LOCUS X06831 2129 bp mRNA linear HUM 13-JUL-1995
DEFINITION Human mRNA fragment for platelet glycoprotein IIb ( GPIIB ).
ACCESSION X06831
VERSION X06831.1
KEYWORDS calcium binding protein; glycoprotein; membrane adhesive protein;
platelet membrane glycoprotein; platelet receptor; transmembrane
protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2129)
AUTHORS Uzan G., Frachet P., Lajmanovich A., Prandini M.H., Denarier E.,
Duperray A., Loftus J., Ginsberg M., Plow E., Marguerie G.
TITLE cDNA clones for human platelet GPIIb corresponding to mRNA from
megakaryocytes and HEL cells. Evidence for an extensive homology to
other Arg-Gly-Asp adhesion receptors
JOURNAL Eur. J. Biochem. 171(1-2), 87-93(1988).
PUBMED 3422188
COMMENT see also J02764 for GPIIB mRNA
FEATURES Location/Qualifiers
source 1..2129
/db_xref="H-InvDB:HIT000321223"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="gt11"
/clone="lambdaIIb1"
/cell_line="HEL"
/cell_type="megakaryocyte"
/db_xref="taxon:9606"
CDS <1..1947
/codon_start=1
/product="platelet glycoprotein IIb (648 AA)"
/db_xref="GOA:P08514"
/db_xref="H-InvDB:HIT000321223.12"
/db_xref="HGNC:HGNC:6138"
/db_xref="InterPro:IPR000413"
/db_xref="InterPro:IPR013517"
/db_xref="InterPro:IPR013519"
/db_xref="InterPro:IPR013649"
/db_xref="InterPro:IPR018184"
/db_xref="InterPro:IPR028994"
/db_xref="InterPro:IPR032695"
/db_xref="PDB:1DPK"
/db_xref="PDB:1DPQ"
/db_xref="PDB:1JX5"
/db_xref="PDB:1KUP"
/db_xref="PDB:1KUZ"
/db_xref="PDB:1M8O"
/db_xref="PDB:1RN0"
/db_xref="PDB:1S4W"
/db_xref="PDB:1TYE"
/db_xref="PDB:1UV9"
/db_xref="PDB:2K1A"
/db_xref="PDB:2K9J"
/db_xref="PDB:2KNC"
/db_xref="PDB:2MTP"
/db_xref="PDB:2N9Y"
/db_xref="PDB:2VC2"
/db_xref="PDB:2VDK"
/db_xref="PDB:2VDL"
/db_xref="PDB:2VDM"
/db_xref="PDB:2VDN"
/db_xref="PDB:2VDO"
/db_xref="PDB:2VDP"
/db_xref="PDB:2VDQ"
/db_xref="PDB:2VDR"
/db_xref="PDB:3FCS"
/db_xref="PDB:3FCU"
/db_xref="PDB:3NID"
/db_xref="PDB:3NIF"
/db_xref="PDB:3NIG"
/db_xref="PDB:3T3M"
/db_xref="PDB:3T3P"
/db_xref="PDB:3ZDX"
/db_xref="PDB:3ZDY"
/db_xref="PDB:3ZDZ"
/db_xref="PDB:3ZE0"
/db_xref="PDB:3ZE1"
/db_xref="PDB:3ZE2"
/db_xref="PDB:4CAK"
/db_xref="PDB:4Z7N"
/db_xref="PDB:4Z7O"
/db_xref="PDB:4Z7Q"
/db_xref="PDB:5HDB"
/db_xref="UniProtKB/Swiss-Prot:P08514"
/protein_id="CAA29987.1"
/translation="APLGDLDRDGYNDIAVAAPYGGPSGRGQVLVFLGQSEGLRSRPS
QVLDSPFPTGSAFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRAQPVVKASVQLLV
QDSLNPAVKSCVLPQTKTPVSCFNIQMCVGATGHNIPQKLSLNAELQLDRQKPRQGRR
VLLLGSQQAGTTLNVDLGGKHSPICHTTMAFLRDEADFRDKLSPIVLSLNVSLPPTEA
GMAPAVVLHGDTHVQEQTRIVLDCGEDDVCVPQLQLTASVTGSPLLVGADNVLELQMD
AANEGEGAYEAELAVHLPQGAHYMRALSNVEGFERLICNQKKENETRVVLCELGNPMK
KNAEIGIAMLVSVGNLEEAGESVSFQLQIRSKNSQNPNSKIVLLDVPVRAEAQVELRG
NSFPASLVVAAEEGEREQNSLDSWGPKVEHTYELHNNGPGTVNGLHLSIHLPGQSQPS
DLLYILDIQPQGGLQCFPQPPVNPLKVDWGLPIPSPSPIHPAHHKRDRRQIFLPEPEQ
PSRLQDPVLVSCDSAPCTVVQCDLQEMARGQRAMVTVLAFLWLPSLYQRPLDQFVLQS
HAWFNVSSLPYAVPPLSLPRGEAQVWTQLLRALEERAIPIWWVLVGVLGGLLLLTILV
LAMWKVGFFKRNRPPLEEDDEEGE"
misc_feature <1..1533
/note="heavy chain of platelet glycoprotein IIb"
