LOCUS X04665 4434 bp mRNA linear HUM 21-OCT-2008
DEFINITION Human mRNA for thrombospondin.
ACCESSION X04665
VERSION X04665.1
KEYWORDS glycoprotein; signal peptide; thrombospondin.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4434)
AUTHORS Lawler J., Hynes R.O.
TITLE The structure of human thrombospondin, an adhesive glycoprotein
with multiple calcium-binding sites and homologies with several
different proteins
JOURNAL J. Cell Biol. 103(5), 1635-1648(1986).
PUBMED 2430973
COMMENT Three types of repeating amino acid sequence are present in
thrombospondin. The first is 57 amino acids long and shows homology
with circumsporozoite protein from Plasmodium falciparum. The
second is 50-60 amino acids long and shows homology with epidermal
growth factor precursor. The third occurs as a continuous eightfold
repeat of a 38-residue sequence; structural homology with
parvalbumin and calmodulin indicates that these repeats constitute
the multiple calcium-binding sites of thrombospondin.
Data kindly reviewed (15-SEP-1987) by Lawler J.
FEATURES Location/Qualifiers
source 1..4434
/db_xref="H-InvDB:HIT000321055"
/organism="Homo sapiens"
/mol_type="mRNA"
/cell_type="umbilical vein endothelial cells"
/db_xref="taxon:9606"
CDS 76..3588
/note="precursor polypeptide (AA -18 to 1152)"
/db_xref="GOA:P07996"
/db_xref="H-InvDB:HIT000321055.14"
/db_xref="HGNC:HGNC:11785"
/db_xref="InterPro:IPR000742"
/db_xref="InterPro:IPR000884"
/db_xref="InterPro:IPR001007"
/db_xref="InterPro:IPR001791"
/db_xref="InterPro:IPR001881"
/db_xref="InterPro:IPR003367"
/db_xref="InterPro:IPR008859"
/db_xref="InterPro:IPR013032"
/db_xref="InterPro:IPR013320"
/db_xref="InterPro:IPR017897"
/db_xref="InterPro:IPR028499"
/db_xref="InterPro:IPR028974"
/db_xref="InterPro:IPR036383"
/db_xref="PDB:1LSL"
/db_xref="PDB:1UX6"
/db_xref="PDB:1Z78"
/db_xref="PDB:1ZA4"
/db_xref="PDB:2ERF"
/db_xref="PDB:2ES3"
/db_xref="PDB:2OUH"
/db_xref="PDB:2OUJ"
/db_xref="PDB:3R6B"
/db_xref="PDB:5FOE"
/db_xref="UniProtKB/Swiss-Prot:P07996"
/protein_id="CAA28370.1"
/translation="MGLAWGLGVLFLMHVCGTNRIPESGGDNSVFDIFELTGAARKGS
GRRLVKGPDPSSPAFRIEDANLIPPVPDDKFQDLVDAVRTEKGFLLLASLRQMKKTRG
TLLALERKDHSGQVFSVVSNGKAGTLDLSLTVQGKQHVVSVEEALLATGQWKSITLFV
QEDRAQLYIDCEKMENAELDVPIQSVFTRDLASIARLRIAKGGVNDNFQGVLQNVRFV
FGTTPEDILRNKGCSSSTSVLLTLDNNVVNGSSPAIRTNYIGHKTKDLQAICGISCDE
LSSMVLELRGLRTIVTTLQDSIRKVTEENKELANELRRPPLCYHNGVQYRNNEEWTVD
SCTECHCQNSVTICKKVSCPIMPCSNATVPDGECCPRCWPSDSADDGWSPWSEWTSCS
TSCGNGIQQRGRSCDSLNNRCEGSSVQTRTCHIQECDKRFKQDGGWSHWSPWSSCSVT
CGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACPINGGWGPWSPWDICSVTC
GGGVQKRSRLCNNPTPQFGGKDCVGDVTENQICNKQDCPIDGCLSNPCFAGVKCTSYP
DGSWKCGACPPGYSGNGIQCTDVDECKEVPDACFNHNGEHRCENTDPGYNCLPCPPRF
TGSQPFGQGVEHATANKQVCKPRNPCTDGTHDCNKNAKCNYLGHYSDPMYRCECKPGY
AGNGIICGEDTDLDGWPNENLVCVANATYHCKKDNCPNLPNSGQEDYDKDGIGDACDD
DDDNDKIPDDRDNCPFHYNPAQYDYDRDDVGDRCDNCPYNHNPDQADTDNNGEGDACA
ADIDGDGILNERDNCQYVYNVDQRDTDMDGVGDQCDNCPLEHNPDQLDSDSDRIGDTC
DNNQDIDEDGHQNNLDNCPYVPNANQADHDKDGKGDACDHDDDNDGIPDDKDNCRLVP
