LOCUS X03795 1308 bp mRNA linear HUM 07-OCT-2008
DEFINITION Human mRNA for platelet derived growth factor A-chain (PDGF-A).
ACCESSION X03795
VERSION X03795.1
KEYWORDS glycoprotein; platelet-derived growth factor 1; signal peptide.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1308)
AUTHORS Betsholtz C., Johnsson A., Heldin C.H., Westermark B., Lind P.,
Urdea M.S., Eddy R., Shows T.B., Philpott K., Mellor A.L.,
Knott T.J., Scott J.
TITLE cDNA sequence and chromosomal localization of human
platelet-derived growth factor A-chain and its expression in tumour
cell lines
JOURNAL Nature 320(6064), 695-699(1986).
PUBMED 3754619
FEATURES Location/Qualifiers
source 1..1308
/db_xref="H-InvDB:HIT000321002"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 388..1023
/note="prepro PDGF-A (aa -20 to 191)"
/db_xref="GOA:P04085"
/db_xref="H-InvDB:HIT000321002.14"
/db_xref="HGNC:HGNC:8799"
/db_xref="InterPro:IPR000072"
/db_xref="InterPro:IPR006782"
/db_xref="InterPro:IPR023581"
/db_xref="InterPro:IPR029034"
/db_xref="PDB:3MJK"
/db_xref="UniProtKB/Swiss-Prot:P04085"
/protein_id="CAA27421.1"
/translation="MRTLACLLLLGCGYLAHVLAEEAEIPREVIERLARSQIHSIRDL
QRLLEIDSVGSEDSLDTSLRAHGVHATKHVPEKRPLPIRRKRSIEEAVPAVCKTRTVI
YEIPRSQVDPTSANFLIWPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRK
KPKLKEVQVRLEEHLECACATTSLNPDYREEDTGRPRESGKKRKRKRLKPT"
sig_peptide 388..447
/note="signal peptide (aa -20 to -1)"
misc_feature 448..1020
/note="pro PDGF-A (aa 1-191)"
misc_feature 448..645
/note="propeptide (aa 1-66)"
mat_peptide 646..1020
/note="mature PDGF-A (aa 67-191)"
misc_feature 787..795
/note="pot. N-linked glycosylation site"
polyA_site 1308..1308
/note="polyA signal"
BASE COUNT 294 a 410 c 380 g 224 t
ORIGIN
1 tccgcaaata tgcagaatta ccggccgggt cgctcctgaa gccagcgcgg ggaggcagcg
61 cggcggcggc cagcaccggg aacgcaccga ggaagaagcc cagcccccgc cctccgcccc
121 ttccgtcccc acccccatcc cggcggccca ggaggctccc cgcgctggcg cgcactccct
181 gtttctcctc ctcctggctg gcgctgcctg cctctccgca ctcactgctc gccgggcgcc
241 gtccgccagc tccgtgctcc ccgcgccacc ctcctccggg ccgcgctccc taagggatgg
301 tactgatttt cgccgccaca ggagaccggc tggagcgccg ccccgcggcc tcgcctctcc
361 tccgagcagc cagcgcctcg ggacgcgatg aggaccttgg cttgcctgct gctcctcggc
421 tgcggatacc tcgcccatgt tctggccgag gaagccgaga tcccccgcga ggtgatcgag
481 aggctggccc gcagtcagat ccacagcatc cgggacctcc agcgactcct ggagatagac
541 tccgtaggga gtgaggattc tttggacacc agcctgagag ctcacggggt ccatgccact
601 aagcatgtgc ccgagaagcg gcccctgccc attcggagga agagaagcat cgaggaagct
661 gtccccgctg tctgcaagac caggacggtc atttacgaga ttcctcggag tcaggtcgac
721 cccacgtccg ccaacttcct gatctggccc ccgtgcgtgg aggtgaaacg ctgcaccggc
781 tgctgcaaca cgagcagtgt caagtgccag ccctcccgcg tccaccaccg cagcgtcaag
841 gtggccaagg tggaatacgt caggaagaag ccaaaattaa aagaagtcca ggtgaggtta
901 gaggagcatt tggagtgcgc ctgcgcgacc acaagcctga atccggatta tcgggaagag
961 gacacgggaa ggcctaggga gtcaggtaaa aaacggaaaa gaaaaaggtt aaaacccacc
1021 taaagcagcc aaccagatgt gaggtgagga tgagccgcag ccctttcctg ggacatggat
1081 gtacatggcg tgttacattc ctgaacctac tatgtacggt gctttattgc cagtgtgcgg
1141 tctttgttct cctccgtgaa aaactgtgtc cgagaacact cgggagaaca aagagacagt
1201 gcacatttgt ttaatgtgac atcaaagcaa gtattgtagc actcggtgaa gcagtaagaa
1261 gcttccttgt caaaaagaga gagagagaaa agaaaaaaaa aggaattc
//