misc_feature 13..48
/note="calcium binding site"
misc_feature 196..231
/note="calcium binding site"
misc_feature 628..636
/note="pot. N-linked glycosylation site"
misc_feature 958..966
/note="pot. N-linked glycosylation site"
misc_feature 1534..1944
/note="light chein of platelet glycoprotein IIb"
misc_feature 1711..1719
/note="pot. N-linked glycosylation site"
misc_feature 1807..1884
/note="transmembrane domain"
polyA_site 2129..2129
/note="polyA site"
BASE COUNT 417 a 646 c 656 g 410 t
ORIGIN
1 gcacccctgg gcgacctcga ccgggatggc tacaatgaca ttgcagtggc tgccccctac
61 gggggtccca gtggccgggg ccaagtgctg gtgttcctgg gtcagagtga ggggctgagg
121 tcacgtccct cccaggtcct ggacagcccc ttccccacag gctctgcctt tggcttctcc
181 cttcgaggtg ccgtagacat cgatgacaac ggatacccag acctgatcgt gggagcttac
241 ggggccaacc aggtggctgt gtacagagct cagccagtgg tgaaggcctc tgtccagcta
301 ctggtgcaag attcactgaa tcctgctgtg aagagctgtg tcctacctca gaccaagaca
361 cccgtgagct gcttcaacat ccagatgtgt gttggagcca ctgggcacaa cattcctcag
421 aagctatccc taaatgccga gctgcagctg gaccggcaga agccccgcca gggccggcgg
481 gtgctgctgc tgggctctca acaggcaggc accaccctga acgtggatct gggcggaaag
541 cacagcccca tctgccacac caccatggcc ttccttcgag atgaggcaga cttccgggac
601 aagctgagcc ccattgtgct cagcctcaat gtgtccctac cgcccacgga ggctggaatg
661 gcccctgctg tcgtgctgca tggagacacc catgtgcagg agcagacacg aatcgtcctg
721 gactgtgggg aagatgacgt atgtgtgccc cagcttcagc tcactgccag cgtgacgggc
781 tccccgctcc tagttggggc agataatgtc ctggagctgc agatggacgc agccaacgag
841 ggcgaggggg cctatgaagc agagctggcc gtgcacctgc cccagggcgc ccactacatg
901 cgggccctaa gcaatgtcga gggctttgag agactcatct gtaatcagaa gaaggagaat
961 gagaccaggg tggtgctgtg tgagctgggc aaccccatga agaagaacgc cgagatagga
1021 atcgcgatgt tggtgagcgt ggggaatctg gaagaggctg gggagtctgt gtccttccag
1081 ctgcagatac ggagcaagaa cagccagaat ccaaacagca agattgtgct gctggacgtg
1141 ccggtccggg cagaggccca agtggagctg cgagggaact cctttccagc ctccctggtg
1201 gtggcagcag aagaaggtga gagggagcag aacagcttgg acagctgggg acccaaagtg
1261 gagcacacct atgagctcca caacaatggc cctgggactg tgaatggtct tcacctcagc
1321 atccaccttc cgggacagtc ccagccctcc gacctgctct acatcctgga tatacagccc
1381 caggggggcc ttcagtgctt cccacagcct cctgtcaacc ctctcaaggt ggactggggg
1441 ctgcccatcc ccagcccctc ccccattcac ccggcccatc acaagcggga tcgcagacag
1501 atcttcctgc cagagcccga gcagccctcg aggcttcagg atccagttct cgtaagctgc
1561 gactcggcgc cctgtactgt ggtgcagtgt gacctgcagg agatggcgcg cgggcagcgg
1621 gccatggtca cggtgctggc cttcctgtgg ctgcccagcc tctaccagag gcctctggat
1681 cagtttgtgc tgcagtcgca cgcatggttc aacgtgtcct ccctccccta tgcggtgccc
1741 ccgctcagcc tgccccgagg ggaagctcag gtgtggacac agctgctccg ggccttggag
1801 gagagggcca ttccaatctg gtgggtgctg gtgggtgtgc tgggtggcct gctgctgctc
1861 accatcctgg tcctggccat gtggaaggtt ggcttcttca agcggaaccg gccacccctg
1921 gaagaagatg atgaagaggg ggagtgatgg tgcagcctac actattctag caggagggtt
1981 gggcgtgcta cctgcaccgc cccttctcca acaagttgcc tccaagcttt gggttggagc
2041 tgttccattg ggtcctcttg gtgtcgtttc cctcccaaca gagctgggct accccccctc
2101 ctgctgccta ataaagagac tgagccctg
//