LOCUS X04502 2657 bp DNA linear HUM 18-APR-2005
DEFINITION Human SLPI gene for secretory leukocyte protease inhibitor.
ACCESSION X04502
VERSION X04502.1
KEYWORDS elastase inhibitor; protease inhibitor; secretory leucocyte
protease inhibitor; trypsin inhibitor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2657)
AUTHORS Stetler G., Brewer M.T., Thompson R.C.
TITLE Isolation and sequence of a human gene encoding a potent inhibitor
of leukocyte proteases
JOURNAL Nucleic Acids Res. 14(20), 7883-7896(1986).
PUBMED 3640338
REFERENCE 2 (bases 1 to 2657)
AUTHORS Rogaev E.I., Keryanov S.A., Malyako Y.K.
TITLE Dinucleotide repeat polymorphisms at the P1, HBE1 and MYH7 loci
JOURNAL Hum. Mol. Genet. 1(4), 285-285(1992).
PUBMED 1363870
FEATURES Location/Qualifiers
source 1..2657
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
regulatory 181..184
/note="put. CAAT-box"
/regulatory_class="promoter"
regulatory 242..247
/note="put. TATA-box"
/regulatory_class="promoter"
precursor_RNA 276..2574
/note="put. primary transcript of SLPI"
mRNA 276..375
/note="put. exon 1"
CDS join(291..375,1092..1250,1668..1817,2397..2401)
/product="secretory leukocyte protease inhibitor (SLPI)"
/db_xref="GOA:P03973"
/db_xref="HGNC:HGNC:11092"
/db_xref="InterPro:IPR008197"
/db_xref="InterPro:IPR036645"
/db_xref="PDB:2Z7F"
/db_xref="PDB:4DOQ"
/db_xref="UniProtKB/Swiss-Prot:P03973"
/protein_id="CAA28187.1"
/translation="MKSSGLFPFLVLLALGTLAPWAVEGSGKSFKAGVCPPKKSAQCL
RYKKPECQSDWQCPGKKRCCPDTCGIKCLDPVDTPNPTRRKPGKCPVTYGQCLMLNPP
NFCEMDGQCKRDLKCCMGMCGKSCVSPVKA"
sig_peptide 291..365
/note="signal peptide (AA -25 to -1)"
mat_peptide join(366..375,1092..1250,1668..1817,2397..2398)
/gene="SLPI"
intron 376..1091
/note="intron I"
mRNA 1092..1250
/note="exon 2"
intron 1251..1667
/note="intron II"
mRNA 1667..1817
/note="exon 3"
intron 1818..2396
/note="intron III"
mRNA 2397..2574
/note="exon 4"
misc_feature 2549..2554
/note="polyA signal"
polyA_site 2574..2574
/note="polyA site"
BASE COUNT 545 a 649 c 704 g 759 t
ORIGIN
1 agggctctag atggacactg agacggcctc tttaatcaac caacttccca ggccaatctc
61 ttccctttct tttctcgata gttgctgtgt ttggcctcat agccttacct ggcataggaa
121 agataaacaa tctccttggt gtcaggattt ctggtttttg gttagggttt cctgcttatg
181 caatagtagc tgggagaggc ccgaaagaat tctggtgggg ccacacccac tggtgaaaga
241 ataaatagtg aggtttggca ttggccatca gagtcactcc tgccttcacc atgaagtcca
301 gcggcctctt ccccttcctg gtgctgcttg ccctgggaac tctggcacct tgggctgtgg
361 aaggctctgg aaagtgtaag ttggagtcac tgtctaatct gggctgcagg gtcagaggtg
421 gggtctcctt gtggtgtggg tgtgtcccct tctgtaggct ctgatccctc agcttagttt
