LOCUS X04714 14112 bp mRNA linear HUM 07-OCT-2008
DEFINITION Human mRNA for apolipoprotein B-100 (apoB-100).
ACCESSION X04714 M15051 M15054
VERSION X04714.1
KEYWORDS apolipoprotein B; apolipoprotein B-100.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 14112)
AUTHORS Cladaras C., Hadzopoulou-Cladaras M., Nolte R.T., Atkinson D.,
Zannis V.I.
TITLE The complete sequence and structural analysis of human
apolipoprotein B-100: relationship between apoB-100 and apoB-48
forms
JOURNAL EMBO J. 5(13), 3495-3507(1986).
PUBMED 3030729
REFERENCE 2 (bases 1 to 14112)
AUTHORS Cladaras C., Hadzopoulou-Cladaras M., Avila R., Nussbaum A.L.,
Nicolosi R., Zannis V.I.
TITLE Complementary DNA derived structure of the amino-terminal domain of
human apolipoprotein B and size of its messenger RNA transcript
JOURNAL Biochemistry 25(19), 5351-5357(1986).
PUBMED 3022788
COMMENT apoB-100 and apoB-48 have common sequences that extend from the
amino terminus of apoB-100 to the vicinity of nucleotide
residue 6300.
FEATURES Location/Qualifiers
source 1..14112
/db_xref="H-InvDB:HIT000321061"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 129..13811
/product="apo-B100 precursor"
/db_xref="GOA:P04114"
/db_xref="H-InvDB:HIT000321061.15"
/db_xref="HGNC:HGNC:603"
/db_xref="InterPro:IPR001747"
/db_xref="InterPro:IPR009454"
/db_xref="InterPro:IPR011030"
/db_xref="InterPro:IPR015255"
/db_xref="InterPro:IPR015816"
/db_xref="InterPro:IPR015819"
/db_xref="InterPro:IPR016024"
/db_xref="InterPro:IPR022176"
/db_xref="UniProtKB/Swiss-Prot:P04114"
/protein_id="CAA28420.1"
/translation="MDPPRPALLALPALLLLLLAGARAEEEMLENVSLVCPKDATRFK
HLRKYTYNYEAESSSGVPGTADSRSATRINCKVELEVPQLCSFILKTSQCTLKEVYGF
NPEGKALLKKTKNSEEFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKRGIISA
LLVPPETEEAKQVLFLDTVYGNCSTHFTVKTRKGNVATEISTERDLGQCDRFKPIRTG
ISPLALIKGMTRPLSTLISSSQSCQYTLDAKRKHVAEAICKEQHLFLPFSYKNKYGMV
AQVTQTLKLEDTPKINSRFFGEGTKKMGLAFESTKSTSPPKQAEAVLKTLQELKKLTI
SEQNIQRANLFNKLVTELRGLSDEAVTSLLPQLIEVSSPITLQALVQCGQPQCSTHIL
QWLKRVHANPLLIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHAVNNYH
KTNPTGTQELLDIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKSSIL
KCVQSTKPSLMIQKAAIQALRKMEPKDKDQEVLLQTFLDDASPGDKRLAAYLMLMRSP
SQADINKIVQILPWEQNEQVKNFVASHIANILNSEELDIQDLKKLVKEVLKESQLPTV
MDFRKFSRNYQLYKSVSLPSLDPASAKIEGNLIFDPNNYLPKESMLKTTLTAFGFASA
DLIEIGLEGKGFEPTLEALFGKQGFFPDSVNKALYWVNGQVPDGVSKVLVDHFGYTKD
DKHEQDMVNGIMLSVEKLIKDLKSKEVPEARAYLRILGEELGFASLHDLQLLGKLLLM
GARTLQGIPQMIGEVIRKGSKNDFFLHYIFMENAFELPTGAGLQLQISSSGVIAPGAK
AGVKLEVANMQAELVAKPSVSVEFVTNMGIIIPDFARSGVQMNTNFFHESGLEAHVAL
KAGKLKFIIPSPKRPVKLLSGGNTLHLVSTTKTEVIPPLIENRQSWSVCKQVFPGLNY
CTSGAYSNASSTDSASYYPLTGDTRLELELRPTGEIEQYSVSATYELQREDRALVDTL
KFVTQAEGAKQTEATMTFKYNRQSMTLSSEVQIPDFDVDLGTILRVNDESTEGKTSYR
LTLDIQNKKITEVALMGDLSCDTKEERKIKGVISIPRLQAEARSEILAHWSPAKLLLQ
MDSSATAYGSTVSKRVAWHYDEEKIEFEWNTGTNVDTKKMTSNFPVDLSDYPKSLHMY
ANRLLDHRVPQTDMTFRHVGSKLIVAMSSWLQKASGSLPYTQTLQDHLNSLKEFNLQN
