LOCUS X03444 2404 bp mRNA linear HUM 07-OCT-2008 DEFINITION Human mRNA for nuclear envelope protein lamin A precursor. ACCESSION X03444 VERSION X03444.1 KEYWORDS intermediate filament; lamin A. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2404) AUTHORS McKeon F.D., Kirschner M.W., Caput D. TITLE Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins JOURNAL Nature 319(6053), 463-468(1986). PUBMED 3453101 REFERENCE 2 AUTHORS Navarro C.L., De Sandre-Giovannoli A., Bernard R., Boccaccio I., Boyer A., Genevieve D., Hadj-Rabia S., Gaudy0-Marqueste C., Smitt H.S., Vabres P., Faivre L., Verloes A., Van Essen T., Flori E., Hennekam R., Beemer F.A., Laurent N., Le Merrer M., Cau P., Levy N. TITLE Lamin A and ZMPSTE24 (FACE-1) defects cause nuclear disorganization and identify restrictive dermopathy as a lethal neonatal laminopathy JOURNAL Hum. Mol. Genet. 13(20), 2493-2503(2004). PUBMED 15317753 FEATURES Location/Qualifiers source 1..2404 /db_xref="H-InvDB:HIT000320979" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" CDS 211..2319 /note="put. lamin A precursor (aa 1-702)" /db_xref="GOA:P02545" /db_xref="H-InvDB:HIT000320979.14" /db_xref="HGNC:HGNC:6636" /db_xref="InterPro:IPR001322" /db_xref="InterPro:IPR018039" /db_xref="InterPro:IPR036415" /db_xref="InterPro:IPR039008" /db_xref="InterPro:IPR042180" /db_xref="PDB:1IFR" /db_xref="PDB:1IVT" /db_xref="PDB:1X8Y" /db_xref="PDB:2XV5" /db_xref="PDB:2YPT" /db_xref="PDB:3GEF" /db_xref="PDB:3V4Q" /db_xref="PDB:3V4W" /db_xref="PDB:3V5B" /db_xref="PDB:6GHD" /db_xref="UniProtKB/Swiss-Prot:P02545" /protein_id="CAA27173.1" /translation="METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAV YIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARL QLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEG ELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRET KRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQ SAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTS RRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPS PTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRSSFSQHARTSGRVAVEEVDEEGK FVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSP PTDLVWKAQNTWGCGNSLRTALINSTGEEVAMRKLVRSVTVVEDDEDEDGDDLLHHHH GSHCSSSGDPAEYNLRLAHRAVRDLRAACRQGICQRLRSPGGRTHLLWLFCLQCHGHS QLPQCGGQWGWQLRGQSGHPLLPPGQLQPPNPEPPELQHHVIWDLPGRGGGGGFLRPP HLMPTPCPARHGRGLEAKEK" polyA_site 2404..2404 /note="polyA site" BASE COUNT 513 a 732 c 780 g 379 t ORIGIN 1 actcagtgtt cgcgggagcc gcacctacac cagccaaccc agatcccgag gtccgacagc 61 gcccggccca gatccccacg cctgccagga gcaagccgag agccagccgg ccggcgcact 121 ccgactccga gcagtctctg tccttcgacc cgagccccgc gccctttccg ggacccctgc 181 cccgcgggca gcgctgccaa cctgccggcc atggagaccc cgtcccagcg gcgcgccacc 241 cgcagcgggg cgcaggccag ctccactccg ctgtcgccca cccgcatcac ccggctgcag 301 gagaaggagg acctgcagga gctcaatgat cgcttggcgg tctacatcga ccgtgtgcgc 361 tcgctggaaa cggagaacgc agggctgcgc cttcgcatca ccgagtctga agaggtggtc 421 agccgcgagg tgtccggcat caaggccgcc tacgaggccg agctcgggga tgcccgcaag 481 acccttgact cagtagccaa ggagcgcgcc cgcctgcagc tggagctgag caaagtgcgt 541 gaggagttta aggagctgaa agcgcgcaat accaagaagg agggtgacct gatagctgct 601 caggctcggc tgaaggacct ggaggctctg ctgaactcca aggaggccgc actgagcact 661 gctctcagtg agaagcgcac gctggagggc gagctgcatg atctgcgggg ccaggtggcc 721 aagcttgagg cagccctagg tgaggccaag aagcaacttc aggatgagat gctgcggcgg 781 gtggatgctg agaacaggct gcagaccatg aaggaggaac tggacttcca gaagaacatc 841 tacagtgagg agctgcgtga gaccaagcgc cgtcatgaga cccgactggt ggagattgac 901 aatgggaagc agcgtgagtt tgagagccgg ctggcggatg cgctgcagga actgcgggcc 961 cagcatgagg accaggtgga gcagtataag aaggagctgg agaagactta ttctgccaag 1021 ctggacaatg ccaggcagtc tgctgagagg aacagcaacc tggtgggggc tgcccacgag 1081 gagctgcagc agtcgcgcat ccgcatcgac agcctctctg cccagctcag ccagctccag 1141 aagcagctgg cagccaagga ggcgaagctt cgagacctgg aggactcact ggcccgtgag 1201 cgggacacca gccggcggct gctggcggaa aaggagcggg agatggccga gatgcgggca 1261 aggatgcagc agcagctgga cgagtaccag gagcttctgg acatcaagct ggccctggac 1321 atggagatcc acgcctaccg caagctcttg gagggcgagg aggagaggct acgcctgtcc 1381 cccagcccta cctcgcagcg cagccgtggc cgtgcttcct ctcactcatc ccagacacag 1441 ggtgggggca gcgtcaccaa aaagcgcaaa ctggagtcca ctgagagccg cagcagcttc 1501 tcacagcacg cacgcactag cgggcgcgtg gccgtggagg aggtggatga ggagggcaag 1561 tttgtccggc tgcgcaacaa gtccaatgag gaccagtcca tgggcaattg gcagatcaag 1621 cgccagaatg gagatgatcc cttgctgact taccggttcc caccaaagtt caccctgaag 1681 gctgggcagg tggtgacgat ctgggctgca ggagctgggg ccacccacag cccccctacc 1741 gacctggtgt ggaaggcaca gaacacctgg ggctgcggga acagcctgcg tacggctctc 1801 atcaactcca ctggggaaga agtggccatg cgcaagctgg tgcgctcagt gactgtggtt 1861 gaggacgacg aggatgagga tggagatgac ctgctccatc accaccacgg ctcccactgc 1921 agcagctcgg gggaccccgc tgagtacaac ctgcgcctcg cgcaccgtgc tgtgcgggac 1981 ctgcgggcag cctgccgaca aggcatctgc cagcggctca ggagcccagg tgggcggacc 2041 catctcctct ggctcttctg cctccagtgt cacggtcact cgcagctacc gcagtgtggg 2101 gggcagtggg ggtggcagct tcggggacaa tctggtcacc cgctcctacc tcctgggcaa 2161 ctccagcccc cgaacccaga gcccccagaa ctgcagcatc atgtaatctg ggacctgcca 2221 ggcaggggtg ggggtggagg cttcctgcgt cctcctcacc tcatgcccac cccctgccct 2281 gcacgtcatg ggagggggct tgaagccaaa gaaaaataac cctttggttt ttttcttctt 2341 gtattttttt ttctaagaga agttattttc tacagtggtt ttatactgaa ggaaaaacac 2401 aagc //