LOCUS X03225 4788 bp mRNA linear HUM 12-SEP-1993
DEFINITION Human mRNA for alpha-glucocorticoid receptor (clone OB7).
ACCESSION X03225 M10901
VERSION X03225.1
KEYWORDS glucocorticoid receptor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4788)
AUTHORS Hollenberg S.M., Weinberger C., Ong E.S., Cerelli G., Oro A.,
Lebo R., Thompson E.B., Rosenfeld M.G., Evans R.M.
TITLE Primary structure and expression of a functional human
glucocorticoid receptor cDNA
JOURNAL Nature 318(6047), 635-641(1985).
PUBMED 2867473
COMMENT About 500 bp of the 5' region were derived from clone OB10 which
represents the beta-glucocorticoid receptor (see X03348).
FEATURES Location/Qualifiers
source 1..4788
/db_xref="H-InvDB:HIT000320970"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 133..2466
/product="alpha-glucocorticoid receptor"
/note="(aa 1-777)"
/db_xref="GOA:P04150"
/db_xref="H-InvDB:HIT000320970.14"
/db_xref="HGNC:HGNC:7978"
/db_xref="InterPro:IPR000536"
/db_xref="InterPro:IPR001409"
/db_xref="InterPro:IPR001628"
/db_xref="InterPro:IPR001723"
/db_xref="InterPro:IPR013088"
/db_xref="InterPro:IPR035500"
/db_xref="PDB:1M2Z"
/db_xref="PDB:1NHZ"
/db_xref="PDB:1P93"
/db_xref="PDB:3BQD"
/db_xref="PDB:3CLD"
/db_xref="PDB:3E7C"
/db_xref="PDB:3H52"
/db_xref="PDB:3K22"
/db_xref="PDB:3K23"
/db_xref="PDB:4CSJ"
/db_xref="PDB:4HN5"
/db_xref="PDB:4HN6"
/db_xref="PDB:4LSJ"
/db_xref="PDB:4MDD"
/db_xref="PDB:4P6W"
/db_xref="PDB:4P6X"
/db_xref="PDB:4UDC"
/db_xref="PDB:4UDD"
/db_xref="PDB:5CBX"
/db_xref="PDB:5CBY"
/db_xref="PDB:5CBZ"
/db_xref="PDB:5CC1"
/db_xref="PDB:5E69"
/db_xref="PDB:5E6A"
/db_xref="PDB:5E6B"
/db_xref="PDB:5E6C"
/db_xref="PDB:5E6D"
/db_xref="PDB:5EMC"
/db_xref="PDB:5EMP"
/db_xref="PDB:5EMQ"
/db_xref="PDB:5G3J"
/db_xref="PDB:5G5W"
/db_xref="PDB:5NFP"
/db_xref="PDB:5NFT"
/db_xref="PDB:5UC3"
/db_xref="PDB:5VA0"
/db_xref="PDB:5VA7"
/db_xref="PDB:6BQU"
/db_xref="PDB:6CFN"
/db_xref="PDB:6DXK"
/db_xref="PDB:6EL6"
/db_xref="PDB:6EL7"
/db_xref="PDB:6EL9"
/db_xref="UniProtKB/Swiss-Prot:P04150"
/protein_id="CAA26976.1"
/translation="MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSAS
SPSLAVASQSDSKQRRLLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDL
GFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTH
SDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLL
IDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQV
KTEKEDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHY
DMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNG
YSSPSMRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVE
GQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVS
QETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNML
GGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFA
PDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKS
QELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTF
LDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK"
misc_feature 3101..3106
