LOCUS       X05978                   439 bp    mRNA    linear   HUM 12-SEP-1993
DEFINITION  Human radiated keratinocyte mRNA for cysteine protease inhibitor.
ACCESSION   X05978
VERSION     X05978.1
KEYWORDS    cystatin A; cysteine protease inhibitor; protease inhibitor;
            stefin.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 439)
  AUTHORS   Kartasova T., Cornelissen B.J.C., Belt P., van de Putte P.
  TITLE     Effects of UV, 4-NQO and TPA on gene expression in cultured human
            epidermal keratinocytes
  JOURNAL   Nucleic Acids Res. 15(15), 5945-5962(1987).
   PUBMED   2442723
COMMENT     clone 283 deduced AA sequence is completely identical to stefin
            AA sequence (isolated from human polymorphonuclear granulocytes);
            stefin has been found to be immunologically identical to cystatin
            A, isolated from human skin
            
            Data kindly reviewed (15-April-1988) by Putte P.
FEATURES             Location/Qualifiers
     source          1..439
                     /db_xref="H-InvDB:HIT000321153"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /clone="283"
                     /cell_type="epidermal keratinocytes(UV radiated)"
                     /db_xref="taxon:9606"
     CDS             46..342
                     /note="gene product (clone 283) (AA 1-98); put. stefin"
                     /db_xref="GOA:P01040"
                     /db_xref="H-InvDB:HIT000321153.14"
                     /db_xref="HGNC:HGNC:2481"
                     /db_xref="InterPro:IPR000010"
                     /db_xref="InterPro:IPR001713"
                     /db_xref="InterPro:IPR018073"
                     /db_xref="PDB:1CYU"
                     /db_xref="PDB:1CYV"
                     /db_xref="PDB:1DVC"
                     /db_xref="PDB:1DVD"
                     /db_xref="PDB:1GD3"
                     /db_xref="PDB:1GD4"
                     /db_xref="PDB:1N9J"
                     /db_xref="PDB:1NB3"
                     /db_xref="PDB:1NB5"
                     /db_xref="PDB:3K9M"
                     /db_xref="PDB:3KFQ"
                     /db_xref="PDB:3KSE"
                     /db_xref="UniProtKB/Swiss-Prot:P01040"
                     /protein_id="CAA29398.1"
                     /translation="MIPGGLSEAKPATPEIQEIVDKVKPQLEEKTNETYGKLEAVQYK
                     TQVVAGTNYYIKVRAGDNKYMHLKVFKSLPGQNEDLVLTGYQVDKNKDDELTGF"
     variation       100..100
                     /note="u is c in clones 301 and 242"
     variation       184..184
                     /note="g is c in clone 301"
     misc_feature    418..423
                     /note="pot. polyA signal"
     polyA_site      439..439
                     /note="polyA site"
BASE COUNT          153 a           87 c           90 g          109 t
ORIGIN      
        1 actttggttc cagcatcctg tccagcaaag aagcaatcag ccaaaatgat acctggaggc
       61 ttatctgagg ccaaacccgc cactccagaa atccaggaga ttgttgataa ggttaaacca
      121 cagcttgaag aaaaaacaaa tgagacttat ggaaaattgg aagctgtgca gtataaaact
      181 caagttgttg ctggaacaaa ttactacatt aaggtacgag caggtgataa taaatatatg
      241 cacttgaaag tattcaaaag tcttcccgga caaaatgagg acttggtact tactggatac
      301 caggttgaca aaaacaagga tgacgagctg acgggctttt agcagcatgt acccaaagtg
      361 ttctgattcc ttcaactggc tactgagtca tgatccttgc tgataaatat aaccatcaat
      421 aaagaagcat tcttttcca
//