LOCUS X03363 4473 bp mRNA linear HUM 30-MAR-1995
DEFINITION Human c-erb-B-2 mRNA.
ACCESSION X03363
VERSION X03363.1
KEYWORDS cell surface glycoprotein; cellular oncogene; erB-2 cellular;
glycoprotein; growth factor receptor; kinase; neu cellular
oncogene; transmembrane protein; tyrosine kinase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4473)
AUTHORS Yamamoto T., Ikawa S., Akiyama T., Semba K., Nomura N.,
Miyajima N., Saito T., Toyoshima K.
TITLE Similarity of protein encoded by the human c-erb-B-2 gene to
epidermal growth factor receptor
JOURNAL Nature 319(6050), 230-234(1986).
PUBMED 3003577
REFERENCE 2
AUTHORS Papewalis J., Nikitin A.Y., Rajewsky M.F.
TITLE G to A polymorphism at amino acid codon 655 of the human
erbB-2/HER2 gene
JOURNAL Nucleic Acids Res. 19(19), 5452-5452(1991).
PUBMED 1681519
COMMENT The c-erb-B-2 protein shows similarity to the epidermal growth
factor receptor.
FEATURES Location/Qualifiers
source 1..4473
/db_xref="H-InvDB:HIT000320977"
/organism="Homo sapiens"
/strain="cell line MKN-7"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 175..3942
/note="c-erb-B-2 precursor"
/db_xref="GOA:P04626"
/db_xref="H-InvDB:HIT000320977.15"
/db_xref="HGNC:HGNC:3430"
/db_xref="InterPro:IPR000494"
/db_xref="InterPro:IPR000719"
/db_xref="InterPro:IPR001245"
/db_xref="InterPro:IPR006211"
/db_xref="InterPro:IPR006212"
/db_xref="InterPro:IPR008266"
/db_xref="InterPro:IPR009030"
/db_xref="InterPro:IPR011009"
/db_xref="InterPro:IPR016245"
/db_xref="InterPro:IPR017441"
/db_xref="InterPro:IPR020635"
/db_xref="InterPro:IPR032778"
/db_xref="InterPro:IPR036941"
/db_xref="PDB:1MFG"
/db_xref="PDB:1MFL"
/db_xref="PDB:1MW4"
/db_xref="PDB:1N8Z"
/db_xref="PDB:1OVC"
/db_xref="PDB:1QR1"
/db_xref="PDB:1S78"
/db_xref="PDB:2A91"
/db_xref="PDB:2JWA"
/db_xref="PDB:2KS1"
/db_xref="PDB:2L4K"
/db_xref="PDB:2N2A"
/db_xref="PDB:3BE1"
/db_xref="PDB:3H3B"
/db_xref="PDB:3MZW"
/db_xref="PDB:3N85"
/db_xref="PDB:3PP0"
/db_xref="PDB:3RCD"
/db_xref="PDB:3WLW"
/db_xref="PDB:3WSQ"
/db_xref="PDB:4GFU"
/db_xref="PDB:4HRL"
/db_xref="PDB:4HRM"
/db_xref="PDB:4HRN"
/db_xref="PDB:5K33"
/db_xref="PDB:5KWG"
/db_xref="PDB:5MY6"
/db_xref="PDB:5O4G"
/db_xref="PDB:5OB4"
/db_xref="PDB:5TQS"
/db_xref="PDB:6ATT"
/db_xref="PDB:6BGT"
/db_xref="PDB:6J71"
/db_xref="PDB:6OGE"
/db_xref="UniProtKB/Swiss-Prot:P04626"
/protein_id="CAA27060.1"
/translation="MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLD
MLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIV
RGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQ
LCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRT
VCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNT
DTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKC
SKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPL
QPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGI
SWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEG
LACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPE
CQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQ
PCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKI
RKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWI
PDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVT
QLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSP
NHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWE
LMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFREL
VSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGF
FCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDG
DLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVR
PQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAA
PQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV"
sig_peptide 175..237
/note="put. signal peptide (aa -21 to -1)"
mat_peptide 238..3939
/note="put. c-erb-B-2 protein (aa 1-1234)"
misc_feature 376..384
/note="pot. glycosylation site"
misc_feature 544..558
/note="pot. glycosylation site"
misc_feature 733..741
/note="pot. glycosylation site"
misc_feature 949..957
/note="pot. glycosylation site"
misc_feature 1762..1770
/note="pot. glycosylation site"
misc_feature 1885..1893
/note="pot. glycosylation site"
misc_feature 2059..2067
/note="pot. glycosylation site"
misc_feature 2353..3132
/note="aa 727-986, seq. homologous to EGF receptor kinase
domain"
misc_feature 2446..2454
/note="pot. glycosylation site"
misc_feature 4455..4460
/note="put. polyA signal"
polyA_site 4473..4473
/note="polyA site"
BASE COUNT 902 a 1383 c 1329 g 859 t
ORIGIN
1 aaggggaggt aaccctggcc cctttggtcg gggccccggg cagccgcgcg ccccttccca
61 cggggccctt tactgcgccg cgcgcccggc ccccacccct cgcagcaccc cgcgccccgc
121 gccctcccag ccgggtccag ccggagccat ggggccggag ccgcagtgag caccatggag
181 ctggcggcct tgtgccgctg ggggctcctc ctcgccctct tgccccccgg agccgcgagc
241 acccaagtgt gcaccggcac agacatgaag ctgcggctcc ctgccagtcc cgagacccac
301 ctggacatgc tccgccacct ctaccagggc tgccaggtgg tgcagggaaa cctggaactc
361 acctacctgc ccaccaatgc cagcctgtcc ttcctgcagg atatccagga ggtgcagggc
421 tacgtgctca tcgctcacaa ccaagtgagg caggtcccac tgcagaggct gcggattgtg
481 cgaggcaccc agctctttga ggacaactat gccctggccg tgctagacaa tggagacccg
541 ctgaacaata ccacccctgt cacaggggcc tccccaggag gcctgcggga gctgcagctt
601 cgaagcctca cagagatctt gaaaggaggg gtcttgatcc agcggaaccc ccagctctgc
661 taccaggaca cgattttgtg gaaggacatc ttccacaaga acaaccagct ggctctcaca
721 ctgatagaca ccaaccgctc tcgggcctgc cacccctgtt ctccgatgtg taagggctcc
781 cgctgctggg gagagagttc tgaggattgt cagagcctga cgcgcactgt ctgtgccggt
841 ggctgtgccc gctgcaaggg gccactgccc actgactgct gccatgagca gtgtgctgcc
901 ggctgcacgg gccccaagca ctctgactgc ctggcctgcc tccacttcaa ccacagtggc
961 atctgtgagc tgcactgccc agccctggtc acctacaaca cagacacgtt tgagtccatg
1021 cccaatcccg agggccggta tacattcggc gccagctgtg tgactgcctg tccctacaac
1081 tacctttcta cggacgtggg atcctgcacc ctcgtctgcc ccctgcacaa ccaagaggtg
1141 acagcagagg atggaacaca gcggtgtgag aagtgcagca agccctgtgc ccgagtgtgc
1201 tatggtctgg gcatggagca cttgcgagag gtgagggcag ttaccagtgc caatatccag
1261 gagtttgctg gctgcaagaa gatctttggg agcctggcat ttctgccgga gagctttgat
1321 ggggacccag cctccaacac tgccccgctc cagccagagc agctccaagt gtttgagact
1381 ctggaagaga tcacaggtta cctatacatc tcagcatggc cggacagcct gcctgacctc
1441 agcgtcttcc agaacctgca agtaatccgg ggacgaattc tgcacaatgg cgcctactcg
1501 ctgaccctgc aagggctggg catcagctgg ctggggctgc gctcactgag ggaactgggc
1561 agtggactgg ccctcatcca ccataacacc cacctctgct tcgtgcacac ggtgccctgg
1621 gaccagctct ttcggaaccc gcaccaagct ctgctccaca ctgccaaccg gccagaggac
1681 gagtgtgtgg gcgagggcct ggcctgccac cagctgtgcg cccgagggca ctgctggggt
