LOCUS X05344 1988 bp mRNA linear HUM 07-OCT-2008 DEFINITION Human mRNA for cathepsin D from oestrogen responsive breast cancer cells. ACCESSION X05344 VERSION X05344.1 KEYWORDS cathepsin D. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1988) AUTHORS Westley B.R., May F.E.B. TITLE Oestrogen regulates cathepsin D mRNA levels in oestrogen responsive human breast cancer cells JOURNAL Nucleic Acids Res. 15(9), 3773-3786(1987). PUBMED 3588310 COMMENT Data kindly reviewed (8.1.88 ) by Westley FEATURES Location/Qualifiers source 1..1988 /db_xref="H-InvDB:HIT000321128" /organism="Homo sapiens" /mol_type="mRNA" /cell_line="ZR-75" /db_xref="taxon:9606" prim_transcript <1..1988 CDS 3..1241 /product="cathepsin D" /db_xref="GOA:P07339" /db_xref="H-InvDB:HIT000321128.12" /db_xref="HGNC:HGNC:2529" /db_xref="InterPro:IPR001461" /db_xref="InterPro:IPR001969" /db_xref="InterPro:IPR012848" /db_xref="InterPro:IPR021109" /db_xref="InterPro:IPR033121" /db_xref="InterPro:IPR033144" /db_xref="PDB:1LYA" /db_xref="PDB:1LYB" /db_xref="PDB:1LYW" /db_xref="PDB:4OBZ" /db_xref="PDB:4OC6" /db_xref="PDB:4OD9" /db_xref="UniProtKB/Swiss-Prot:P07339" /protein_id="CAA28955.1" /translation="MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVE DLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSN LWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPC QSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNL MQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQ VEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVST LPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGR YYTVFDRDNNRVGFAEAARL" sig_peptide 3..62 misc_feature 63..194 /note="propeptide (AA 1-44)" mat_peptide 195..1238 /note="mature cathepsin D (AA 45-392)" variation 1308..1308 /replace="g" regulatory 1959..1964 /regulatory_class="polyA_signal_sequence" variation 1979..1979 /replace="a" polyA_site 1988..1988 BASE COUNT 350 a 666 c 590 g 382 t ORIGIN 1 ccatgcagcc ctccagcctt ctgccgctcg ccctctgcct gctggctgca cccgcctccg 61 cgctcgtcag gatcccgctg cacaagttca cgtccatccg ccggaccatg tcggaggttg 121 ggggctctgt ggaggacctg attgccaaag gccccgtctc aaagtactcc caggcggtgc 181 cagccgtgac cgaggggccc attcccgagg tgctcaagaa ctacatggac gcccagtact 241 acggggagat tggcatcggg acgccccccc agtgcttcac agtcgtcttc gacacgggct 301 cctccaacct gtgggtcccc tccatccact gcaaactgct ggacatcgct tgctggatcc 361 accacaagta caacagcgac aagtccagca cctacgttaa gaatggtacc tcgtttgaca 421 tccactatgg ctcgggcagc ctctccgggt acctgagcca ggacactgtg tcggtgccct 481 gccagtcagc gtcgtcagcc tctgccctgg gcggtgtcaa agtggagagg caggtctttg 541 gggaggccac caagcagcca ggcatcacct tcatcgcagc caagttcgat ggcatcctgg 601 gcatggccta cccccgcatc tccgtcaaca acgtgctgcc cgtcttcgac aacctgatgc 661 agcagaagct ggtggaccag aacatcttct ccttctacct gagcagggac ccagatgcgc 721 agcctggggg tgagctgatg ctgggtggca cagactccaa gtattacaag ggttctctgt 781 cctacctgaa tgtcacccgc aaggcctact ggcaggtcca cctggaccag gtggaggtgg 841 ccagcgggct gaccctgtgc aaggagggct gtgaggccat tgtggacaca ggcacttccc 901 tcatggtggg cccggtggat gaggtgcgcg agctgcagaa ggccatcggg gccgtgccgc 961 tgattcaggg cgagtacatg atcccctgtg agaaggtgtc caccctgccc gcgatcacac 1021 tgaagctggg aggcaaaggc tacaagctgt ccccagagga ctacacgctc aaggtgtcgc 1081 aggccgggaa gaccctctgc ctgagcggct tcatgggcat ggacatcccg ccacccagcg 1141 ggccactctg gatcctgggc gacgtcttca tcggccgcta ctacactgtg tttgaccgtg 1201 acaacaacag ggtgggcttc gccgaggctg cccgcctcta gttcccaagg cgtccgcgcg 1261 ccagcacaga aacagaggag agtcccagag caggaggccc ctggcccagc ggcccctccc 1321 acacacaccc acacactcgc ccgcccactg tcctgggcgc cctggaagcc ggcggcccaa 1381 gcccgacttg ctgttttgtt ctgtggtttt cccctccctg ggttcagaaa tgctgcctgc 1441 ctgtctgtct ctccatctgt ttggtggggg tagagctgat ccagagcaca gatctgtttc 1501 gtgcattgga agaccccacc caagcttggc agccgagctc gtgtatcctg gggctccctt 1561 catctccagg gagtcccctc cccggcccta ccagcgcccg ctggctgagc ccctacccca 1621 caccaggccg tcctcccggg ccctcccttg gaaacctgcc ctgcctgagg gcccctctgc 1681 ccagcttggg cccagctggg ctctgccacc ctacctgttc agtgtcccgg gcccgttgag 1741 gatgaggccg ctagaggcct gaggatgagc tggaaggagt gagaggggac aaaacccacc 1801 ttgttggagc ctgcagggtg gtgctgggac tgagccagtc ccaggggcat gtattggcct 1861 ggaggtgggg ttgggattgg gggctggtgc cagccttcct ctgcagctga cctctgttgt 1921 cctccccttg ggcggctgag agccccagct gacatggaaa tacagttgtt ggcctccggc 1981 ctcccctc //