LOCUS       X12701                  1482 bp    mRNA    linear   HUM 31-MAR-1995
DEFINITION  H.sapiens mRNA for endothelial plasminogen activator inhibitor PAI.
ACCESSION   X12701
VERSION     X12701.1
KEYWORDS    plasminogen activator inhibitor; serine protease inhibitor.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1482)
  AUTHORS   Pannekoek H.
  JOURNAL   Unpublished.
COMMENT     Data kindly supplied by Derwents Biotechnology Abstracts:
            Patent (EP_0_260_757, 12.09.87_NL_8602307)
            Stichting Centraal Laboratorium van de Bloedtransfusiedienst van
            het Nederlandse Rode Kruis.
FEATURES             Location/Qualifiers
     source          1..1482
                     /db_xref="H-InvDB:HIT000321322"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /clone_lib="pUC9"
                     /clone="pPAI2350"
                     /db_xref="taxon:9606"
     CDS             127..1335
                     /product="PAI precursor polypeptide"
                     /db_xref="GOA:P05121"
                     /db_xref="H-InvDB:HIT000321322.14"
                     /db_xref="HGNC:HGNC:8583"
                     /db_xref="InterPro:IPR000215"
                     /db_xref="InterPro:IPR023795"
                     /db_xref="InterPro:IPR023796"
                     /db_xref="InterPro:IPR036186"
                     /db_xref="InterPro:IPR042178"
                     /db_xref="InterPro:IPR042185"
                     /db_xref="PDB:1A7C"
                     /db_xref="PDB:1B3K"
                     /db_xref="PDB:1C5G"
                     /db_xref="PDB:1DB2"
                     /db_xref="PDB:1DVM"
                     /db_xref="PDB:1DVN"
                     /db_xref="PDB:1LJ5"
                     /db_xref="PDB:1OC0"
                     /db_xref="PDB:3CVM"
                     /db_xref="PDB:3EOX"
                     /db_xref="PDB:3PB1"
                     /db_xref="PDB:3Q02"
                     /db_xref="PDB:3Q03"
                     /db_xref="PDB:3R4L"
                     /db_xref="PDB:3UT3"
                     /db_xref="PDB:4AQH"
                     /db_xref="PDB:4G8O"
                     /db_xref="PDB:4G8R"
                     /db_xref="PDB:4IC0"
                     /db_xref="PDB:5BRR"
                     /db_xref="PDB:5ZLZ"
                     /db_xref="PDB:6I8S"
                     /db_xref="PDB:9PAI"
                     /db_xref="UniProtKB/Swiss-Prot:P05121"
                     /protein_id="CAA31208.1"
                     /translation="MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQ
                     QVAQASKDANVVFSPYGVASVLAMLQLTTGVETQQQIQAAMGFKIDDKGMAPALRHLY
                     KELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFKLFRSTVKQVDFSEVERARFIIN
                     DWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGS
                     TVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNI
                     LSAHVMSHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSD
                     QEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGT
                     VLFMGQVMEP"
     sig_peptide     127..195
                     /note="signal peptide"
     mat_peptide     196..1332
                     /note="mat. PAI polypeptide"
BASE COUNT          361 a          443 c          386 g          292 t
ORIGIN      
        1 ggcagggcaa gagcgctgtc aagaagaccc acacgccccc ctccagcagc tgaattcctg
       61 cagctcagca gccgccgcca gagcaggacg aaccgccaat cgcaaggcac ctctgagaac
      121 ttcaggatgc agatgtctcc agccctcacc tgcctagtcc tgggcctggc ccttgtcttt
      181 ggtgaagggt ctgctgtgca ccatccccca tcctacgtgg cccacctggc ctcagacttc
      241 ggggtgaggg tgtttcagca ggtggcgcag gcctccaagg acgcgaacgt ggttttctca
      301 ccctatgggg tggcctcggt gttggccatg ctccagctga caacaggagt agaaacccag
      361 cagcagattc aagcagctat gggattcaag attgatgaca agggcatggc ccccgccctc
      421 cggcatctgt acaaggagct catggggcca tggaacaagg acgagatcag caccacagac
      481 gcgatcttcg tccagcggga tctgaagctg gtccagggct tcatgcccca cttcttcaag
      541 ctgttccgga gcacggtcaa gcaagtggac ttttcagagg tggagagagc cagattcatc
      601 atcaatgact gggtgaagac acacacaaaa ggtatgatca gcaacttgct tgggaaagga
      661 gccgtggacc agctgacacg gctggtgctg gtgaatgccc tctacttcaa cggccagtgg
      721 aagactccct tccccgactc cagcacccac cgccgcctct tccacaaatc agacggcagc
      781 actgtctctg tgcccatgat ggctcagacc aacaagttca actatactga gttcaccacg
      841 cccgatggcc attactacga catcctggaa ctgccctacc acggggacac cctcagcatg
      901 ttcattgctg ccccttatga aaaagaggtg cctctctctg ccctcaccaa cattctgagt
      961 gcccacgtca tgagccactg gaaaggcaac atgaccaggc tgccccgcct cctggttctg
     1021 cccaagttct ccctggagac tgaagtcgac ctcaggaagc ccctagagaa cctgggaatg
     1081 accgacatgt tcagacagtt tcaggctgac ttcacgagtc tttcagacca agagcctctc
     1141 cacgtcgcgc aggcgctgca gaaagtgaag atcgaggtga acgagagtgg cacggtggcc
     1201 tcctcatcca cagctgtcat agtctcagcc cgcatggccc ccgaggagat catcatggac
     1261 agacccttcc tctttgtggt ccggcacaac cccacaggaa cagtcctttt catgggccaa
     1321 gtgatggaac cctgaccctg gggaaagacg ccttcatctg ggacaaaact ggagatgcat
     1381 cgggaaagaa gaaactccga agaaaagaat tttagtgtta atgactcttt ctgaaggaag
     1441 agaagacatt tgccttttgt taaaagatgg taaaccagat ct
//