LOCUS       X04429                  1482 bp    mRNA    linear   HUM 21-MAR-1995
DEFINITION  Human mRNA for endothelial plasminogen activator inhibitor (PAI).
ACCESSION   X04429
VERSION     X04429.1
KEYWORDS    glycoprotein; plasminogen activator inhibitor; serine protease
            inhibitor; serpin; signal peptide.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1482)
  AUTHORS   Pannekoek H., Veerman H., Lambers H., Diergaarde P., Verweij C.L.,
            van Zonneveld A.J., van Mourik J.A.
  TITLE     Endothelial plasminogen activator inhibitor (PAI): a new member of
            the Serpin gene family
  JOURNAL   EMBO J. 5(10), 2539-2544(1986).
   PUBMED   2430793
FEATURES             Location/Qualifiers
     source          1..1482
                     /db_xref="H-InvDB:HIT000321038"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /clone="PAI2350"
                     /cell_type="vascular endothelial cells"
                     /db_xref="taxon:9606"
     CDS             127..1335
                     /note="precursor polypeptide"
                     /db_xref="GOA:P05121"
                     /db_xref="H-InvDB:HIT000321038.14"
                     /db_xref="HGNC:HGNC:8583"
                     /db_xref="InterPro:IPR000215"
                     /db_xref="InterPro:IPR023795"
                     /db_xref="InterPro:IPR023796"
                     /db_xref="InterPro:IPR036186"
                     /db_xref="InterPro:IPR042178"
                     /db_xref="InterPro:IPR042185"
                     /db_xref="PDB:1A7C"
                     /db_xref="PDB:1B3K"
                     /db_xref="PDB:1C5G"
                     /db_xref="PDB:1DB2"
                     /db_xref="PDB:1DVM"
                     /db_xref="PDB:1DVN"
                     /db_xref="PDB:1LJ5"
                     /db_xref="PDB:1OC0"
                     /db_xref="PDB:3CVM"
                     /db_xref="PDB:3EOX"
                     /db_xref="PDB:3PB1"
                     /db_xref="PDB:3Q02"
                     /db_xref="PDB:3Q03"
                     /db_xref="PDB:3R4L"
                     /db_xref="PDB:3UT3"
                     /db_xref="PDB:4AQH"
                     /db_xref="PDB:4G8O"
                     /db_xref="PDB:4G8R"
                     /db_xref="PDB:4IC0"
                     /db_xref="PDB:5BRR"
                     /db_xref="PDB:5ZLZ"
                     /db_xref="PDB:6I8S"
                     /db_xref="PDB:9PAI"
                     /db_xref="UniProtKB/Swiss-Prot:P05121"
                     /protein_id="CAA28025.1"
                     /translation="MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQ
                     QVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLY
                     KELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIIN
                     DWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGS
                     TVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNI
                     LSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSD
                     QEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGT
                     VLFMGQVMEP"
     sig_peptide     127..195
                     /note="put. signal peptide (AA -23 to -1)"
     mat_peptide     196..1332
                     /note="mature polypeptide (AA 1-379)"
     misc_feature    820..828
                     /note="pot. N-glycosylation site"
     misc_feature    988..996
                     /note="pot. N-glycosylation site"
     misc_feature    1180..1188
                     /note="pot. N-glycosylation site"
     variation       1213..1214
                     /note="21bp insertion site in one out of 15 clones"
BASE COUNT          360 a          445 c          386 g          291 t
ORIGIN      
        1 ggcagggcaa gagcgctgtc aagaagaccc acacgccccc ctccagcagc tgaattcctg
       61 cagctcagca gccgccgcca gagcaggacg aaccgccaat cgcaaggcac ctctgagaac
      121 ttcaggatgc agatgtctcc agccctcacc tgcctagtcc tgggcctggc ccttgtcttt
      181 ggtgaagggt ctgctgtgca ccatccccca tcctacgtgg cccacctggc ctcagacttc
      241 ggggtgaggg tgtttcagca ggtggcgcag gcctccaagg accgcaacgt ggttttctca
      301 ccctatgggg tggcctcggt gttggccatg ctccagctga caacaggagg agaaacccag
      361 cagcagattc aagcagctat gggattcaag attgatgaca agggcatggc ccccgccctc
      421 cggcatctgt acaaggagct catggggcca tggaacaagg acgagatcag caccacagac
      481 gcgatcttcg tccagcggga tctgaagctg gtccagggct tcatgcccca cttcttcagg
      541 ctgttccgga gcacggtcaa gcaagtggac ttttcagagg tggagagagc cagattcatc
      601 atcaatgact gggtgaagac acacacaaaa ggtatgatca gcaacttgct tgggaaagga
      661 gccgtggacc agctgacacg gctggtgctg gtgaatgccc tctacttcaa cggccagtgg
      721 aagactccct tccccgactc cagcacccac cgccgcctct tccacaaatc agacggcagc
      781 actgtctctg tgcccatgat ggctcagacc aacaagttca actatactga gttcaccacg
      841 cccgatggcc attactacga catcctggaa ctgccctacc acggggacac cctcagcatg
      901 ttcattgctg ccccttatga aaaagaggtg cctctctctg ccctcaccaa cattctgagt
      961 gcccagctca tcagccactg gaaaggcaac atgaccaggc tgccccgcct cctggttctg
     1021 cccaagttct ccctggagac tgaagtcgac ctcaggaagc ccctagagaa cctgggaatg
     1081 accgacatgt tcagacagtt tcaggctgac ttcacgagtc tttcagacca agagcctctc
     1141 cacgtcgcgc aggcgctgca gaaagtgaag atcgaggtga acgagagtgg cacggtggcc
     1201 tcctcatcca cagctgtcat agtctcagcc cgcatggccc ccgaggagat catcatggac
     1261 agacccttcc tctttgtggt ccggcacaac cccacaggaa cagtcctttt catgggccaa
     1321 gtgatggaac cctgaccctg gggaaagacg ccttcatctg ggacaaaact ggagatgcat
     1381 cgggaaagaa gaaactccga agaaaagaat tttagtgtta atgactcttt ctgaaggaag
     1441 agaagacatt tgccttttgt taaaagatgg taaaccagat ct
//