactata acgagaagta cggaggcccc aaccaccacc tgccccttcc agacaactgg
781 aaaagtcagg tggaacccga gacccgggcg gtgatccggt ggatgcactc cttcaacttt
841 gttctttcag ccaatctcca cggaggggcg gtggtggcca attacccgta tgacaagtcc
901 tttgagcacc gggtccgagg ggtccgccgc accgccagca cccccacgcc tgacgacaag
961 ctcttccaga agctggccaa ggtctactcc tatgcacatg gatggatgtt ccaaggttgg
1021 aactgcggag attacttccc agatggcatc accaatgggg cttcctggta ttctctcagc
1081 aagggaatgc aagactttaa ttatctccat accaactgct ttgagatcac gctggaactg
1141 agttgcgaca agtttccccc cgaagaggag ttacagcggg agtggctggg taatcgggaa
1201 gccctaatcc agttcctgga acaggttcac cagggcatca agggaatggt gcttgatgag
1261 aattacaata atctcgccaa tgctgtcatt tctgtcagtg ggattaacca tgatgtcact
1321 tcaggtgacc atggtgatta cttccggctg ctgcttccag gtatctacac tgttagtgcc
1381 acagcacctg ggtatgaccc agagacagta actgtgaccg tgggtcctgc ggaaccaacg
1441 ttggttaact tccacctcaa aagaagcatc cctcaagtaa gccctgtgag gagagctccc
1501 agcagaaggc acggagtcag agccaaagtg cagccccaag ccagaaagaa agaaatggag
1561 atgaggcagc tgcagagagg ccctgcctga aacccacagt gccaggcaac ccttcagaaa
1621 ggctttgctc ctgctctcag atcagatcaa gcattctttc tattttatta tctgggacat
1681 atttaaatac aaacatattc ag
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