LOCUS       X06537                  1447 bp    mRNA    linear   HUM 26-SEP-1999
DEFINITION  Human mRNA for lecithin:cholesterol acyltransferase (LCAT); EC
            2.3.1.43.
ACCESSION   X06537
VERSION     X06537.1
KEYWORDS    phosphatidylcholine-sterol acyltransferase.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1447)
  AUTHORS   Tata F., Chaves M.E., Markham A.F., Scrace G.D., Waterfield M.D.,
            McIntyre N., Williamson R., Humphries S.E.
  TITLE     The isolation and characterisation of cDNA and genomic clones for
            human lecithin: cholesterol acyltransferase
  JOURNAL   Biochim. Biophys. Acta 910(2), 142-148(1987).
   PUBMED   2823898
COMMENT     Data kindly reviewed (2-Feb-1989) by Humprhies S.E.
            
            no in-frame 'atg'-codon found,may be due to a cloning artefact!
            see also M12625 for human LCAT cDNA
FEATURES             Location/Qualifiers
     source          1..1447
                     /db_xref="H-InvDB:HIT000321191"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /clone_lib="human liver cDNA"
                     /clone="pLCAT2"
                     /db_xref="taxon:9606"
     CDS             <151..1426
                     /codon_start=2
                     /gene="LCAT"
                     /standard_name="phosphatidylcholine-sterol
                     O-acyltransferase"
                     /product="lectin cholesterol acyltransferase"
                     /EC_number="2.3.1.43"
                     /db_xref="GOA:P04180"
                     /db_xref="H-InvDB:HIT000321191.14"
                     /db_xref="HGNC:HGNC:6522"
                     /db_xref="InterPro:IPR003386"
                     /db_xref="InterPro:IPR029058"
                     /db_xref="PDB:4X96"
                     /db_xref="PDB:4XWG"
                     /db_xref="PDB:4XX1"
                     /db_xref="PDB:5BV7"
                     /db_xref="PDB:5TXF"
                     /db_xref="PDB:6MVD"
                     /db_xref="UniProtKB/Swiss-Prot:P04180"
                     /protein_id="CAB56610.1"
                     /translation="LLLPPAAPFWLLNVLFPPHTTPKAELSNHTRPVILVPGCLGNQL
                     EAKLDKPDVVNWMCYRKTEDFFTIWLDLNMFLPLGVDCWIDNTRVVYNRSSGLVSNAP
                     GVQIRVPGFGKTYSVEYLDSSKLAGYLHTLVQNLVNNGYVRDETVRAAPYDWRLEPGQ
                     QEEYYRKLAGLVEEMHAAYGKPVFLIGHSLGCLHLLYFLLRQPQAWKDRFIDGFISLG
                     APWGGSIKPMLVLASGDNQGIPHMSSIKLKEEQRITTTSPWMFPSRMAWPEDHVFIST
                     PSFNYTGRDFQRFFADLHFEEGWYMWLQSRDLLAGLPAPGVEVYCLYGVGLPTPRTYI
                     YDHGFPYTDPVGVLYEDGDDTVATRSTELCGLWQGRQPQPVHLLPLHGIQHLNMVFSN
                     LTLEHINAILLGAYRQGPPASPTASPEPPPPE"
     mat_peptide     176..1423
                     /gene="LCAT"
                     /product="lectin cholesterol acyltransferase"
     regulatory      1422..1427
                     /regulatory_class="polyA_signal_sequence"
BASE COUNT          275 a          484 c          378 g          310 t
ORIGIN      
        1 catagtaact ggttgctctt cctattggtc atagataaat gacacctgca caattctccg
       61 agtgctttaa gcaacttcgg gaggcgtgac taagaccctt tccttgctcc cagcttccta
      121 tgtcccaggg ctgcctgtgg cacctggact gctgctgctc cctcctgccg cccccttctg
      181 gctcctcaat gtgctcttcc ccccgcacac cacgcccaag gctgagctca gtaaccacac
      241 acggcccgtc atcctcgtgc ccggctgcct ggggaatcag ctagaagcca agctggacaa
      301 accagatgtg gtgaactgga tgtgctaccg caagacagag gacttcttca ccatctggct
      361 ggatctcaac atgttcctac cccttggggt agactgctgg atcgataaca ccagggttgt
      421 ctacaaccgg agctctgggc tcgtgtccaa cgcccctggt gtccagatcc gcgtccctgg
      481 ctttggcaag acctactctg tggagtacct ggacagcagc aagctggcag ggtacctgca
      541 cacactggtg cagaacctgg tcaacaatgg ctacgtgcgg gacgagactg tgcgcgccgc
      601 cccctatgac tggcggctgg agcccggcca gcaggaggag tactaccgca agctcgcagg
      661 gctggtggag gagatgcacg ctgcctatgg gaagcctgtc ttcctcattg gccacagcct
      721 cggctgtcta cacttgctct atttcctgct gcgccagccc caggcctgga aggaccgctt
      781 tattgatggc ttcatctctc ttggggctcc ctggggtggc tccatcaagc ccatgctggt
      841 cttggcctca ggtgacaacc agggcatccc ccatatgtcc agcatcaagc tgaaagagga
      901 gcagcgcata accaccacct ccccctggat gtttccctct cgcatggcgt ggcctgagga
      961 ccacgtgttc atttccacac ccagcttcaa ctacacaggc cgtgacttcc aacgcttctt
     1021 tgcagacctg cactttgagg aaggctggta catgtggctg cagtcacgtg acctcctggc
     1081 aggactccca gcacctggtg tggaagtata ctgtctttac ggcgtgggcc tgcccacgcc
     1141 ccgcacctac atctacgacc acggcttccc ctacacggac cctgtgggtg tgctctatga
     1201 ggatggtgat gacacggtgg cgacccgcag caccgagctc tgtggcctgt ggcagggccg
     1261 ccagccacag cctgtgcacc tgctgcccct gcacgggata cagcatctca acatggtctt
     1321 cagcaacctg accctggagc acatcaatgc catcctgctg ggtgcctacc gccagggtcc
     1381 ccctgcatcc ccgactgcca gcccagagcc cccgcctcct gaataaagac cttcctttgc
     1441 taccgta
//