MGLPDFHIPENLFLKSDGRVKYTLNKNSLKIEIPLPFGGKSSRDLKMLETVRTPALHF
KSVGFHLPSREFQVPTFTIPKLYQLQVPLLGVLDLSTNVYSNLYNWSASYSGGNTSTD
HFSLRARYHMKADSVVDLLSYNVQGSGETTYDHKNTSTLSCDGSLRHKFLDSNIKFSH
VEKLGNNPVSKGLLIFDASSSWGPQMSASVHLDSKKKQHLFVKEVKIDGQFRVSSFYA
KGTYGLSCQRDPNTGRLNGESNLRFNSSYLQGTNQITGRYEDGTLSLTSTSDLQSGII
KNTASLKYENYELTLKSDTNGKYKNFATSNKMDMTFSKQNALLRSEYQADYESLRFFS
LLSGSLNSHGLELNADILGTDKINSGAHKATLRIGQDGISTSATTNLKCSLLVLENEL
NAELGLSGASMKLTTNGRFREHNAKFSLDGKAALTELSLGSAYQAMILGVDSKNIFNF
KVSQEGLKLSNDMMGSYAEMKFDHTNSLNIAGLSLDFSSKLDNIYSSDKFYKQTVNLQ
LQPYSLVTTLNSDLKYNALDLTNNGKLRLEPLKLHVAGNLKGAYQNNEIKHIYAISSA
ALSASYKADTVAKVQGVEFSHRLNTDIAGLASAIDMSTNYNSDSLHFSNVFRSVMAPF
TMTIDAHTNGNGKLALWGEHTGQLYSKFLLKAEPLAFTFSHDYKGSTSHHLVSRKSIS
AALEHKVSALLTPAEQTGTWKLKTQFNNNEYSQDLDAYNTKDKIGVELTGRTLADLTL
LDSPIKVPLLLSEPINIIDALEMRDAVEKPQEFTIVAFVKYDKNQDVHSINLPFFETL
QEYFERNRQTIIVVLENVQRKLKHINIDQFVRKYRAALGKLPQQANDYLNSFNWERQV
SHAKEKLTALTKKYRITENDIQIALDDAKINFNEKLSQLQTYMIQFDQYIKDSYDLHD
LKIAIANIIDEIIEKLKSLDEHYHIRVILVKTIHDLHLFIENIDFNKSGSSTASWIQN
VDTKYQIRIQIQEKLQQLKRHIQNIDIQHLAGKLKQHIEAIDVRVLLDQLGTTISFER
INDVLEHVKHFVINLIGDFEVAEKINAFRAKVHELIERYEVDQQIQVLMDKLVELAHQ
YKLKETIQKLSNVLQQVKIKDYFEKLVGFIDDAVKKLNELSFKTFIEDVNKFLDMLIK
KLKSFDYHQFVDETNDKIREVTQRLNGEIQALELPQKAEALKLFLEETKATVAVYLES
LQDTKITLIINWLQEALSSASLAHMKAKFRETLEDTRDRMYQMDIQQELQRYLSLVSQ
VYSTLVTYISDWWTLAAKNLTDFAEQYSIQDWAKRMKALVEQGFTVPEIKTILGTMPA
FEVSLQALQKATFQTPDFIVPLTDLRIPSVQINFKDLKNIKIPSRFSTPEFTILNTFH
IPSFTIDFVEMKVKIIRTIDQMLNSELQWPVPDIYLRDLKVEDIPLARITLPDFRLPE
IAIPEFIIPTLNLNDFQVPDLHIPEFQLPHISHTIEVPTFGKLYSILKIQSPLFTLDA
NADIGNGTTSANEAGIAASITAKGESKLEVLNFDFQANAQLSNPKINPLALKESVKFS
SKYLRTEHGSEMLFFGNAIEGKSNTVASLHTEKNTLELSNGVIVKINNQLTLDSNTKY
FHKLNIPKLDFSSQADLRNEIKTLLKAGHIAWTSSGKGSWKWACPRFSDEGTHESQIS
FTIEGPLTSFGLSNKINSKHLRVNQNLVYESGSLNFSKLEIQSQVDSQHVGHSVLTAK
GMALFGEGKAEFTGRHDAHLNGKVIGTLKNSLFFSAQPFEITASTNNEGNLKVRFPLR
LTGKIDFLNNYALFLSPSAQQASWQVSARFNQYKYNQNFSAGNNENIMEAHVGINGEA
NLDFLNIPLTIPEMRLPYTIITTPPLKDFSLWEKTGLKEFLKTTKQSFDLSVKAQYKK
NKHRHSITNPLAVLCEFISQSIKSFDRHFEKNRNNALDFVTKSYNETKIKFDKYKAEK
SQDELPRTFQIPGYTVPVVNVEVSPFTIEMSAFGYVFPKAVSMPSFSILGSDVRVPSY
TLILPSLELPVLHVPRNLKLSLPHFKELCTISHIFIPAMGNITYDFSFKSSVITLNTN
AELFNQSDIVAHLLSSSSSVIDALQYKLEGTTRLTRKRGLKLATALSLSNKFVEGSHN
STVSLTTKNMEVSVAKTTKAEIPILRMNFKQELNGNTKSKPTVSSSMEFKYDFNSSML
YSTAKGAVDHKLSLESLTSYFSIESSTKGDVKGSVLSREYSGTIASEANTYLNSKSTR
SSVKLQGTSKIDDIWNLEVKENFAGEATLQRIYSLWEHSTKNHLQLEGLFFTNGEHTS
KATLELSPWQMSALVQVHASQPSSFHDFPDLGQEVALNANTKNQKIRWKNEVRIHSGS
FQSQVELSNDQEKAHLDIAGSLEGHLRFLKNIILPVYDKSLWDFLKLDVTTSIGRRQH
LRVSTAFVYTKNPNGYSFSIPVKVLADKFITPGLKLNDLNSVLVMPTFHVPFTDLQVP
SCKLDFREIQIYKKLRTSSFALNLPTLPEVKFPEVDVLTKYSQPEDSLIPFFEITVPE
SQLTVSRFTLPKSVSDGIAALDLNAVANKIADFELPTIIVPEQTIEIPSIKFSVPAGI
VIPSFQALTARFEVDSPVYNATWSASLKNKADYVETVLDSTCSSTVQFLEYELNVLGT
HKIEDGTLASKTKGTLAHRDFSAEYEEDGKFEGLQEWEGKAHLNIKSPAFTDLHLRYQ
KDKKGISTSAASPAVGTVGMDMDEDDDFSKWNFYYSPQSSPDKKLTIFKTELRVRESD
EETQIKVNWEEEAASGLLTSLKDNVPKATGVLYDYVNKYHWEHTGLTLREVSSKLRRN
LQNNAEWVYQGAIRQIDDIDVRFQKAASGTTGTYQEWKDKAQNLYQELLTQEGQASFQ
