LOCUS X03072 4522 bp DNA linear HUM 10-FEB-1999
DEFINITION Human int-1 mammary oncogene.
ACCESSION X03072
VERSION X03072.1
KEYWORDS int-1 oncogene; oncogene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4522)
AUTHORS van Ooyen A.J.J., Kwee V., Nusse R.
TITLE The nucleotide sequence of the human int-1 mammary oncogene;
evolutionary conservation of coding and non-coding sequences
JOURNAL EMBO J. 4(11), 2905-2909(1985).
PUBMED 2998762
COMMENT Data kindly reviewed (15-JUN-1986) by R. Nusse
FEATURES Location/Qualifiers
source 1..4522
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
regulatory 259..263
/note="pot. TATA-box"
/regulatory_class="promoter"
CDS join(465..568,1282..1535,2238..2503,2966..3454)
/product="int-1 protein"
/db_xref="GOA:P04628"
/db_xref="HGNC:HGNC:12774"
/db_xref="InterPro:IPR005817"
/db_xref="InterPro:IPR009139"
/db_xref="InterPro:IPR018161"
/db_xref="UniProtKB/Swiss-Prot:P04628"
/protein_id="CAA26874.1"
/translation="MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASST
NLLTDSKSLQLVLEPSLQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRW
NCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGP
GGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQEC
KCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEP
EDPAHKPPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGH
RTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL"
intron 569..1281
/note="intron I"
intron 1536..2237
/note="intron II"
intron 2504..2965
/note="intron III"
misc_feature 4410..4415
/note="pot. polyadenylation signal"
BASE COUNT 805 a 1523 c 1320 g 874 t
ORIGIN
1 cagctgagtg aggcgggcgc gcgtgggagg gtgtcccaag gggaggggtc cgcggccagt
61 gcaggcccgg aggcgggggc caccgggcag ggggcggggg tgagccccga cggccaaccc
121 gtcagctctc ggctcagacg ggcgggaacc acagccccgc tcgctgccca ttgtctgcgc
181 ccctaaccgg tgcgccctgg tgccacagtg cggcccggag gggcagcctc ctcccgtcac
241 ttcagccagc gccgcaacta taagaggcgg tgccgcccgc cgtggccgcc tcagcccacc
301 agccgggacc gcgagccatg ctgtccgccg cccgccccca gggttgttaa agccagactg
361 cgaactctcg ccactgccgc caccgccgcg tcccgtccca ccgtcgcggg caacaaccaa
421 agtcgccgca actgcagcac agagcgggca aagccaggca ggccatgggg ctctgggcgc
481 tgttgcctgg ctgggtttct gctacgctgc tgctggcgct ggccgctctg cccgcagccc
541 tggctgccaa cagcagtggc cgatggtggt aagtgagctg gtgcggggtc gccacttgtc
601 ccgcggcaca gagccagggg ccaaccctac ccagctccca cgctctggga tccgtctgcc
661 gacaggctcc ctccccgctc tgacttccct ccgcgacacc gaagggcgat ctggcatgaa
721 actgccccag actccagctc tgtacaagtg gggcgaatga tccgcccgcg gaggcctaag
781 ataccccagg cagggagccc actctcatct agcaccgccc ttcccctttg agcgccaact
841 ccagcctcac ggcggtggct caccacaggt ttccccacct cgggaagtga agggccagga
901 gttcgcctag aaaggagggg agaagagggt gggactccta agcatttcac gccttgggtg
961 ggcaagaact gcaggccatg attatctcgc tcaggctgac cggaagaggc tcggagatcc
1021 aaggtagaca ctcggtctcc gggtacctcc tctgtccagt ctccggacct agggctcagg
1081 cgagcagccc tgggactact gggcacacac aagtctggac gcccagttct ttcaaattag
1141 tgagcctggg agagcgggta ttattaatct cccgccattc tctccagcca cataccccca
1201 ggaagaggac cgggtggcac agtttttatg gttagggtgc ggatcccctt cctgagcctg
1261 agctatcata cgtcccacca ggggtattgt gaacgtagcc tcctccacga acctgcttac
1321 agactccaag agtctgcaac tggtactcga gcccagtctg cagctgttga gccgcaaaca
1381 gcggcgcctg atacgccaaa atccggggat cctgcacagc gtgagtgggg ggctgcagag
1441 tgccgtgcgc gagtgcaagt ggcagttccg gaatcgccgc tggaactgtc ccactgctcc
1501 agggccccac ctcttcggca agatcgtcaa ccgaggtggg tgcccaggaa ggcgacgctt
1561 ccgggagcag gggaaacgcg gggtcacccc cagggcatgg gcgggcgagt tcagagaagg