/note="pot. polyA signal"
misc_feature 4679..4684
/note="pot. polyA signal"
misc_feature 4762..4767
/note="pot. polyA signal"
polyA_site 4788..4788
BASE COUNT 1471 a 939 c 970 g 1408 t
ORIGIN
1 tttttagaaa aaaaaaatat atttccctcc tgctccttct gcgttcacaa gctaagttgt
61 ttatctcggc tgcggcggga actgcggacg gtggcgggcg agcggctcct ctgccagagt
121 tgatattcac tgatggactc caaagaatca ttaactcctg gtagagaaga aaaccccagc
181 agtgtgcttg ctcaggagag gggagatgtg atggacttct ataaaaccct aagaggagga
241 gctactgtga aggtttctgc gtcttcaccc tcactggctg tcgcttctca atcagactcc
301 aagcagcgaa gacttttggt tgattttcca aaaggctcag taagcaatgc gcagcagcca
361 gatctgtcca aagcagtttc actctcaatg ggactgtata tgggagagac agaaacaaaa
421 gtgatgggaa atgacctggg attcccacag cagggccaaa tcagcctttc ctcgggggaa
481 acagacttaa agcttttgga agaaagcatt gcaaacctca ataggtcgac cagtgttcca
541 gagaacccca agagttcagc atccactgct gtgtctgctg cccccacaga gaaggagttt
601 ccaaaaactc actctgatgt atcttcagaa cagcaacatt tgaagggcca gactggcacc
661 aacggtggca atgtgaaatt gtataccaca gaccaaagca cctttgacat tttgcaggat
721 ttggagtttt cttctgggtc cccaggtaaa gagacgaatg agagtccttg gagatcagac
781 ctgttgatag atgaaaactg tttgctttct cctctggcgg gagaagacga ttcattcctt
841 ttggaaggaa actcgaatga ggactgcaag cctctcattt taccggacac taaacccaaa
901 attaaggata atggagatct ggttttgtca agccccagta atgtaacact gccccaagtg
961 aaaacagaaa aagaagattt catcgaactc tgcacccctg gggtaattaa gcaagagaaa
1021 ctgggcacag tttactgtca ggcaagcttt cctggagcaa atataattgg taataaaatg
1081 tctgccattt ctgttcatgg tgtgagtacc tctggaggac agatgtacca ctatgacatg
1141 aatacagcat ccctttctca acagcaggat cagaagccta tttttaatgt cattccacca
1201 attcccgttg gttccgaaaa ttggaatagg tgccaaggat ctggagatga caacttgact
1261 tctctgggga ctctgaactt ccctggtcga acagtttttt ctaatggcta ttcaagcccc
1321 agcatgagac cagatgtaag ctctcctcca tccagctcct caacagcaac aacaggacca
1381 cctcccaaac tctgcctggt gtgctctgat gaagcttcag gatgtcatta tggagtctta
1441 acttgtggaa gctgtaaagt tttcttcaaa agagcagtgg aaggacagca caattaccta
1501 tgtgctggaa ggaatgattg catcatcgat aaaattcgaa gaaaaaactg cccagcatgc
1561 cgctatcgaa aatgtcttca ggctggaatg aacctggaag ctcgaaaaac aaagaaaaaa
1621 ataaaaggaa ttcagcaggc cactacagga gtctcacaag aaacctctga aaatcctggt
1681 aacaaaacaa tagttcctgc aacgttacca caactcaccc ctaccctggt gtcactgttg
1741 gaggttattg aacctgaagt gttatatgca ggatatgata gctctgttcc agactcaact
1801 tggaggatca tgactacgct caacatgtta ggagggcggc aagtgattgc agcagtgaaa
1861 tgggcaaagg caataccagg tttcaggaac ttacacctgg atgaccaaat gaccctactg
1921 cagtactcct ggatgtttct tatggcattt gctctggggt ggagatcata tagacaatca
1981 agtgcaaacc tgctgtgttt tgctcctgat ctgattatta atgagcagag aatgactcta
2041 ccctgcatgt acgaccaatg taaacacatg ctgtatgttt cctctgagtt acacaggctt
2101 caggtatctt atgaagagta tctctgtatg aaaaccttac tgcttctctc ttcagttcct
2161 aaggacggtc tgaagagcca agagctattt gatgaaatta gaatgaccta catcaaagag
2221 ctaggaaaag ccattgtcaa gagggaagga aactccagcc agaactggca gcggttttat
2281 caactgacaa aactcttgga ttctatgcat gaagtggttg aaaatctcct taactattgc
