LOCUS       X04506                 14121 bp    mRNA    linear   HUM 07-OCT-2008
DEFINITION  Human mRNA for apolipoprotein B-100.
ACCESSION   X04506
VERSION     X04506.1
KEYWORDS    apolipoprotein B-100; low density lipoprotein.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 14121)
  AUTHORS   Knott T.C., Wallis S.C., Powell L.M., Pease R.J., Lusis A.J.,
            Blackhart B., Mccarthy B.J., Mahley R.W., Levy-Wilson B., Scott J.
  TITLE     Complete cDNA and derived protein sequence of human apolipoprotein
            B-100
  JOURNAL   Nucleic Acids Res. 14(18), 7501-7503(1986).
   PUBMED   3763409
REFERENCE   2  (bases 1 to 14121)
  AUTHORS   Knott T.J.
  JOURNAL   Submitted (31-OCT-1986) to the INSDC. Knott T.J., Molecular
            Medicine Research Group, MRC Clinical Research Centre, Watford
            Road, Harrow, Middlesex, England.
FEATURES             Location/Qualifiers
     source          1..14121
                     /db_xref="H-InvDB:HIT000321047"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     CDS             129..13820
                     /note="precursor"
                     /db_xref="GOA:P04114"
                     /db_xref="H-InvDB:HIT000321047.15"
                     /db_xref="HGNC:HGNC:603"
                     /db_xref="InterPro:IPR001747"
                     /db_xref="InterPro:IPR009454"
                     /db_xref="InterPro:IPR011030"
                     /db_xref="InterPro:IPR015255"
                     /db_xref="InterPro:IPR015816"
                     /db_xref="InterPro:IPR015819"
                     /db_xref="InterPro:IPR016024"
                     /db_xref="InterPro:IPR022176"
                     /db_xref="UniProtKB/Swiss-Prot:P04114"
                     /protein_id="CAA28191.1"
                     /translation="MDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDAT
                     RFKHLRKYTYNYEAESSSGVPGTADSRSATRINCKVELEVPQLCSFILKTSQCTLKEV
                     YGFNPEGKALLKKTKNSEEFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKRGI
                     ISALLVPPETEEAKQVLFLDTVYGNCSTHFTVKTRKGNVATEISTERDLGQCDRFKPI
                     RTGISPLALIKGMTRPLSTLISSSQSCQYTLDAKRKHVAEAICKEQHLFLPFSYNNKY
                     GMVAQVTQTLKLEDTPKINSRFFGEGTKKMGLAFESTKSTSPPKQAEAVLKTLQELKK
                     LTISEQNIQRANLFNKLVTELRGLSDEAVTSLLPQLIEVSSPITLQALVQCGQPQCST
                     HILQWLKRVHANPLLIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHAVN
                     NYHKTNPTGTQELLDIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKS
                     SILKCVQSTKPSLMIQKAAIQALRKMEPKDKDQEVLLQTFLDDASPGDKRLAAYLMLM
                     RSPSQADINKIVQILPWEQNEQVKNFVASHIANILNSEELDIQDLKKLVKEALKESQL
                     PTVMDFRKFSRNYQLYKSVSLPSLDPASAKIEGNLIFDPNNYLPKESMLKTTLTAFGF
                     ASADLIEIGLEGKGFEPTLEALFGKQGFFPDSVNKALYWVNGQVPDGVSKVLVDHFGY
                     TKDDKHEQDMVNGIMLSVEKLIKDLKSKEVPEARAYLRILGEELGFASLHDLQLLGKL
                     LLMGARTLQGIPQMIGEVIRKGSKNDFFLHYIFMENAFELPTGAGLQLQISSSGVIAP
                     GAKAGVKLEVANMQAELVAKPSVSVEFVTNMGIIIPDFARSGVQMNTNFFHESGLEAH
                     VALKAGKLKFIIPSPKRPVKLLSGGNTLHLVSTTKTEVIPPLIENRQSWSVCKQVFPG
                     LNYCTSGAYSNASSTDSASYYPLTGDTRLELELRPTGEIEQYSVSATYELQREDRALV
