LOCUS X13444 1411 bp mRNA linear HUM 31-MAR-1995
DEFINITION Human mRNA for CD8 beta-chain glycoprotein (CD8 beta.1).
ACCESSION X13444 M37601
VERSION X13444.1
KEYWORDS alternative splicing; CD8 beta-chain glycoprotein; CD8
glycoprotein; glycoprotein; transmembrane protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1411)
AUTHORS Norment A.M., Littman D.R.
TITLE A second subunit of CD8 is expressed in human T cells
JOURNAL EMBO J. 7(11), 3433-3439(1988).
PUBMED 3145195
FEATURES Location/Qualifiers
source 1..1411
/db_xref="H-InvDB:HIT000321370"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="lambda gt10"
/clone="CD8-beta.1"
/cell_type="T-cell"
/db_xref="taxon:9606"
CDS 51..683
/product="CD8beta.1 preprotein (AA -21 to 189)"
/db_xref="GOA:P10966"
/db_xref="H-InvDB:HIT000321370.12"
/db_xref="HGNC:HGNC:1707"
/db_xref="InterPro:IPR003599"
/db_xref="InterPro:IPR007110"
/db_xref="InterPro:IPR013106"
/db_xref="InterPro:IPR013783"
/db_xref="InterPro:IPR036179"
/db_xref="InterPro:IPR042414"
/db_xref="UniProtKB/Swiss-Prot:P10966"
/protein_id="CAA31795.1"
/translation="MRPRLWLLLAAQLTVLHGNSVLQQTPAYIKVQTNKMVMLSCEAK
ISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASRFILN
LTSVKPEDSGIYFCMIVGSPELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRP
ETQKGPLCSPITLGLLVAGVLVLLVSLGVAIHLCCRRRRARLRFMKQFYK"
sig_peptide 51..113
/note="signal peptide (AA -21 to -1)"
mat_peptide 114..680
/note="CD8beta.1 protein (AA 1 - 189)"
misc_feature 114..452
/note="immunoglobulin V-like domain"
misc_feature 354..362
/note="pot. N-linked glycosylation site"
misc_feature 453..542
/note="membrane proximal domain"
misc_feature 543..632
/note="transmembrane domain"
misc_feature 633..668
/note="cytoplasmic domain c1"
misc_feature 669..680
/note="cytoplasmic domain c2"
misc_feature 1406..1411
/note="pot. polyA signal"
BASE COUNT 289 a 380 c 391 g 351 t
ORIGIN
1 gcgactgtct ccgccgagcc cccggggcca ggtgtcccgg gcgcgccacg atgcggccgc
61 ggctgtggct cctcctggcc gcgcagctga cagttctcca tggcaactca gtcctccagc
121 agacccctgc atacataaag gtgcaaacca acaagatggt gatgctgtcc tgcgaggcta
181 aaatctccct cagtaacatg cgcatctact ggctgagaca gcgccaggca ccgagcagtg
241 acagtcacca cgagttcctg gccctctggg attccgcaaa agggactatc cacggtgaag
301 aggtggaaca ggagaagata gctgtgtttc gggatgcaag ccggttcatt ctcaatctca
361 caagcgtgaa gccggaagac agtggcatct acttctgcat gatcgtcggg agccccgagc
421 tgaccttcgg gaagggaact cagctgagtg tggttgattt ccttcccacc actgcccagc
481 ccaccaagaa gtccaccctc aagaagagag tgtgccggtt acccaggcca gagacccaga
541 agggcccact ttgtagcccc atcacccttg gcctgctggt ggctggcgtc ctggttctgc
601 tggtttccct gggagtggcc atccacctgt gctgccggcg gaggagagcc cggcttcgtt
661 tcatgaaaca attttacaaa taagcagaga atacggtttt ggtgtcctgc tacaaaaaga
721 catcggtcag taatgagcac gatgtggaaa aatgagagaa gggacacatt caaccctgga
781 gagttcaatg gctgctgaag ctgcctgctt ttcactgctg caaggccttt ctgtgtgtga
841 tgtgcatggg agcaacttgt tcgtgggtca tcgggaatac tagggagaag gtttcattgc
901 ccccagggca cttcacagag tgtgctggag gactgagtaa gaaatgctgc ccatgccacc
961 gcttccggct cctgtgcttt ccctgaactg ggacctttag tggtggccat ttagccacca
1021 tctttgcagg ttgctttgcc ctggtagggc agtaacattg ggtcctgggt ctttcatggg
1081 gtgatgctgg gctggctccc tcttggtctt cccaggctgg ggctgacctt cctcgcagag
1141 aggccaggtg caggttggga atgaggcttg ctgagagggg ctgtccagtt cccagaaggc
1201 atatcagtct ctgagggctt cctttggggc cgggaacttg cgggtttgag gataggagtt
1261 cacttcatct tctcagctcc catttctact cttaagtttc tccccatttc tactcttaag
1321 tttctcagct cccatttcta ctctcccatg gcttcatgct tctttcattt ttctgtttgt
1381 tttatacaaa tgtgttagtt gtacaaataa a
//