GLKDNVFDGLVRVTQKFHMKVKHLIDSLIDFLNFPRFQFPGKPGIYTREELCTMFIRE
VGTVLSQVYSKVHNGSEILFSYFQDLVITLPFELRKHKLIDVISMYRELLKDLSKEAQ
EVFKAIQSLKTTEVLRNLQDLLQFIFQLIEDNIKQLKEMKFTYLINYIQDEINTIFND
YIPYVFKLLKENLCLNLHKFNEFIQNELQEASQELQQIHQYIMALREEYFDPSIVGWT
VKYYELEEKIVSLIKNLLVALKDFHSEYIVSASNFTSQLSSQVEQFLHRNIQEYLSIL
TDPDGKGKEKIAELSATAQEIIKSQAIATKKIISDYHQQFRYKLQDFSDQLSDYYEKF
IAESKRLIDLSIQNYHTFLIYITELLKKLQSTTVMNPYMKLAPGELTIIL"
sig_peptide 129..200
/product="apoB-100"
mat_peptide 201..13808
/product="apoB-100"
variation 3444
/gene="APOB"
/replace="c"
/note="g in lambda-B25; c in lambda B1"
misc_feature 10254..10307
/note="LDL receptor binding site (AA 3352-3369)"
polyA_site 14012..14012
/note="polyA site"
regulatory 14085..14090
/note="putative"
/regulatory_class="polyA_signal_sequence"
BASE COUNT 4371 a 3237 c 2899 g 3605 t
ORIGIN
1 attcccaccg ggacctgcgg ggctgagtgc ccttctcggt tgctgccgct gaggagcccg
61 cccagccagc cagggccgcg aggccgaggc caggccgcag cccaggagcc gccccaccgc
121 agctggcgat ggacccgccg aggcccgcgc tgctggcgct gcctgcgctg ctgctgctgc
181 tgctggcggg cgccagggcc gaagaggaaa tgctggaaaa tgtcagcctg gtctgtccaa
241 aagatgcgac ccgattcaag cacctccgga agtacacata caactatgag gctgagagtt
301 ccagtggagt ccctgggact gctgattcaa gaagtgccac caggatcaac tgcaaggttg
361 agctggaggt tccccagctc tgcagcttca tcctgaagac cagccagtgc accctgaaag
421 aggtgtatgg cttcaaccct gagggcaaag ccttgctgaa gaaaaccaag aactctgagg
481 agtttgctgc agccatgtcc aggtatgagc tcaagctggc cattccagaa gggaagcagg
541 ttttccttta cccggagaaa gatgaaccta cttacatcct gaacatcaag aggggcatca
601 tttctgccct cctggttccc ccagagacag aagaagccaa gcaagtgttg tttctggata
661 ccgtgtatgg aaactgctcc actcacttta ccgtcaagac gaggaagggc aatgtggcaa
721 cagaaatatc cactgaaaga gacctgggcc agtgtgatcg cttcaagccc atccgcacag
781 gcatcagccc acttgctctc atcaaaggca tgacccgccc cttgtcaact ctgatcagca
841 gcagccagtc ctgtcagtac acactggacg ctaagaggaa gcatgtggca gaagccatct
901 gcaaggagca acacctcttc ctgcctttct cctacaagaa taagtatggg atggtagcac
961 aagtgacaca gactttgaaa cttgaagaca caccaaagat caacagccgc ttctttggtg
1021 aaggtactaa gaagatgggc ctcgcatttg agagcaccaa atccacatca cctccaaagc
1081 aggccgaagc tgttttgaag actctccagg aactgaaaaa actaaccatc tctgagcaaa
1141 atatccagag agctaatctc ttcaataagc tggttactga gctgagaggc ctcagtgatg
1201 aagcagtcac atctctcttg ccacagctga ttgaggtgtc cagccccatc actttacaag
1261 ccttggttca gtgtggacag cctcagtgct ccactcacat cctccagtgg ctgaaacgtg
1321 tgcatgccaa cccccttctg atagatgtgg tcacctacct ggtggccctg atccccgagc
1381 cctcagcaca gcagctgcga gagatcttca acatggcgag ggatcagcgc agccgagcca
1441 ccttgtatgc gctgagccac gcggtcaaca actatcataa gacaaaccct acagggaccc
1501 aggagctgct ggacattgct aattacctga tggaacagat tcaagatgac tgcactgggg
1561 atgaagatta cacctatttg attctgcggg tcattggaaa tatgggccaa accatggagc
1621 agttaactcc agaactcaag tcttcaatcc tgaaatgtgt ccaaagtaca aagccatcac
1681 tgatgatcca gaaagctgcc atccaggctc tgcggaaaat ggagcctaaa gacaaggacc
1741 aggaggttct tcttcagact ttccttgatg atgcttctcc gggagataag cgactggctg
