LOCUS X06537 1447 bp mRNA linear HUM 26-SEP-1999 DEFINITION Human mRNA for lecithin:cholesterol acyltransferase (LCAT); EC 2.3.1.43. ACCESSION X06537 VERSION X06537.1 KEYWORDS phosphatidylcholine-sterol acyltransferase. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1447) AUTHORS Tata F., Chaves M.E., Markham A.F., Scrace G.D., Waterfield M.D., McIntyre N., Williamson R., Humphries S.E. TITLE The isolation and characterisation of cDNA and genomic clones for human lecithin: cholesterol acyltransferase JOURNAL Biochim. Biophys. Acta 910(2), 142-148(1987). PUBMED 2823898 COMMENT Data kindly reviewed (2-Feb-1989) by Humprhies S.E. no in-frame 'atg'-codon found,may be due to a cloning artefact! see also M12625 for human LCAT cDNA FEATURES Location/Qualifiers source 1..1447 /db_xref="H-InvDB:HIT000321191" /organism="Homo sapiens" /mol_type="mRNA" /clone_lib="human liver cDNA" /clone="pLCAT2" /db_xref="taxon:9606" CDS <151..1426 /codon_start=2 /gene="LCAT" /standard_name="phosphatidylcholine-sterol O-acyltransferase" /product="lectin cholesterol acyltransferase" /EC_number="2.3.1.43" /db_xref="GOA:P04180" /db_xref="H-InvDB:HIT000321191.14" /db_xref="HGNC:HGNC:6522" /db_xref="InterPro:IPR003386" /db_xref="InterPro:IPR029058" /db_xref="PDB:4X96" /db_xref="PDB:4XWG" /db_xref="PDB:4XX1" /db_xref="PDB:5BV7" /db_xref="PDB:5TXF" /db_xref="PDB:6MVD" /db_xref="UniProtKB/Swiss-Prot:P04180" /protein_id="CAB56610.1" /translation="LLLPPAAPFWLLNVLFPPHTTPKAELSNHTRPVILVPGCLGNQL EAKLDKPDVVNWMCYRKTEDFFTIWLDLNMFLPLGVDCWIDNTRVVYNRSSGLVSNAP GVQIRVPGFGKTYSVEYLDSSKLAGYLHTLVQNLVNNGYVRDETVRAAPYDWRLEPGQ QEEYYRKLAGLVEEMHAAYGKPVFLIGHSLGCLHLLYFLLRQPQAWKDRFIDGFISLG APWGGSIKPMLVLASGDNQGIPHMSSIKLKEEQRITTTSPWMFPSRMAWPEDHVFIST PSFNYTGRDFQRFFADLHFEEGWYMWLQSRDLLAGLPAPGVEVYCLYGVGLPTPRTYI YDHGFPYTDPVGVLYEDGDDTVATRSTELCGLWQGRQPQPVHLLPLHGIQHLNMVFSN LTLEHINAILLGAYRQGPPASPTASPEPPPPE" mat_peptide 176..1423 /gene="LCAT" /product="lectin cholesterol acyltransferase" regulatory 1422..1427 /regulatory_class="polyA_signal_sequence" BASE COUNT 275 a 484 c 378 g 310 t ORIGIN 1 catagtaact ggttgctctt cctattggtc atagataaat gacacctgca caattctccg 61 agtgctttaa gcaacttcgg gaggcgtgac taagaccctt tccttgctcc cagcttccta 121 tgtcccaggg ctgcctgtgg cacctggact gctgctgctc cctcctgccg cccccttctg 181 gctcctcaat gtgctcttcc ccccgcacac cacgcccaag gctgagctca gtaaccacac 241 acggcccgtc atcctcgtgc ccggctgcct ggggaatcag ctagaagcca agctggacaa 301 accagatgtg gtgaactgga tgtgctaccg caagacagag gacttcttca ccatctggct 361 ggatctcaac atgttcctac cccttggggt agactgctgg atcgataaca ccagggttgt 421 ctacaaccgg agctctgggc tcgtgtccaa cgcccctggt gtccagatcc gcgtccctgg 481 ctttggcaag acctactctg tggagtacct ggacagcagc aagctggcag ggtacctgca 541 cacactggtg cagaacctgg tcaacaatgg ctacgtgcgg gacgagactg tgcgcgccgc 601 cccctatgac tggcggctgg agcccggcca gcaggaggag tactaccgca agctcgcagg 661 gctggtggag gagatgcacg ctgcctatgg gaagcctgtc ttcctcattg gccacagcct 721 cggctgtcta cacttgctct atttcctgct gcgccagccc caggcctgga aggaccgctt 781 tattgatggc ttcatctctc ttggggctcc ctggggtggc tccatcaagc ccatgctggt 841 cttggcctca ggtgacaacc agggcatccc ccatatgtcc agcatcaagc tgaaagagga 901 gcagcgcata accaccacct ccccctggat gtttccctct cgcatggcgt ggcctgagga 961 ccacgtgttc atttccacac ccagcttcaa ctacacaggc cgtgacttcc aacgcttctt 1021 tgcagacctg cactttgagg aaggctggta catgtggctg cagtcacgtg acctcctggc 1081 aggactccca gcacctggtg tggaagtata ctgtctttac ggcgtgggcc tgcccacgcc 1141 ccgcacctac atctacgacc acggcttccc ctacacggac cctgtgggtg tgctctatga 1201 ggatggtgat gacacggtgg cgacccgcag caccgagctc tgtggcctgt ggcagggccg 1261 ccagccacag cctgtgcacc tgctgcccct gcacgggata cagcatctca acatggtctt 1321 cagcaacctg accctggagc acatcaatgc catcctgctg ggtgcctacc gccagggtcc 1381 ccctgcatcc ccgactgcca gcccagagcc cccgcctcct gaataaagac cttcctttgc 1441 taccgta //