LOCUS X02596 4739 bp mRNA linear HUM 07-OCT-2008
DEFINITION Human mRNA for bcr (breakpoint cluster region) gene in Philadelphia
chromosome.
ACCESSION X02596 M24603
VERSION X02596.1
KEYWORDS abl cellular oncogene; bcr-abl oncogene; breakpoint cluster region
gene; oncogene cellular; Philadelphia chromosome breakpoint;
tyrosine kinase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 2533 to 4739)
AUTHORS Heisterkamp N., Stam K., Groffen J., De Klein A., Grosveld G.
TITLE Structural organization of the bcr gene and its role in the Ph'
translocation
JOURNAL Nature 315(6022), 758-761(1985).
PUBMED 2989703
REFERENCE 2 (bases 1 to 3104)
AUTHORS Hariharan I.K., Adams J.M.
TITLE cDNA sequence for human bcr, the gene that translocates to the abl
oncogene in chronic myeloid leukaemia
JOURNAL EMBO J. 6(1), 115-119(1987).
PUBMED 3107980
COMMENT bcr is the breakpoint cluster region in the 9:22 chromosomal
translocation (Philadelphia chromosome) associated with chronic
myelocytic leukemia. The unrearranged chromosomal region spans
about 45 kb with a minimum of 13 exons present. All breakpoints
studied so far occur within intron sequences.
FEATURES Location/Qualifiers
source 1..4739
/db_xref="H-InvDB:HIT000320935"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
misc_feature 96..375
/note="pot. stem-loop structure"
CDS 489..4304
/gene="bcr"
/db_xref="GOA:P11274"
/db_xref="H-InvDB:HIT000320935.14"
/db_xref="HGNC:HGNC:1014"
/db_xref="InterPro:IPR000008"
/db_xref="InterPro:IPR000198"
/db_xref="InterPro:IPR000219"
/db_xref="InterPro:IPR001331"
/db_xref="InterPro:IPR001849"
/db_xref="InterPro:IPR008936"
/db_xref="InterPro:IPR015123"
/db_xref="InterPro:IPR035892"
/db_xref="InterPro:IPR035899"
/db_xref="InterPro:IPR036481"
/db_xref="InterPro:IPR037769"
/db_xref="PDB:1K1F"
/db_xref="PDB:2AIN"
/db_xref="PDB:5N6R"
/db_xref="PDB:5N7E"
/db_xref="PDB:5OC7"
/db_xref="UniProtKB/Swiss-Prot:P11274"
/protein_id="CAA26441.1"
/translation="MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRR
LEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEPRASASRPQPAPA
DGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFER
IRKGHGQPGADAEKPFYVNVEFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHG
AGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPPWPPLEY
QPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSS
NENLTSSEEDFSSGQSSRVSPSPTTYRMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRH
RHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ
DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILA
SEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQIETIFFKVPELYEIHKEFYDGLFP
RVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRA
RSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQ
NFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHVFLFTELLLCTKL
KKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKSDI
QREKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAE
WRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTINKEDDESPGLYGFLN
VIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTAEPNWNEEFEIELEGSQTL
RILCYEKCYNKTKIPKEDGESTDRLMGKGQVQLDPQALQDRDWQRTVIAMNGIEVKLS
VKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGI
YRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYP
NFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLA
TVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLYFLQLEAIPAPDSKR
QSILFSTEV"
misc_feature 2714..2719
/note="pot. polyA signal"
polyA_site 4739..4739
BASE COUNT 994 a 1458 c 1529 g 758 t
ORIGIN
1 ggggagatag gtaggagtag cgtggtaagg gcgatgagtg tgggccgggc gggagtgcgg
61 cgagagccgg ctggctgagc ttagcgtccg aggaggcggc ggcggcggcg gcggcagcgg
121 cggcggcggg gctgtggggc ggtgcggaag cgagaggcga ggagcgcgcg ggccgtggcc
181 agagtctggc ggcggcctgg cggagcggag agcagcgccc gcgcctcgcc gtgcggagga
241 gccccgcaca caatagcggc gcgcgcagcc cgcgcccttc cccccggcgc gccccgcccc
301 gcgcgccgag cgccccgctc cgcctcacct gccaccaggg agtgggcggg cattgttcgc
361 cgccgccgcc gccgcgcggg gccatggggg ccgcccggcg cccggggccg ggcctggcga
421 ggccgccgcg ccgccgctga gacgggcccc gcgcgcagcc cggcggcgca ggtaaggccg
481 gccgcgccat ggtggacccg gtgggcttcg cggaggcgtg gaaggcgcag ttcccggact
541 cagagccccc gcgcatggag ctgcgctcag tgggcgacat cgagcaggag ctggagcgct