1801 cctatcttat gttgatgagg agtccttcac aggcagatat taacaaaatt gtccaaattc
1861 taccatggga acagaatgag caagtgaaga actttgtggc ttcccatatt gccaatatct
1921 tgaactcaga agaattggat atccaagatc tgaaaaagtt agtgaaagaa gttctgaaag
1981 aatctcaact tccaactgtc atggacttca gaaaattctc tcggaactat caactctaca
2041 aatctgtttc tcttccatca cttgacccag cctcagccaa aatagaaggg aatcttatat
2101 ttgatccaaa taactacctt cctaaagaaa gcatgctgaa aactaccctc actgcctttg
2161 gatttgcttc agctgacctc atcgagattg gcttggaagg aaaaggcttt gagccaacat
2221 tggaagctct ttttgggaag caaggatttt tcccagacag tgtcaacaaa gctttgtact
2281 gggttaatgg tcaagttcct gatggtgtct ctaaggtctt agtggaccac tttggctata
2341 ccaaagatga taaacatgag caggatatgg taaatggaat aatgctcagt gttgagaagc
2401 tgattaaaga tttgaaatcc aaagaagtcc cggaagccag agcctacctc cgcatcttgg
2461 gagaggagct tggttttgcc agtctccatg acctccagct cctgggaaag ctgcttctga
2521 tgggtgcccg cactctgcag gggatccccc agatgattgg agaggtcatc aggaagggct
2581 caaagaatga cttttttctt cactacatct tcatggagaa tgcctttgaa ctccccactg
2641 gagctggatt acagttgcaa atatcttcat ctggagtcat tgctcccgga gccaaggctg
2701 gagtaaaact ggaagtagcc aacatgcagg ctgaactggt ggcaaaaccc tccgtgtctg
2761 tggagtttgt gacaaatatg ggcatcatca ttccggactt cgctaggagt ggggtccaga
2821 tgaacaccaa cttcttccac gagtcgggtc tggaggctca tgttgcccta aaagctggga
2881 agctgaagtt tatcattcct tccccaaaga gaccagtcaa gctgctcagt ggaggcaaca
2941 cattacattt ggtctctacc accaaaacgg aggtgatccc acctctcatt gagaacaggc
3001 agtcctggtc agtttgcaag caagtctttc ctggcctgaa ttactgcacc tcaggcgctt
3061 actccaacgc cagctccaca gactccgcct cctactatcc gctgaccggg gacaccagat
3121 tagagctgga actgaggcct acaggagaga ttgagcagta ttctgtcagc gcaacctatg
3181 agctccagag agaggacaga gccttggtgg ataccctgaa gtttgtaact caagcagaag
3241 gtgcgaagca gactgaggct accatgacat tcaaatataa tcggcagagt atgaccttgt
3301 ccagtgaagt ccaaattccg gattttgatg ttgacctcgg aacaatcctc agagttaatg
3361 atgaatctac tgagggcaaa acgtcttaca gactcaccct ggacattcag aacaagaaaa
3421 ttactgaggt cgccctcatg ggcgacctaa gttgtgacac aaaggaagaa agaaaaatca
3481 agggtgttat ttccataccc cgtttgcaag cagaagccag aagtgagatc ctcgcccact
3541 ggtcgcctgc caaactgctt ctccaaatgg actcatctgc tacagcttat ggctccacag
3601 tttccaagag ggtggcatgg cattatgatg aagagaagat tgaatttgaa tggaacacag
3661 gcaccaatgt agataccaaa aaaatgactt ccaatttccc tgtggatctc tccgattatc
3721 ctaagagctt gcatatgtat gctaatagac tcctggatca cagagtccct caaacagaca
3781 tgactttccg gcacgtgggt tccaaattaa tagttgcaat gagctcatgg cttcagaagg
3841 catctgggag tcttccttat acccagactt tgcaagacca cctcaatagc ctgaaggagt
3901 tcaacctcca gaacatggga ttgccagact tccacatccc agaaaacctc ttcttaaaaa
3961 gcgatggccg ggtcaaatat accttgaaca agaacagttt gaaaattgag attcctttgc
4021 cttttggtgg caaatcctcc agagatctaa agatgttaga gactgttagg acaccagccc
4081 tccacttcaa gtctgtggga ttccatctgc catctcgaga gttccaagtc cctactttta
4141 ccattcccaa gttgtatcaa ctgcaagtgc ctctcctggg tgttctagac ctctccacga
4201 atgtctacag caacttgtac aactggtccg cctcctacag tggtggcaac accagcacag
