LOCUS       X06290                 13938 bp    mRNA    linear   HUM 30-MAR-1995
DEFINITION  Human mRNA for apolipoprotein(a).
ACCESSION   X06290 M17399 X06696
VERSION     X06290.1
KEYWORDS    apolipoprotein; apolipoprotein A; glycoprotein; lipoprotein;
            plasminogen; serine protease.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13938)
  AUTHORS   McLean J.W.
  JOURNAL   Submitted (23-NOV-1987) to the INSDC. McLean J.W., Genentech Inc,
            460 Point San Bruno Blvd, So. San Francisco CA 94080.
REFERENCE   2  (bases 1 to 13938)
  AUTHORS   McLean J.W., Tomlinson J.E., Kuang W.J., Eaton D.L., Chen E.Y.,
            Fless G.M., Scanu A.M., Lawn R.M.
  TITLE     cDNA sequence of human apolipoprotein(a) is homologous to
            plasminogen
  JOURNAL   Nature 330(6144), 132-137(1987).
   PUBMED   3670400
FEATURES             Location/Qualifiers
     source          1..13938
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /clone_lib="lambda gt10, lambda ZAP"
                     /tissue_type="liver"
                     /db_xref="taxon:9606"
     CDS             46..13692
                     /note="apolipopreprotein (a) (AA -19 to 4529)"
                     /db_xref="GOA:P08519"
                     /db_xref="HGNC:HGNC:6667"
                     /db_xref="InterPro:IPR000001"
                     /db_xref="InterPro:IPR001254"
                     /db_xref="InterPro:IPR001314"
                     /db_xref="InterPro:IPR009003"
                     /db_xref="InterPro:IPR013806"
                     /db_xref="InterPro:IPR018056"
                     /db_xref="InterPro:IPR018114"
                     /db_xref="InterPro:IPR033116"
                     /db_xref="InterPro:IPR038178"
                     /db_xref="PDB:1I71"
                     /db_xref="PDB:1JFN"
                     /db_xref="PDB:1KIV"
                     /db_xref="PDB:2FEB"
                     /db_xref="PDB:3KIV"
                     /db_xref="PDB:4BV5"
                     /db_xref="PDB:4BV7"
                     /db_xref="PDB:4BVC"
                     /db_xref="PDB:4BVD"
                     /db_xref="PDB:4BVV"
                     /db_xref="PDB:4BVW"
                     /db_xref="PDB:4KIV"
                     /db_xref="UniProtKB/Swiss-Prot:P08519"
                     /protein_id="CAA29618.1"
                     /translation="MEHKEVVLLLLLFLKSAAPEQSHVVQDCYHGDGQSYRGTYSTTV
                     TGRTCQAWSSMTPHQHNRTTENYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNL
                     TQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTG
                     RTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQ
                     CSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRT
                     CQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCS
                     DAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQ
                     AWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDA
                     EGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAW
                     SSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEG
                     TAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSS
                     MTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTA
                     VAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMT
