LOCUS X04790 2458 bp mRNA linear HUM 18-APR-2005
DEFINITION Human mRNA for A-raf-1 oncogene.
ACCESSION X04790
VERSION X04790.1
KEYWORDS A-raf-1-oncogene cellular; oncogene cellular; raf cellular
oncogene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2458)
AUTHORS Beck T.W., Huleihel M., Gunnell M., Bonner T.I., Rapp U.R.
TITLE The complete coding sequence of the human A-raf-1 oncogene and
transforming activity of a human A-raf carrying retrovirus
JOURNAL Nucleic Acids Res. 15(2), 595-609(1987).
PUBMED 3029685
COMMENT A cysteine-rich region located near the amino terminus (highly
conserved in A-raf and c-raf ) shows significant homology with
protein kinase C.
FEATURES Location/Qualifiers
source 1..2458
/db_xref="H-InvDB:HIT000321068"
/organism="Homo sapiens"
/mol_type="mRNA"
/cell_type="T-cell"
/db_xref="taxon:9606"
CDS 195..2015
/note="ORF (A-raf) (AA 1-606)"
/db_xref="GOA:P10398"
/db_xref="H-InvDB:HIT000321068.13"
/db_xref="HGNC:HGNC:646"
/db_xref="InterPro:IPR000719"
/db_xref="InterPro:IPR001245"
/db_xref="InterPro:IPR002219"
/db_xref="InterPro:IPR003116"
/db_xref="InterPro:IPR008271"
/db_xref="InterPro:IPR011009"
/db_xref="InterPro:IPR017441"
/db_xref="InterPro:IPR020454"
/db_xref="InterPro:IPR029071"
/db_xref="PDB:1WXM"
/db_xref="PDB:2MSE"
/db_xref="UniProtKB/Swiss-Prot:P10398"
/protein_id="CAA28476.1"
/translation="MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDS
LDKALKVRGLNQDCCVVYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFV
RKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQD
LSGGSRQHEAPSNRPLNELLTPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNV
HMVSTTAPMDSNLIQLTGQSFSTDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPA
EQRERKSLADDKKKVKNLGYRXSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVA
VKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYH
HLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGL
ATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLP
YSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILAT
IELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP"
variation 653
/note="g is a in variant clone (fetal liver) (changing phe
to leu)"
variation 656
/note="c is g in variant clone (fetal liver)"
variation 1070
/note="g is a in variant clone (fetal liver)"
variation 1297
/note="u is c in variant clone (fetal liver) (changing leu
to pro)"
BASE COUNT 506 a 781 c 666 g 504 t
ORIGIN
1 tgacccaata agggtggaag gctgagtccc gcagagccaa taacgagagt ccgagaggcg
61 acggaggcgg actctgtgag gaaacaagaa gagaggccca agatggagac ggcggcggct
121 gtagcggcgt gacaggagcc ccatggcacc tgcccagccc cacctcagcc catcttgaca
181 aaatctaagg ctccatggag ccaccacggg gcccccctgc caatggggcc gagccatccc
241 gggcagtggg caccgtcaaa gtatacctgc ccaacaagca acgcacggtg gtgactgtcc
301 gggatggcat gagtgtctac gactctctag acaaggccct gaaggtgcgg ggtctaaatc
361 aggactgctg tgtggtctac cgactcatca agggacgaaa gacggtcact gcctgggaca
421 cagccattgc tcccctggat ggcgaggagc tcattgtcga ggtccttgaa gatgtcccgc
481 tgaccatgca caattttgta cggaagacct tcttcagcct ggcgttctgt gacttctgcc
541 ttaagtttct gttccatggc ttccgttgcc aaacctgtgg ctacaagttc caccagcatt
601 gttcctccaa ggtccccaca gtctgtgttg acatgagtac caaccgccaa cagttctacc
661 acagtgtcca ggatttgtcc ggaggctcca gacagcatga ggctccctcg aaccgccccc
721 tgaatgagtt gctaaccccc cagggtccca gcccccgcac ccagcactgt gacccggagc
781 acttcccctt ccctgcccca gccaatgccc ccctacagcg catccgctcc acgtccactc
841 ccaacgtcca tatggtcagc accacggccc ccatggactc caacctcatc cagctcactg
901 gccagagttt cagcactgat gctgccggta gtagaggagg tagtgatgga accccccggg
961 ggagccccag cccagccagc gtgtcctcgg ggaggaagtc cccacattcc aagtcaccag
1021 cagagcagcg cgagcggaag tccttggccg atgacaagaa gaaagtgaag aacctggggt
1081 accgggantc aggctattac tgggaggtac cacccagtga ggtgcagctg ctgaagagga
1141 tcgggacggg ctcgtttggc accgtgtttc gagggcggtg gcatggcgat gtggccgtga
1201 aggtgctcaa ggtgtcccag cccacagctg agcaggccca ggctttcaag aatgagatgc
1261 aggtgctcag gaagacgcga catgtcaaca tcttgctgtt tatgggcttc atgacccggc
1321 cgggatttgc catcatcaca cagtggtgtg agggctccag cctctaccat cacctgcatg
1381 tggccgacac acgcttcgac atggtccagc tcatcgacgt ggcccggcag actgcccagg
1441 gcatggacta cctccatgcc aagaacatca tccaccgaga tctcaagtct aacaacatct
1501 tcctacatga ggggctcacg gtgaagatcg gtgactttgg cttggccaca gtgaagactc
1561 gatggagcgg ggcccagccc ttggagcagc cctcaggatc tgtgctgtgg atggcagctg
1621 aggtgatccg tatgcaggac ccgaacccct acagcttcca gtcagacgtc tatgcctacg
1681 gggttgtgct ctacgagctt atgactggct cactgcctta cagccacatt ggctgccgtg
1741 accagattat ctttatggtg ggccgtggct atctgtcccc ggacctcagc aaaatctcca
1801 gcaactgccc caaggccatg cggcgcctgc tgtctgactg cctcaagttc cagcgggagg
1861 agcggcccct cttcccccag atcctggcca caattgagct gctgcaacgg tcactcccca
1921 agattgagcg gagtgcctcg gaaccctcct tgcaccgcac ccaggccgat gagttgcctg
1981 cctgcctact cagcgcagcc cgccttgtgc cttaggcccc gcccaagcca ccagggagcc
2041 aatctcagcc ctccacgcca aggagccttg cccaccagcc aatcaatgtt cgtctctgcc
2101 ctgatgctgc ctcaggatcc cccattcccc accctgggag atgagggggt ccccatgtgc
2161 ttttccagtt cttctggaat tgggggaccc ccgccaaaga ctgagccccc tgtctcctcc
2221 atcatttggt ttcctcttgg ctttggggat acttctaaat tttgggagct cctccatctc
2281 caatggctgg gatttgtggc agggattcca ctcagaacct ctctggaatt tgtgcctgat
2341 gtgccttcca ctggattttg gggttcccag caccccatgt ggattttggg gggtcccttt
2401 tgtgtctccc ccgccattca aggactcctc tctttcttca ccaagaagca cagaattc
//