4261 accatttcag ccttcgggct cgttaccaca tgaaggctga ctctgtggtt gacctgcttt
4321 cctacaatgt gcaaggatct ggagaaacaa catatgacca caagaatacg tctacactat
4381 catgtgatgg gtctctacgc cacaaatttc tagattcgaa tatcaaattc agtcatgtag
4441 aaaaacttgg aaacaaccca gtctcaaaag gtttactaat attcgatgca tctagttcct
4501 ggggaccaca gatgtctgct tcagttcatt tggactccaa aaagaaacag catttgtttg
4561 tcaaagaagt caagattgat gggcagttca gagtctcttc gttctatgct aaaggcacat
4621 atggcctgtc ttgtcagagg gatcctaaca ctggccggct caatggagag tccaacctga
4681 ggtttaactc ctcctacctc caaggcacca accagataac aggaagatat gaagatggaa
4741 ccctctccct cacctccacc tctgatctgc aaagtggcat cattaaaaat actgcttccc
4801 taaagtatga gaactacgag ctgactttaa aatctgacac caatgggaag tataagaact
4861 ttgccacttc taacaagatg gatatgacct tctctaagca aaatgcactg ctgcgttctg
4921 aatatcaggc tgattacgag tcattgaggt tcttcagcct gctttctgga tcactaaatt
4981 cccatggtct tgagttaaat gctgacatct taggcactga caaaattaat agtggtgctc
5041 acaaggcgac actaaggatt ggccaagatg gaatatctac cagtgcaacg accaacttga
5101 agtgtagtct cctggtgctg gagaatgagc tgaatgcaga gcttggcctc tctggggcat
5161 ctatgaaatt aacaacaaat ggccgcttca gggaacacaa tgcaaaattc agtctggatg
5221 ggaaagccgc cctcacagag ctatcactgg gaagtgctta tcaggccatg attctgggtg
5281 tcgacagcaa aaacattttc aacttcaagg tcagtcaaga aggacttaag ctctcaaatg
5341 acatgatggg ctcatatgct gaaatgaaat ttgaccacac aaacagtctg aacattgcag
5401 gcttatcact ggacttctct tcaaaacttg acaacattta cagctctgac aagttttata
5461 agcaaactgt taatttacag ctacagccct attctctggt aactacttta aacagtgacc
5521 tgaaatacaa tgctctggat ctcaccaaca atgggaaact acggctagaa cccctgaagc
5581 tgcatgtggc tggtaaccta aaaggagcct accaaaataa tgaaataaaa cacatctatg
5641 ccatctcttc tgctgcctta tcagcaagct ataaagcaga cactgttgct aaggttcagg
5701 gtgtggagtt tagccatcgg ctcaacacag acatcgctgg gctggcttca gccattgaca
5761 tgagcacaaa ctataattca gactcactgc atttcagcaa tgtcttccgt tctgtaatgg
5821 ccccgtttac catgaccatc gatgcacata caaatggcaa tgggaaactc gctctctggg
5881 gagaacatac tgggcagctg tatagcaaat tcctgttgaa agcagaacct ctggcattta
5941 ctttctctca tgattacaaa ggctccacaa gtcatcatct cgtgtctagg aaaagcatca
6001 gtgcagctct tgaacacaaa gtcagtgccc tgcttactcc agctgagcag acaggcacct
6061 ggaaactcaa gacccaattt aacaacaatg aatacagcca ggacttggat gcttacaaca
6121 ctaaagataa aattggcgtg gagcttactg gacgaactct ggctgaccta actctactag
6181 actccccaat taaagtgcca cttttactca gtgagcccat caatatcatt gatgctttag
6241 agatgagaga tgccgttgag aagccccaag aatttacaat tgttgctttt gtaaagtatg
6301 ataaaaacca agatgttcac tccattaacc tcccattttt tgagaccttg caagaatatt
6361 ttgagaggaa tcgacaaacc attatagttg tactggaaaa cgtacagaga aagctgaagc
6421 acatcaatat tgatcaattt gtaagaaaat acagagcagc cctgggaaaa ctcccacagc
6481 aagctaatga ttatctgaat tcattcaatt gggagagaca agtttcacat gccaaggaga
6541 aactgactgc tctcacaaaa aagtatagaa ttacagaaaa tgatatacaa attgcattag
6601 atgatgccaa aatcaacttt aatgaaaaac tatctcaact gcagacatat atgatacaat
6661 ttgatcagta tattaaagat agttatgatt tacatgattt gaaaatagct attgctaata
6721 ttattgatga aatcattgaa aaattaaaaa gtcttgatga gcactatcat atccgtgtaa
