LOCUS       X02811                  2137 bp    mRNA    linear   HUM 27-MAR-1995
DEFINITION  Human mRNA for platelet-derived growth factor B chain (PDGF-B).
ACCESSION   X02811
VERSION     X02811.1
KEYWORDS    growth factor.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2137)
  AUTHORS   Collins T., Ginsburg D., Boss J.M., Orkin S.H., Pober J.S.
  TITLE     Cultured human endothelial cells express platelet-derived growth
            factor B chain: cDNA cloning and structural analysis
  JOURNAL   Nature 316(6030), 748-750(1985).
   PUBMED   4033772
COMMENT     The genomic sequence is reported in Gazit, A. et.al; Cell 39, 89-97
            (1984). The sequence is identical from 866 to 1045 to a mRNA of
            c-sis proto-oncogene from T lymphoma cell line (see HSSISA1) from
            1047 to 3' end homologue to v-sis and in the coding region to the
            exons of normal c-sis gene (see HSSISA3-7, HSSIS1-5)
FEATURES             Location/Qualifiers
     source          1..2137
                     /db_xref="H-InvDB:HIT000320946"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     misc_feature    294..294
                     /note="reported 5' end of genomic sequence"
     CDS             983..1708
                     /note="PDGF-B (propeptide (aa 1-241)"
                     /db_xref="GOA:P01127"
                     /db_xref="H-InvDB:HIT000320946.14"
                     /db_xref="HGNC:HGNC:8800"
                     /db_xref="InterPro:IPR000072"
                     /db_xref="InterPro:IPR006782"
                     /db_xref="InterPro:IPR015583"
                     /db_xref="InterPro:IPR023581"
                     /db_xref="InterPro:IPR029034"
                     /db_xref="PDB:1PDG"
                     /db_xref="PDB:3MJG"
                     /db_xref="PDB:4HQU"
                     /db_xref="PDB:4HQX"
                     /db_xref="PDB:4QCI"
                     /db_xref="UniProtKB/Swiss-Prot:P01127"
                     /protein_id="CAA26579.1"
                     /translation="MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDL
                     QRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTE
                     VFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVR
                     KKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRP
                     PKGKHRKFKHTHDKTALKETLGA"
     mat_peptide     1226..1552
                     /note="mature PDGF-B (aa 82-191)"
BASE COUNT          391 a          734 c          661 g          351 t
ORIGIN      
        1 ccctgcctgc ctccctgcgc acccgcagcc tcccccgctg cctccctagg gctcccctcc
       61 ggccgccagc gcccattttt cattccctag atagagatac tttgcgcgca cacacataca
      121 tacgcgcgca aaaaggaaaa aaaaaaaaaa aagcccaccc tccagcctcg ctgcaaagag
      181 aaaaccggag cagccgcagc tcgcagctcg cagcccgcag cccgcagagg acgcccagag
      241 cggcgagcgg gcgggcagac ggaccgacgg actcgcgccg cgtccacctg tcggccgggc
      301 ccagccgagc gcgcagcggg cacgccgcgc gcgcggagca gccgtgcccg ccgcccgggc
      361 ccgccgccag ggcgcacacg ctcccgcccc cctacccggc ccgggcggga gtttgcacct
      421 ctccctgccc gggtgctcga gctgccgttg caaagccaac tttggaaaaa gttttttggg
      481 ggagacttgg gccttgaggt gcccagctcc gcgctttccg attttggggg cctttccaga
      541 aaatgttgca aaaaagctaa gccggcgggc agaggaaaac gcctgtagcc ggcgagtgaa
      601 gacgaaccat cgactgccgt gttccttttc ctcttggagg ttggagtccc ctgggcgccc
      661 ccacacggct agacgcctcg gctggttcgc gacgcagccc cccggccgtg gatgctgcac
      721 tcgggctcgg gatccgccca ggtagcggcc tcggacccag gtcctgcgcc caggtcctcc
      781 cctgcccccc agcgacggag ccggggccgg gggcggcggc gccgggggca tgcgggtgag
      841 ccgcggctgc agaggcctga gcgcctgatc gccgcggacc cgagccgagc ccacccccct
      901 ccccagcccc ccaccctggc cgcgggggcg gcgcgctcga tctacgcgtt cggggccccg
      961 cggggccggg cccggagtcg gcatgaatcg ctgctgggcg ctcttcctgt ctctctgctg
     1021 ctacctgcgt ctggtcagcg ccgaggggga ccccattccc gaggagcttt atgagatgct
     1081 gagtgaccac tcgatccgct cctttgatga tctccaacgc ctgctgcacg gagaccccgg
     1141 agaggaagat ggggccgagt tggacctgaa catgacccgc tcccactctg gaggcgagct
     1201 ggagagcttg gctcgtggaa gaaggagcct gggttccctg accattgctg agccggccat
     1261 gatcgccgag tgcaagacgc gcaccgaggt gttcgagatc tcccggcgcc tcatagaccg
     1321 caccaacgcc aacttcctgg tgtggccgcc ctgtgtggag gtgcagcgct gctccggctg
     1381 ctgcaacaac cgcaacgtgc agtgccgccc cacccaggtg cagctgcgac ctgtccaggt
     1441 gagaaagatc gagattgtgc ggaagaagcc aatctttaag aaggccacgg tgacgctgga
     1501 agaccacctg gcatgcaagt gtgagacagt ggcagctgca cggcctgtga cccgaagccc
     1561 ggggggttcc caggagcagc gagccaaaac gccccaaact cgggtgacca ttcggacggt
     1621 gcgagtccgc cggcccccca agggcaagca ccggaaattc aagcacacgc atgacaagac
     1681 ggcactgaag gagacccttg gagcctaggg gcatcggcag gagagtgtgt gggcagggtt
     1741 atttaatatg gtatttgctg tattgccccc atggggcctt ggagtagata atattgtttc
     1801 cctcgtccgt ctgtctcgat gcctgattcg gacggccaat ggtgcctccc ccacccctcc
     1861 acgtgtccgt ccacccttcc atcagcgggt ctcctcccag cggcctccgg ctcttgccca
     1921 gcagctcaag aagaaaaaga aggactgaac tccatcgcca tcttcttccc ttaactccaa
     1981 gaacttggga taagagtgtg agagagactg atggggtcgc tctttggggg aaacgggttc
     2041 cttcccctgc acctggcctg ggccacacct gagcgctgtg gactgtcctg aggagccctg
     2101 aggacctctc agcatagcct gcctgatccc tgaaccc
//