LOCUS X02811 2137 bp mRNA linear HUM 27-MAR-1995 DEFINITION Human mRNA for platelet-derived growth factor B chain (PDGF-B). ACCESSION X02811 VERSION X02811.1 KEYWORDS growth factor. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2137) AUTHORS Collins T., Ginsburg D., Boss J.M., Orkin S.H., Pober J.S. TITLE Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis JOURNAL Nature 316(6030), 748-750(1985). PUBMED 4033772 COMMENT The genomic sequence is reported in Gazit, A. et.al; Cell 39, 89-97 (1984). The sequence is identical from 866 to 1045 to a mRNA of c-sis proto-oncogene from T lymphoma cell line (see HSSISA1) from 1047 to 3' end homologue to v-sis and in the coding region to the exons of normal c-sis gene (see HSSISA3-7, HSSIS1-5) FEATURES Location/Qualifiers source 1..2137 /db_xref="H-InvDB:HIT000320946" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" misc_feature 294..294 /note="reported 5' end of genomic sequence" CDS 983..1708 /note="PDGF-B (propeptide (aa 1-241)" /db_xref="GOA:P01127" /db_xref="H-InvDB:HIT000320946.14" /db_xref="HGNC:HGNC:8800" /db_xref="InterPro:IPR000072" /db_xref="InterPro:IPR006782" /db_xref="InterPro:IPR015583" /db_xref="InterPro:IPR023581" /db_xref="InterPro:IPR029034" /db_xref="PDB:1PDG" /db_xref="PDB:3MJG" /db_xref="PDB:4HQU" /db_xref="PDB:4HQX" /db_xref="PDB:4QCI" /db_xref="UniProtKB/Swiss-Prot:P01127" /protein_id="CAA26579.1" /translation="MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDL QRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTE VFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVR KKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRP PKGKHRKFKHTHDKTALKETLGA" mat_peptide 1226..1552 /note="mature PDGF-B (aa 82-191)" BASE COUNT 391 a 734 c 661 g 351 t ORIGIN 1 ccctgcctgc ctccctgcgc acccgcagcc tcccccgctg cctccctagg gctcccctcc 61 ggccgccagc gcccattttt cattccctag atagagatac tttgcgcgca cacacataca 121 tacgcgcgca aaaaggaaaa aaaaaaaaaa aagcccaccc tccagcctcg ctgcaaagag 181 aaaaccggag cagccgcagc tcgcagctcg cagcccgcag cccgcagagg acgcccagag 241 cggcgagcgg gcgggcagac ggaccgacgg actcgcgccg cgtccacctg tcggccgggc 301 ccagccgagc gcgcagcggg cacgccgcgc gcgcggagca gccgtgcccg ccgcccgggc 361 ccgccgccag ggcgcacacg ctcccgcccc cctacccggc ccgggcggga gtttgcacct 421 ctccctgccc gggtgctcga gctgccgttg caaagccaac tttggaaaaa gttttttggg 481 ggagacttgg gccttgaggt gcccagctcc gcgctttccg attttggggg cctttccaga 541 aaatgttgca aaaaagctaa gccggcgggc agaggaaaac gcctgtagcc ggcgagtgaa 601 gacgaaccat cgactgccgt gttccttttc ctcttggagg ttggagtccc ctgggcgccc 661 ccacacggct agacgcctcg gctggttcgc gacgcagccc cccggccgtg gatgctgcac 721 tcgggctcgg gatccgccca ggtagcggcc tcggacccag gtcctgcgcc caggtcctcc 781 cctgcccccc agcgacggag ccggggccgg gggcggcggc gccgggggca tgcgggtgag 841 ccgcggctgc agaggcctga gcgcctgatc gccgcggacc cgagccgagc ccacccccct 901 ccccagcccc ccaccctggc cgcgggggcg gcgcgctcga tctacgcgtt cggggccccg 961 cggggccggg cccggagtcg gcatgaatcg ctgctgggcg ctcttcctgt ctctctgctg 1021 ctacctgcgt ctggtcagcg ccgaggggga ccccattccc gaggagcttt atgagatgct 1081 gagtgaccac tcgatccgct cctttgatga tctccaacgc ctgctgcacg gagaccccgg 1141 agaggaagat ggggccgagt tggacctgaa catgacccgc tcccactctg gaggcgagct 1201 ggagagcttg gctcgtggaa gaaggagcct gggttccctg accattgctg agccggccat 1261 gatcgccgag tgcaagacgc gcaccgaggt gttcgagatc tcccggcgcc tcatagaccg 1321 caccaacgcc aacttcctgg tgtggccgcc ctgtgtggag gtgcagcgct gctccggctg 1381 ctgcaacaac cgcaacgtgc agtgccgccc cacccaggtg cagctgcgac ctgtccaggt 1441 gagaaagatc gagattgtgc ggaagaagcc aatctttaag aaggccacgg tgacgctgga 1501 agaccacctg gcatgcaagt gtgagacagt ggcagctgca cggcctgtga cccgaagccc 1561 ggggggttcc caggagcagc gagccaaaac gccccaaact cgggtgacca ttcggacggt 1621 gcgagtccgc cggcccccca agggcaagca ccggaaattc aagcacacgc atgacaagac 1681 ggcactgaag gagacccttg gagcctaggg gcatcggcag gagagtgtgt gggcagggtt 1741 atttaatatg gtatttgctg tattgccccc atggggcctt ggagtagata atattgtttc 1801 cctcgtccgt ctgtctcgat gcctgattcg gacggccaat ggtgcctccc ccacccctcc 1861 acgtgtccgt ccacccttcc atcagcgggt ctcctcccag cggcctccgg ctcttgccca 1921 gcagctcaag aagaaaaaga aggactgaac tccatcgcca tcttcttccc ttaactccaa 1981 gaacttggga taagagtgtg agagagactg atggggtcgc tctttggggg aaacgggttc 2041 cttcccctgc acctggcctg ggccacacct gagcgctgtg gactgtcctg aggagccctg 2101 aggacctctc agcatagcct gcctgatccc tgaaccc //