6781 ttttagtaaa aacaatccat gatctacatt tgtttattga aaatattgat tttaacaaaa
6841 gtggaagtag tactgcatct tggattcaaa atgtggatac taagtaccaa atcagaatcc
6901 agatacaaga aaaactgcag cagcttaaga gacacataca gaatatagac atccagcacc
6961 tagctggaaa gttaaaacaa cacattgagg ctattgatgt tagagtgctt ttagatcaat
7021 tgggaactac aatttcattt gaaagaataa atgacgttct tgagcatgtc aaacactttg
7081 ttataaatct tattggggat tttgaagtag ctgagaaaat caatgccttc agagccaaag
7141 tccatgagtt aatcgagagg tatgaagtag accaacaaat ccaggtttta atggataaat
7201 tagtagagtt ggcccaccaa tacaagttga aggagactat tcagaagcta agcaatgtcc
7261 tacaacaagt taagataaaa gattactttg agaaattagt tggatttatt gatgatgctg
7321 tcaagaagct taatgaatta tcttttaaaa cattcattga agatgttaac aaattccttg
7381 acatgttgat aaagaaatta aagtcatttg attaccacca gtttgtagat gaaaccaatg
7441 acaaaatccg tgaggtgact cagagactca atggtgaaat tcaggctctg gaactaccac
7501 aaaaagctga agcattaaaa ctgtttttag aggaaaccaa ggccacagtt gcagtgtatc
7561 tggaaagcct acaggacacc aaaataacct taatcatcaa ttggttacag gaggctttaa
7621 gttcagcatc tttggctcac atgaaggcca aattccgaga gaccctagaa gatacacgag
7681 accgaatgta tcaaatggac attcagcagg aacttcaacg atacctgtct ctggtcagcc
7741 aggtttatag cacacttgtc acctacattt ctgattggtg gactcttgct gctaagaacc
7801 ttactgactt tgcagagcaa tattctatcc aagattgggc taaacgtatg aaagcattgg
7861 tagagcaagg gttcactgtt cctgaaatca agaccatcct tgggaccatg cctgcctttg
7921 aagtcagtct tcaggctctt cagaaagcta ccttccagac acctgatttt atagtccccc
7981 taacagattt gaggattcca tcagttcaga taaacttcaa agacttaaaa aatataaaaa
8041 tcccatccag gttttccaca ccagaattta ccatccttaa caccttccac attccttcct
8101 ttacaattga ctttgtagaa atgaaagtaa agatcatcag aaccattgac cagatgctga
8161 acagtgagct gcagtggccc gttccagata tatatctcag ggatctgaag gtggaggaca
8221 ttcctctagc gagaatcacc ctgccagact tccgtttacc agaaatcgca ataccagaat
8281 tcataatccc aactctcaac cttaatgatt ttcaagttcc tgaccttcac ataccagaat
8341 tccagcttcc ccacatctca cacacaattg aagtacctac ttttggcaag ctatacagta
8401 ttctgaaaat ccaatctcct cttttcacat tagatgcaaa tgctgacata gggaatggaa
8461 ccacctcagc aaacgaagca ggtatcgcag cttccatcac tgccaaagga gagtccaaat
8521 tagaagttct caattttgat tttcaagcaa atgcacaact ctcaaaccct aagattaatc
8581 cgctggctct gaaggagtca gtgaagttct ccagcaagta cctgagaacg gagcatggga
8641 gtgaaatgct gttttttgga aatgccattg agggaaaatc aaacacagtg gcaagtttac
8701 acacagaaaa aaatacactg gagcttagta atggagtgat tgtcaagata aacaatcagc
8761 ttaccctgga tagcaacact aaatacttcc acaaattgaa catccccaaa ctggacttct
8821 ctagtcaggc tgacctgcgc aacgagatca agacactgtt gaaagctggc cacatagcat
8881 ggacttcttc tggaaaaggg tcatggaaat gggcctgccc cagattctca gatgagggaa
8941 cacatgaatc acaaattagt ttcaccatag aaggacccct cacttccttt ggactgtcca
9001 ataagatcaa tagcaaacac ctaagagtaa accaaaactt ggtttatgaa tctggctccc
9061 tcaacttttc taaacttgaa attcaatcac aagtcgattc ccagcatgtg ggccacagtg
9121 ttctaactgc taaaggcatg gcactgtttg gagaagggaa ggcagagttt actgggaggc
9181 atgatgctca tttaaatgga aaggttattg gaactttgaa aaattctctt ttcttttcag
