LOCUS X05290 1816 bp mRNA linear HUM 18-APR-2005
DEFINITION Human mRNA for tyrosine hydroxylase (HTH-1).
ACCESSION X05290
VERSION X05290.1
KEYWORDS tyrosine hydroxylase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1816)
AUTHORS Grima B., Lamouroux A., Boni C., Julien J.F., Javoy-Agid F.,
Mallet J.
TITLE A single human gene encoding multiple tyrosine hydroxylases with
different predicted functional characteristics
JOURNAL Nature 326(6114), 707-711(1987).
PUBMED 2882428
FEATURES Location/Qualifiers
source 1..1816
/db_xref="H-InvDB:HIT000321124"
/organism="Homo sapiens"
/mol_type="mRNA"
/tissue_type="pheochromocytoma tumour"
/db_xref="taxon:9606"
CDS 20..1513
/note="HTH-1 (AA 1-497)"
/db_xref="GOA:P07101"
/db_xref="H-InvDB:HIT000321124.11"
/db_xref="HGNC:HGNC:11782"
/db_xref="InterPro:IPR001273"
/db_xref="InterPro:IPR005962"
/db_xref="InterPro:IPR018301"
/db_xref="InterPro:IPR019773"
/db_xref="InterPro:IPR019774"
/db_xref="InterPro:IPR021164"
/db_xref="InterPro:IPR036329"
/db_xref="InterPro:IPR036951"
/db_xref="InterPro:IPR041903"
/db_xref="PDB:2XSN"
/db_xref="PDB:4J6S"
/db_xref="UniProtKB/Swiss-Prot:P07101"
/protein_id="CAA28908.1"
/translation="MPTPDATTPQAKGFRRAVSELDAKQAEAIMSPRFIGRRQSLIED
ARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPRATKPSALSRAVKV
FETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQVSEDVRSPAG
PKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDP
IPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVS
RFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLG
HVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLSWFTVEFGLCKQNGEVKAYGAGL
LSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASR
IQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG"
misc_feature 1795..1800
/note="pot. polyA signal"
polyA_site 1816..1816
/note="poly A site"
BASE COUNT 295 a 623 c 573 g 325 t
ORIGIN
1 cggacctcca cactgagcca tgcccacccc cgacgccacc acgccacagg ccaagggctt
61 ccgcagggcc gtgtctgagc tggacgccaa gcaggcagag gccatcatgt ccccgcggtt
121 cattgggcgc aggcagagcc tcatcgagga cgcccgcaag gagcgggagg cggcggtggc
181 agcagcggcc gctgcagtcc cctcggagcc cggggacccc ctggaggctg tggcctttga
241 ggagaaggag gggaaggccg tgctaaacct gctcttctcc ccgagggcca ccaagccctc
301 ggcgctgtcc cgagctgtga aggtgtttga gacgtttgaa gccaaaatcc accatctaga
361 gacccggccc gcccagaggc cgcgagctgg gggcccccac ctggagtact tcgtgcgcct
421 cgaggtgcgc cgaggggacc tggccgccct gctcagtggt gtgcgccagg tgtcagagga
481 cgtgcgcagc cccgcggggc ccaaggtccc ctggttccca agaaaagtgt cagagctgga
541 caagtgtcat cacctggtca ccaagttcga ccctgacctg gacttggacc acccgggctt
601 ctcggaccag gtgtaccgcc agcgcaggaa gctgattgct gagatcgcct tccagtacag
661 gcacggcgac ccgattcccc gtgtggagta caccgccgag gagattgcca cctggaagga
721 ggtctacacc acgctgaagg gcctctacgc cacgcacgcc tgcggggagc acctggaggc
781 ctttgctttg ctggagcgct tcagcggcta ccgggaagac aatatccccc agctggagga
841 cgtctcccgc ttcctgaagg agcgcacggg cttccagctg cggcctgtgg ccggcctgct
901 gtccgcccgg gacttcctgg ccagcctggc cttccgcgtg ttccagtgca cccagtatat
961 ccgccacgcg tcctcgccca tgcactcccc tgagccggac tgctgccacg agctgctggg
1021 gcacgtgccc atgctggccg accgcacctt cgcgcagttc tcgcaggaca ttggcctggc
1081 gtccctgggg gcctcggatg aggaaattga gaagctgtcc acgctgtcat ggttcacggt
1141 ggagttcggg ctgtgtaagc agaacgggga ggtgaaggcc tatggtgccg ggctgctgtc
1201 ctcctacggg gagctcctgc actgcctgtc tgaggagcct gagattcggg ccttcgaccc
1261 tgaggctgcg gccgtgcagc cctaccaaga ccagacgtac cagtcagtct acttcgtgtc
1321 tgagagcttc agtgacgcca aggacaagct caggagctat gcctcacgca tccagcgccc
1381 cttctccgtg aagttcgacc cgtacacgct ggccatcgac gtgctggaca gcccccaggc
1441 cgtgcggcgc tccctggagg gtgtccagga tgagctggac acccttgccc atgcgctgag
1501 tgccattggc taggtgcacg gcgtccctga gggcccttcc caacctcccc tggtcctgca
1561 ctgtcccgga gctcaggccc tggtgagggg ctgggtcccg ggtgcccccc atgccctccc
1621 tgctgccagg ctcccactgc ccctgcacct gcttctcagc gcaacagctg tgtgtgcccg
1681 tggtgaggtt gtgctgcctg tggtgaggtc ctgtcctggc tcccagggtc ctgggggctg
1741 ctgcactgcc ctccgccctt ccctgacact gtctgctgcc ccaatcaccg tcacaataaa
1801 agaaactgtg gtctct
//