1741 ccagggccca cccagtgtgt caactgcagc cagttccttc ggggccagga gtgcgtggag
1801 gaatgccgag tactgcaggg gctccccagg gagtatgtga atgccaggca ctgtttgccg
1861 tgccaccctg agtgtcagcc ccagaatggc tcagtgacct gttttggacc ggaggctgac
1921 cagtgtgtgg cctgtgccca ctataaggac cctcccttct gcgtggcccg ctgccccagc
1981 ggtgtgaaac ctgacctctc ctacatgccc atctggaagt ttccagatga ggagggcgca
2041 tgccagcctt gccccatcaa ctgcacccac tcctgtgtgg acctggatga caagggctgc
2101 cccgccgagc agagagccag ccctctgacg tccatcatct ctgcggtggt tggcattctg
2161 ctggtcgtgg tcttgggggt ggtctttggg atcctcatca agcgacggca gcagaagatc
2221 cggaagtaca cgatgcggag actgctgcag gaaacggagc tggtggagcc gctgacacct
2281 agcggagcga tgcccaacca ggcgcagatg cggatcctga aagagacgga gctgaggaag
2341 gtgaaggtgc ttggatctgg cgcttttggc acagtctaca agggcatctg gatccctgat
2401 ggggagaatg tgaaaattcc agtggccatc aaagtgttga gggaaaacac atcccccaaa
2461 gccaacaaag aaatcttaga cgaagcatac gtgatggctg gtgtgggctc cccatatgtc
2521 tcccgccttc tgggcatctg cctgacatcc acggtgcagc tggtgacaca gcttatgccc
2581 tatggctgcc tcttagacca tgtccgggaa aaccgcggac gcctgggctc ccaggacctg
2641 ctgaactggt gtatgcagat tgccaagggg atgagctacc tggaggatgt gcggctcgta
2701 cacagggact tggccgctcg gaacgtgctg gtcaagagtc ccaaccatgt caaaattaca
2761 gacttcgggc tggctcggct gctggacatt gacgagacag agtaccatgc agatgggggc
2821 aaggtgccca tcaagtggat ggcgctggag tccattctcc gccggcggtt cacccaccag
2881 agtgatgtgt ggagttatgg tgtgactgtg tgggagctga tgacttttgg ggccaaacct
2941 tacgatggga tcccagcccg ggagatccct gacctgctgg aaaaggggga gcggctgccc
3001 cagcccccca tctgcaccat tgatgtctac atgatcatgg tcaaatgttg gatgattgac
3061 tctgaatgtc ggccaagatt ccgggagttg gtgtctgaat tctcccgcat ggccagggac
3121 ccccagcgct ttgtggtcat ccagaatgag gacttgggcc cagccagtcc cttggacagc
3181 accttctacc gctcactgct ggaggacgat gacatggggg acctggtgga tgctgaggag
3241 tatctggtac cccagcaggg cttcttctgt ccagaccctg ccccgggcgc tgggggcatg
3301 gtccaccaca ggcaccgcag ctcatctacc aggagtggcg gtggggacct gacactaggg
3361 ctggagccct ctgaagagga ggcccccagg tctccactgg caccctccga aggggctggc
3421 tccgatgtat ttgatggtga cctgggaatg ggggcagcca aggggctgca aagcctcccc
3481 acacatgacc ccagccctct acagcggtac agtgaggacc ccacagtacc cctgccctct
3541 gagactgatg gctacgttgc ccccctgacc tgcagccccc agcctgaata tgtgaaccag
3601 ccagatgttc ggccccagcc cccttcgccc cgagagggcc ctctgcctgc tgcccgacct
3661 gctggtgcca ctctggaaag gcccaagact ctctccccag ggaagaatgg ggtcgtcaaa
3721 gacgtttttg cctttggggg tgccgtggag aaccccgagt acttgacacc ccagggagga
3781 gctgcccctc agccccaccc tcctcctgcc ttcagcccag ccttcgacaa cctctattac
3841 tgggaccagg acccaccaga gcggggggct ccacccagca ccttcaaagg gacacctacg
3901 gcagagaacc cagagtacct gggtctggac gtgccagtgt gaaccagaag gccaagtccg
3961 cagaagccct gatgtgtcct cagggagcag ggaaggcctg acttctgctg gcatcaagag
4021 gtgggagggc cctccgacca cttccagggg aacctgccat gccaggaacc tgtcctaagg
4081 aaccttcctt cctgcttgag ttcccagatg gctggaaggg gtccagcctc gttggaagag
4141 gaacagcact ggggagtctt tgtggattct gaggccctgc ccaatgagac tctagggtcc
4201 agtggatgcc acagcccagc ttggcccttt ccttccagat cctgggtact gaaagcctta
4261 gggaagctgg cctgagaggg gaagcggccc taagggagtg tctaagaaca aaagcgaccc
4321 attcagagac tgtccctgaa acctagtact gccccccatg aggaaggaac agcaatggtg
4381 tcagtatcca ggctttgtac agagtgcttt tctgtttagt ttttactttt tttgttttgt
4441 ttttttaaag atgaaataaa gacccagggg gag
//