9241 cccagccatt tgagatcacg gcatccacaa acaatgaagg gaatttgaaa gttcgttttc
9301 cattaaggtt aacagggaag atagacttcc tgaataacta tgcactgttt ctgagtccca
9361 gtgcccagca agcaagttgg caagtaagtg ctaggttcaa tcagtataag tacaaccaaa
9421 atttctctgc tggaaacaac gagaacatta tggaggccca tgtaggaata aatggagaag
9481 caaatctgga tttcttaaac attcctttaa caattcctga aatgcgtcta ccttacacaa
9541 taatcacaac tcctccactg aaagatttct ctctatggga aaaaacaggc ttgaaggaat
9601 tcttgaaaac gacaaagcaa tcatttgatt taagtgtaaa agctcagtat aagaaaaaca
9661 aacacaggca ttccatcaca aatcctttgg ctgtgctttg tgagtttatc agtcagagca
9721 tcaaatcctt tgacaggcat tttgaaaaaa acagaaacaa tgcattagat tttgtcacca
9781 aatcctataa tgaaacaaaa attaagtttg ataagtacaa agctgaaaaa tctcaggacg
9841 agctccccag gacctttcaa attcctggat acactgttcc agttgtcaat gttgaagtgt
9901 ctccattcac catagagatg tcggcattcg gctatgtgtt cccaaaagca gtcagcatgc
9961 ctagtttctc catcctaggt tctgacgtcc gtgtgccttc atacacatta atcctgccat
10021 cattagagct gccagtcctt catgtcccta gaaatctcaa gctttctctt ccacatttca
10081 aggaattgtg taccataagc catattttta ttcctgccat gggcaatatt acctatgatt
10141 tctcctttaa atcaagtgtc atcacactga ataccaatgc tgaacttttt aaccagtcag
10201 atattgttgc tcatctcctt tcttcatctt catctgtcat tgatgcactg cagtacaaat
10261 tagagggcac cacaagattg acaagaaaaa ggggattgaa gttagccaca gctctgtctc
10321 tgagcaacaa atttgtggag ggtagtcata acagtactgt gagcttaacc acgaaaaata
10381 tggaagtgtc agtggcaaaa accacaaaag ccgaaattcc aattttgaga atgaatttca
10441 agcaagaact taatggaaat accaagtcaa aacctactgt ctcttcctcc atggaattta
10501 agtatgattt caattcttca atgctgtact ctaccgctaa aggagcagtt gaccacaagc
10561 ttagcttgga aagcctcacc tcttactttt ccattgagtc atctaccaaa ggagatgtca
10621 agggttcggt tctttctcgg gaatattcag gaactattgc tagtgaggcc aacacttact
10681 tgaattccaa gagcacacgg tcttcagtga agctgcaggg cacttccaaa attgatgata
10741 tctggaacct tgaagtaaaa gaaaattttg ctggagaagc cacactccaa cgcatatatt
10801 ccctctggga gcacagtacg aaaaaccact tacagctaga gggcctcttt ttcaccaacg
10861 gagaacatac aagcaaagcc accctggaac tctctccatg gcaaatgtca gctcttgttc
10921 aggtccatgc aagtcagccc agttccttcc atgatttccc tgaccttggc caggaagtgg
10981 ccctgaatgc taacactaag aaccagaaga tcagatggaa aaatgaagtc cggattcatt
11041 ctgggtcttt ccagagccag gtcgagcttt ccaatgacca agaaaaggca caccttgaca
11101 ttgcaggatc cttagaagga cacctaaggt tcctcaaaaa tatcatccta ccagtctatg
11161 acaagagctt atgggatttc ctaaagctgg atgtaaccac cagcattggt aggagacagc
11221 atcttcgtgt ttcaactgcc tttgtgtaca ccaaaaaccc caatggctat tcattctcca
11281 tccctgtaaa agttttggct gataaattca ttactcctgg gctgaaacta aatgatctaa
11341 attcagttct tgtcatgcct acgttccatg tcccatttac agatcttcag gttccatcgt
11401 gcaaacttga cttcagagaa atacaaatct ataagaagct gagaacttca tcatttgccc
11461 tcaacctacc aacactcccc gaggtaaaat tccctgaagt tgatgtgtta acaaaatatt
11521 ctcaaccaga agactccttg attccctttt ttgagataac cgtgcctgaa tctcagttaa
11581 ctgtgtcccg attcacgctt ccaaaaagtg tttcagatgg cattgctgct ttggatctaa
11641 atgcagtagc caacaagatc gcagactttg agttgcccac catcatcgtg cctgagcaga
