LOCUS       X12451                  1575 bp    mRNA    linear   HUM 07-OCT-2008
DEFINITION  Human mRNA for pro-cathepsin L (major excreted protein MEP).
ACCESSION   X12451
VERSION     X12451.1
KEYWORDS    cathepsin; cathepsin L; major excreted protein.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1575)
  AUTHORS   Gal S., Gottesman M.M.
  TITLE     Isolation and sequence of a cDNA for human pro-(cathepsin L)
  JOURNAL   Biochem. J. 253(1), 303-306(1988).
   PUBMED   3421948
COMMENT     Data kindly reviewed (25/4/89) by Gal S.
FEATURES             Location/Qualifiers
     source          1..1575
                     /db_xref="H-InvDB:HIT000321303"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /clone_lib="GM637 (Okayama-Berg expression library)"
                     /clone="pHu-16."
                     /cell_type="SV40-transformed fibroblasts"
                     /db_xref="taxon:9606"
     mRNA            <1..1575
                     /note="cathepsin L mRNA"
     CDS             289..1290
                     /product="pro-(cathepsin L)"
                     /db_xref="GOA:P07711"
                     /db_xref="H-InvDB:HIT000321303.14"
                     /db_xref="HGNC:HGNC:2537"
                     /db_xref="InterPro:IPR000169"
                     /db_xref="InterPro:IPR000668"
                     /db_xref="InterPro:IPR013201"
                     /db_xref="InterPro:IPR025660"
                     /db_xref="InterPro:IPR025661"
                     /db_xref="InterPro:IPR038765"
                     /db_xref="InterPro:IPR039417"
                     /db_xref="PDB:1CJL"
                     /db_xref="PDB:1CS8"
                     /db_xref="PDB:1ICF"
                     /db_xref="PDB:1MHW"
                     /db_xref="PDB:2NQD"
                     /db_xref="PDB:2VHS"
                     /db_xref="PDB:2XU1"
                     /db_xref="PDB:2XU3"
                     /db_xref="PDB:2XU4"
                     /db_xref="PDB:2XU5"
                     /db_xref="PDB:2YJ2"
                     /db_xref="PDB:2YJ8"
                     /db_xref="PDB:2YJ9"
                     /db_xref="PDB:2YJB"
                     /db_xref="PDB:2YJC"
                     /db_xref="PDB:3BC3"
                     /db_xref="PDB:3H89"
                     /db_xref="PDB:3H8B"
                     /db_xref="PDB:3H8C"
                     /db_xref="PDB:3HHA"
                     /db_xref="PDB:3HWN"
                     /db_xref="PDB:3IV2"
                     /db_xref="PDB:3K24"
                     /db_xref="PDB:3KSE"
                     /db_xref="PDB:3OF8"
                     /db_xref="PDB:3OF9"
                     /db_xref="PDB:4AXL"
                     /db_xref="PDB:4AXM"
                     /db_xref="PDB:5F02"
                     /db_xref="PDB:5I4H"
                     /db_xref="PDB:5MAE"
                     /db_xref="PDB:5MAJ"
                     /db_xref="PDB:5MQY"
                     /db_xref="PDB:6EZP"
                     /db_xref="PDB:6EZX"
                     /db_xref="PDB:6F06"
                     /db_xref="UniProtKB/Swiss-Prot:P07711"
                     /protein_id="CAA30981.1"
                     /translation="MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNE
                     EGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRK
                     GKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLIS
                     LSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYS
                     VANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDH
                     GVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV"
     sig_peptide     289..339
                     /note="signal peptide (AA -17 to -1)"
     mat_peptide     340..1287
                     /note="mat. cathepsin L (AA 1-316)"
     misc_feature    1554..1559
                     /note="pot. polyA signal"
     polyA_site      1575..1575
                     /note="polyA site"
BASE COUNT          419 a          322 c          455 g          379 t
ORIGIN      
        1 agaaccgcga cctccgcaac cttgagcggc atccgtggag tgcgcctgca gctacgaccg
       61 cagcaggaaa gcgccgccgg ccaggcccag ctgtggccgg acagggactg gaagagagga
      121 cgcggtcgag taggtgtgca ccagccctgg caacgagagc gtctaccccg aactctgctg
      181 gccttgaggt ggggaagccg gggagggcag ttgaggaccc cgcggaggcg cgtgactggt
      241 tgagcgggca ggccagcctc cgagccgggt ggacacaggt tttaaaacat gaatcctaca
      301 ctcatccttg ctgccttttg cctgggaatt gcctcagcta ctctaacatt tgatcacagt
      361 ttagaggcac agtggaccaa gtggaaggcg atgcacaaca gattatacgg catgaatgaa
      421 gaaggatgga ggagagcagt gtgggagaag aacatgaaga tgattgaact gcacaatcag
      481 gaatacaggg aagggaaaca cagcttcaca atggccatga acgcctttgg agacatgacc
      541 agtgaagaat tcaggcaggt gatgaatggc tttcaaaacc gtaagcccag gaaggggaaa
      601 gtgttccagg aacctctgtt ttatgaggcc cccagatctg tggattggag agagaaaggc
      661 tacgtgactc ctgtgaagaa tcagggtcag tgtggttctt gttgggcttt tagtgctact
      721 ggtgctcttg aaggacagat gttccggaaa actgggaggc ttatctcact gagtgagcag
      781 aatctggtag actgctctgg gcctcaaggc aatgaaggct gcaatggtgg cctaatggat
      841 tatgctttcc agtatgttca ggataatgga ggcctggact ctgaggaatc ctatccatat
      901 gaggcaacag aagaatcctg taagtacaat cccaagtatt ctgttgctaa tgacaccggc
      961 tttgtggaca tccctaagca ggagaaggcc ctgatgaagg cagttgcaac tgtggggccc
     1021 atttctgttg ctattgatgc aggtcatgag tccttcctgt tctataaaga aggcatttat
     1081 tttgagccag actgtagcag tgaagacatg gatcatggtg tgctggtggt tggctacgga
     1141 tttgaaagca cagaatcaga taacaataaa tattggctgg tgaagaacag ctggggtgaa
     1201 gaatggggca tgggtggcta cgtaaagatg gccaaagacc ggagaaacca ttgtggaatt
     1261 gcctcagcag ccagctaccc cactgtgtga gctggtggac ggtgatgagg aaggacttga
     1321 ctggggatgg cgcatgcatg ggaggaattc atcttcagtc taccagcccc cgctgtgtcg
     1381 gatacacact cgaatcattg aagatccgag tgtgatttga attctgtgat attttcacac
     1441 tggtaaatgt tacctctatt ttaattactg ctataaatag gtttatatta ttgattcact
     1501 tactgacttt gcattttcgt ttttaaaagg atgtataaat ttttacctgt ttaaataaaa
     1561 tttaatttca aatgt
//