                     DTLKFVTQAEGAKQTEATMTFKYNRQSMTLSSEVQIPDFDVDLGTILRVNDESTEGKT
                     SYRLTLDIQNKKITEVALMGHLSCDTKEERKIKGVISIPRLQAEARSEILAHWSPAKL
                     LLQMDSSATAYGSTVSKRVAWHYDEEKIEFEWNTGTNVDTKKMTSNFPVDLSDYPKSL
                     HMYANRLLDHRVPETDMTFRHVGSKLIVAMSSWLQKASGSLPYTQTLQDHLNSLKEFN
                     LQNMGLPDFHIPENLFLKSDGRVKYTLNKNSLKIEIPLPFGGKSSRDLKMLETVRTPA
                     LHFKSVGFHLPSREFQVPTFTIPKLYQLQVPLLGVLDLSTNVYSNLYNWSASYSGGNT
                     STDHFSLRARYHMKADSVVDLLSYNVQGSGETTYDHKNTFTLSCDGSLRHKFLDSNIK
                     FSHVEKLGNNPVSKGLLIFDASSSWGPQMSASVHLDSKKKQHLFVKEVKIDGQFRVSS
                     FYAKGTYGLSCQRDPNTGRLNGESNLRFNSSYLQGTNQITGRYEDGTLSLTSTSDLQS
                     GIIKNTASLKYENYELTLKSDTNGKYKNFATSNKMDMTFSKQNALLRSEYQADYESLR
                     FFSLLSGSLNSHGLELNADILGTDKINSGAHKATLRIGQDGISTSATTNLKCSLLVLE
                     NELNAELGLSGASMKLTTNGRFREHNAKFSLDGKAALTELSLGSAYQAMILGVDSKNI
                     FNFKVSQEGLKLSNDMMGSYAEMKFDHTNSLNIAGLSLDFSSKLDNIYSSDKFYKQTV
                     NLQLQPYSLVTTLNSDLKYNALDLTNNGKLRLEPLKLHVAGNLKGAYQNNEIKHIYAI
                     SSAALSASYKADTVAKVQGVEFSHRLNTDIAGLASAIDMSTNYNSDSLHFSNVFRSVM
                     APFTMTIDAHTNGNGKLALWGEHTGQLYSKFLLKAEPLAFTFSHDYKGSTSHHLVSRK
                     SISAALEHKVSALLTPAEQTGTWKLKTQFNNNEYSQDLDAYNTKDKIGVELTGRTLAD
                     LTLLDSPIKVPLLLSEPINIIDALEMRDAVEKPQEFTIVAFVKYDKNQDVHSINLPFF
                     ETLQEYFERNRQTIIVVVENVQRNLKHINIDQFVRKYRAALGKLPQQANDYLNSFNWE
                     RQVSHAKEKLTALTKKYRITENDIQIALDDAKINFNEKLSQLQTYMIQFDQYIKDSYD
                     LHDLKIAIANIIDEIIEKLKSLDEHYHIRVNLVKTIHDLHLFIENIDFNKSGSSTASW
                     IQNVDTKYQIRIQIQEKLQQLKRHIQNIDIQHLAGKLKQHIEAIDVRVLLDQLGTTIS
                     FERINDVLEHVKHFVINLIGDFEVAEKINAFRAKVHELIERYEVDQQIQVLMDKLVEL
                     THQYKLKETIQKLSNVLQQVKIKDYFEKLVGFIDDAVKKLNELSFKTFIEDVNKFLDM
                     LIKKLKSFDYHQFVDETNDKIREVTQRLNGEIQALELPQKAEALKLFLEETKATVAVY
                     LESLQDTKITLIINWLQEALSSASLAHMKAKFRETLEDTRDRMYQMDIQQELQRYLSL
                     VGQVYSTLVTYISDWWTLAAKNLTDFAEQYSIQDWAKRMKALVEQGFTVPEIKTILGT
                     MPAFEVSLQALQKATFQTPDFIVPLTDLRIPSVQINFKDLKNIKIPSRFSTPEFTILN
                     TFHIPSFTIDFVEMKVKIIRTIDQMQNSELQWPVPDIYLRDLKVEDIPLARITLPDFR
                     LPEIAIPEFIIPTLNLNDFQVPDLHIPEFQLPHISHTIEVPTFGKLYSILKIQSPLFT
                     LDANADIGNGTTSANEAGIAASITAKGESKLEVLNFDFQANAQLSNPKINPLALKESV
                     KFSSKYLRTEHGSEMLFFGNAIEGKSNTVASLHTEKNTLELSNGVIVKINNQLTLDSN
                     TKYFHKLNIPKLDFSSQADLRNEIKTLLKAGHIAWTSSGKGSWKWACPRFSDEGTHES
                     QISFTIEGPLTSFGLSNKINSKHLRVNQNLVYESGSLNFSKLEIQSQVDSQHVGHSVL
                     TAKGMALFGEGKAEFTGRHDAHLNGKVIGTLKNSLFFSAQPFEITASTNNEGNLKVRF
                     PLRLTGKIDFLNNYALFLSPSAQQASWQVSARFNQYKYNQNFSAGNNENIMEAHVGIN
                     GEANLDFLNIPLTIPEMRLPYTIITTPPLKDFSLWEKTGLKEFLKTTKQSFDLSVKAQ
                     YKKNKHRHSITNPLAVLCEFISQSIKSFDRHFEKNRNNALDFVTKSYNETKIKFDKYK
                     AEKSHDELPRTFQIPGYTVPVVNVEVSPFTIEMSAFGYVFPKAVSMPSFSILGSDVRV
                     PSYTLILPSLELPVLHVPRNLKLSLPHFKELCTISHIFIPAMGNITYDFSFKSSVITL
                     NTNAELFNQSDIVAHLLSSSSSVIDALQYKLEGTTRLTRKRGLKLATALSLSNKFVEG
                     SHNSTVSLTTKNMEVSVAKTTKAEIPILRMNFKQELNGNTKSKPTVSSSMEFKYDFNS
