LOCUS X02744 2498 bp mRNA linear HUM 07-OCT-2008
DEFINITION Human mRNA for c-sis gene (clone pSM-1).
ACCESSION X02744
VERSION X02744.1
KEYWORDS oncogene cellular; platelet-derived growth factor; sis cellular
oncogene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2498)
AUTHORS Ratner L., Josephs S.F., Jarrett R., Reitz M.S., Wong-staal F.
TITLE Nucleotide sequence of transforming human c-sis cDNA clones with
homology to platelet-derived growth factor
JOURNAL Nucleic Acids Res. 13(14), 5007-5018(1985).
PUBMED 2991848
FEATURES Location/Qualifiers
source 1..2498
/db_xref="H-InvDB:HIT000320940"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 118..843
/note="open reading frame (c-sis) (aa 1-241)"
/db_xref="GOA:P01127"
/db_xref="H-InvDB:HIT000320940.13"
/db_xref="HGNC:HGNC:8800"
/db_xref="InterPro:IPR000072"
/db_xref="InterPro:IPR006782"
/db_xref="InterPro:IPR015583"
/db_xref="InterPro:IPR023581"
/db_xref="InterPro:IPR029034"
/db_xref="PDB:1PDG"
/db_xref="PDB:3MJG"
/db_xref="PDB:4HQU"
/db_xref="PDB:4HQX"
/db_xref="PDB:4QCI"
/db_xref="UniProtKB/Swiss-Prot:P01127"
/protein_id="CAA26524.1"
/translation="MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDL
QRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTE
VFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVR
KKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRP
PKGKHRKFKHTHDKTALKETLGA"
misc_feature 180..181
/note="RNA splice (-1)-1 site"
misc_feature 277..278
/note="RNA splice 1-2 site"
misc_feature 361..687
/note="PDGF homology region"
misc_feature 367..368
/note="RNA splice 2-3 site"
misc_feature 552..553
/note="RNA splice 3-4 site"
misc_feature 717..718
/note="RNA splice 4-5 site"
misc_feature 871..872
/note="RNA splice 5-6 site"
polyA_site 2498..2498
/note="polyadenylation site"
BASE COUNT 505 a 771 c 680 g 542 t
ORIGIN
1 tgatcgccgc ggacccgagc cgagcccacc cccctcccca gccccccacc ctggccgcgg
61 gggcggcgcg ctcgatctac gcgtccgggg ccccgcgggg ccgggcccgg agtcggcatg
121 aatcgctgct gggcgctctt cctgtctctc tgctgctacc tgcgtctggt cagcgccgag
181 ggggacccca ttcccgagga gctttatgag atgctgagtg accactcgat ccgctccttt
241 gatgatctcc aacgcctgct gcacggagac cccggagagg aagatggggc cgagttggac
301 ctgaacatga cccgctccca ctctggaggc gagctggaga gcttggctcg tggaagaagg
361 agcctgggtt ccctgaccat tgctgagccg gccatgatcg ccgagtgcaa gacgcgcacc
421 gaggtgttcg agatctcccg gcgcctcata gaccgcacca acgccaactt cctggtgtgg
481 ccgccctgtg tggaggtgca gcgctgctcc ggctgctgca acaaccgcaa cgtgcagtgc
541 cgccccaccc aggtgcagct gcgacctgtc caggtgagaa agatcgagat tgtgcggaag
601 aagccaatct ttaagaaggc cacggtgacg ctggaagacc acctggcatg caagtgtgag
661 acagtggcag ctgcacggcc tgtgacccga agcccggggg gttcccagga gcagcgagcc
721 aaaacgcccc aaactcgggt gaccattcgg acggtgcgag tccgccggcc ccccaagggc
781 aagcaccgga aattcaagca cacgcatgac aagacggcac tgaaggagac ccttggagcc
841 taggggcatc ggcaggagag tgtgtgggca gggttattta atatggtatt tgctgtattg
901 cccccatggg gccttcggag cgataatatt gtttccctcg tccgtctgtc tcgatgcctg
961 attcggacgg ccaatggtgc ttcccccacc cctccacgtg tccgtccacc cttccatcag
1021 cgggtctcct cccagcggcc tccggtcttg cccagcagct caagaagaaa aagaaggact
1081 gaactccatc gccatcttct tcccttaact ccaagaactt gggataagag tgtgagagag
1141 actgatgggg tcgctctttg ggggaaacgg gttccttccc ctgcacctgg cctgggccac
1201 acctgagcgc tgtggactgt cctgaggagc cctgaggacc tctcagcata gcctgcctga
1261 tccctgaacc cctagccagc tctgagggga ggcacctcca ggcaggccag gccaggctgc
1321 ctcggactcc atggctaaga ccacagacgg gcacacagac tggagaaaac ccctcccacg
1381 gtgcccaaac accagtcact cgtctccctg tgcctctgtg cacagtggct tcttttcgtt
1441 ttcgttttga agacgtggac tcctcttggt gggtgtggcc agcacaccaa gtggctgggt
1501 gccctctcag gtgggttaga gatggagttt gctgttgagg tggctgtaga tggtgacctg
1561 ggtatcccct gcctcctgcc accccttcct ccccacactc cactctgatt cacctcttcc
1621 tctggttcct ttcatctctc tacctccacc ctgcattttc ctcttgtcct ggcccttcag
1681 tctgctccac caaggggctc ttgaacccct tattaaggcc ccagatgatc ccagtcactc
1741 ctctctaggg cagaagacta gaggccaggg cagcaaggga cctgctcatc atattccaac
1801 ccagccacga ctgccatgta aggttgtgca gggtgtgtac tgcacaagga cattgtatgc
1861 agggagcact gttcacatca tagataaagc tgatttgtat atttattatg acaatttctg
1921 gcagatgtag gtaaagagga aaaggatcct ttcctaattc acacaaagac tccttgtgga
1981 ctggctgtgc ccctgatgca gcctgtggct tggagtggcc aaataggagg gagactgtgg
2041 taggggcagg gaggcaacac tgctgtccac atgacctcca tttcccaaag tcctccgctc
2101 cagcaactgc ccttctaggt gggtgtggga cacttgggag aaggtctcca agggagggtg
2161 cagccctctt gcccgcaccc ctccctgctt gcacacttcc ccatctttga tccttccgag
2221 ctccacctcc ggcggctcct cctaggaaac cagctcgtgg gccgggaacg ggggagagaa
2281 gggaaaagat tcccaagacc ccctggggtg ggatctgagc tcccacctcc cttcccacct
2341 actgcacttt cccccttccc gccttccaaa acctgcttcc ttcagtttgt aaagtcggtg
2401 attatatttt tgggggcttt ccttttattt tttaaatgta aaatttattt atatttcgta
2461 tttaaagttg taaaaaaaaa taaccacaaa acaaaacc
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