LOCUS X04371 1377 bp mRNA linear HUM 28-JUL-1999
DEFINITION Human 1.6Kb mRNA for 2-5A synthetase induced by interferon.
ACCESSION X04371 M25352
VERSION X04371.1
KEYWORDS 2-5A synthetase; alternative splicing; interferon response;
synthetase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1377)
AUTHORS Wathelet M., Moutschen S., Cravador A., DeWit L., Defilippi P.,
Huez G., Content J.
TITLE Full-length sequence and expression of the 42 kDa 2-5A synthetase
induced by human interferon
JOURNAL FEBS Lett. 196(1), 113-120(1986).
PUBMED 3753689
REFERENCE 2 (bases 4 to 5)
AUTHORS Wathelet M.
JOURNAL Submitted (05-NOV-1986) to the INSDC.
COMMENT Two different mRNAs (1.6 and 1.8 Kb long) coding for this protein
are transcribed from the same gene and are produced by differential
splicing. The sequence below is corresponding to the 1.6Kb mRNA.
Data kindly reviewed (05-NOV-1986) by M. Wathelet
FEATURES Location/Qualifiers
source 1..1377
/db_xref="H-InvDB:HIT000321030"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
prim_transcript <1..1377
old_sequence 4..5
/note="cg was cug in [1]"
/citation=[1]
CDS 94..1188
/note="2-5A synthetase (aa 1-364)"
/db_xref="GOA:P00973"
/db_xref="H-InvDB:HIT000321030.12"
/db_xref="HGNC:HGNC:8086"
/db_xref="InterPro:IPR002934"
/db_xref="InterPro:IPR006116"
/db_xref="InterPro:IPR006117"
/db_xref="InterPro:IPR018952"
/db_xref="InterPro:IPR026774"
/db_xref="InterPro:IPR038121"
/db_xref="PDB:4IG8"
/db_xref="UniProtKB/Swiss-Prot:P00973"
/protein_id="CAB51602.1"
/translation="MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKER
CFRGSSYPVCVSKVVKGGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEI
RRQLEACQRERAFSVKFEVQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLT
GSYKPNPQIYVKLIEECTDLQKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQN
CKKKLGKLPPQYALELLTVYAWERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYY
DFKNPIIEKYLRRQLTKPTPVILDPADPTGNLGGGDPKRWRQLAQEAEAWLNYPCFKN
WDGSPVSSWILLVRPPASSLPFIPAPLHEA"
polyA_site 1377
BASE COUNT 355 a 368 c 332 g 322 t
ORIGIN
1 aacgaaacca acagcagtcc aagctcagtc agcagaagag ataaaagcaa acaggtctgg
61 gaggcagttc tgttgccact ctctctcctg tcaatgatgg atctcagaaa taccccagcc
121 aaatctctgg acaagttcat tgaagactat ctcttgccag acacgtgttt ccgcatgcaa
181 atcaaccatg ccattgacat catctgtggg ttcctgaagg aaaggtgctt ccgaggtagc
241 tcctaccctg tgtgtgtgtc caaggtggta aagggtggct cctcaggcaa gggcaccacc
301 ctcagaggcc gatctgacgc tgacctggtt gtcttcctca gtcctctcac cacttttcag
361 gatcagttaa atcgccgggg agagttcatc caggaaatta ggagacagct ggaagcctgt
421 caaagagaga gagcattttc cgtgaagttt gaggtccagg ctccacgctg gggcaacccc
481 cgtgcgctca gcttcgtact gagttcgctc cagctcgggg agggggtgga gttcgatgtg
541 ctgcctgcct ttgatgccct gggtcagttg actggcagct ataaacctaa cccccaaatc
601 tatgtcaagc tcatcgagga gtgcaccgac ctgcagaaag agggcgagtt ctccacctgc
661 ttcacagaac tacagagaga cttcctgaag cagcgcccca ccaagctcaa gagcctcatc
721 cgcctagtca agcactggta ccaaaattgt aagaagaagc ttgggaagct gccacctcag
781 tatgccctgg agctcctgac ggtctatgct tgggagcgag ggagcatgaa aacacatttc
841 aacacagccc agggatttcg gacggtcttg gaattagtca taaactacca gcaactctgc
901 atctactgga caaagtatta tgactttaaa aaccccatta ttgaaaagta cctgagaagg
961 cagctcacga aacccacgcc tgtgatcctg gacccggcgg accctacagg aaacttgggt
1021 ggtggagacc caaagcgttg gaggcagctg gcacaagagg ctgaggcctg gctgaattac
1081 ccatgcttta agaattggga tgggtcccca gtgagctcct ggattctgct ggtgagacct
1141 cctgcttcct ccctgccatt catccctgcc cctctccatg aagcttgaga catatagctg
1201 gagaccattc tttccaaaga acttacctct tgccaaaggc catttatatt catatagtga
1261 caggctgtgc tccatatttt acagtcattt tggtcacaat cgagggtttc tggaattttc
1321 acatcccttg tccagaattc attcccctaa gagtaataat aaataatctc taacacc
//