                     SMLYSTAKGAVDHKLSLESLTSYFSIESSTKGDVKGSVLSREYSGTIASEANTYLNSK
                     STRSSVKLQGTSKIDDIWNLEVKENFAGEATLQRIYSLWEHSTKNHLQLEGLFFTNGE
                     HTSKATLELSPWQMSALVQVHASQPSSFHDFPDLGQEVALNANTKNQKIRWKNEVRIH
                     SGSFQSQVELSNDQEKAHLDIAGSLEGHLRFLKNIILPVYDKSLWDFLKLDVTTSIGR
                     RQHLRVSTAFVYTKNPNGYSFSIPVKVLADKFITPGLKLNDLNSVLVMPTFHVPFTDL
                     QVPSCKLDFREIQIYKKLRTSSFALNLPTLPEVKFPEVDVLTKYSQPEDSLIPFFEIT
                     VPESQLTVSQFTLPKSVSDGIAALDLNAVANKIADFELPTIIVPEQTIEIPSIKFSVP
                     AGIVIPSFQALTARFEVDSPVYNATWSASLKNKADYVETVLDSTCSSTVQFLEYELNV
                     LGTHKIEDGTLASKTKGTLAHRDFSAEYEEDGKFEGLQEWEGKAHLNIKSPAFTDLHL
                     RYQKDKKGISTSAASPAVGTVGMDMDEDDDFSKWNFYYSPQSSPDKKLTIFKTELRVR
                     ESDEETQIKVNWEEEAASGLLTSLKDNVPKATGVLYDYVNKYHWEHTGLTLREVSSKL
                     RRNLQNNAEWVYQGAIRQIDDIDVRFQKAASGTTGTYQEWKDKAQNLYQELLTQEGQA
                     SFQGLKDNVFDGLVRVTQKFHMKVKHLIDSLIDFLNFPRFQFPGKPGIYTREELCTMF
                     IREVGTVLSQVYSKVHNGSEILFSYFQDLVITLPFELRKHKLIDVISMYRELLKDLSK
                     EAQEVFKAIQSLKTTEVLRNLQDLLQFIFQLIEDNIKQLKEMKFTYLINYIQDEINTI
                     FNDYIPYVFKLLKENLCLNLHKFNEFIQNELQEASQELQQIHQYIMALREEYFDPSIV
                     GWTVKYYELEEKIVSLIKNLLVALKDFHSEYIVSASNFTSQLSSQVEQFLHRNIQEYL
                     SILTDPDGKGKEKIAELSATAQEIIKSQAIATKKIISDYHQQFRYKLQDFSDQLSDYY
                     EKFIAESKRLIDLSIQNYHTFLIYITELLKKLQSTTVMNPYMKLAPGELTIIL"
     sig_peptide     129..209
                     /note="signal peptide (aa -27 to -1)"
     mat_peptide     210..13817
                     /note="apolipoprotein B-100"
     misc_feature    14093..14098
                     /note="polyA signal"
     polyA_site      14121..14121
                     /note="polyA site"
BASE COUNT         4371 a         3240 c         2903 g         3607 t
ORIGIN      
        1 attcccaccg ggacctgcgg ggctgagtgc ccttctcggt tgctgccgct gaggagcccg
       61 cccagccagc cagggccgcg aggccgaggc caggccgcag cccaggagcc gccccaccgc
      121 agctggcgat ggacccgccg aggcccgcgc tgctggcgct gctggcgctg cctgcgctgc
      181 tgctgctgct gctggcgggc gccagggccg aagaggaaat gctggaaaat gtcagcctgg
      241 tctgtccaaa agatgcgacc cgattcaagc acctccggaa gtacacatac aactatgagg
      301 ctgagagttc cagtggagtc cctgggactg ctgattcaag aagtgccacc aggatcaact
      361 gcaaggttga gctggaggtt ccccagctct gcagcttcat cctgaagacc agccagtgca
      421 ccctgaaaga ggtgtatggc ttcaaccctg agggcaaagc cttgctgaag aaaaccaaga
      481 actctgagga gtttgctgca gccatgtcca ggtatgagct caagctggcc attccagaag
      541 ggaagcaggt tttcctttac ccggagaaag atgaacctac ttacatcctg aacatcaaga
      601 ggggcatcat ttctgccctc ctggttcccc cagagacaga agaagccaag caagtgttgt
      661 ttctggatac cgtgtatgga aactgctcca ctcactttac cgtcaagacg aggaagggca
      721 atgtggcaac agaaatatcc actgaaagag acctggggca gtgtgatcgc ttcaagccca
      781 tccgcacagg catcagccca cttgctctca tcaaaggcat gacccgcccc ttgtcaactc
      841 tgatcagcag cagccagtcc tgtcagtaca cactggacgc taagaggaag catgtggcag
      901 aagccatctg caaggagcaa cacctcttcc tgcctttctc ctacaacaat aagtatggga
      961 tggtagcaca agtgacacag actttgaaac ttgaagacac accaaagatc aacagccgct
     1021 tctttggtga aggtactaag aagatgggcc tcgcatttga gagcaccaaa tccacatcac
