LOCUS X02750 1843 bp mRNA linear HUM 07-OCT-2008
DEFINITION Human liver mRNA for protein C.
ACCESSION X02750
VERSION X02750.1
KEYWORDS protein C; signal peptide.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1843)
AUTHORS Beckmann R.J., Schmidt R.J., Santerre R.F., Plutzky J.,
Crabtree G.R., Long G.L.
TITLE The structure and evolution of a 461 amino acid human protein C
precursor and its messenger RNA, based upon the DNA sequence of
cloned human liver cDNAs
JOURNAL Nucleic Acids Res. 13(14), 5233-5247(1985).
PUBMED 2991859
COMMENT Data kindly reviewed (27-MAR-1986) by G. Long
FEATURES Location/Qualifiers
source 1..1843
/db_xref="H-InvDB:HIT000320942"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 98..1483
/note="protein C precursor"
/db_xref="GOA:P04070"
/db_xref="H-InvDB:HIT000320942.14"
/db_xref="HGNC:HGNC:9451"
/db_xref="InterPro:IPR000152"
/db_xref="InterPro:IPR000294"
/db_xref="InterPro:IPR000742"
/db_xref="InterPro:IPR001254"
/db_xref="InterPro:IPR001314"
/db_xref="InterPro:IPR001881"
/db_xref="InterPro:IPR009003"
/db_xref="InterPro:IPR012224"
/db_xref="InterPro:IPR013032"
/db_xref="InterPro:IPR017857"
/db_xref="InterPro:IPR018097"
/db_xref="InterPro:IPR018114"
/db_xref="InterPro:IPR033116"
/db_xref="InterPro:IPR035972"
/db_xref="PDB:1AUT"
/db_xref="PDB:1LQV"
/db_xref="PDB:1PCU"
/db_xref="PDB:2PCT"
/db_xref="PDB:3F6U"
/db_xref="PDB:3JTC"
/db_xref="PDB:4DT7"
/db_xref="UniProtKB/Swiss-Prot:P04070"
/protein_id="CAA26528.1"
/translation="MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRAN
SFLEELRHSSLERECIEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCA
SLCCGHGTCIDGIGSFSCDCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRC
SCAPGYKLGDDLLQCHPAVKFPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMT
RRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKW
ELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAG
QETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGILG
DRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIR
DKEAPQKSWAP"
sig_peptide 98..196
/note="signal peptide (aa -42 to -10)"
misc_feature 197..223
/note="propeptide (aa -9 to -1)"
misc_feature 224..688
/note="light chain (aa 1-155)"
misc_feature 224..358
/note="gamma carboxylation domain (aa 1-45)"
misc_feature 359..496
/note="EGF-domain I (aa 46-91)"
misc_feature 497..634
/note="EGF-domain II (aa 92-137)"
misc_feature 653..730
/note="activation peptide region (aa 144-169)"
misc_feature 695..1531
/note="heavy chain (aa 57-419)"
misc_feature 731..1531
/note="serine protease region (aa 170-419)"
misc_feature 1759..1764
/note="polyA signal"
BASE COUNT 417 a 530 c 564 g 332 t
ORIGIN
1 ctgcaggggg gggggggggg gggggctgtc atggcggcag gacggcgaac ttgcagtatc
61 tccacgaccc gcccctacag gtgccagtgc ctccagaatg tggcagctca caagcctcct
121 gctgttcgtg gccacctggg gaatttccgg cacaccagct cctcttgact cagtgttctc
181 cagcagcgag cgtgcccacc aggtgctgcg gatccgcaaa cgtgccaact ccttcctgga
241 ggagctccgt cacagcagcc tggagcggga gtgcatagag gagatctgtg acttcgagga
301 ggccaaggaa attttccaaa atgtggatga cacactggcc ttctggtcca agcacgtcga
361 cggtgaccag tgcttggtct tgcccttgga gcacccgtgc gccagcctgt gctgcgggca
421 cggcacgtgc atcgacggca tcggcagctt cagctgcgac tgccgcagcg gctgggaggg
481 ccgcttctgc cagcgcgagg tgagcttcct caattgctcg ctggacaacg gcggctgcac
541 gcattactgc ctagaggagg tgggctggcg gcgctgtagc tgtgcgcctg gctacaagct
601 gggggacgac ctcctgcagt gtcaccccgc agtgaagttc ccttgtggga ggccctggaa
661 gcggatggag aagaagcgca gtcacctgaa acgagacaca gaagaccaag aagaccaagt
721 agatccgcgg ctcattgatg ggaagatgac caggcgggga gacagcccct ggcaggtggt
781 cctgctggac tcaaagaaga agctggcctg cggggcagtg ctcatccacc cctcctgggt
841 gctgacagcg gcccactgca tggatgagtc caagaagctc cttgtcaggc ttggagagta
901 tgacctgcgg cgctgggaga agtgggagct ggacctggac atcaaggagg tcttcgtcca
961 ccccaactac agcaagagca ccaccgacaa tgacatcgca ctgctgcacc tggcccagcc
1021 cgccaccctc tcgcagacca tagtgcccat ctgcctcccg gacagcggcc ttgcagagcg
1081 cgagctcaat caggccggcc aggagaccct cgtgacgggc tggggctacc acagcagccg
1141 agagaaggag gccaagagaa accgcacctt cgtcctcaac ttcatcaaga ttcccgtggt
1201 cccgcacaat gagtgcagcg aggtcatgag caacatggtg tctgagaaca tgctgtgtgc
1261 gggcatcctc ggggaccggc aggatgcctg cgagggcgac agtggggggc ccatggtcgc
1321 ctccttccac ggcacctggt tcctggtggg cctggtgagc tggggtgagg gctgtgggct
1381 ccttcacaac tacggcgttt acaccaaagt cagccgctac ctcgactgga tccatgggca
1441 catcagagac aaggaagccc cccagaagag ctgggcacct tagcgaccct ccctgcaggg
1501 ctgggctttt gcatggcaat ggatgggaca ttaaagggac atgtaacaag cacaccggcc
1561 tgctgttctg tccttccatc cctcttttgg gctcttctgg agggaagtaa catttactga
1621 gcacctgttg tatgtcacat gccttatgaa tagaatctta actcctagag caactctgtg
1681 gggtggggag gagcagatcc aagttttgcg gggtctaaag ctgtgtgtgt tgagggggat
1741 actctgttta tgaaaaagaa taaaaaacac aaccacgaaa aaaaaaaaaa aaaaaaaaaa
1801 aaaaaaaaaa aaaaaaaccc ccccccgccc cccccccctg cag
//