LOCUS X03444 2404 bp mRNA linear HUM 07-OCT-2008
DEFINITION Human mRNA for nuclear envelope protein lamin A precursor.
ACCESSION X03444
VERSION X03444.1
KEYWORDS intermediate filament; lamin A.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2404)
AUTHORS McKeon F.D., Kirschner M.W., Caput D.
TITLE Homologies in both primary and secondary structure between nuclear
envelope and intermediate filament proteins
JOURNAL Nature 319(6053), 463-468(1986).
PUBMED 3453101
REFERENCE 2
AUTHORS Navarro C.L., De Sandre-Giovannoli A., Bernard R., Boccaccio I.,
Boyer A., Genevieve D., Hadj-Rabia S., Gaudy0-Marqueste C.,
Smitt H.S., Vabres P., Faivre L., Verloes A., Van Essen T.,
Flori E., Hennekam R., Beemer F.A., Laurent N., Le Merrer M.,
Cau P., Levy N.
TITLE Lamin A and ZMPSTE24 (FACE-1) defects cause nuclear disorganization
and identify restrictive dermopathy as a lethal neonatal
laminopathy
JOURNAL Hum. Mol. Genet. 13(20), 2493-2503(2004).
PUBMED 15317753
FEATURES Location/Qualifiers
source 1..2404
/db_xref="H-InvDB:HIT000320979"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 211..2319
/note="put. lamin A precursor (aa 1-702)"
/db_xref="GOA:P02545"
/db_xref="H-InvDB:HIT000320979.14"
/db_xref="HGNC:HGNC:6636"
/db_xref="InterPro:IPR001322"
/db_xref="InterPro:IPR018039"
/db_xref="InterPro:IPR036415"
/db_xref="InterPro:IPR039008"
/db_xref="InterPro:IPR042180"
/db_xref="PDB:1IFR"
/db_xref="PDB:1IVT"
/db_xref="PDB:1X8Y"
/db_xref="PDB:2XV5"
/db_xref="PDB:2YPT"
/db_xref="PDB:3GEF"
/db_xref="PDB:3V4Q"
/db_xref="PDB:3V4W"
/db_xref="PDB:3V5B"
/db_xref="PDB:6GHD"
/db_xref="UniProtKB/Swiss-Prot:P02545"
/protein_id="CAA27173.1"
/translation="METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAV
YIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARL
QLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEG
ELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRET
KRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQ
SAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTS
RRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPS
PTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRSSFSQHARTSGRVAVEEVDEEGK
FVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSP
PTDLVWKAQNTWGCGNSLRTALINSTGEEVAMRKLVRSVTVVEDDEDEDGDDLLHHHH
GSHCSSSGDPAEYNLRLAHRAVRDLRAACRQGICQRLRSPGGRTHLLWLFCLQCHGHS
QLPQCGGQWGWQLRGQSGHPLLPPGQLQPPNPEPPELQHHVIWDLPGRGGGGGFLRPP
HLMPTPCPARHGRGLEAKEK"
polyA_site 2404..2404
/note="polyA site"
BASE COUNT 513 a 732 c 780 g 379 t
ORIGIN
1 actcagtgtt cgcgggagcc gcacctacac cagccaaccc agatcccgag gtccgacagc
61 gcccggccca gatccccacg cctgccagga gcaagccgag agccagccgg ccggcgcact
121 ccgactccga gcagtctctg tccttcgacc cgagccccgc gccctttccg ggacccctgc
181 cccgcgggca gcgctgccaa cctgccggcc atggagaccc cgtcccagcg gcgcgccacc
241 cgcagcgggg cgcaggccag ctccactccg ctgtcgccca cccgcatcac ccggctgcag
301 gagaaggagg acctgcagga gctcaatgat cgcttggcgg tctacatcga ccgtgtgcgc
361 tcgctggaaa cggagaacgc agggctgcgc cttcgcatca ccgagtctga agaggtggtc
421 agccgcgagg tgtccggcat caaggccgcc tacgaggccg agctcgggga tgcccgcaag
481 acccttgact cagtagccaa ggagcgcgcc cgcctgcagc tggagctgag caaagtgcgt
541 gaggagttta aggagctgaa agcgcgcaat accaagaagg agggtgacct gatagctgct
601 caggctcggc tgaaggacct ggaggctctg ctgaactcca aggaggccgc actgagcact
661 gctctcagtg agaagcgcac gctggagggc gagctgcatg atctgcgggg ccaggtggcc
721 aagcttgagg cagccctagg tgaggccaag aagcaacttc aggatgagat gctgcggcgg
781 gtggatgctg agaacaggct gcagaccatg aaggaggaac tggacttcca gaagaacatc
841 tacagtgagg agctgcgtga gaccaagcgc cgtcatgaga cccgactggt ggagattgac
901 aatgggaagc agcgtgagtt tgagagccgg ctggcggatg cgctgcagga actgcgggcc
961 cagcatgagg accaggtgga gcagtataag aaggagctgg agaagactta ttctgccaag
1021 ctggacaatg ccaggcagtc tgctgagagg aacagcaacc tggtgggggc tgcccacgag
1081 gagctgcagc agtcgcgcat ccgcatcgac agcctctctg cccagctcag ccagctccag
1141 aagcagctgg cagccaagga ggcgaagctt cgagacctgg aggactcact ggcccgtgag
1201 cgggacacca gccggcggct gctggcggaa aaggagcggg agatggccga gatgcgggca
1261 aggatgcagc agcagctgga cgagtaccag gagcttctgg acatcaagct ggccctggac
1321 atggagatcc acgcctaccg caagctcttg gagggcgagg aggagaggct acgcctgtcc
1381 cccagcccta cctcgcagcg cagccgtggc cgtgcttcct ctcactcatc ccagacacag
1441 ggtgggggca gcgtcaccaa aaagcgcaaa ctggagtcca ctgagagccg cagcagcttc
1501 tcacagcacg cacgcactag cgggcgcgtg gccgtggagg aggtggatga ggagggcaag
1561 tttgtccggc tgcgcaacaa gtccaatgag gaccagtcca tgggcaattg gcagatcaag
1621 cgccagaatg gagatgatcc cttgctgact taccggttcc caccaaagtt caccctgaag
1681 gctgggcagg tggtgacgat ctgggctgca ggagctgggg ccacccacag cccccctacc
1741 gacctggtgt ggaaggcaca gaacacctgg ggctgcggga acagcctgcg tacggctctc
1801 atcaactcca ctggggaaga agtggccatg cgcaagctgg tgcgctcagt gactgtggtt
1861 gaggacgacg aggatgagga tggagatgac ctgctccatc accaccacgg ctcccactgc
1921 agcagctcgg gggaccccgc tgagtacaac ctgcgcctcg cgcaccgtgc tgtgcgggac
1981 ctgcgggcag cctgccgaca aggcatctgc cagcggctca ggagcccagg tgggcggacc
2041 catctcctct ggctcttctg cctccagtgt cacggtcact cgcagctacc gcagtgtggg
2101 gggcagtggg ggtggcagct tcggggacaa tctggtcacc cgctcctacc tcctgggcaa
2161 ctccagcccc cgaacccaga gcccccagaa ctgcagcatc atgtaatctg ggacctgcca
2221 ggcaggggtg ggggtggagg cttcctgcgt cctcctcacc tcatgcccac cccctgccct
2281 gcacgtcatg ggagggggct tgaagccaaa gaaaaataac cctttggttt ttttcttctt
2341 gtattttttt ttctaagaga agttattttc tacagtggtt ttatactgaa ggaaaaacac
2401 aagc
//