     1081 ctccaaagca ggccgaagct gttttgaaga ctctccagga actgaaaaaa ctaaccatct
     1141 ctgagcaaaa tatccagaga gctaatctct tcaataagct ggttactgag ctgagaggcc
     1201 tcagtgatga agcagtcaca tctctcttgc cacagctgat tgaggtgtcc agccccatca
     1261 ctttacaagc cttggttcag tgtggacagc ctcagtgctc cactcacatc ctccagtggc
     1321 tgaaacgtgt gcatgccaac ccccttctga tagatgtggt cacctacctg gtggccctga
     1381 tccccgagcc ctcagcacag cagctgcgag agatcttcaa catggcgagg gatcagcgca
     1441 gccgagccac cttgtatgcg ctgagccacg cggtcaacaa ctatcataag acaaacccta
     1501 cagggaccca ggagctgctg gacattgcta attacctgat ggaacagatt caagatgact
     1561 gcactgggga tgaagattac acctatttga ttctgcgggt cattggaaat atgggccaaa
     1621 ccatggagca gttaactcca gaactcaagt cttcaatcct caaatgtgtc caaagtacaa
     1681 agccatcact gatgatccag aaagctgcca tccaggctct gcggaaaatg gagcctaaag
     1741 acaaggacca ggaggttctt cttcagactt tccttgatga tgcttctccg ggagataagc
     1801 gactggctgc ctatcttatg ttgatgagga gtccttcaca ggcagatatt aacaaaattg
     1861 tccaaattct accatgggaa cagaatgagc aagtgaagaa ctttgtggct tcccatattg
     1921 ccaatatctt gaactcagaa gaattggata tccaagatct gaaaaagtta gtgaaagaag
     1981 ctctgaaaga atctcaactt ccaactgtca tggacttcag aaaattctct cggaactatc
     2041 aactctacaa atctgtttct cttccatcac ttgacccagc ctcagccaaa atagaaggga
     2101 atcttatatt tgatccaaat aactaccttc ctaaagaaag catgctgaaa actaccctca
     2161 ctgcctttgg atttgcttca gctgacctca tcgagattgg cttggaagga aaaggctttg
     2221 agccaacatt ggaagctctt tttgggaagc aaggattttt cccagacagt gtcaacaaag
     2281 ctttgtactg ggttaatggt caagttcctg atggtgtctc taaggtctta gtggaccact
     2341 ttggctatac caaagatgat aaacatgagc aggatatggt aaatggaata atgctcagtg
     2401 ttgagaagct gattaaagat ttgaaatcca aagaagtccc ggaagccaga gcctacctcc
     2461 gcatcttggg agaggagctt ggttttgcca gtctccatga cctccagctc ctgggaaagc
     2521 tgcttctgat gggtgcccgc actctgcagg ggatccccca gatgattgga gaggtcatca
     2581 ggaagggctc aaagaatgac ttttttcttc actacatctt catggagaat gcctttgaac
     2641 tccccactgg agctggatta cagttgcaaa tatcttcatc tggagtcatt gctcccggag
     2701 ccaaggctgg agtaaaactg gaagtagcca acatgcaggc tgaactggtg gcaaaaccct
     2761 ccgtgtctgt ggagtttgtg acaaatatgg gcatcatcat tccggacttc gctaggagtg
     2821 gggtccagat gaacaccaac ttcttccacg agtcgggtct ggaggctcat gttgccctaa
     2881 aagctgggaa gctgaagttt atcattcctt ccccaaagag accagtcaag ctgctcagtg
     2941 gaggcaacac attacatttg gtctctacca ccaaaacgga ggtgatccca cctctcattg
     3001 agaacaggca gtcctggtca gtttgcaagc aagtctttcc tggcctgaat tactgcacct
     3061 caggcgctta ctccaacgcc agctccacag actccgcctc ctactatccg ctgaccgggg
     3121 acaccagatt agagctggaa ctgaggccta caggagagat tgagcagtat tctgtcagcg
     3181 caacctatga gctccagaga gaggacagag ccttggtgga taccctgaag tttgtaactc
     3241 aagcagaagg tgcgaagcag actgaggcta ccatgacatt caaatataat cggcagagta
     3301 tgaccttgtc cagtgaagtc caaattccgg attttgatgt tgacctcgga acaatcctca
     3361 gagttaatga tgaatctact gagggcaaaa cgtcttacag actcaccctg gacattcaga
     3421 acaagaaaat tactgaggtc gccctcatgg gccacctaag ttgtgacaca aaggaagaaa
     3481 gaaaaatcaa gggtgttatt tccatacccc gtttgcaagc agaagccaga agtgagatcc
     3541 tcgcccactg gtcgcctgcc aaactgcttc tccaaatgga ctcatctgct acagcttatg
     3601 gctccacagt ttccaagagg gtggcatggc attatgatga agagaagatt gaatttgaat
