LOCUS X02812 2745 bp mRNA linear HUM 27-MAR-1995
DEFINITION Human mRNA for transforming growth factor-beta (TGF-beta).
ACCESSION X02812 J05114
VERSION X02812.1
KEYWORDS signal peptide; transforming growth factor-beta.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2745)
AUTHORS Derynck R., Jarrett J.A., Chen E.Y., Eaton D.H., Bell J.R.,
Assoian R.K., Roberts A.B., Sporn M.B., Goeddel D.V.
TITLE Human transforming growth factor-beta complementary DNA sequence
and expression in normal and transformed cells
JOURNAL Nature 316(6030), 701-705(1985).
PUBMED 3861940
COMMENT The sequence downstream from the translational stop codon
(2015-2017) was taken from a genomic clone
FEATURES Location/Qualifiers
source 1..2745
/db_xref="H-InvDB:HIT000320947"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
misc_feature 37..113
/note="pot. hairpin loops-forming region"
CDS 842..2017
/note="TGF-beta precursor"
/db_xref="GOA:P01137"
/db_xref="H-InvDB:HIT000320947.13"
/db_xref="HGNC:HGNC:11766"
/db_xref="InterPro:IPR001111"
/db_xref="InterPro:IPR001839"
/db_xref="InterPro:IPR003939"
/db_xref="InterPro:IPR015615"
/db_xref="InterPro:IPR016319"
/db_xref="InterPro:IPR017948"
/db_xref="InterPro:IPR029034"
/db_xref="PDB:1KLA"
/db_xref="PDB:1KLC"
/db_xref="PDB:1KLD"
/db_xref="PDB:3KFD"
/db_xref="PDB:4KV5"
/db_xref="PDB:5FFO"
/db_xref="PDB:5VQP"
/db_xref="UniProtKB/Swiss-Prot:P01137"
/protein_id="CAA26580.1"
/translation="MPPSGLRLLPLLLPLLWLLVLTPGPPAAGLSTCKTIDMELVKRK
RIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEAD
YYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRR
LKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGF
RLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSR
HRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLD
TQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS"
misc_feature 863..910
/note="pot. core sequence of signal peptide (aa -272 to
-257)"
misc_feature 953..953
/note="pot. altern. translation start site"
misc_feature 1035..1043
/note="put. glycosylation site"
misc_feature 1247..1255
/note="put. glycosylation site"
misc_feature 1370..1378
/note="put. glycosylation site"
mat_peptide 1679..2014
/note="mature TGF-beta (aa 1-112)"
misc_feature 2018..2096
/note="GC-rich region"
regulatory 2097..2103
/note="TATA-box-like region"
/regulatory_class="promoter"
misc_feature 2517..2522
/note="put. polyadenylation signal"
polyA_site 2539..2539
/note="polyadenylation site"
BASE COUNT 527 a 938 c 801 g 479 t
ORIGIN
1 acctccctcc gcggagcagc cagacagcga gggccccggc cgggggcagg ggggacgccc
61 cgtccggggc accccccccg gctctgagcc gcccgcgggg ccggcctcgg cccggagcgg
121 aggaaggagt cgccgaggag cagcctgagg ccccagagtc tgagacgagc cgccgccgcc
181 cccgccactg cggggaggag ggggaggagg agcgggagga gggacgagct ggtcgggaga
241 agaggaaaaa aacttttgag acttttccgt tgccgctggg agccggaggc gcggggacct
