LOCUS X06418 1365 bp mRNA linear HUM 10-FEB-1999
DEFINITION Human bcr-abl mRNA of acute lymphocytic leukaemia (ALL) patients.
ACCESSION X06418
VERSION X06418.1
KEYWORDS abl oncogene; bcr gene; fused gene; protein kinase; rearranged DNA;
translocation.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1365)
AUTHORS Fainstein E., Marcelle C., Rosner A., Canaani E., Gale R.P.,
Dreazen O., Smith S.D., Croce C.M.
TITLE A new fused transcript in Philadelphia chromosome positive acute
lymphocytic leukaemia
JOURNAL Nature 330(6146), 386-388(1987).
PUBMED 2825022
COMMENT first exon of bcr is linked to second abl exon
FEATURES Location/Qualifiers
source 1..1365
/db_xref="H-InvDB:HIT000321188"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="lambda gt10"
/clone="lambda 7"
/db_xref="taxon:9606"
CDS 209..>1365
/note="bcr-abl protein ( 385 AA) (1365 is 2nd base in
codon)"
/db_xref="GOA:Q13746"
/db_xref="H-InvDB:HIT000321188.14"
/db_xref="InterPro:IPR015123"
/db_xref="InterPro:IPR037769"
/db_xref="UniProtKB/TrEMBL:Q13746"
/protein_id="CAA29726.1"
/translation="MIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEPRASASRPQP
APADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSN
FERIRKGHGQPGADAEKPFYVNVEFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKS
QHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPPWPP
LEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPD
CSSNENLTSSEEDFSSGQSSRVSPSPTTYRMFRDKSRSPSQNSQQSFDSSSPPTPQCH
KRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDAEALQRPVASDFQPQG"
misc_feature 1322..1323
/note="bcr/abl recombination site"
BASE COUNT 249 a 483 c 463 g 170 t
ORIGIN
1 gccccgcgcg cagcccggcg gcgcaggtaa ggccggccgc gccatggtgg acccggtggg
61 cttcgcggag gcgtggaagg cgcagttccc ggactcagag cccccgcgca tggagctgcg
121 ctcagtgggc gacatcgagc aggagctgga gcgctgcaag gcctccattc ggcgcctgga
181 gcaggaggtg aactaggagc gcttccgcat gatctacctg cagacgttgc tggccaagga
241 aaagaagagc tatgaccggc agcgatgggg cttccggcgc gcggcgcagg cccccgacgg
301 cgcctccgag ccccgagcgt ccgcgtcgcg cccgcagcca gcgcccgccg acggagccga
361 cccgccgccc gccgaggagc ccgaggcccg gcccgacggc gagggttctc cgggtaaggc
421 caggcccggg accgcccgca ggcccggggc agccgcgtcg ggggaacggg acgaccgggg
481 accccccgcc agcgtggcgg cgctcaggtc caacttcgag cggatccgca agggccatgg
541 ccagcccggg gcggacgccg agaagccctt ctacgtgaac gtcgagtttc accacgagcg
601 cggcctggtg aaggtcaacg acaaagaggt gtcggaccgc atcagctccc tgggcagcca
661 ggccatgcag atggagcgca aaaagtccca gcacggcgcg ggctcgagcg tgggggatgc
721 atccaggccc ccttaccggg gacgctcctc ggagagcagc tgcggcgtcg acggcgacta
781 cgaggacgcc gagttgaacc cccgcttcct gaaggacaac ctgatcgacg ccaatggcgg
841 tagcaggccc ccttggccgc ccctggagta ccagccctac cagagcatct acgtcggggg
901 catgatggaa ggggagggca agggcccgct cctgcgcagc cagagcacct ctgagcagga
961 gaagcgcctt acctggcccc gcaggtccta ctccccccgg agttttgagg attgcggagg
1021 cggctatacc ccggactgca gctccaatga gaacctcacc tccagcgagg aggacttctc
1081 ctctggccag tccagccgcg tgtccccaag ccccaccacc taccgcatgt tccgggacaa
1141 aagccgctct ccctcgcaga actcgcaaca gtccttcgac agcagcagtc cccccacgcc
1201 gcagtgccat aagcggcacc ggcactgccc ggttgtcgtg tccgaggcca ccatcgtggg
1261 cgtccgcaag accgggcaga tctggcccaa cgatggcgag ggcgccttcc atggagacgc
1321 agaagccctt cagcggccag tagcatctga ctttcagcct caggg
//