NPDQKDSDGDGRGDACKDDFDHDSVPDIDDICPENVDISETDFRRFQMIPLDPKGTSQ
NDPNWVVRHQGKELVQTVNCDPGLAVGYDEFNAVDFSGTFFINTERDDDYAGFVFGYQ
SSSRFYVVMWKQVTQSYWDTNPTRAQGYSGLSVKVVNSTTGPGEHLRNALWHTGNTPG
QVRTLWHDPRHIGWKDFTAYRWRLSHRPKTGFIRVVMYEGKKIMADSGPIYDKTYAGG
RLGLFVFSQEMVFFSDLKYECRDP"
sig_peptide 76..129
/note="put. signal peptide (AA -18 to -1)"
mat_peptide 130..3585
/note="mature peptide (AA 1-1152)"
misc_feature 817..825
/note="pot. N-glycosylation site"
misc_feature 1153..1161
/note="pot. N-glycosylation site"
misc_feature 1636..1644
/note="pot. N-glycosylation site"
misc_feature 2197..2205
/note="pot. N-glycosylation site"
misc_feature 3226..3234
/note="pot. N-glycosylation site"
misc_feature 3274..3282
/note="pot. N-glycosylation site"
BASE COUNT 1139 a 1185 c 1177 g 933 t
ORIGIN
1 gccgccctcg ccaccgctcc cggccgccgc gctccggtac acacaggatc cctgctgggc
61 accaacagct ccaccatggg gctggcctgg ggactaggcg tcctgttcct gatgcatgtg
121 tgtggcacca accgcattcc agagtctggc ggagacaaca gcgtgtttga catctttgaa
181 ctcaccgggg ccgcccgcaa ggggtctggg cgccgactgg tgaagggccc cgacccttcc
241 agcccagctt tccgcatcga ggatgccaac ctgatccccc ctgtgcctga tgacaagttc
301 caagacctgg tggatgctgt gcggacagaa aagggtttcc tccttctggc atccctgagg
361 cagatgaaga agacccgggg cacgctgctg gccctggagc ggaaagacca ctctggccag
421 gtcttcagcg tggtgtccaa tggcaaggcg ggcaccctgg acctcagcct gaccgtccaa
481 ggaaagcagc acgtggtgtc tgtggaagaa gctctcctgg caaccggcca gtggaagagc
541 atcaccctgt ttgtgcagga agacagggcc cagctgtaca tcgactgtga aaagatggag
601 aatgctgagt tggacgtccc catccaaagc gtcttcacca gagacctggc cagcatcgcc
661 agactccgca tcgcaaaggg gggcgtcaat gacaatttcc agggggtgct gcagaatgtg
721 aggtttgtct ttggaaccac accagaagac atcctcagga acaaaggctg ctccagctct
781 accagtgtcc tcctcaccct tgacaacaac gtggtgaatg gttccagccc tgccatccgc
841 actaactaca ttggccacaa gacaaaggac ttgcaagcca tctgcggcat ctcctgtgat
901 gagctgtcca gcatggtcct ggaactcagg ggcctgcgca ccattgtgac cacgctgcag
961 gacagcatcc gcaaagtgac tgaagagaac aaagagttgg ccaatgagct gaggcggcct
1021 cccctatgct atcacaacgg agttcagtac agaaataacg aggaatggac tgttgatagc
1081 tgcactgagt gtcactgtca gaactcagtt accatctgca aaaaggtgtc ctgccccatc
1141 atgccctgct ccaatgccac agttcctgat ggagaatgct gtcctcgctg ttggcccagc
1201 gactctgcgg acgatggctg gtctccatgg tccgagtgga cctcctgttc tacgagctgt
1261 ggcaatggaa ttcagcagcg cggccgctcc tgcgatagcc tcaacaaccg atgtgagggc
1321 tcctcggtcc agacacggac ctgccacatt caggagtgtg acaagagatt taaacaggat
1381 ggtggctgga gccactggtc cccgtggtca tcttgttctg tgacatgtgg tgatggtgtg
1441 atcacaagga tccggctctg caactctccc agcccccaga tgaacgggaa accctgtgaa
1501 ggcgaagcgc gggagaccaa agcctgcaag aaagacgcct gccccatcaa tggaggctgg
1561 ggtccttggt caccatggga catctgttct gtcacctgtg gaggaggggt acagaaacgt
1621 agtcgtctct gcaacaaccc cacaccccag tttggaggca aggactgcgt tggtgatgta
1681 acagaaaacc agatctgcaa caagcaggac tgtccaattg atggatgcct gtccaatccc
1741 tgctttgccg gcgtgaagtg tactagctac cctgatggca gctggaaatg tggtgcttgt
1801 ccccctggtt acagtggaaa tggcatccag tgcacagatg ttgatgagtg caaagaagtg
1861 cctgatgcct gcttcaacca caatggagag caccggtgtg agaacacgga ccccggctac