                     PHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVA
                     PPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPH
                     SHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPP
                     TVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSH
                     SRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTV
                     TPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSR
                     TPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTP
                     VPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTP
                     EYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVP
                     SLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEY
                     YPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSL
                     EAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYP
                     NAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEA
                     PSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNA
                     GLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPS
                     EQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGL
                     IMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQ
                     APTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIM
                     NYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAP
                     TEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNY
                     CRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTE
                     QRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCR
                     NPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQR
                     PGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNP
                     DAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPG
                     VQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDA
                     VAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQ
                     ECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVA
                     APYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQEC
                     YHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAP
                     YCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYH
                     GNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYC
                     YTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGN
                     GQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYT
                     RDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQ
                     SYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRD
                     PGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSY
                     RGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPG
                     VRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRG
                     TYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVR
                     WEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTY
                     STTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWE
                     YCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYST
                     TVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYC
                     NLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTV
                     TGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDPVAAPYCYTRDPSVRWEYCNL
                     TQCSDAEGTAVAPPTITPIPSLEAPSEQAPTEQRPGVQECYHGNGQSYQGTYFITVTG
                     RTCQAWSSMTPHSHSRTPAYYPNAGLIKNYCRNPDPVAAPWCYTTDPSVRWEYCNLTR
                     CSDAEWTAFVPPNVILAPSLEAFFEQALTEETPGVQDCYYHYGQSYRGTYSTTVTGRT
                     CQAWSSMTPHQHSRTPENYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTQCL
                     VTESSVLATLTVVPDPSTEASSEEAPTEQSPGVQDCYHGDGQSYRGSFSTTVTGRTCQ
                     SWSSMTPHWHQRTTEYYPNGGLTRNYCRNPDAEISPWCYTMDPNVRWEYCNLTQCPVT
                     ESSVLATSTAVSEQAPTEQSPTVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWH
                     QRTTEYYPNGGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTQCPVMESTLLTTPTV
                     VPVPSTELPSEEAPTENSTGVQDCYRGDGQSYRGTLSTTITGRTCQSWSSMTPHWHRR
                     IPLYYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTRCPVTESSVLTTPTVAP
                     VPSTEAPSEQAPPEKSPVVQDCYHGDGRSYRGISSTTVTGRTCQSWSSMIPHWHQRTP
                     ENYPNAGLTENYCRNPDSGKQPWCYTTDPCVRWEYCNLTQCSETESGVLETPTVVPVP
                     SMEAHSEAAPTEQTPVVRQCYHGNGQSYRGTFSTTVTGRTCQSWSSMTPHRHQRTPEN
                     YPNDGLTMNYCRNPDADTGPWCFTMDPSIRWEYCNLTRCSDTEGTVVAPPTVIQVPSL
                     GPPSEQDCMFGNGKGYRGKKATTVTGTPCQEWAAQEPHRHSTFIPGTNKWAGLEKNYC
                     RNPDGDINGPWCYTMNPRKLFDYCDIPLCASSSFDCGKPQVEPKKCPGSIVGGCVAHP
                     HSWPWQVSLRTRFGKHFCGGTLISPEWVLTAAHCLKKSSRPSSYKVILGAHQEVNLES
                     HVQEIEVSRLFLEPTQADIALLKLSRPAVITDKVMPACLPSPDYMVTARTECYITGWG
                     ETQGTFGTGLLKEAQLLVIENEVCNHYKYICAEHLARGTDSCQGDSGGPLVCFEKDKY
                     ILQGVTSWGLGCARPNKPGVYARVSRFVTWIEGMMRNN"
     sig_peptide     46..102
                     /note="signal peptide (AA -19 to -)"
     mat_peptide     103..13689
                     /note="apolipoprotein (a) (AA 1- 4529)"
     repeat_region   436..7959
                     /note="direct repeat region A (22x)"
     repeat_region   7960..8301
                     /note="direct repeat B"
     repeat_region   8302..8985
                     /note="direct repeat region A (2x)"
     repeat_region   8986..10011
                     /note="direct repeat region B (3x)"
     misc_feature    13911..13916
                     /note="polyA signal"
     polyA_site      13938..13938
                     /note="polyA site"
BASE COUNT         3613 a         3889 c         3560 g         2876 t
ORIGIN      
        1 ctgggattgg gacacacttt ctggacactg ctggccagtc ccaaaatgga acataaggaa
       61 gtggttcttc tacttctttt atttctgaaa tcagcagcac ctgagcaaag ccatgtggtc
      121 caggattgct accatggtga tggacagagt tatcgaggca cgtactccac cactgtcaca
      181 ggaaggacct gccaagcttg gtcatctatg acaccacatc aacataatag gaccacagaa
      241 aactacccaa atgctggctt gatcatgaac tactgcagga atccagatgc tgtggcagct
      301 ccttattgtt atacgaggga tcccggtgtc aggtgggagt actgcaacct gacgcaatgc
      361 tcagacgcag aagggactgc cgtcgcgcct ccgactgtta ccccggttcc aagcctagag
      421 gctccttccg aacaagcacc gactgagcaa aggcctgggg tgcaggagtg ctaccatggt
      481 aatggacaga gttatcgagg cacatactcc accactgtca caggaagaac ctgccaagct
