LOCUS       X04744                  1962 bp    mRNA    linear   HUM 27-MAR-1995
DEFINITION  Human mRNA for plasminogen activator inhibitor (PAI-1).
ACCESSION   X04744
VERSION     X04744.1
KEYWORDS    glycoprotein; plasminogen activator inhibitor.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1962)
  AUTHORS   Wun T.C., Kretzmer K.K.
  TITLE     cDNA cloning and expression in E. coli of a plasminogen activator
            inhibitor (PAI) related to a PAI produced by Hep G2 hepatoma cell
  JOURNAL   FEBS Lett. 210(1), 11-16(1987).
   PUBMED   3026837
COMMENT     Data kindly reviewed (20-AUG-1987) by Wun T.-C.
FEATURES             Location/Qualifiers
     source          1..1962
                     /db_xref="H-InvDB:HIT000321065"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /clone_lib="(lambda)gt11 placental cDNA"
                     /cell_line="HEP G2 hepatoma"
                     /db_xref="taxon:9606"
     CDS             <1..1161
                     /codon_start=1
                     /product="plasminogen activator inhibitor"
                     /db_xref="GOA:P05121"
                     /db_xref="H-InvDB:HIT000321065.15"
                     /db_xref="HGNC:HGNC:8583"
                     /db_xref="InterPro:IPR000215"
                     /db_xref="InterPro:IPR023795"
                     /db_xref="InterPro:IPR023796"
                     /db_xref="InterPro:IPR036186"
                     /db_xref="InterPro:IPR042178"
                     /db_xref="InterPro:IPR042185"
                     /db_xref="PDB:1A7C"
                     /db_xref="PDB:1B3K"
                     /db_xref="PDB:1C5G"
                     /db_xref="PDB:1DB2"
                     /db_xref="PDB:1DVM"
                     /db_xref="PDB:1DVN"
                     /db_xref="PDB:1LJ5"
                     /db_xref="PDB:1OC0"
                     /db_xref="PDB:3CVM"
                     /db_xref="PDB:3EOX"
                     /db_xref="PDB:3PB1"
                     /db_xref="PDB:3Q02"
                     /db_xref="PDB:3Q03"
                     /db_xref="PDB:3R4L"
                     /db_xref="PDB:3UT3"
                     /db_xref="PDB:4AQH"
                     /db_xref="PDB:4G8O"
                     /db_xref="PDB:4G8R"
                     /db_xref="PDB:4IC0"
                     /db_xref="PDB:5BRR"
                     /db_xref="PDB:5ZLZ"
                     /db_xref="PDB:6I8S"
                     /db_xref="PDB:9PAI"
                     /db_xref="UniProtKB/Swiss-Prot:P05121"
                     /protein_id="CAA28444.1"
                     /translation="VFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY
                     GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTD
                     AIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLG
                     KGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYT
                     EFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRL
                     PRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIE
                     VNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP"
     mat_peptide     1..1158
                     /note="mature plasminogen activator inhibitor (AA +1 to
                     +386)"
     misc_feature    645..647
                     /note="pot. N-glycosylatin site"
     misc_feature    814..816
                     /note="pot. N-glycosylation site"
     misc_feature    1006..1008
                     /note="pot. N-glycosylation site"
BASE COUNT          456 a          569 c          505 g          432 t
ORIGIN      
        1 gtctttggtg aagggtctgc tgtgcaccat cccccatcct acgtggccca cctggcctca
       61 gacttcgggg tgagggtgtt tcagcaggtg gcgcaggcct ccaaggaccg caacgtggtt
      121 ttctcaccct atggggtggc ctcggtgttg gccatgctcc agctgacaac aggaggagaa
      181 acccagcagc agattcaagc agctatggga ttcaagattg atgacaaggg catggccccc
      241 gccctccggc atctgtacaa ggagctcatg gggccatgga acaaggatga gatcagcacc
      301 acagacgcga tcttcgtcca gcgggatctg aagctggtcc agggcttcat gccccacttc
      361 ttcaggctgt tccggagcac ggtcaagcaa gtggactttt cagaggtgga gagagccaga
      421 ttcatcatca atgactgggt gaagacacac acaaaaggta tgatcagcaa cttgcttggg
      481 aaaggagccg tggaccagct gacacggctg gtgctggtga atgccctcta cttcaacggc
      541 cagtggaaga ctcccttccc cgactccagc acccaccgcc gcctcttcca caaatcagac
      601 ggcagcactg tctctgtgcc catgatggct cagaccaaca agttcaacta tactgagttc
      661 accacgcccg atggccatta ctacgacatc ctggaactgc cctaccacgg ggacaccctc
      721 agcatgttca ttgctgcccc ttatgaaaaa gaggtgcctc tctctgccct caccaacatt
      781 ctgagtgccc agctcatcag ccactggaaa ggcaacatga ccaggctgcc ccgcctcctg
      841 gttctgccca agttctccct ggagactgaa gtcgacctca ggaagcccct agagaacctg
      901 ggaatgaccg acatgttcag acagtttcag gctgacttca cgagtctttc agaccaagag
      961 cctctccacg tcgcgcaggc gctgcagaaa gtgaagatcg aggtgaacga gagtggcacg
     1021 gtggcctcct catccacagc tgtcatagtc tcagcccgca tggcccccga ggagatcatc
     1081 atggacagac ccttcctctt tgtggtccgg cacaacccca caggaacagt ccttttcatg
     1141 ggccaagtga tggaaccctg accctgggga aagacgcctt catctgggac aaaactggag
     1201 atgcatcggg aaagaagaaa ctccgaagaa aagaatttta gtgttaatga ctctttctga
     1261 aggaagagaa gacatttgcc ttttgttaaa agatggtaaa ccagatctgt ctccaagacc
     1321 ttggcctctc cttggaggac ctttaggtca aactccctag tctccacctg agaccctggg
     1381 agagaagttt gaagcacaac tcccttaagg tctccaaacc agacggtgac gcctgcggga
     1441 ccatctgggg cacctgcttc cacccgtctc tctgcccact cgggtctgca gacctggttc
     1501 ccactgaggc cctttgcagg acggaactac ggggcttaca ggagcttttg tgtgcctggt
     1561 agaaactatt tctgttccag tcacattgcc atcactcttg tactgcctgc caccgcggag
     1621 gaggctggtg acaggccaaa ggccagtgga agaaacaccc tttcatctca gagtccactg
     1681 tggcactggc cacccctccc cagtacaggg gtgctgcagg tggcagagtg aatgtccccc
     1741 atcatgtggc ccaactctcc tggcctggcc atctccctcc ccagaaacag tgtgcatggg
     1801 ttattttgga gtgtaggtga cttgtttact cattgaagca gatttctgct tccttttatt
     1861 tttataggaa tagaggaaga aaggtcagat gcgtgcccag ctcttcaccc cccaatctct
     1921 tggtggggag gggtgtacct aaatatttat catatccttg cc
//