LOCUS       X04494                  1221 bp    mRNA    linear   HUM 07-OCT-2008
DEFINITION  Human mRNA for alpha-1-microglobulin and HI-30.
ACCESSION   X04494
VERSION     X04494.1
KEYWORDS    alpha-1-microglobulin; glycoprotein; proteinase inhibitor; serum
            protein; signal peptide.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1221)
  AUTHORS   Kaumeyer J.F., Polazzi J.O., Kotick M.P.
  TITLE     The mRNA for a proteinase inhibitor related to the HI-30 domain of
            inter-alpha-trypsin inhibitor also encodes alpha-1-microglobulin
            (protein HC)
  JOURNAL   Nucleic Acids Res. 14(20), 7839-7850(1986).
   PUBMED   2430261
COMMENT     Data kindly reviewed (11-MAY-1987) by Polazzi J.O.
FEATURES             Location/Qualifiers
     source          1..1221
                     /db_xref="H-InvDB:HIT000321045"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /tissue_type="liver"
                     /db_xref="taxon:9606"
     CDS             46..1104
                     /note="precursor polypeptide"
                     /db_xref="GOA:P02760"
                     /db_xref="H-InvDB:HIT000321045.12"
                     /db_xref="HGNC:HGNC:453"
                     /db_xref="InterPro:IPR000566"
                     /db_xref="InterPro:IPR002223"
                     /db_xref="InterPro:IPR002968"
                     /db_xref="InterPro:IPR012674"
                     /db_xref="InterPro:IPR020901"
                     /db_xref="InterPro:IPR022272"
                     /db_xref="InterPro:IPR029856"
                     /db_xref="InterPro:IPR036880"
                     /db_xref="PDB:1BIK"
                     /db_xref="PDB:3QKG"
                     /db_xref="PDB:4ES7"
                     /db_xref="PDB:4U30"
                     /db_xref="PDB:6EJ7"
                     /db_xref="PDB:6EJ8"
                     /db_xref="PDB:6EJ9"
                     /db_xref="PDB:6EJA"
                     /db_xref="PDB:6EJB"
                     /db_xref="PDB:6EJC"
                     /db_xref="PDB:6EJD"
                     /db_xref="UniProtKB/Swiss-Prot:P02760"
                     /protein_id="CAA28182.1"
                     /translation="MRSLGALLLLLSACLAVSAGPVPTPPDNIQVQENFNISRIYGKW
                     YNLAIGSTCPWLKKIMDRMTVSTLVLGEGATEAEISMTSTRWRKGVCEETSGAYEKTD
                     TDGKFLYHKSKWNITMESYVVHTNYDEYAIFLTKKFSRHHGPTITAKLYGRAPQLRET
                     LLQDFRVVAQGVGIPEDSIFTMADRGECVPGEQEPEPILIPRVRRAVLPQEEEGSGGG
                     QLVTEVTKKEDSCQLGYSAGPCMGMTSRYFYNGTSMACETFQYGGCMGNGNNFVTEKE
                     CLQTCRTVAACNLPIVRGPCRAFIQLWAFDAVKGKCVLFPYGGCQGNGNKFYSEKECR
                     EYCGVPGDGDEELLRFSN"
     sig_peptide     46..102
                     /note="pot. signal peptide (AA -19 to -1)"
     mat_peptide     103..1101
                     /note="alpha-1-microglobulin-HI-30 protein (AA 1-333)"
     mat_peptide     103..651
                     /note="alpha-1-microglobulin"
     mat_peptide     661..1095
                     /note="HI-30"
     misc_feature    724..891
                     /note="domain I"
     misc_feature    892..1095
                     /note="domain II"
     misc_feature    1188..1192
                     /note="put. polyA signal"
BASE COUNT          296 a          322 c          363 g          240 t
ORIGIN      
        1 tagaccgagc ctgtgggata taccaaggca gaggagccca tagccatgag gagcctcggg
       61 gccctgctct tgctgctgag cgcctgcctg gcggtgagcg ctggccctgt gccaacgccg
      121 cccgacaaca tccaagtgca ggaaaacttc aatatctctc ggatctatgg gaagtggtac
      181 aacctggcca tcggttccac ctgcccctgg ctgaagaaga tcatggacag gatgacagtg
      241 agcacgctgg tgctgggaga gggcgctaca gaggcggaga tcagcatgac cagcactcgt
      301 tggcggaaag gtgtctgtga ggagacgtct ggagcttatg agaaaacaga tactgatggg
      361 aagtttctct atcacaaatc caaatggaac ataaccatgg agtcctatgt ggtccacacc
      421 aactatgatg agtatgccat tttcctgacc aagaaattca gccgccatca tggacccacc
      481 attactgcca agctctacgg gcgggcgccg cagctgaggg aaactctcct gcaggacttc
      541 agagtggttg cccagggtgt gggcatccct gaggactcca tcttcaccat ggctgaccga
      601 ggtgaatgtg tccctgggga gcaggaacca gagcccatct taatcccgag agtccggagg
      661 gctgtgctac cccaagaaga ggaaggatca gggggtgggc aactggtaac tgaagtcacc
      721 aagaaagaag attcctgcca gctgggctac tcggccggtc cctgcatggg aatgaccagc
      781 aggtatttct ataatggtac atccatggcc tgtgagactt tccagtacgg cggctgcatg
      841 ggcaacggta acaacttcgt cacagaaaag gagtgtctgc agacctgccg aactgtggcg
      901 gcctgcaatc tccccatagt ccggggcccc tgccgagcct tcatccagct ctgggcattt
      961 gatgctgtca aggggaagtg cgtcctcttc ccctacgggg gctgccaggg caacgggaac
     1021 aagttctact cagagaagga gtgcagagag tactgcggtg tccctggtga tggtgatgag
     1081 gagctgctgc gcttctccaa ctgacaactg gccggtctgc aagtcagagg atggccagtg
     1141 tctgtcccgg ggtcctgtgg caggcagcgc caagcaacct gggtccaaat aaaaactaaa
     1201 ttgtaaactc ctgaaaaaaa a
//