2341 ttccaaacat ttttggataa gaccatgagt attgaattcc ccgagatgtt agctgaaatc
2401 atcaccaatc agataccaaa atattcaaat ggaaatatca aaaaacttct gtttcatcaa
2461 aagtgactgc cttaataaga atggttgcct taaagaaagt cgaattaata gcttttattg
2521 tataaactat cagtttgtcc tgtagaggtt ttgttgtttt attttttatt gttttcatct
2581 gttgttttgt tttaaatacg cactacatgt ggtttataga gggccaagac ttggcaacag
2641 aagcagttga gtcgtcatca cttttcagtg atgggagagt agatggtgaa atttattagt
2701 taatatatcc cagaaattag aaaccttaat atgtggacgt aatctccaca gtcaaagaag
2761 gatggcacct aaaccaccag tgcccaaagt ctgtgtgatg aactttctct tcatactttt
2821 tttcacagtt ggctggatga aattttctag actttctgtt ggtgtatccc ccccctgtat
2881 agttaggata gcatttttga tttatgcatg gaaacctgaa aaaaagttta caagtgtata
2941 tcagaaaagg gaagttgtgc cttttatagc tattactgtc tggttttaac aatttccttt
3001 atatttagtg aactacgctt gctcattttt tcttacataa ttttttattc aagttattgt
3061 acagctgttt aagatgggca gctagttcgt agctttccca aataaactct aaacattaat
3121 caatcatctg tgtgaaaatg ggttggtgct tctaacctga tggcacttag ctatcagaag
3181 accacaaaaa ttgactcaaa tctccagtat tcttgtcaaa aaaaaaaaaa aaaaagctca
3241 tattttgtat atatctgctt cagtggagaa ttatataggt tgtgcaaatt aacagtccta
3301 actggtatag agcacctagt ccagtgacct gctgggtaaa ctgtggatga tggttgcaaa
3361 agactaattt aaaaaataac taccaagagg ccctgtctgt acctaacgcc ctatttttgc
3421 aatggctata tggcaagaaa gctggtaaac tatttgtctt tcaggacctt ttgaagtagt
3481 ttgtataact tcttaaaagt tgtgattcca gataaccagc tgtaacacag ctgagagact
3541 tttaatcaga caaagtaatt cctctcacta aactttaccc aaaaactaaa tctctaatat
3601 ggcaaaaatg gctagacacc cattttcaca ttcccatctg tcaccaattg gttaatcttt
3661 cctgatggta caggaaagct cagctactga tttttgtgat ttagaactgt atgtcagaca
3721 tccatgtttg taaaactaca catccctaat gtgtgccata gagtttaaca caagtcctgt
3781 gaatttcttc actgttgaaa attattttaa acaaaataga agctgtagta gccctttctg
3841 tgtgcacctt accaactttc tgtaaactca aaacttaaca tatttactaa gccacaagaa
3901 atttgatttc tattcaaggt ggccaaatta tttgtgtaat agaaaactga aaatctaata
3961 ttaaaaatat ggaacttcta atatattttt atatttagtt atagtttcag atatatatca
4021 tattggtatt cactaatctg ggaagggaag ggctactgca gctttacatg caatttatta
4081 aaatgattgt aaaatagctt gtatagtgta aaataagaat gatttttaga tgagattgtt
4141 ttatcatgac atgttatata ttttttgtag gggtcaaaga aatgctgatg gataacctat
4201 atgatttata gtttgtacat gcattcatac aggcagcgat ggtctcagaa accaaacagt
4261 ttgctctagg ggaagaggga gatggagact ggtcctgtgt gcagtgaagg ttgctgaggc
4321 tctgacccag tgagattaca gaggaagtta tcctctgcct cccattctga ccacccttct
4381 cattccaaca gtgagtctgt cagcgcaggt ttagtttact caatctcccc ttgcactaaa
4441 gtatgtaaag tatgtaaaca ggagacagga aggtggtgct tacatcctta aaggcaccat
4501 ctaatagcgg gttactttca catacagccc tcccccagca gttgaatgac aacagaagct
4561 tcagaagttt ggcaatagtt tgcatagagg taccagcaat atgtaaatag tgcagaatct
4621 cataggttgc caataataca ctaattcctt tctatcctac aacaagagtt tatttccaaa
4681 taaaatgagg acatgttttt gttttctttg aatgcttttt gaatgttatt tgttattttc
4741 agtattttgg agaaattatt taataaaaaa acaatcattt gctttttg
//