1621 tgtcccaggc gcctggaggg tcacacaatc aaccttgcca agtgcctcgt gcccagcgcc
1681 agctcggggc cagacttcta ccaggcgttt tccagccgtg caccctggaa acgaagctta
1741 acttttctga gctactgccc cagataaaga aagtttcggg tcgcggacgc cggctgaccg
1801 ccgctttccc ccagcctctc tcaaaagcgc ctgggaagct gctctctgca ggcgtgtgtc
1861 tggcctctcg cccagcaagg cttgcaccgc caaaatgggc cgaaagtttt gggctgcgaa
1921 gaagtcttgg ggatgtatgg ttcttccgct cccctctctt cggtttgtct ctctggggct
1981 gctccacttc cgctatcgag ccaaaatgcg ccctagaatc tcccagtaag gtgtgattac
2041 gcccgtggac gtggctgcgt gcccacgcac ctgctttctc tactagccct agagaccagc
2101 tttccagcac tgccggccct ggtcctcagg actcaaagtg cggagtcggg ggtgggattc
2161 cggtcccaag cccttcatga gggtgctggc cgcgccccgc gtaccccctc gctgatcccc
2221 gctcccttct cccacaggct gtcgagaaac ggcgtttatc ttcgctatca cctccgccgg
2281 ggtcacccat tcggtggcgc gctcctgctc agaaggttcc atcgaatcct gcacgtgtga
2341 ctaccggcgg cgcggccccg ggggccccga ctggcactgg gggggctgca gcgacaacat
2401 tgacttcggc cgcctcttcg gccgggagtt cgtggactcc ggggagaagg ggcgggacct
2461 gcgcttcctc atgaaccttc acaacaacga ggcaggccgt acggtgagct ttgagaggct
2521 ccgcacccta agcggagcgg caggggccaa cctcgggctg gggaagtgac ggtcggtgag
2581 ataaggcaag gggcaccagg agagggcgtc ctgggagagc cggaggcttg gaacgaagac
2641 ggagaataga ggagacagtg gctgagggca aaggtatgtc tggcccgcgg acaggtagaa
2701 gaggttgcaa atcaagcaca gtctcttcgc tgtacagatt cgaaaaataa gcctgagagg
2761 ccgagactga ctcgccgcgg cggagcaggg ttgggcaggg tttccaaatc tcagcggaac
2821 atttcgcgcc tcccttcccc tgggctcagc taggcctggg cctttgctga ggtccggccc
2881 ccgtggcgtc cgggagaggg cagtgtctgg gagggtgact ctggcccggt gccctgggac
2941 actctttctt cccctatccc cgcagaccgt attctccgag atgcgccagg agtgcaagtg
3001 ccacgggatg tccggctcat gcacggtgcg cacgtgctgg atgcggctgc ccacgctgcg
3061 cgccgtgggc gatgtgctgc gcgaccgctt cgacggcgcc tcgcgcgtcc tgtacggcaa
3121 ccgcggcagc aaccgcgctt cgcgagcgga gctgctgcgc ctggagccgg aagacccggc
3181 ccacaaaccg ccctcccccc acgacctcgt ctacttcgag aaatcgccca acttctgcac
3241 gtacagcgga cgcctgggca cagcaggcac ggcagggcgc gcctgtaaca gctcgtcgcc
3301 cgcgctggac ggctgcgagc tgctctgctg cggcaggggc caccgcacgc gcacgcagcg
3361 cgtcaccgag cgctgcaact gcaccttcca ctggtgctgc cacgtcagct gccgcaactg
3421 cacgcacacg cgcgtactgc acgagtgtct gtgaggcgct gcgcggactc gcccccagga
3481 acgctctcct cgagccctcc cccaaacaga ctcgctagca ctcaagaccc ggttattcgc
3541 ccacccgagt acctccagtc acactccccg cggttcatac gcatcccatc tctcccactt
3601 cctcctacct ggggactcct caaaccactt gcctggggcg gcatgaaccc tcttgccatc
3661 ctgatggacc tgccccggac ctaacctccc tccctctccg cgggagaccc cttgttgcac
3721 tgccccctgc ttggccagga ggtgagagaa ggatgggtcc cctccgccat ggggtcggct
3781 cctgatggtg tcattctgcc tgctccatcg cgccagcgac ctctctgcct ctcttcttcc
3841 cctttgtcct gcgttttctc cgggtcctcc taagtccctt cctattctcc tgccatgggt
3901 gcagaccctg aacccacacc tgggcatcag ggcctttctc ctccccacct gtagctgaag
3961 caggaggtta cagggcaaaa gggcagctgt gatgatgtgg gaatgaggtt gggggaacca
4021 gcagaaatgc ccccattctc ccagtctctg tcgtggagcc attgaacagc tgtgagccat
4081 gcctccctgg gccacctcct accccttcct gtcctgcctc ctcatcagtg tgtaaataat
4141 ttgcactgaa acgtggatac agagccacga gtttggatgt tgtaaataaa actatttatt
4201 gtgctgggtc ccagcctggt ttgcaaagac cacctccaac ccaacccaat ccctctccac
4261 tcttctctcc tttctccctg cagccttttc tggtccctct tctctcctca gtttctcaaa
4321 gatgcgtttg cctcctggaa tcagtatttc cttccactgt agctattagc ggctcctcgc
4381 ccccaccagt gtagcatctt cctctgcaga ataaaatctc tatttttatc gatgacttgg
4441 tggcttttcc ttgaatccag aacacaacct tgtttgtggt gtcccctatc ctcccctttt
4501 accactccca gcttggaagc tt
//