LOCUS X07166 3181 bp mRNA linear HUM 12-SEP-1993
DEFINITION Human mRNA for enkephalinase (EC 3.4.24.11).
ACCESSION X07166
VERSION X07166.1
KEYWORDS enkephalinase; metalloprotein; neutral endopeptidase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3181)
AUTHORS Malfroy B., Kuang W.J., Seeburg P.H., Mason A.J., Schofield P.R.
TITLE Molecular cloning and amino acid sequence of human enkephalinase
(neutral endopeptidase)
JOURNAL FEBS Lett. 229(1), 206-210(1988).
PUBMED 3162217
FEATURES Location/Qualifiers
source 1..3181
/db_xref="H-InvDB:HIT000321242"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="lambda gt10"
/clone="lambda H7"
/tissue_type="placenta"
/db_xref="taxon:9606"
CDS 18..2249
/note="enkephalinase (AA 1-743)"
/db_xref="GOA:P08473"
/db_xref="H-InvDB:HIT000321242.13"
/db_xref="HGNC:HGNC:7154"
/db_xref="InterPro:IPR000718"
/db_xref="InterPro:IPR008753"
/db_xref="InterPro:IPR018497"
/db_xref="InterPro:IPR024079"
/db_xref="InterPro:IPR029727"
/db_xref="InterPro:IPR042089"
/db_xref="PDB:1DL9"
/db_xref="PDB:1DMT"
/db_xref="PDB:1QVD"
/db_xref="PDB:1R1H"
/db_xref="PDB:1R1I"
/db_xref="PDB:1R1J"
/db_xref="PDB:1Y8J"
/db_xref="PDB:2QPJ"
/db_xref="PDB:2YB9"
/db_xref="PDB:4CTH"
/db_xref="PDB:5JMY"
/db_xref="PDB:6GID"
/db_xref="UniProtKB/Swiss-Prot:P08473"
/protein_id="CAA30157.1"
/translation="MDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYAT
YDDGICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDI
LRDELEVVLKDVLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGW
PVATENWEQKYGASWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLG
LPSRDYYECTGIYKEACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEI
ANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNE
EDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALY
GTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDD
LTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNL
KFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSL
NYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQSQCMVYQYGNFSW
DLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPGLDLNHKQLFFLN
FAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKC
RVW"
misc_feature 3073..3078
/note="poly A signal"
BASE COUNT 1055 a 582 c 657 g 887 t
ORIGIN
1 gcaagtcaga aagtcagatg gatataactg atatcaacac tccaaagcca aagaagaaac
61 agcgatggac tccactggag atcagcctct cggtccttgt cctgctcctc accatcatag
121 ctgtgacaat gatcgcactc tatgcaacct acgatgatgg tatttgcaag tcatcagact
181 gcataaaatc agctgctcga ctgatccaaa acatggatgc caccactgag ccttgtacag
241 actttttcaa atatgcttgc ggaggctggt tgaaacgtaa tgtcattccc gagaccagct
301 cccgttacgg caactttgac attttaagag atgaactaga agtcgttttg aaagatgtcc
361 ttcaagaacc caaaactgaa gatatagtag cagtgcagaa agcaaaagca ttgtacaggt
421 cttgtataaa tgaatctgct attgatagca gaggtggaga acctctactc aaactgttac
481 cagacatata tgggtggcca gtagcaacag aaaactggga gcaaaaatat ggtgcttctt
541 ggacagctga aaaagctatt gcacaactga attctaaata tgggaaaaaa gtccttatta
601 atttgtttgt tggcactgat gataagaatt ctgtgaatca tgtaattcat attgaccaac