11701 ccattgagat tccctccatt aagttctctg tacctgctgg aattgtcatt ccttcctttc
11761 aagcactgac tgcacgcttt gaggtagact ctcccgtgta taatgccact tggagtgcca
11821 gtttgaaaaa caaagcagat tatgttgaaa cagtcctgga ttccacatgc agctcaaccg
11881 tacagttcct agaatatgaa ctaaatgttt tgggaacaca caaaatcgaa gatggtacgt
11941 tagcctctaa gactaaagga acacttgcac accgtgactt cagtgcagaa tatgaagaag
12001 atggcaaatt tgaaggactt caggaatggg aaggaaaagc gcacctcaat atcaaaagcc
12061 cagcgttcac cgatctccat ctgcgctacc agaaagacaa gaaaggcatc tccacctcag
12121 cagcctcccc agccgtaggc accgtgggca tggatatgga tgaagatgac gacttttcta
12181 aatggaactt ctactacagc cctcagtcct ctccagataa aaaactcacc atattcaaaa
12241 ctgagttgag ggtccgggaa tctgatgagg aaactcagat caaagttaat tgggaagaag
12301 aggcagcttc tggcttgcta acctctctga aagacaacgt gcccaaggcc acaggggtcc
12361 tttatgatta tgtcaacaag taccactggg aacacacagg gctcaccctg agagaagtgt
12421 cttcaaagct gagaagaaat ctgcagaaca atgctgagtg ggtttatcaa ggggccatta
12481 ggcaaattga tgatatcgac gtgaggttcc agaaagcagc cagtggcacc actgggacct
12541 accaagagtg gaaggacaag gcccagaatc tgtaccagga actgttgact caggaaggcc
12601 aagccagttt ccagggactc aaggataacg tgtttgatgg cttggtacga gttactcaaa
12661 aattccatat gaaagtcaag catctgattg actcactcat tgattttctg aacttcccca
12721 gattccagtt tccggggaaa cctgggatat acactaggga ggaactttgc actatgttca
12781 taagggaggt agggacggta ctgtcccagg tatattcgaa agtccataat ggttcagaaa
12841 tactgttttc ctatttccaa gacctagtga ttacacttcc tttcgagtta aggaaacata
12901 aactaataga tgtaatctcg atgtataggg aactgttgaa agatttatca aaagaagccc
12961 aagaggtatt taaagccatt cagtctctca agaccacaga ggtgctacgt aatcttcagg
13021 accttttaca attcattttc caactaatag aagataacat taaacagctg aaagagatga
13081 aatttactta tcttattaat tatatccaag atgagatcaa cacaatcttc aatgattata
13141 tcccatatgt ttttaaattg ttgaaagaaa acctatgcct taatcttcat aagttcaatg
13201 aatttattca aaacgagctt caggaagctt ctcaagagtt acagcagatc catcaataca
13261 ttatggccct tcgtgaagaa tattttgatc caagtatagt tggctggaca gtgaaatatt
13321 atgaacttga agaaaagata gtcagtctga tcaagaacct gttagttgct cttaaggact
13381 tccattctga atatattgtc agtgcctcta actttacttc ccaactctca agtcaagttg
13441 agcaatttct gcacagaaat attcaggaat atcttagcat ccttaccgat ccagatggaa
13501 aagggaaaga gaagattgca gagctttctg ccactgctca ggaaataatt aaaagccagg
13561 ccattgcgac gaagaaaata atttctgatt accaccagca gtttagatat aaactgcaag
13621 atttttcaga ccaactctct gattactatg aaaaatttat tgctgaatcc aaaagattga
13681 ttgacctgtc cattcaaaac taccacacat ttctgatata catcacggag ttactgaaaa
13741 agctgcaatc aaccacagtc atgaacccct acatgaagct tgctccagga gaacttacta
13801 tcatcctcta attttttaaa agaaatcttc aatttattct tcttttccaa ttgaactttc
13861 acatagcaca gaaaaaattc aaactgccta tattgataaa accatacagt gagccagcct
13921 tgcagtaggc agtagactat aagcagaagc acatatgaac tggacctgca ccaaagctgg
13981 caccagggct cggaaggtct ctgaactcag aaggatggca ttttttgcaa gttaaagaaa
14041 atcaggatct gagttatttt gctaaacttg ggggaggagg aacaaataaa tggagtcttt
14101 attgtgtatc at
//