301 cttggcgcga cgctgccccg cgaggaggca ggacttgggg accccagacc gcctcccttt
361 gccgccgggg acgcttgctc cctccctgcc ccctacacgg cgtccctcag gcgcccccat
421 tccggaccag ccctcgggag tcgccgaccc ggcctcccgc aaagactttt ccccagacct
481 cgggcgcacc ccctgcacgc cgccttcatc cccggcctgt ctcctgagcc cccgcgcatc
541 ctagaccctt tctcctccag gagacggatc tctctccgac ctgccacaga tcccctattc
601 aagaccaccc accttctggt accagatcgc gcccatctag gttatttccg tgggatactg
661 agacaccccc ggtccaagcc tcccctccac cactgcgccc ttctccctga ggagcctcag
721 ctttccctcg aggccctcct accttttgcc gggagacccc cagcccctgc aggggcgggg
781 cctccccacc acaccagccc tgttcgcgct ctcggcagtg ccggggggcg ccgcctcccc
841 catgccgccc tccgggctgc ggctgctgcc gctgctgcta ccgctgctgt ggctactggt
901 gctgacgcct ggcccgccgg ccgcgggact atccacctgc aagactatcg acatggagct
961 ggtgaagcgg aagcgcatcg aggccatccg cggccagatc ctgtccaagc tgcggctcgc
1021 cagccccccg agccaggggg aggtgccgcc cggcccgctg cccgaggccg tgctcgccct
1081 gtacaacagc acccgcgacc gggtggccgg ggagagtgca gaaccggagc ccgagcctga
1141 ggccgactac tacgccaagg aggtcacccg cgtgctaatg gtggaaaccc acaacgaaat
1201 ctatgacaag ttcaagcaga gtacacacag catatatatg ttcttcaaca catcagagct
1261 ccgagaagcg gtacctgaac ccgtgttgct ctcccgggca gagctgcgtc tgctgaggag
1321 gctcaagtta aaagtggagc agcacgtgga gctgtaccag aaatacagca acaattcctg
1381 gcgatacctc agcaaccggc tgctggcacc cagcgactcg ccagagtggt tatcttttga
1441 tgtcaccgga gttgtgcggc agtggttgag ccgtggaggg gaaattgagg gctttcgcct
1501 tagcgcccac tgctcctgtg acagcaggga taacacactg caagtggaca tcaacgggtt
1561 cactaccggc cgccgaggtg acctggccac cattcatggc atgaaccggc ctttcctgct
1621 tctcatggcc accccgctgg agagggccca gcatctgcaa agctcccggc accgccgagc
1681 cctggacacc aactattgct tcagctccac ggagaagaac tgctgcgtgc ggcagctgta
1741 cattgacttc cgcaaggacc tcggctggaa gtggatccac gagcccaagg gctaccatgc
1801 caacttctgc ctcgggccct gcccctacat ttggagcctg gacacgcagt acagcaaggt
1861 cctggccctg tacaaccagc ataacccggg cgcctcggcg gcgccgtgct gcgtgccgca
1921 ggcgctggag ccgctgccca tcgtgtacta cgtgggccgc aagcccaagg tggagcagct
1981 gtccaacatg atcgtgcgct cctgcaagtg cagctgaggt cccgccccgc cccgccccgc
2041 cccggcaggc ccggccccac cccgccccgc ccccgctgcc ttgcccatgg gggctgtatt
2101 taaggacacc gtgccccaag cccacctggg gccccattaa agatggagag aggactgcgg
2161 atctctgtgt cattgggcgc ctgcctgggg tctccatccc tgacgttccc ccactcccac
2221 tccctctctc tccctctctg cctcctcctg cctgtctgca ctattccttt gcccggcatc
2281 aaggcacagg ggaccagtgg ggaacactac tgtagttaga tctatttatt gagcaccttg
2341 ggcactgttg aagtgcctta cattaatgaa ctcattcagt caccatagca acactctgag
2401 atggcaggga ctctgataac acccatttta aaggttgagg aaacaagccc agagaggtta
2461 agggaggagt tcctgcccac caggaacctg ctttagtggg ggatagtgaa gaagacaata
2521 aaagatagta gttcaggcca ggcggggtgc tcacgcctgt aatcctagca cttttgggag
2581 gcagagatgg gaggatactt gaatccaggc atttgagacc agcctgggta acatagtgag
2641 accctatctc tacaaaacac ttttaaaaaa tgtacacctg tggtcccagc tactctggag
2701 gctaaggtgg gaggatcact tgatcctggg aggtcaaggc tgcag
//