1921 aactgcctgc cctgcccccc acgcttcacc ggctcacagc ccttcggcca gggtgtcgaa
1981 catgccacgg ccaacaaaca ggtgtgcaag ccccgtaacc cctgcacgga tgggacccac
2041 gactgcaaca agaacgccaa gtgcaactac ctgggccact atagcgaccc catgtaccgc
2101 tgcgagtgca agcctggcta cgctggcaat ggcatcatct gcggggagga cacagacctg
2161 gatggctggc ccaatgagaa cctggtgtgc gtggccaatg cgacttacca ctgcaaaaag
2221 gataattgcc ccaaccttcc caactcaggg caggaagact atgacaagga tggaattggt
2281 gatgcctgtg atgatgacga tgacaatgat aaaattccag atgacaggga caactgtcca
2341 ttccattaca acccagctca gtatgactat gacagagatg atgtgggaga ccgctgtgac
2401 aactgtccct acaaccacaa cccagatcag gcagacacag acaacaatgg ggaaggagac
2461 gcctgtgctg cagacattga tggagacggt atcctcaatg aacgggacaa ctgccagtac
2521 gtctacaatg tggaccagag agacactgat atggatgggg ttggagatca gtgtgacaat
2581 tgccccttgg aacacaatcc ggatcagctg gactctgact cagaccgcat tggagatacc
2641 tgtgacaaca atcaggatat tgatgaagat ggccaccaga acaatctgga caactgtccc
2701 tatgtgccca atgccaacca ggctgaccat gacaaagatg gcaagggaga tgcctgtgac
2761 cacgatgatg acaacgatgg cattcctgat gacaaggaca actgcagact cgtgcccaat
2821 cccgaccaga aggactctga cggcgatggt cgaggtgatg cctgcaaaga tgattttgac
2881 catgacagtg tgccagacat cgatgacatc tgtcctgaga atgttgacat cagtgagacc
2941 gatttccgcc gattccagat gattcctctg gaccccaaag ggacatccca aaatgaccct
3001 aactgggttg tacgccatca gggtaaagaa ctcgtccaga ctgtcaactg tgatcctgga
3061 ctcgctgtag gttatgatga gtttaatgct gtggacttca gtggcacctt cttcatcaac
3121 accgaaaggg acgatgacta tgctggattt gtctttggct accagtccag cagccgcttt
3181 tatgttgtga tgtggaagca agtcacccag tcctactggg acaccaaccc cacgagggct
3241 cagggatact cgggcctttc tgtgaaagtt gtaaactcca ccacagggcc tggcgagcac
3301 ctgcggaacg ccctgtggca cacaggaaac acccctggcc aggtgcgcac cctgtggcat
3361 gaccctcgtc acataggctg gaaagatttc accgcctaca gatggcgtct cagccacagg
3421 ccaaagacgg gtttcattag agtggtgatg tatgaaggga agaaaatcat ggctgactca
3481 ggacccatct atgataaaac ctatgctggt ggtagactag ggttgtttgt cttctctcaa
3541 gaaatggtgt tcttctctga cctgaaatac gaatgtagag atccctaatc atcaaattgt
3601 tgattgaaag actgatcata aaccaatgct ggtattgcac cttctggaac tatgggcttg
3661 agaaaacccc caggatcact tctccttggc ttccttcttt tctgtgcttg catcagtgtg
3721 gactcctaga acgtgcgacc tgcctcaaga aaatgcagtt ttcaaaaaca gactcagcat
3781 tcagcctcca atgaataaga catcttccaa gcatataaac aattgctttg gtttcctttt
3841 gaaaaagcat ctacttgctt cagttgggaa ggtgcccatt ccactctgcc tttgtcacag
3901 agcagggtgc tattgtgagg ccatctctga gcagtggact caaaagcatt ttcaggcatg
3961 tcagagaagg gaggactcac tagaattagc aaacaaaacc accctgacat cctccttcag
4021 gaacacgggg agcagaggcc aaagcactaa ggggagggcg catacccgag acgattgtat
4081 gaagaaaata tggaggaact gttacatgtt cggtactaag tcattttcag gggattgaaa
4141 gactattgct ggatttcatg atgctgactg gcgttagctg attaacccat gtaaataggc
4201 acttaaatag aagcaggaaa gggagacaaa gactggcttc tggacttcct ccctgatccc
4261 cacccttact catcacctgc agtggccaga attagggaat cagaatcgaa accagtgtaa
4321 ggcagtgctg gctgccattg cctggtcaca ttgaaattgg tggcttcatt ctagatgtag
4381 cttgtgcaga tgtagcagga aaataggaaa acctaccatc tcagtgagca ccag
//