     3661 ggaacacagg caccaatgta gataccaaaa aaatgacttc caatttccct gtggatctct
     3721 ccgattatcc taagagcttg catatgtatg ctaatagact cctggatcac agagtccctg
     3781 aaacagacat gactttccgg cacgtgggtt ccaaattaat agttgcaatg agctcatggc
     3841 ttcagaaggc atctgggagt cttccttata cccagacttt gcaagaccac ctcaatagcc
     3901 tgaaggagtt caacctccag aacatgggat tgccagactt ccacatccca gaaaacctct
     3961 tcttaaaaag cgatggccgg gtcaaatata ccttgaacaa gaacagtttg aaaattgaga
     4021 ttcctttgcc ttttggtggc aaatcctcca gagatctaaa gatgttagag actgttagga
     4081 caccagccct ccacttcaag tctgtgggat tccatctgcc atctcgagag ttccaagtcc
     4141 ctacttttac cattcccaag ttgtatcaac tgcaagtgcc tctcctgggt gttctagacc
     4201 tctccacgaa tgtctacagc aacttgtaca actggtccgc ctcctacagt ggtggcaaca
     4261 ccagcacaga ccatttcagc cttcgggctc gttaccacat gaaggctgac tctgtggttg
     4321 acctgctttc ctacaatgtg caaggatctg gagaaacaac atatgaccac aagaatacgt
     4381 tcacactatc atgtgatggg tctctacgcc acaaatttct agattcgaat atcaaattca
     4441 gtcatgtaga aaaacttgga aacaacccag tctcaaaagg tttactaata ttcgatgcat
     4501 ctagttcctg gggaccacag atgtctgctt cagttcattt ggactccaaa aagaaacagc
     4561 atttgtttgt caaagaagtc aagattgatg ggcagttcag agtctcttcg ttctatgcta
     4621 aaggcacata tggcctgtct tgtcagaggg atcctaacac tggccggctc aatggagagt
     4681 ccaacctgag gtttaactcc tcctacctcc aaggcaccaa ccagataaca ggaagatatg
     4741 aagatggaac cctctccctc acctccacct ctgatctgca aagtggcatc attaaaaata
     4801 ctgcttccct aaagtatgag aactacgagc tgactttaaa atctgacacc aatgggaagt
     4861 ataagaactt tgccacttct aacaagatgg atatgacctt ctctaagcaa aatgcactgc
     4921 tgcgttctga atatcaggct gattacgagt cattgaggtt cttcagcctg ctttctggat
     4981 cactaaattc ccatggtctt gagttaaatg ctgacatctt aggcactgac aaaattaata
     5041 gtggtgctca caaggcgaca ctaaggattg gccaagatgg aatatctacc agtgcaacga
     5101 ccaacttgaa gtgtagtctc ctggtgctgg agaatgagct gaatgcagag cttggcctct
     5161 ctggggcatc tatgaaatta acaacaaatg gccgcttcag ggaacacaat gcaaaattca
     5221 gtctggatgg gaaagccgcc ctcacagagc tatcactggg aagtgcttat caggccatga
     5281 ttctgggtgt cgacagcaaa aacattttca acttcaaggt cagtcaagaa ggacttaagc
     5341 tctcaaatga catgatgggc tcatatgctg aaatgaaatt tgaccacaca aacagtctga
     5401 acattgcagg cttatcactg gacttctctt caaaacttga caacatttac agctctgaca
     5461 agttttataa gcaaactgtt aatttacagc tacagcccta ttctctggta actactttaa
     5521 acagtgacct gaaatacaat gctctggatc tcaccaacaa tgggaaacta cggctagaac
     5581 ccctgaagct gcatgtggct ggtaacctaa aaggagccta ccaaaataat gaaataaaac
     5641 acatctatgc catctcttct gctgccttat cagcaagcta taaagcagac actgttgcta
     5701 aggttcaggg tgtggagttt agccatcggc tcaacacaga catcgctggg ctggcttcag
     5761 ccattgacat gagcacaaac tataattcag actcactgca tttcagcaat gtcttccgtt
     5821 ctgtaatggc cccgtttacc atgaccatcg atgcacatac aaatggcaat gggaaactcg
     5881 ctctctgggg agaacatact gggcagctgt atagcaaatt cctgttgaaa gcagaacctc
     5941 tggcatttac tttctctcat gattacaaag gctccacaag tcatcatctc gtgtctagga
     6001 aaagcatcag tgcagctctt gaacacaaag tcagtgccct gcttactcca gctgagcaga
     6061 caggcacctg gaaactcaag acccaattta acaacaatga atacagccag gacttggatg
     6121 cttacaacac taaagataaa attggcgtgg agcttactgg acgaactctg gctgacctaa
     6181 ctctactaga ctccccaatt aaagtgccac ttttactcag tgagcccatc aatatcattg
     6241 atgctttaga gatgagagat gccgttgaga agccccaaga atttacaatt gttgcttttg