      541 tggtcatcta tgacaccaca ctcgcatagt cggaccccag aatactaccc aaatgctggc
      601 ttgatcatga actactgcag gaatccagat gctgtggcag ctccttattg ttatacgagg
      661 gatcccggtg tcaggtggga gtactgcaac ctgacgcaat gctcagacgc agaagggact
      721 gccgtcgcgc ctccgactgt taccccggtt ccaagcctag aggctccttc cgaacaagca
      781 ccgactgagc aaaggcctgg ggtgcaggag tgctaccatg gtaatggaca gagttatcga
      841 ggcacatact ccaccactgt cacaggaaga acctgccaag cttggtcatc tatgacacca
      901 cactcgcata gtcggacccc agaatactac ccaaatgctg gcttgatcat gaactactgc
      961 aggaatccag atgctgtggc agctccttat tgttatacga gggatcccgg tgtcaggtgg
     1021 gagtactgca acctgacgca atgctcagac gcagaaggga ctgccgtcgc gcctccgact
     1081 gttaccccgg ttccaagcct agaggctcct tccgaacaag caccgactga gcaaaggcct
     1141 ggggtgcagg agtgctacca tggtaatgga cagagttatc gaggcacata ctccaccact
     1201 gtcacaggaa gaacctgcca agcttggtca tctatgacac cacactcgca tagtcggacc
     1261 ccagaatact acccaaatgc tggcttgatc atgaactact gcaggaatcc agatgctgtg
     1321 gcagctcctt attgttatac gagggatccc ggtgtcaggt gggagtactg caacctgacg
     1381 caatgctcag acgcagaagg gactgccgtc gcgcctccga ctgttacccc ggttccaagc
     1441 ctagaggctc cttccgaaca agcaccgact gagcaaaggc ctggggtgca ggagtgctac
     1501 catggtaatg gacagagtta tcgaggcaca tactccacca ctgtcacagg aagaacctgc
     1561 caagcttggt catctatgac accacactcg catagtcgga ccccagaata ctacccaaat
     1621 gctggcttga tcatgaacta ctgcaggaat ccagatgctg tggcagctcc ttattgttat
     1681 acgagggatc ccggtgtcag gtgggagtac tgcaacctga cgcaatgctc agacgcagaa
     1741 gggactgccg tcgcgcctcc gactgttacc ccggttccaa gcctagaggc tccttccgaa
     1801 caagcaccga ctgagcaaag gcctggggtg caggagtgct accatggtaa tggacagagt
     1861 tatcgaggca catactccac cactgtcaca ggaagaacct gccaagcttg gtcatctatg
     1921 acaccacact cgcatagtcg gaccccagaa tactacccaa atgctggctt gatcatgaac
     1981 tactgcagga atccagatgc tgtggcagct ccttattgtt atacgaggga tcccggtgtc
     2041 aggtgggagt actgcaacct gacgcaatgc tcagacgcag aagggactgc cgtcgcgcct
     2101 ccgactgtta ccccggttcc aagcctagag gctccttccg aacaagcacc gactgagcaa
     2161 aggcctgggg tgcaggagtg ctaccatggt aatggacaga gttatcgagg cacatactcc
     2221 accactgtca caggaagaac ctgccaagct tggtcatcta tgacaccaca ctcgcatagt
     2281 cggaccccag aatactaccc aaatgctggc ttgatcatga actactgcag gaatccagat
     2341 gctgtggcag ctccttattg ttatacgagg gatcccggtg tcaggtggga gtactgcaac
     2401 ctgacgcaat gctcagacgc agaagggact gccgtcgcgc ctccgactgt taccccggtt
     2461 ccaagcctag aggctccttc cgaacaagca ccgactgagc aaaggcctgg ggtgcaggag
     2521 tgctaccatg gtaatggaca gagttatcga ggcacatact ccaccactgt cacaggaaga
     2581 acctgccaag cttggtcatc tatgacacca cactcgcata gtcggacccc agaatactac
     2641 ccaaatgctg gcttgatcat gaactactgc aggaatccag atgctgtggc agctccttat
     2701 tgttatacga gggatcccgg tgtcaggtgg gagtactgca acctgacgca atgctcagac
     2761 gcagaaggga ctgccgtcgc gcctccgact gttaccccgg ttccaagcct agaggctcct
     2821 tccgaacaag caccgactga gcaaaggcct ggggtgcagg agtgctacca tggtaatgga
     2881 cagagttatc gaggcacata ctccaccact gtcacaggaa gaacctgcca agcttggtca
     2941 tctatgacac cacactcgca tagtcggacc ccagaatact acccaaatgc tggcttgatc
     3001 atgaactact gcaggaatcc agatgctgtg gcagctcctt attgttatac gagggatccc
     3061 ggtgtcaggt gggagtactg caacctgacg caatgctcag acgcagaagg gactgccgtc
     3121 gcgcctccga ctgttacccc ggttccaagc ctagaggctc cttccgaaca agcaccgact
     3181 gagcaaaggc ctggggtgca ggagtgctac catggtaatg gacagagtta tcgaggcaca
