LOCUS       X12830                  3319 bp    mRNA    linear   HUM 07-OCT-2008
DEFINITION  Human mRNA for interleukin-6 (IL-6) receptor.
ACCESSION   X12830 M20566
VERSION     X12830.1
KEYWORDS    BSF-2 receptor; glycoprotein; interferon beta II receptor;
            interleukin 6 receptor; receptor; transmembrane protein.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3319)
  AUTHORS   Hirano T.
  JOURNAL   Submitted (05-SEP-1988) to the INSDC. Hirano T., Division of
            Immunology, Institute for Molecular and Cellular Biology, Osaka
            University , 1-3 Yamada oka, Suita, Osaka 565, Japan.
REFERENCE   2  (bases 1 to 3319)
  AUTHORS   Yamasaki K., Taga T., Hirata Y., Yawata H., Kawanishi Y., Seed B.,
            Taniguchi T., Hirano T., Kishimoto T.
  TITLE     Cloning and expression of the human interleukin-6 (BSF-2/IFN beta
            2) receptor
  JOURNAL   Science, e1252229 241(4867), 825-828(1988).
   PUBMED   3136546
FEATURES             Location/Qualifiers
     source          1..3319
                     /db_xref="H-InvDB:HIT000321327"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /clone="pBSF2R.236"
                     /cell_line="YT"
                     /db_xref="taxon:9606"
     CDS             438..1844
                     /product="IL-6 receptor precursor (AA -19 to 449)"
                     /db_xref="GOA:P08887"
                     /db_xref="H-InvDB:HIT000321327.14"
                     /db_xref="HGNC:HGNC:6019"
                     /db_xref="InterPro:IPR003530"
                     /db_xref="InterPro:IPR003598"
                     /db_xref="InterPro:IPR003599"
                     /db_xref="InterPro:IPR003961"
                     /db_xref="InterPro:IPR007110"
                     /db_xref="InterPro:IPR013151"
                     /db_xref="InterPro:IPR013783"
                     /db_xref="InterPro:IPR015321"
                     /db_xref="InterPro:IPR036116"
                     /db_xref="InterPro:IPR036179"
                     /db_xref="PDB:1N26"
                     /db_xref="PDB:1N2Q"
                     /db_xref="PDB:1P9M"
                     /db_xref="PDB:2ARW"
                     /db_xref="PDB:5FUC"
                     /db_xref="UniProtKB/Swiss-Prot:P08887"
                     /protein_id="CAA31312.1"
                     /translation="MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVT
                     LTCPGVEPEDNATVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRP
                     AGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAED
                     FQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDP
                     PANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHH
                     CVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPMQAL
                     TTNKDDDNILFRDSANATSLPVQDSSSVPLPTFLVAGGSLAFGTLLCIAIVLRFKKTW
                     KLRALKEGKTSMHPPYSLGQLVPERPRPTPVLVPLISPPVSPSSLGSDNTSSHNRPDA
                     RDPRSPYDISNTDYFFPR"
     sig_peptide     438..494
                     /note="signal peptide (AA -19 to -1)"
     mat_peptide     495..1841
                     /note="IL-6 receptor (AA 1-449)"
     misc_feature    495..764
                     /note="Ig superfamily domain"
     misc_feature    600..608
                     /note="pot. N-linked glycosylation site"
     misc_feature    714..722
                     /note="pot. N-linked glycosylation site"
     misc_feature    1098..1106
                     /note="pot. N-linked glycosylation site"
     misc_feature    1170..1178
                     /note="pot. N-linked glycosylation site"
     misc_feature    1485..1493
                     /note="pot. N-linked glycosylation site"
     misc_feature    1512..1595
                     /note="transmembrane domain"
     misc_feature    1758..1766
                     /note="pot. N-linked glycosylation site"
     misc_feature    3134..3139
                     /note="pot. polyA signal"
     misc_feature    3159..3164
                     /note="pot.alt. polyA signal"
     polyA_site      3319..3319
                     /note="polyA site"
BASE COUNT          735 a          935 c          962 g          687 t
ORIGIN      