     6301 taaagtatga taaaaaccaa gatgttcact ccattaacct cccatttttt gagaccttgc
     6361 aagaatattt tgagaggaat cgacaaacca ttatagttgt agtggaaaac gtacagagaa
     6421 acctgaagca catcaatatt gatcaatttg taagaaaata cagagcagcc ctgggaaaac
     6481 tcccacagca agctaatgat tatctgaatt cattcaattg ggagagacaa gtttcacatg
     6541 ccaaggagaa actgactgct ctcacaaaaa agtatagaat tacagaaaat gatatacaaa
     6601 ttgcattaga tgatgccaaa atcaacttta atgaaaaact atctcaactg cagacatata
     6661 tgatacaatt tgatcagtat attaaagata gttatgattt acatgatttg aaaatagcta
     6721 ttgctaatat tattgatgaa atcattgaaa aattaaaaag tcttgatgag cactatcata
     6781 tccgtgtaaa tttagtaaaa acaatccatg atctacattt gtttattgaa aatattgatt
     6841 ttaacaaaag tggaagtagt actgcatcct ggattcaaaa tgtggatact aagtaccaaa
     6901 tcagaatcca gatacaagaa aaactgcagc agcttaagag acacatacag aatatagaca
     6961 tccagcacct agctggaaag ttaaaacaac acattgaggc tattgatgtt agagtgcttt
     7021 tagatcaatt gggaactaca atttcatttg aaagaataaa tgatgttctt gagcatgtca
     7081 aacactttgt tataaatctt attggggatt ttgaagtagc tgagaaaatc aatgccttca
     7141 gagccaaagt ccatgagtta atcgagaggt atgaagtaga ccaacaaatc caggttttaa
     7201 tggataaatt agtagagttg acccaccaat acaagttgaa ggagactatt cagaagctaa
     7261 gcaatgtcct acaacaagtt aagataaaag attactttga gaaattggtt ggatttattg
     7321 atgatgctgt gaagaagctt aatgaattat cttttaaaac attcattgaa gatgttaaca
     7381 aattccttga catgttgata aagaaattaa agtcatttga ttaccaccag tttgtagatg
     7441 aaaccaatga caaaatccgt gaggtgactc agagactcaa tggtgaaatt caggctctgg
     7501 aactaccaca aaaagctgaa gcattaaaac tgtttttaga ggaaaccaag gccacagttg
     7561 cagtgtatct ggaaagccta caggacacca aaataacctt aatcatcaat tggttacagg
     7621 aggctttaag ttcagcatct ttggctcaca tgaaggccaa attccgagag actctagaag
     7681 atacacgaga ccgaatgtat caaatggaca ttcagcagga acttcaacga tacctgtctc
     7741 tggtaggcca ggtttatagc acacttgtca cctacatttc tgattggtgg actcttgctg
     7801 ctaagaacct tactgacttt gcagagcaat attctatcca agattgggct aaacgtatga
     7861 aagcattggt agagcaaggg ttcactgttc ctgaaatcaa gaccatcctt gggaccatgc
     7921 ctgcctttga agtcagtctt caggctcttc agaaagctac cttccagaca cctgatttta
     7981 tagtccccct aacagatttg aggattccat cagttcagat aaacttcaaa gacttaaaaa
     8041 atataaaaat cccatccagg ttttccacac cagaatttac catccttaac accttccaca
     8101 ttccttcctt tacaattgac tttgtcgaaa tgaaagtaaa gatcatcaga accattgacc
     8161 agatgcagaa cagtgagctg cagtggcccg ttccagatat atatctcagg gatctgaagg
     8221 tggaggacat tcctctagcg agaatcaccc tgccagactt ccgtttacca gaaatcgcaa
     8281 ttccagaatt cataatccca actctcaacc ttaatgattt tcaagttcct gaccttcaca
     8341 taccagaatt ccagcttccc cacatctcac acacaattga agtacctact tttggcaagc
     8401 tatacagtat tctgaaaatc caatctcctc ttttcacatt agatgcaaat gctgacatag
     8461 ggaatggaac cacctcagca aacgaagcag gtatcgcagc ttccatcact gccaaaggag
     8521 agtccaaatt agaagttctc aattttgatt ttcaagcaaa tgcacaactc tcaaacccta
     8581 agattaatcc gctggctctg aaggagtcag tgaagttctc cagcaagtac ctgagaacgg
     8641 agcatgggag tgaaatgctg ttttttggaa atgctattga gggaaaatca aacacagtgg
     8701 caagtttaca cacagaaaaa aatacactgg agcttagtaa tggagtgatt gtcaagataa
     8761 acaatcagct taccctggat agcaacacta aatacttcca caaattgaac atccccaaac
     8821 tggacttctc tagtcaggct gacctgcgca acgagatcaa gacactgttg aaagctggcc