     3241 tactccacca ctgtcacagg aagaacctgc caagcttggt catctatgac accacactcg
     3301 catagtcgga ccccagaata ctacccaaat gctggcttga tcatgaacta ctgcaggaat
     3361 ccagatgctg tggcagctcc ttattgttat acgagggatc ccggtgtcag gtgggagtac
     3421 tgcaacctga cgcaatgctc agacgcagaa gggactgccg tcgcgcctcc gactgttacc
     3481 ccggttccaa gcctagaggc tccttccgaa caagcaccga ctgagcaaag gcctggggtg
     3541 caggagtgct accatggtaa tggacagagt tatcgaggca catactccac cactgtcaca
     3601 ggaagaacct gccaagcttg gtcatctatg acaccacact cgcatagtcg gaccccagaa
     3661 tactacccaa atgctggctt gatcatgaac tactgcagga atccagatgc tgtggcagct
     3721 ccttattgtt atacgaggga tcccggtgtc aggtgggagt actgcaacct gacgcaatgc
     3781 tcagacgcag aagggactgc cgtcgcgcct ccgactgtta ccccggttcc aagcctagag
     3841 gctccttccg aacaagcacc gactgagcaa aggcctgggg tgcaggagtg ctaccatggt
     3901 aatggacaga gttatcgagg cacatactcc accactgtca caggaagaac ctgccaagct
     3961 tggtcatcta tgacaccaca ctcgcatagt cggaccccag aatactaccc aaatgctggc
     4021 ttgatcatga actactgcag gaatccagat gctgtggcag ctccttattg ttatacgagg
     4081 gatcccggtg tcaggtggga gtactgcaac ctgacgcaat gctcagacgc agaagggact
     4141 gccgtcgcgc ctccgactgt taccccggtt ccaagcctag aggctccttc cgaacaagca
     4201 ccgactgagc aaaggcctgg ggtgcaggag tgctaccatg gtaatggaca gagttatcga
     4261 ggcacatact ccaccactgt cacaggaaga acctgccaag cttggtcatc tatgacacca
     4321 cactcgcata gtcggacccc agaatactac ccaaatgctg gcttgatcat gaactactgc
     4381 aggaatccag atgctgtggc agctccttat tgttatacga gggatcccgg tgtcaggtgg
     4441 gagtactgca acctgacgca atgctcagac gcagaaggga ctgccgtcgc gcctccgact
     4501 gttaccccgg ttccaagcct agaggctcct tccgaacaag caccgactga gcaaaggcct
     4561 ggggtgcagg agtgctacca tggtaatgga cagagttatc gaggcacata ctccaccact
     4621 gtcacaggaa gaacctgcca agcttggtca tctatgacac cacactcgca tagtcggacc
     4681 ccagaatact acccaaatgc tggcttgatc atgaactact gcaggaatcc agatgctgtg
     4741 gcagctcctt attgttatac gagggatccc ggtgtcaggt gggagtactg caacctgacg
     4801 caatgctcag acgcagaagg gactgccgtc gcgcctccga ctgttacccc ggttccaagc
     4861 ctagaggctc cttccgaaca agcaccgact gagcaaaggc ctggggtgca ggagtgctac
     4921 catggtaatg gacagagtta tcgaggcaca tactccacca ctgtcacagg aagaacctgc
     4981 caagcttggt catctatgac accacactcg catagtcgga ccccagaata ctacccaaat
     5041 gctggcttga tcatgaacta ctgcaggaat ccagatgctg tggcagctcc ttattgttat
     5101 acgagggatc ccggtgtcag gtgggagtac tgcaacctga cgcaatgctc agacgcagaa
     5161 gggactgccg tcgcgcctcc gactgttacc ccggttccaa gcctagaggc tccttccgaa
     5221 caagcaccga ctgagcaaag gcctggggtg caggagtgct accatggtaa tggacagagt
     5281 tatcgaggca catactccac cactgtcaca ggaagaacct gccaagcttg gtcatctatg
     5341 acaccacact cgcatagtcg gaccccagaa tactacccaa atgctggctt gatcatgaac
     5401 tactgcagga atccagatgc tgtggcagct ccttattgtt atacgaggga tcccggtgtc
     5461 aggtgggagt actgcaacct gacgcaatgc tcagacgcag aagggactgc cgtcgcgcct
     5521 ccgactgtta ccccggttcc aagcctagag gctccttccg aacaagcacc gactgagcaa
     5581 aggcctgggg tgcaggagtg ctaccatggt aatggacaga gttatcgagg cacatactcc
     5641 accactgtca caggaagaac ctgccaagct tggtcatcta tgacaccaca ctcgcatagt
     5701 cggaccccag aatactaccc aaatgctggc ttgatcatga actactgcag gaatccagat
     5761 gctgtggcag ctccttattg ttatacgagg gatcccggtg tcaggtggga gtactgcaac
     5821 ctgacgcaat gctcagacgc agaagggact gccgtcgcgc ctccgactgt taccccggtt
     5881 ccaagcctag aggctccttc cgaacaagca ccgactgagc aaaggcctgg ggtgcaggag