661 ctcgacttgg cctcccttct agagattact atgaatgcac tggaatctat aaagaggctt
721 gtacagcata tgtggatttt atgatttctg tggccagatt gattcgtcag gaagaaagat
781 tgcccatcga tgaaaaccag cttgctttgg aaatgaataa agttatggaa ttggaaaaag
841 aaattgccaa tgctacggct aaacctgaag atcgaaatga tccaatgctt ctgtataaca
901 agatgacatt ggcccagatc caaaataact tttcactaga gatcaatggg aagccattca
961 gctggttgaa tttcacaaat gaaatcatgt caactgtgaa tattagtatt acaaatgagg
1021 aagatgtggt tgtttatgct ccagaatatt taaccaaact taagcccatt cttaccaaat
1081 attctgccag agatcttcaa aatttaatgt cctggagatt cataatggat cttgtaagca
1141 gcctcagccg aacctacaag gagtccagaa atgctttccg caaggccctt tatggtacaa
1201 cctcagaaac agcaacttgg agacgttgtg caaactatgt caatgggaat atggaaaatg
1261 ctgtggggag gctttatgtg gaagcagcat ttgctggaga gagtaaacat gtggtcgagg
1321 atttgattgc acagatccga gaagttttta ttcagacttt agatgacctc acttggatgg
1381 atgccgagac aaaaaagaga gctgaagaaa aggccttagc aattaaagaa aggatcggct
1441 atcctgatga cattgtttca aatgataaca aactgaataa tgagtacctc gagttgaact
1501 acaaagaaga tgaatacttc gagaacataa ttcaaaattt gaaattcagc caaagtaaac
1561 aactgaagaa gctccgagaa aaggtggaca aagatgagtg gataagtgga gcagctgtag
1621 tcaatgcatt ttactcttca ggaagaaatc agatagtctt cccagccggc attctgcagc
1681 cccccttctt tagtgcccag cagtccaact cattgaacta tgggggcatc ggcatggtca
1741 taggacacga aatcacccat ggcttcgatg acaatggcag aaactttaac aaagatggag
1801 acctcgttga ctggtggact caacagtctg caagtaactt taaggagcaa tcccagtgca
1861 tggtgtatca gtatggaaac ttttcctggg acctggcagg tggacagcac cttaatggaa
1921 ttaatacact gggagaaaac attgctgata atggaggtct tggtcaagca tacagagcct
1981 atcagaatta tattaaaaag aatggcgaag aaaaattact tcctggactt gacctaaatc
2041 acaaacaact atttttcttg aactttgcac aggtgtggtg tggaacctat aggccagagt
2101 atgcggttaa ctccattaaa acagatgtgc acagtccagg caatttcagg attattggga
2161 ctttgcagaa ctctgcagag ttttcagaag cctttcactg ccgcaagaat tcatacatga
2221 atccagaaaa gaagtgccgg gtttggtgat cttcaaaaga agcattgcag cccttggcta
2281 gacttgccaa caccacagaa atggggaatt ctctaatcga aagaaaatgg gccctagggg
2341 tcactgtact gacttgaggg tgattaacag agagggcacc atcacaatac agataacatt
2401 aggttgtcct agaaagggtg tggagggagg aagggggtct aaggtctatc aagtcaatca
2461 tttctcactg tgtacataat gcttaatttc taaagataat attactgttt atttctgttt
2521 ctcatatggt ctaccagttt gctgatgtcc ctagaaaaca atgcaaaacc tttgaggtag
2581 accaggattt ctaatcaaaa gggaaaagaa gatgttgaag aatacagtta ggcaccagaa
2641 gaacagtagg tgacactata gtttaaaaca cattgcctaa ctactagttt ttacttttat
2701 ttgcaacatt tacagtcctt caaaatcctt ccaaagaatt cttatacaca ttggggcctt
2761 ggagcttaca tagttttaaa ctcatttttg ccatacatca gttattcatt ctgtgatcat
2821 ttattttaag cactcttaaa gcaaaaaatg aatgtctaaa attgtttttt gttgtacctg
2881 ctttgactga tgctgagatt cttcaggctt cctgcaattt tctaagcaat ttcttgctct
2941 atctctcaaa acttggtatt tttcagagat ttatataaat gtaaaaataa taatttttat
3001 atttaattat taactacatt tatgagtaac tattattata ggtaatcaat gaatattgaa
3061 gtttcagctt aaaataaaca gttgtgaacc aagatctata aagcgatata cagatgaaaa
3121 tttgagacta tttaaactta taaatcatat tgatgaaaag atttaagcac aaactttagg
3181 g
//