LOCUS X04876 3213 bp mRNA linear HUM 27-MAR-1995
DEFINITION Human mRNA for myeloperoxidase (EC 1.11.1.7).
ACCESSION X04876
VERSION X04876.1
KEYWORDS glycoprotein; myeloperoxidase; unidentified reading frame.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3213)
AUTHORS Johnson K.R., Nauseef W.M., Care A., Wheelock M.J., Shane S.,
Hudson S., Koeffler H.P., Selsted M., Miller C., Rovera G.
TITLE Characterization of cDNA clones for human myeloperoxidase:
predicted amino acid sequence and evidence for multiple mRNA
species
JOURNAL Nucleic Acids Res. 15(5), 2013-2028(1987).
PUBMED 3031585
FEATURES Location/Qualifiers
source 1..3213
/db_xref="H-InvDB:HIT000321072"
/organism="Homo sapiens"
/mol_type="mRNA"
/cell_line="HL-60 promyelocytic leukemia cells"
/db_xref="taxon:9606"
CDS 31..66
/note="ORF (AA 1-11)"
/db_xref="GOA:A2NU82"
/db_xref="H-InvDB:HIT000321072.14"
/db_xref="UniProtKB/TrEMBL:A2NU82"
/protein_id="CAA28564.1"
/translation="MTAAGKGIREQ"
CDS 164..2401
/product="prepro-myeloperoxidase"
/note="(AA -41 to 699)"
/db_xref="GOA:P05164"
/db_xref="HGNC:HGNC:7218"
/db_xref="InterPro:IPR010255"
/db_xref="InterPro:IPR019791"
/db_xref="InterPro:IPR029609"
/db_xref="InterPro:IPR037120"
/db_xref="PDB:1CXP"
/db_xref="PDB:1D2V"
/db_xref="PDB:1D5L"
/db_xref="PDB:1D7W"
/db_xref="PDB:1DNU"
/db_xref="PDB:1DNW"
/db_xref="PDB:1MHL"
/db_xref="PDB:1MYP"
/db_xref="PDB:3F9P"
/db_xref="PDB:3ZS0"
/db_xref="PDB:3ZS1"
/db_xref="PDB:4C1M"
/db_xref="PDB:4DL1"
/db_xref="PDB:4EJX"
/db_xref="PDB:5FIW"
/db_xref="PDB:5MFA"
/db_xref="PDB:5UZU"
/db_xref="PDB:6AZP"
/db_xref="PDB:6BMT"
/db_xref="UniProtKB/Swiss-Prot:P05164"
/protein_id="CAA28565.1"
/translation="MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGVLAILATPQ
PSEGAAPAVLGEVDTSLVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYF
KQPVAATRTAVRAADYLHVALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAY
QDVGVTCPEQDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVK
RNGFPVALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFV
TGVNCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSCPACPGSNITIRNQINALT
SFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNR
SARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIV
GAMVQIITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVFTNAFRYGHTLIQPF
MFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVD
EIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNL
KLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWEN
EGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLAS
WREAS"
sig_peptide 164..286
misc_feature 287..661
/note="pot. pro-piece of myeloperoxidase"
misc_feature 578..586
/note="pot. N-glycosylation site (AA 139-141)"
mat_peptide 662..2398
/product="mature myeloperoxidase"
/note="(AA 126-699)"
misc_feature 662..997
/product="light subunit of myeloperoxidase"
/note="(AA 126-237)"
misc_feature 998..2398
/product="heavy subunit of myeloperoxidase"
/note="(AA 238-699)"
misc_feature 1130..1138
/note="pot. N-glycosylation site (AA 323-325)"
misc_feature 1226..1234
/note="pot. N-glycosylation site (AA 355-357)"
misc_feature 1334..1342
/note="pot. N-glycosylation site (AA 391-393)"
misc_feature 2348..2356
/note="pot. N-glycosylation site (AA 729-731)"
misc_feature 3172..3177
/note="polyadenylation signal"
misc_feature 3207..3213
/note="seq. pot. involved in 3' end formation"
BASE COUNT 647 a 950 c 934 g 682 t
ORIGIN
1 agctgtggag gtggggtcct tggaagctgg atgacagcag ctggcaaggg gataagagag
61 cagtgagccc ctccctcaag gaggtctggc tttatccata gacagggccc tctgaggtgg
121 ggctgaggta caaaggggga ttgagcagcc caggagaaga gagatggggg ttcccttctt