     5941 tgctaccatg gtaatggaca gagttatcga ggcacatact ccaccactgt cacaggaaga
     6001 acctgccaag cttggtcatc tatgacacca cactcgcata gtcggacccc agaatactac
     6061 ccaaatgctg gcttgatcat gaactactgc aggaatccag atgctgtggc agctccttat
     6121 tgttatacga gggatcccgg tgtcaggtgg gagtactgca acctgacgca atgctcagac
     6181 gcagaaggga ctgccgtcgc gcctccgact gttaccccgg ttccaagcct agaggctcct
     6241 tccgaacaag caccgactga gcaaaggcct ggggtgcagg agtgctacca tggtaatgga
     6301 cagagttatc gaggcacata ctccaccact gtcacaggaa gaacctgcca agcttggtca
     6361 tctatgacac cacactcgca tagtcggacc ccagaatact acccaaatgc tggcttgatc
     6421 atgaactact gcaggaatcc agatgctgtg gcagctcctt attgttatac gagggatccc
     6481 ggtgtcaggt gggagtactg caacctgacg caatgctcag acgcagaagg gactgccgtc
     6541 gcgcctccga ctgttacccc ggttccaagc ctagaggctc cttccgaaca agcaccgact
     6601 gagcaaaggc ctggggtgca ggagtgctac catggtaatg gacagagtta tcgaggcaca
     6661 tactccacca ctgtcacagg aagaacctgc caagcttggt catctatgac accacactcg
     6721 catagtcgga ccccagaata ctacccaaat gctggcttga tcatgaacta ctgcaggaat
     6781 ccagatgctg tggcagctcc ttattgttat acgagggatc ccggtgtcag gtgggagtac
     6841 tgcaacctga cgcaatgctc agacgcagaa gggactgccg tcgcgcctcc gactgttacc
     6901 ccggttccaa gcctagaggc tccttccgaa caagcaccga ctgagcaaag gcctggggtg
     6961 caggagtgct accatggtaa tggacagagt tatcgaggca catactccac cactgtcaca
     7021 ggaagaacct gccaagcttg gtcatctatg acaccacact cgcatagtcg gaccccagaa
     7081 tactacccaa atgctggctt gatcatgaac tactgcagga atccagatgc tgtggcagct
     7141 ccttattgtt atacgaggga tcccggtgtc aggtgggagt actgcaacct gacgcaatgc
     7201 tcagacgcag aagggactgc cgtcgcgcct ccgactgtta ccccggttcc aagcctagag
     7261 gctccttccg aacaagcacc gactgagcaa aggcctgggg tgcaggagtg ctaccatggt
     7321 aatggacaga gttatcgagg cacatactcc accactgtca caggaagaac ctgccaagct
     7381 tggtcatcta tgacaccaca ctcgcatagt cggaccccag aatactaccc aaatgctggc
     7441 ttgatcatga actactgcag gaatccagat gctgtggcag ctccttattg ttatacgagg
     7501 gatcccggtg tcaggtggga gtactgcaac ctgacgcaat gctcagacgc agaagggact
     7561 gccgtcgcgc ctccgactgt taccccggtt ccaagcctag aggctccttc cgaacaagca
     7621 ccgactgagc aaaggcctgg ggtgcaggag tgctaccatg gtaatggaca gagttatcga
     7681 ggcacatact ccaccactgt cacaggaaga acctgccaag cttggtcatc tatgacacca
     7741 cactcgcata gtcggacccc agaatactac ccaaatgctg gcttgatcat gaactactgc
     7801 aggaatccag atgctgtggc agctccttat tgttatacga gggatcccgg tgtcaggtgg
     7861 gagtactgca acctgacgca atgctcagac gcagaaggga ctgccgtcgc gcctccgact
     7921 gttaccccgg ttccaagcct agaggctcct tccgaacaag caccgactga gcagaggcct
     7981 ggggtgcagg agtgctacca cggtaatgga cagagttatc gaggcacata ctccaccact
     8041 gtcactggaa gaacctgcca agcttggtca tctatgacac cacactcgca tagtcggacc
     8101 ccagaatact acccaaatgc tggcttgatc atgaactact gcaggaatcc agatgctgtg
     8161 gcagctcctt attgttatac gagggatccc ggtgtcaggt gggagtactg caacctgacg
     8221 caatgctcag acgcagaagg gactgccgtc gcgcctccga ctgttacccc ggttccaagc
     8281 ctagaggctc cttccgaaca agcaccgact gagcaaaggc ctggggtgca ggagtgctac
     8341 catggtaatg gacagagtta tcgaggcaca tactccacca ctgtcacagg aagaacctgc
     8401 caagcttggt catctatgac accacactcg catagtcgga ccccagaata ctacccaaat
     8461 gctggcttga tcatgaacta ctgcaggaat ccagatgctg tggcagctcc ttattgttat
     8521 acgagggatc ccggtgtcag gtgggagtac tgcaacctga cgcaatgctc agacgcagaa