     8881 acatagcatg gacttcttct ggaaaagggt catggaaatg ggcctgcccc agattctcag
     8941 atgagggaac acatgaatca caaattagtt tcaccataga aggacccctc acttcctttg
     9001 gactgtccaa taagatcaat agcaaacacc taagagtaaa ccaaaacttg gtttatgaat
     9061 ctggctccct caacttttct aaacttgaaa ttcaatcaca agtcgattcc cagcatgtgg
     9121 gccacagtgt tctaactgct aaaggcatgg cactgtttgg agaagggaag gcagagttta
     9181 ctgggaggca tgatgctcat ttaaatggaa aggttattgg aactttgaaa aattctcttt
     9241 tcttttcagc ccagccattt gagatcacgg catccacaaa caatgaaggg aatttgaaag
     9301 ttcgttttcc attaaggtta acagggaaga tagacttcct gaataactat gcactgtttc
     9361 tgagtcccag tgcccagcaa gcaagttggc aagtaagtgc taggttcaat cagtataagt
     9421 acaaccaaaa tttctctgct ggaaacaacg agaacattat ggaggcccat gtaggaataa
     9481 atggagaagc aaatctggat ttcttaaaca ttcctttaac aattcctgaa atgcgtctac
     9541 cttacacaat aatcacaact cctccactga aagatttctc tctatgggaa aaaacaggct
     9601 tgaaggaatt cttgaaaacg acaaagcaat catttgattt aagtgtaaaa gctcagtata
     9661 agaaaaacaa acacaggcat tccatcacaa atcctttggc tgtgctttgt gagtttatca
     9721 gtcagagcat caaatccttt gacaggcatt ttgaaaaaaa cagaaacaat gcattagatt
     9781 ttgtcaccaa atcctataat gaaacaaaaa ttaagtttga taagtacaaa gctgaaaaat
     9841 ctcacgacga gctccccagg acctttcaaa ttcctggata cactgttcca gttgtcaatg
     9901 ttgaagtgtc tccattcacc atagagatgt cggcattcgg ctatgtgttc ccaaaagcag
     9961 tcagcatgcc tagtttctcc atcctaggtt ctgacgtccg tgtgccttca tacacattaa
    10021 tcctgccatc attagagctg ccagtccttc atgtccctag aaatctcaag ctttctcttc
    10081 cacatttcaa ggaattgtgt accataagcc atatttttat tcctgccatg ggcaatatta
    10141 cctatgattt ctcctttaaa tcaagtgtca tcacactgaa taccaatgct gaacttttta
    10201 accagtcaga tattgttgct catctccttt cttcatcttc atctgtcatt gatgcactgc
    10261 agtacaaatt agagggcacc acaagattga caagaaaaag gggattgaag ttagccacag
    10321 ctctgtctct gagcaacaaa tttgtggagg gtagtcataa cagtactgtg agcttaacca
    10381 cgaaaaatat ggaagtgtca gtggcaaaaa ccacaaaagc cgaaattcca attttgagaa
    10441 tgaatttcaa gcaagaactt aatggaaata ccaagtcaaa acctactgtc tcttcctcca
    10501 tggaatttaa gtatgatttc aattcttcaa tgctgtactc taccgctaaa ggagcagttg
    10561 accacaagct tagcttggaa agcctcacct cttacttttc cattgagtca tctaccaaag
    10621 gagatgtcaa gggttcggtt ctttctcggg aatattcagg aactattgct agtgaggcca
    10681 acacttactt gaattccaag agcacacggt cttcagtgaa gctgcagggc acttccaaaa
    10741 ttgatgatat ctggaacctt gaagtaaaag aaaattttgc tggagaagcc acactccaac
    10801 gcatatattc cctctgggag cacagtacga aaaaccactt acagctagag ggcctctttt
    10861 tcaccaacgg agaacataca agcaaagcca ccctggaact ctctccatgg caaatgtcag
    10921 ctcttgttca ggtccatgca agtcagccca gttccttcca tgatttccct gaccttggcc
    10981 aggaagtggc cctgaatgct aacactaaga accagaagat cagatggaaa aatgaagtcc
    11041 ggattcattc tgggtctttc cagagccagg tcgagctttc caatgaccaa gaaaaggcac
    11101 accttgacat tgcaggatcc ttagaaggac acctaaggtt cctcaaaaat atcatcctac
    11161 cagtctatga caagagctta tgggatttcc taaagctgga tgtaaccacc agcattggta
    11221 ggagacagca tcttcgtgtt tcaactgcct ttgtgtacac caaaaacccc aatggctatt
    11281 cattctccat ccctgtaaaa gttttggctg ataaattcat tactcctggg ctgaaactaa
    11341 atgatctaaa ttcagttctt gtcatgccta cgttccatgt cccatttaca gatcttcagg
    11401 ttccatcgtg caaacttgac ttcagagaaa tacaaatcta taagaagctg agaacttcat
    11461 catttgccct caacctacca acactccccg aggtaaaatt ccctgaagtt gatgtgttaa