181 ctcttctctc agatgcatgg tggacttagg accttgctgg gctgggggtc tcactgcaga
241 gatgaagctg cttctggccc tagcaggcgt cctggccatt ctggccacgc cccagccctc
301 tgaaggtgct gctccagctg tcctggggga ggtggacacc tcgttggtgc tgagctccat
361 ggaggaggcc aagcagctgg tggacaaggc ctacaaggag cggcgggaaa gcatcaagca
421 gcggcttcgc agcggctcag ccagccccat ggaactccta tcctacttca agcagccggt
481 ggcagccacc aggacggcgg tgagggccgc tgactacctg cacgtggctc tagacctgct
541 ggagaggaag ctgcggtccc tgtggcgaag gccattcaat gtcactgatg tgctgacgcc
601 cgcccagctg aatgtgttgt ccaagtcaag cggctgcgcc taccaggacg tgggggtgac
661 ttgcccggag caggacaaat accgcaccat caccgggatg tgcaacaaca gacgcagccc
721 cacgctgggg gcctccaacc gtgcctttgt gcgctggctg ccggcggagt atgaggacgg
781 cttctctctt ccctacggct ggacgcccgg ggtcaagcgc aacggcttcc cggtggctct
841 ggctcgcgcg gtctccaacg agatcgtgcg cttccccact gatcagctga ctccggacca
901 ggagcgctca ctcatgttca tgcaatgggg ccagctgttg gaccacgacc tcgacttcac
961 ccctgagccg gccgcccggg cctccttcgt cactggcgtc aactgcgaga ccagctgcgt
1021 tcagcagccg ccctgcttcc cgctcaagat cccgcccaat gacccccgca tcaagaacca
1081 agccgactgc atcccgttct tccgctcctg cccggcttgc cccgggagca acatcaccat
1141 ccgcaaccag atcaacgcgc tcacttcctt cgtggacgcc agcatggtgt acggcagcga
1201 ggagcccctg gccaggaacc tgcgcaacat gtccaaccag ctggggctgc tggccgtcaa
1261 ccagcgcttc caagacaacg gccgggccct gctgcccttt gacaacctgc acgatgaccc
1321 ctgtctcctc accaaccgct cagcgcgcat cccctgcttc ctggcagggg acacccgttc
1381 cagtgagatg cccgagctca cctccatgca caccctctta cttcgggagc acaaccggct
1441 ggccacagag ctcaagagcc tgaaccctag gtgggatggg gagaggctct accaggaagc
1501 ccggaagatc gtgggggcca tggtccagat catcacttac cgggactacc tgcccctggt
1561 gctggggcca acggccatga ggaagtacct gcccacgtac cgttcctaca atgactcagt
1621 ggacccacgc atcgccaacg tcttcaccaa tgccttccgc tacggccaca ccctcatcca
1681 acccttcatg ttccgcctgg acaatcggta ccagcccatg gaacccaacc cccgtgtccc
1741 cctcagcagg gtcttttttg cctcctggag ggtcgtgctg gaaggtggca ttgaccccat
1801 cctccggggc ctcatggcca cccctgccaa gctgaatcgt cagaaccaaa ttgcagtgga
1861 tgagatccgg gagcgattgt ttgagcaggt catgaggatt gggctggacc tgcctgctct
1921 gaacatgcag cgcagcaggg accacggcct cccaggatac aatgcctgga ggcgcttctg
1981 tgggctcccg cagcctgaaa ctgtgggcca gctgggcacg gtgctgagga acctgaaatt
2041 ggcgaggaaa ctgatggagc agtatggcac gcccaacaac atcgacatct ggatgggcgg
2101 cgtgtccgag cctctgaagc gcaaaggccg cgtgggccca ctcctcgcct gcatcatcgg
2161 tacccagttc aggaagctcc gggatggtga tcggttttgg tgggagaacg agggtgtgtt
2221 cagcatgcag cagcgacagg ccctggccca gatctcattg ccccggatca tctgcgacaa
2281 cacaggcatc accaccgtgt ctaagaacaa catcttcatg tccaactcat atccccggga
2341 ctttgtcaac tgcagtacac ttcctgcatt gaacctggct tcctggaggg aagcctccta
2401 gaggccaggt aagggggtgc agcagtgagg ggtatatctg ggctggccag ttggaaccac
2461 ggagatctcc ttgccctaga tgagcccagc cctgttctgg gtgcagctga gaaaatgagt
2521 gactagacgt tcatttgtgt gctcatgtat gtgcgaagta tataaattgg cttttcatgc
2581 gtgtgtgttg tctgaacatg gggagtgttt catgggttat gtgtatgtgc catttatgtg
2641 agtgtgtgtt tgtgctgatg agaatactga gtatgtggaa ggcagcagag cggactggtg
2701 aggagcacag ctcaggaact agacgtgcct gggttccaat cctggctctg tggcttgcta
2761 gctatgtgac cttgagcaaa ttaccctcct taaacaagag ttttcttcct tgtaaattac
2821 atctgtcatg gtttcttgga gggcccactt gtatcctctg gttcttcatt tattgagcac
2881 ctactacatg caaggcactg tactaggcgt gagaagcata tagaggcaag aaagagatac
2941 caagatgcca tctgtgtcct ggttagcaga gctggaccag tggtgccttg gagggataag
3001 ccagctgcag ctgggctgtg tggttgactt atgggcccag ccagccaggc tcaggccatg
3061 gctccccttt ttcttcctca ccctgatttc ttgcttattc actgaagttc tcctgaagag
3121 gaactgggcc tgttgccctt tctgtaccat tagtgctccc atgtttatga taataaaggc
3181 accgtgatgg ggacctccac tctgtctgtg tct
//