     8581 gggactgccg tcgcgcctcc gactgttacc ccggttccaa gcctagaggc tccttccgaa
     8641 caagcaccga ctgagcaaag gcctggggtg caggagtgct accatggtaa tggacagagt
     8701 tatcgaggca catactccac cactgtcaca ggaagaacct gccaagcttg gtcatctatg
     8761 acaccacact cgcatagtcg gaccccagaa tactacccaa atgctggctt gatcatgaac
     8821 tactgcagga atccagatgc tgtggcagct ccttattgtt atacgaggga tcccggtgtc
     8881 aggtgggagt actgcaacct gacgcaatgc tcagacgcag aagggactgc cgtcgcgcct
     8941 ccgactgtta ccccggttcc aagcctagag gctccttccg aacaagcacc gactgagcag
     9001 aggcctgggg tgcaggagtg ctaccacggt aatggacaga gttatcgagg cacatactcc
     9061 accactgtca ctggaagaac ctgccaagct tggtcatcta tgacaccaca ctcgcatagt
     9121 cggaccccag aatactaccc aaatgctggc ttgatcatga actactgcag gaatccagat
     9181 gctgtggcag ctccttattg ttatacgagg gatcccggtg tcaggtggga gtactgcaac
     9241 ctgacgcaat gctcagacgc agaagggact gccgtcgcgc ctccgactgt taccccggtt
     9301 ccaagcctag aggctccttc cgaacaagca ccgactgagc agaggcctgg ggtgcaggag
     9361 tgctaccacg gtaatggaca gagttatcga ggcacatact ccaccactgt cactggaaga
     9421 acctgccaag cttggtcatc tatgacacca cactcgcata gtcggacccc agaatactac
     9481 ccaaatgctg gcttgatcat gaactactgc aggaatccag atgctgtggc agctccttat
     9541 tgttatacga gggatcccgg tgtcaggtgg gagtactgca acctgacgca atgctcagac
     9601 gcagaaggga ctgccgtcgc gcctccgact gttaccccgg ttccaagcct agaggctcct
     9661 tccgaacaag caccgactga gcagaggcct ggggtgcagg agtgctacca cggtaatgga
     9721 cagagttatc gaggcacata ctccaccact gtcactggaa gaacctgcca agcttggtca
     9781 tctatgacac cacactcgca tagtcggacc ccagaatact acccaaatgc tggcttgatc
     9841 atgaactact gcaggaatcc agatgctgtg gcagctcctt attgttatac gagggatccc
     9901 ggtgtcaggt gggagtactg caacctgacg caatgctcag acgcagaagg gactgccgtc
     9961 gcgcctccga ctgttacccc ggttccaagc ctagaggctc cttccgaaca agcaccgact
    10021 gagcagaggc ctggggtgca ggagtgctac cacggtaatg gacagagtta tcgaggcaca
    10081 tactccacca ctgtcactgg aagaacctgc caagcttggt catctatgac accacactcg
    10141 catagtcgga ccccagaata ctacccaaat gctggcttga tcatgaacta ctgcaggaat
    10201 ccagatcctg tggcagcccc ttattgttat acgagggatc ccagtgtcag gtgggagtac
    10261 tgcaacctga cacaatgctc agacgcagaa gggactgccg tcgcgcctcc aactattacc
    10321 ccgattccaa gcctagaggc tccttctgaa caagcaccaa ctgagcaaag gcctggggtg
    10381 caggagtgct accacggaaa tggacagagt tatcaaggca catacttcat tactgtcaca
    10441 ggaagaacct gccaagcttg gtcatctatg acaccacact cgcatagtcg gaccccagca
    10501 tactacccaa atgctggctt gatcaagaac tactgccgaa atccagatcc tgtggcagcc
    10561 ccttggtgtt atacaacaga tcccagtgtc aggtgggagt actgcaacct gacacgatgc
    10621 tcagatgcag aatggactgc cttcgtccct ccgaatgtta ttctggctcc aagcctagag
    10681 gctttttttg aacaagcact gactgaggaa acccccgggg tacaggactg ctactaccat
    10741 tatggacaga gttaccgagg cacatactcc accactgtca caggaagaac ttgccaagct
    10801 tggtcatcta tgacaccaca ccagcatagt cggaccccag aaaactaccc aaatgctggc
    10861 ctgaccagga actactgcag gaatccagat gctgagattc gcccttggtg ttacaccatg
    10921 gatcccagtg tcaggtggga gtactgcaac ctgacacaat gcctggtgac agaatcaagt
    10981 gtccttgcaa ctctcacggt ggtcccagat ccaagcacag aggcttcttc tgaagaagca
    11041 ccaacggagc aaagccccgg ggtccaggat tgctaccatg gtgatggaca gagttatcga
    11101 ggctcattct ctaccactgt cacaggaagg acatgtcagt cttggtcctc tatgacacca
    11161 cactggcatc agaggacaac agaatattat ccaaatggtg gcctgaccag gaactactgc
    11221 aggaatccag atgctgagat tagtccttgg tgttatacca tggatcccaa tgtcagatgg