    11521 caaaatattc tcaaccagaa gactccttga ttcccttttt tgagataacc gtgcctgaat
    11581 ctcagttaac tgtgtcccag ttcacgcttc caaaaagtgt ttcagatggc attgctgctt
    11641 tggatctaaa tgcagtagcc aacaagatcg cagactttga gttgcccacc atcatcgtgc
    11701 ctgagcagac cattgagatt ccctccatta agttctctgt acctgctgga attgtcattc
    11761 cttcctttca agcactgact gcacgctttg aggtagactc tcccgtgtat aatgccactt
    11821 ggagtgccag tttgaaaaac aaagcagatt atgttgaaac agtcctggat tccacatgca
    11881 gctcaaccgt acagttccta gaatatgaac taaatgtttt gggaacacac aaaatcgaag
    11941 atggtacgtt agcctctaag actaaaggaa cacttgcaca ccgtgacttc agtgcagaat
    12001 atgaagaaga tggcaaattt gaaggacttc aggaatggga aggaaaagcg cacctcaata
    12061 tcaaaagccc agcgttcacc gatctccatc tgcgctacca gaaagacaag aaaggcatct
    12121 ccacctcagc agcctcccca gccgtaggca ccgtgggcat ggatatggat gaagatgacg
    12181 acttttctaa atggaacttc tactacagcc ctcagtcctc tccagataaa aaactcacca
    12241 tattcaaaac tgagttgagg gtccgggaat ctgatgagga aactcagatc aaagttaatt
    12301 gggaagaaga ggcagcttct ggcttgctaa cctctctgaa agacaacgtg cccaaggcca
    12361 caggggtcct ttatgattat gtcaacaagt accactggga acacacaggg ctcaccctga
    12421 gagaagtgtc ttcaaagctg agaagaaatc tgcagaacaa tgctgagtgg gtttatcaag
    12481 gggccattag gcaaattgat gatatcgacg tgaggttcca gaaagcagcc agtggcacca
    12541 ctgggaccta ccaagagtgg aaggacaagg cccagaatct gtaccaggaa ctgttgactc
    12601 aggaaggcca agccagtttc cagggactca aggataacgt gtttgatggc ttggtacgag
    12661 ttactcaaaa attccatatg aaagtcaagc atctgattga ctcactcatt gattttctga
    12721 acttccccag attccagttt ccggggaaac ctgggatata cactagggag gaactttgca
    12781 ctatgttcat aagggaggta gggacggtac tgtcccaggt atattcgaaa gtccataatg
    12841 gttcagaaat actgttttcc tatttccaag acctagtgat tacacttcct ttcgagttaa
    12901 ggaaacataa actaatagat gtaatctcga tgtataggga actgttgaaa gatttatcaa
    12961 aagaagccca agaggtattt aaagccattc agtctctcaa gaccacagag gtgctacgta
    13021 atcttcagga ccttttacaa ttcattttcc aactaataga agataacatt aaacagctga
    13081 aagagatgaa atttacttat cttattaatt atatccaaga tgagatcaac acaatcttca
    13141 atgattatat cccatatgtt tttaaattgt tgaaagaaaa cctatgcctt aatcttcata
    13201 agttcaatga atttattcaa aacgagcttc aggaagcttc tcaagagtta cagcagatcc
    13261 atcaatacat tatggccctt cgtgaagaat attttgatcc aagtatagtt ggctggacag
    13321 tgaaatatta tgaacttgaa gaaaagatag tcagtctgat caagaacctg ttagttgctc
    13381 ttaaggactt ccattctgaa tatattgtca gtgcctctaa ctttacttcc caactctcaa
    13441 gtcaagttga gcaatttctg cacagaaata ttcaggaata tcttagcatc cttaccgatc
    13501 cagatggaaa agggaaagag aagattgcag agctttctgc cactgctcag gaaataatta
    13561 aaagccaggc cattgcgacg aagaaaataa tttctgatta ccaccagcag tttagatata
    13621 aactgcaaga tttttcagac caactctctg attactatga aaaatttatt gctgaatcca
    13681 aaagattgat tgacctgtcc attcaaaact accacacatt tctgatatac atcacggagt
    13741 tactgaaaaa gctgcaatca accacagtca tgaaccccta catgaagctt gctccaggag
    13801 aacttactat catcctctaa ttttttaaaa gaaatcttca tttattcttc ttttccaatt
    13861 gaactttcac atagcacaga aaaaattcaa actgcctata ttgataaaac catacagtga
    13921 gccagccttg cagtaggcag tagactataa gcagaagcac atatgaactg gacctgcacc
    13981 aaagctggca ccagggctcg gaaggtctct gaactcagaa ggatggcatt ttttgcaagt
    14041 taaagaaaat caggatctga gttattttgc taaacttggg ggaggaggaa caaataaatg
    14101 gagtctttat tgtgtatcat a
//