481 cgggagacct ccctgagggt ggaatacatg tctggctgag ctccaaggtt tgtgtgacag
541 tttgagcttc tggaaatgct tcctctatgc agccatgctg tcagcccagg tcccactctc
601 tctctctctc tctctctctc tctctctcat actccgcctt cttcttcacc ttgctgcgac
661 tctcaaatca ttagtttctg actctgcttc cgttgtgtct ttgcttctgc tattttgtct
721 ctgtgcttct cgcttgggat ttagctctca acttctctca cactggttct atttatcttt
781 gtttacctct ctccatctcc atcactccca gccttcctct ctgcctttgt gtagccttgt
841 tttgctcttg ggtggaggtc ttgactagaa gcctgctgcc cttttcttgg gtgtgaaacg
901 tcccctgtcc atttgtctaa tttaatcaag cccatcaata cacctggaga tcaggcaggc
961 atgacctttg ggctttgtgg acagctactg aggtaagggt ctctccccct caaaagtggt
1021 gctttgttca ggaggcatga tgggtcctca gtacccagcc tcctcctacc tcttgacttt
1081 ctcttcaaaa gccttcaaag ctggagtctg tcctcctaag aaatctgccc agtgccttag
1141 atacaagaaa cctgagtgcc agagtgactg gcagtgtcca gggaagaaga gatgttgtcc
1201 tgacacttgt ggcatcaaat gcctggatcc tgttgacacc ccaaacccaa gtaagcaggt
1261 cggggaactg ggtagagaga tagcctgggg acacagcatt agagggacgg aactgggtga
1321 tgggtcctgc caggcctcct tgtcaatgcc gtagtgagtc acagtgccct aagagaagta
1381 gccagctggt gaagcagcgg gcatttagat agccaggtag ttggaagcct cccacctagt
1441 cagcactggg cggctggcac ctgcataatg gggggcctga agttctagga gagccaggtg
1501 ctatgtttgg gggccgcctt agggagaagg tggtggtgat agaggtgggg aggggatgat
1561 cccccctgct gaagctggac gaggggctca ctctaaaaag tggggatggg aggggttgta
1621 taaagtacaa ggcctctgac cggtagcctc actctcaccc aacccagcaa ggaggaagcc
1681 tgggaagtgc ccagtgactt atggccaatg tttgatgctt aaccccccca atttctgtga
1741 gatggatggc cagtgcaagc gtgacttgaa gtgttgcatg ggcatgtgtg ggaaatcctg
1801 cgtttcccct gtgaaaggta agcaggggac gagggcacac tgagctccct cagccctctc
1861 agcctcaacc ctctggaggc ccaggcatat gggcaggggg actcctgaac cctactccaa
1921 gcacagcctc tgtctgactc ccttgtcctt caagagaact gttctccagg tctcagggcc
1981 aggatttcca taggagtcgc ctgtggcttt gattctattc tagtgtctct gggtgggggt
2041 cctgggcaag tgtctttctg agtctagttt ctttatcggt aaaatgtaca taatgagatg
2101 aaagtgctct gcaaagacct atgtgcacta agaattatta ttcaggtgtt tccatcatgt
2161 tttctgaggt gaaatcacaa aggatcagtg gagtttgagg attatctagt tcaatgcttt
2221 gagtttagag ttttacgtga aaatgagact tgtctcctga cactaagtct ctctcaacta
2281 tagcgctatc ttgctatttt ctctatctca gaaggatcct tgggcaggag gaaggatgtg
2341 gatatatgat ttggctggtt tctatgctga agctctgatc tgattttctc tcacagcttg
2401 attcctgcca tatggaggag gctctggagt cctgctctgt gtggtccagg tcctttccac
2461 cctgagactt ggctccacca ctgatatcct cctttgggga aaggcttggc acacagcagg
2521 ctttcaagaa gtgccagttg atcgaatgaa taaataaacg agcctatttc tctttgcaca
2581 tcctgcttct gtgattcgtt ggggggatga gtggggtggg acgtgtgagg gaagatctag
2641 tatgaggcct ccttcct
//