    11281 gagtactgca acctgacaca atgtccagtg acagaatcaa gtgtccttgc gacgtccacg
    11341 gctgtttctg aacaagcacc aacggagcaa agccccacag tccaggactg ctaccatggt
    11401 gatggacaga gttatcgagg ctcattctcc accactgtta caggaaggac atgtcagtct
    11461 tggtcctcta tgacaccaca ctggcatcag agaaccacag aatactaccc aaatggtggc
    11521 ctgaccagga actactgcag gaatccagat gctgagattc gcccttggtg ttataccatg
    11581 gatcccagtg tcagatggga gtactgcaac ctgacgcaat gtccagtgat ggaatcaact
    11641 ctcctcacaa ctcccacggt ggtcccagtt ccaagcacag agcttccttc tgaagaagca
    11701 ccaactgaaa acagcactgg ggtccaggac tgctaccgag gtgatggaca gagttatcga
    11761 ggcacactct ccaccactat cacaggaaga acatgtcagt cttggtcgtc tatgacacca
    11821 cattggcatc ggaggatccc attatactat ccaaatgctg gcctgaccag gaactactgc
    11881 aggaatccag atgctgagat tcgcccttgg tgttacacca tggatcccag tgtcaggtgg
    11941 gagtactgca acctgacacg atgtccagtg acagaatcga gtgtcctcac aactcccaca
    12001 gtggccccgg ttccaagcac agaggctcct tctgaacaag caccacctga gaaaagccct
    12061 gtggtccagg attgctacca tggtgatgga cggagttatc gaggcatatc ctccaccact
    12121 gtcacaggaa ggacctgtca atcttggtca tctatgatac cacactggca tcagaggacc
    12181 ccagaaaact acccaaatgc tggcctgacc gagaactact gcaggaatcc agattctggg
    12241 aaacaaccct ggtgttacac aaccgatccg tgtgtgaggt gggagtactg caatctgaca
    12301 caatgctcag aaacagaatc aggtgtccta gagactccca ctgttgttcc agttccaagc
    12361 atggaggctc attctgaagc agcaccaact gagcaaaccc ctgtggtccg gcagtgctac
    12421 catggtaatg gccagagtta tcgaggcaca ttctccacca ctgtcacagg aaggacatgt
    12481 caatcttggt catccatgac accacaccgg catcagagga ccccagaaaa ctacccaaat
    12541 gatggcctga caatgaacta ctgcaggaat ccagatgccg atacaggccc ttggtgtttt
    12601 accatggacc ccagcatcag gtgggagtac tgcaacctga cgcgatgctc agacacagaa
    12661 gggactgtgg tcgctcctcc gactgtcatc caggttccaa gcctagggcc tccttctgaa
    12721 caagactgta tgtttgggaa tgggaaagga taccggggca agaaggcaac cactgttact
    12781 gggacgccat gccaggaatg ggctgcccag gagccccata gacacagcac gttcattcca
    12841 gggacaaata aatgggcagg tctggaaaaa aattactgcc gtaaccctga tggtgacatc
    12901 aatggtccct ggtgctacac aatgaatcca agaaaacttt ttgactactg tgatatccct
    12961 ctctgtgcat cctcttcatt tgattgtggg aagcctcaag tggagccgaa gaaatgtcct
    13021 ggaagcattg taggggggtg tgtggcccac ccacattcct ggccctggca agtcagtctc
    13081 agaacaaggt ttggaaagca cttctgtgga ggcaccttaa tatccccaga gtgggtgctg
    13141 actgctgctc actgcttgaa gaagtcctca aggccttcat cctacaaggt catcctgggt
    13201 gcacaccaag aagtgaacct cgaatctcat gttcaggaaa tagaagtgtc taggctgttc
    13261 ttggagccca cacaagcaga tattgccttg ctaaagctaa gcaggcctgc cgtcatcact
    13321 gacaaagtaa tgccagcttg tctgccatcc ccagactaca tggtcaccgc caggactgaa
    13381 tgttacatca ctggctgggg agaaacccaa ggtacctttg ggactggcct tctcaaggaa
    13441 gcccagctcc ttgttattga gaatgaagtg tgcaatcact ataagtatat ttgtgctgag
    13501 catttggcca gaggcactga cagttgccag ggtgacagtg gagggcctct ggtttgcttc
    13561 gagaaggaca aatacatttt acaaggagtc acttcttggg gtcttggctg tgcacgcccc
    13621 aataagcctg gtgtctatgc tcgtgtttca aggtttgtta cttggattga gggaatgatg
    13681 agaaataatt aattggacgg gagacagagt gaagcatcaa cctacttaga agctgaaacg
    13741 tgggtaagga tttagcatgc tggaaataat agacagcaat caaacgaaga cactgttccc
    13801 agctaccagc tatgccaaac cttggcattt ttggtatttt tgtgtataag cttttaaggt
    13861 ctgactgaca aattctgtat taaggtgtca tagctatgac atttgttaaa aataaactct
    13921 gcacttattt tgatttga
//