        1 ggcggtcccc tgttctcccc gctcaggtgc ggcgctgtgg caggaagcca ccccctcggt
       61 cggccggtgc gcggggctgt tgcgccatcc gctccggctt tcgtaaccgc accctgggac
      121 ggcccagaga cgctccagcg cgagttcctc aaatgttttc ctgcgttgcc aggaccgtcc
      181 gccgctctga gtcatgtgcg agtgggaagt cgcactgaca ctgagccggg ccagagggag
      241 aggagccgag cgcggcgcgg ggccgaggga ctcgcagtgt gtgtagagag ccgggctcct
      301 gcggatgggg gctgcccccg gggcctgagc ccgcctgccc gcccaccgcc ccgccccgcc
      361 cctgccaccc ctgccgcccg gttcccatta gcctgtccgc ctctgcggga ccatggagtg
      421 gtagccgagg aggaagcatg ctggccgtcg gctgcgcgct gctggctgcc ctgctggccg
      481 cgccgggagc ggcgctggcc ccaaggcgct gccctgcgca ggaggtggca agaggcgtgc
      541 tgaccagtct gccaggagac agcgtgactc tgacctgccc gggggtagag ccggaagaca
      601 atgccactgt tcactgggtg ctcaggaagc cggctgcagg ctcccacccc agcagatggg
      661 ctggcatggg aaggaggctg ctgctgaggt cggtgcagct ccacgactct ggaaactatt
      721 catgctaccg ggccggccgc ccagctggga ctgtgcactt gctggtggat gttccccccg
      781 aggagcccca gctctcctgc ttccggaaga gccccctcag caatgttgtt tgtgagtggg
      841 gtcctcggag caccccatcc ctgacgacaa aggctgtgct cttggtgagg aagtttcaga
      901 acagtccggc cgaagacttc caggagccgt gccagtattc ccaggagtcc cagaagttct
      961 cctgccagtt agcagtcccg gagggagaca gctctttcta catagtgtcc atgtgcgtcg
     1021 ccagtagtgt cgggagcaag ttcagcaaaa ctcaaacctt tcagggttgt ggaatcttgc
     1081 agcctgatcc gcctgccaac atcacagtca ctgccgtggc cagaaacccc cgctggctca
     1141 gtgtcacctg gcaagacccc cactcctgga actcatcttt ctacagacta cggtttgagc
     1201 tcagatatcg ggctgaacgg tcaaagacat tcacaacatg gatggtcaag gacctccagc
     1261 atcactgtgt catccacgac gcctggagcg gcctgaggca cgtggtgcag cttcgtgccc
     1321 aggaggagtt cgggcaaggc gagtggagcg agtggagccc ggaggccatg ggcacgcctt
     1381 ggacagaatc caggagtcct ccagctgaga acgaggtgtc cacccccatg caggcactta
     1441 ctactaataa agacgatgat aatattctct tcagagattc tgcaaatgcg acaagcctcc
     1501 cagtgcaaga ttcttcttca gtaccactgc ccacattcct ggttgctgga gggagcctgg
     1561 ccttcggaac gctcctctgc attgccattg ttctgaggtt caagaagacg tggaagctgc
     1621 gggctctgaa ggaaggcaag acaagcatgc atccgccgta ctctttgggg cagctggtcc
     1681 cggagaggcc tcgacccacc ccagtgcttg ttcctctcat ctccccaccg gtgtccccca
     1741 gcagcctggg gtctgacaat acctcgagcc acaaccgacc agatgccagg gacccacgga
     1801 gcccttatga catcagcaat acagactact tcttccccag atagctggct gggtggcacc
     1861 agcagcctgg accctgtgga tgacaaaaca caaacgggct cagcaaaaga tgcttctcac
     1921 tgccatgcca gcttatctca ggggtgtgcg gcctttggct tcacggaaga gccttgcgga
     1981 aggttctacg ccaggggaaa atcagcctgc tccagctgtt cagctggttg aggtttcaaa
     2041 cctccctttc caaatgccca gcttaaaggg gttagagtga acttgggcca ctgtgaagag
     2101 aaccatatca agactctttg gacactcaca cggacactca aaagctgggc aggttggtgg
     2161 gggcctcggt gtggagaagc ggctggcagc ccacccctca acacctctgc acaagctgca
     2221 ccctcaggca ggtgggatgg atttccagcc aaagcctcct ccagccgcca tgctcctggc
     2281 ccactgcatc gtttcatctt ccaactcaaa ctcttaaaac ccaagtgccc ttagcaaatt
     2341 ctgtttttct aggcctgggg acggctttta cttaaacgcc aaggcctggg ggaagaagct
     2401 ctctcctccc tttcttccct acagttcaaa aacagctgag ggtgagtggg tgaataatac
     2461 agtatgtcag ggcctggtcg ttttcaacag aattataatt agttcctcat tagcagtttt
     2521 gcctaaatgt gaatgatgat cctaggcatt tgctgaatac agaggcaact gcattggctt
     2581 tgggttgcag gacctcaggt gagaagcaga ggaaggagag gagaggggca cagggtctct
     2641 accatcccct gtagagtggg agctgagtgg gggatcacag cctctgaaaa ccaatgttct
     2701 ctcttctcca cctcccacaa aggagagcta gcagcaggga gggcttctgc catttctgag
     2761 atcaaaacgg ttttactgca gctttgtttg ttgtcagctg aacctgggta actagggaag
     2821 ataatattaa ggaagacaat gtgaaaagaa aaatgagcct ggcaagaatg cgtttaaact
     2881 tggtttttaa aaaactgctg actgttttct cttgagaggg tggaatatcc aatattcgct
     2941 gtgtcagcat agaagtaact tacttaggtg tgggggaagc accataactt tgtttagccc
     3001 aaaaccaagt caagtgaaaa aggaggaaga gaaaaaatat tttcctgcca ggcatggagg
     3061 cccacgcact tcgggaggtc gaggcaggag gatcacttga gtccagaagt ttgagatcag
     3121 cctgggcaat gtgataaaac cccatctcta caaaaagcat aaaaattagc caagtgtggt
     3181 agagtgtgcc tgaagtccca gatacttggg gggctgaggt gggaggatct cttgagcctg
     3241 ggaggtcaag gctgcagtga gccgagattg caccactgca ctccagcctg gggtgacaga
     3301 gcaagtgaga ccctgtctc
//