LOCUS       X12883                  1334 bp    mRNA    linear   HUM 18-APR-2005
DEFINITION  Human mRNA for cytokeratin 18.
ACCESSION   X12883 M26325
VERSION     X12883.1
KEYWORDS    cytokeratin; cytokeratin 18; intermediate filament.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1334)
  AUTHORS   Franke W.W.
  JOURNAL   Submitted (14-SEP-1988) to the INSDC. Franke W.W., Institute of
            Cell and Tumor Biology, German Cancer Research Center, Im
            Neuenheimer Feld 280, D-6900 Heidelberg, FRG.
REFERENCE   2  (bases 1 to 1334)
  AUTHORS   Leube R.E., Bosch F.X., Romano V., Zimbelmann R., Hofler H.,
            Franke W.W.
  TITLE     Cytokeratin expression in simple epithelia. III. Detection of mRNAs
            encoding human cytokeratins nos. 8 and 18 in normal and tumor cells
            by hybridization with cDNA sequences in vitro and in situ
  JOURNAL   Differentiation 33(1), 69-85(1986).
   PUBMED   2434381
FEATURES             Location/Qualifiers
     source          1..1334
                     /db_xref="H-InvDB:HIT000321331"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /clone_lib="lambda gt10"
                     /clone="pKH18"
                     /cell_line="A-431"
                     /cell_type="vulvar carcinoma cells"
                     /db_xref="taxon:9606"
     CDS             <1..1275
                     /codon_start=1
                     /product="cytokeratin 18 (424 AA)"
                     /db_xref="GOA:P05783"
                     /db_xref="H-InvDB:HIT000321331.12"
                     /db_xref="HGNC:HGNC:6430"
                     /db_xref="InterPro:IPR002957"
                     /db_xref="InterPro:IPR018039"
                     /db_xref="InterPro:IPR027695"
                     /db_xref="InterPro:IPR039008"
                     /db_xref="InterPro:IPR042180"
                     /db_xref="UniProtKB/Swiss-Prot:P05783"
                     /protein_id="CAA31377.1"
                     /translation="STFSTNYRSLGSVQAPSYGARPVSSAASVYAGAGGSGSRISVSR
                     STSFRGGMGSGGLATGIAGGLAGMGGIQNEKETMQSLNDRLASYLDRVRSLETENRRL
                     ESKIREHLEKKGPQVRDWSHYFKIIEDLRAQIFANTVDNARIVLQIDNARLAADDFRV
                     KYETELAMRQSVENDIHGLRKVIDDTNITRLQLETEIEALKEELLFMKKNHEEEVKGL
                     QAQIASSGLTVEVDAPKSQDLAKIMADIRAQYDELARKNREELDKYWSQQIEESTTVV
                     TTQSAEVGAAETTLTELRRTVQSLEIDLDSMRNLKASLENSLREVEARYALQMEQLNG
                     ILLHLESELAQTRAEGQRQAQEYEALLNIKVKLEAEIATYRRLLEDGEDFNLGDALDS
                     SNSMQTIQKTTTRRIVDGKVVSETNDTKVLRH"
     misc_feature    <1..1146
                     /note="alpha-helical domain"
     regulatory      1315..1320
                     /note="pot. polyA signal"
                     /regulatory_class="polyA_signal_sequence"
     polyA_site      1334..1334
                     /note="polyA site"
BASE COUNT          339 a          364 c          410 g          221 t
ORIGIN      
        1 tccaccttct ccaccaacta ccggtccctg ggctctgtcc aggcgcccag ctacggcgcc
       61 cggccggtca gcagcgcggc cagcgtctat gcaggcgctg ggggctctgg ttcccggatc
      121 tccgtgtccc gctccaccag cttcaggggc ggcatggggt ccgggggcct ggccaccggg
      181 atagccgggg gtctggcagg aatgggaggc atccagaacg agaaggagac catgcaaagc
      241 ctgaacgacc gcctggcctc ttacctggac agagtgagga gcctggagac cgagaaccgg
      301 aggctggaga gcaaaatccg ggagcacttg gagaagaagg gaccccaggt cagagactgg
      361 agccattact tcaagatcat cgaggacctg agggctcaga tcttcgcaaa tactgtggac
      421 aatgcccgca tcgttctgca gattgacaat gcccgtcttg ctgctgatga ctttagagtc
      481 aagtatgaga cagagctggc catgcgccag tctgtggaga acgacatcca tgggctccgc
      541 aaggtcattg atgacaccaa tatcacacga ctgcagctgg agacagagat cgaggctctc
      601 aaggaggagc tgctcttcat gaagaagaac cacgaagagg aagtaaaagg cctacaagcc
      661 cagattgcca gctctgggtt gaccgtggag gtagatgccc ccaaatctca ggacctcgcc
      721 aagatcatgg cagacatccg ggcccaatat gacgagctgg ctcggaagaa ccgagaggag
      781 ctagacaagt actggtctca gcagattgag gagagcacca cagtggtcac cacacagtct
      841 gctgaggttg gagctgctga gacgacgctc acagagctga gacgtacagt ccagtccttg
      901 gagatcgacc tggactccat gagaaatctg aaggccagct tggagaacag cctgagggag
      961 gtggaggccc gctacgccct acagatggag cagctcaacg ggatcctgct gcaccttgag
     1021 tcagagctgg cacagacccg ggcagaggga cagcgccagg cccaggagta tgaggccctg
     1081 ctgaacatca aggtcaagct ggaggctgag atcgccacct accgccgcct gctggaagat
     1141 ggcgaggact ttaatcttgg tgatgccttg gacagcagca actccatgca aaccatccaa
     1201 aagaccacca cccgccggat agtggatggc aaagtggtgt ctgagaccaa tgacaccaaa
     1261 gttctgaggc attaagccag cagaagcagg gtaccctttg gggagcagga ggccaataaa
     1321 aagttcagag ttca
//