601 gcaaggcctc cattcggcgc ctggagcagg aggtgaacca ggagcgcttc cgcatgatct
661 acctgcagac gttgctggcc aaggaaaaga agagctatga ccggcagcga tggggcttcc
721 ggcgcgcggc gcaggccccc gacggcgcct ccgagccccg agcgtccgcg tcgcgcccgc
781 agccagcgcc cgccgacgga gccgacccgc cgcccgccga ggagcccgag gcccggcccg
841 acggcgaggg ttctccgggt aaggccaggc ccgggaccgc ccgcaggccc ggggcagccg
901 cgtcggggga acgggacgac cggggacccc ccgccagcgt ggcggcgctc aggtccaact
961 tcgagcggat ccgcaagggc catggccagc ccggggcgga cgccgagaag cccttctacg
1021 tgaacgtcga gtttcaccac gagcgcggcc tggtgaaggt caacgacaaa gaggtgtcgg
1081 accgcatcag ctccctgggc agccaggcca tgcagatgga gcgcaaaaag tcccagcacg
1141 gcgcgggctc gagcgtgggg gatgcatcca ggccccctta ccggggacgc tcctcggaga
1201 gcagctgcgg cgtcgacggc gactacgagg acgccgagtt gaacccccgc ttcctgaagg
1261 acaacctgat cgacgccaat ggcggtagca ggcccccttg gccgcccctg gagtaccagc
1321 cctaccagag catctacgtc gggggcatga tggaagggga gggcaagggc ccgctcctgc
1381 gcagccagag cacctctgag caggagaagc gccttacctg gccccgcagg tcctactccc
1441 cccggagttt tgaggattgc ggaggcggct ataccccgga ctgcagctcc aatgagaacc
1501 tcacctccag cgaggaggac ttctcctctg gccagtccag ccgcgtgtcc ccaagcccca
1561 ccacctaccg catgttccgg gacaaaagcc gctctccctc gcagaactcg caacagtcct
1621 tcgacagcag cagtcccccc acgccgcagt gccataagcg gcaccggcac tgcccggttg
1681 tcgtgtccga ggccaccatc gtgggcgtcc gcaagaccgg gcagatctgg cccaacgatg
1741 gcgagggcgc cttccatgga gacgcagatg gctcgttcgg aacaccacct ggatacggct
1801 gcgctgcaga ccgggcagag gagcagcgcc ggcaccaaga tgggctgccc tacattgatg
1861 actcgccctc ctcatcgccc cacctcagca gcaagggcag gggcagccgg gatgcgctgg
1921 tctcgggagc cctggagtcc actaaagcga gtgagctgga cttggaaaag ggcttggaga
1981 tgagaaaatg ggtcctgtcg ggaatcctgg ctagcgagga gacttacctg agccacctgg
2041 aggcactgct gctgcccatg aagcctttga aagccgctgc caccacctct cagccggtgc
2101 tgacgagtca gcagatcgag accatcttct tcaaagtgcc tgagctctac gagatccaca
2161 aggagttcta tgatgggctc ttcccccgcg tgcagcagtg gagccaccag cagcgggtgg
2221 gcgacctctt ccagaagctg gccagccagc tgggtgtgta ccgggccttc gtggacaact
2281 acggagttgc catggaaatg gctgagaagt gctgtcaggc caatgctcag tttgcagaaa
2341 tctccgagaa cctgagagcc agaagcaaca aagatgccaa ggatccaacg accaagaact
2401 ctctggaaac tctgctctac aagcctgtgg accgtgtgac gaggagcacg ctggtcctcc
2461 atgacttgct gaagcacact cctgccagcc accctgacca ccccttgctg caggacgccc
2521 tccgcatctc acagaacttc ctgtccagca tcaatgagga gatcacaccc cgacggcagt
2581 ccatgacggt gaagaaggga gagcaccggc agctgctgaa ggacagcttc atggtggagc
2641 tggtggaggg ggcccgcaag ctgcgccacg tcttcctgtt caccgagctg cttctctgca
2701 ccaagctcaa gaagcagagc ggaggcaaaa cgcagcagta tgactgcaaa tggtacattc
2761 cgctcacgga tctcagcttc cagatggtgg atgaactgga ggcagtgccc aacatccccc
2821 tggtgcccga tgaggagctg gacgctttga agatcaagat ctcccagatc aagagtgaca
2881 tccagagaga gaagagggcg aacaagggca gcaaggctac ggagaggctg aagaagaagc
2941 tgtcggagca ggagtcactg ctgctgctta tgtctcccag catggccttc agggtgcaca
3001 gccgcaacgg caagagttac acgttcctga tctcctctga ctatgagcgt gcagagtgga
3061 gggagaacat ccgggagcag cagaagaagt gtttcagaag cttctccctg acatccgtgg
3121 agctgcagat gctgaccaac tcgtgtgtga aactccagac tgtccacagc attccgctga
3181 ccatcaataa ggaagatgat gagtctccgg ggctctatgg gtttctgaat gtcatcgtcc
3241 actcagccac tggatttaag cagagttcaa atctgtactg caccctggag gtggattcct
3301 ttgggtattt tgtgaataaa gcaaagacgc gcgtctacag ggacacagct gagccaaact
3361 ggaacgagga atttgagata gagctggagg gctcccagac cctgaggata ctgtgctatg
3421 aaaagtgtta caacaagacg aagatcccca aggaggacgg cgagagcacg gacagactca
3481 tggggaaggg ccaggtccag ctggacccgc aggccctgca ggacagagac tggcagcgca
3541 ccgtcatcgc catgaatggg atcgaagtaa agctctcggt caagttcaac agcagggagt
3601 tcagcttgaa gaggatgccg tcccgaaaac agacaggggt cttcggagtc aagattgctg
3661 tggtcaccaa gagagagagg tccaaggtgc cctacatcgt gcgccagtgc gtggaggaga
3721 tcgagcgccg aggcatggag gaggtgggca tctaccgcgt gtccggtgtg gccacggaca
3781 tccaggcact gaaggcagcc ttcgacgtca ataacaagga tgtgtcggtg atgatgagcg
3841 agatggacgt gaacgccatc gcaggcacgc tgaagctgta cttccgtgag ctgcccgagc
3901 ccctcttcac tgacgagttc taccccaact tcgcagaggg catcgctctt tcagacccgg
3961 ttgcaaagga gagctgcatg ctcaacctgc tgctgtccct gccggaggcc aacctgctca
4021 ccttcctttt ccttctggac cacctgaaaa gggtggcaga gaaggaggca gtcaataaga
4081 tgtccctgca caacctcgcc acggtctttg gccccacgct gctccggccc tccgagaagg
4141 agagcaagct ccctgccaac cccagccagc ctatcaccat gactgacagc tggtccttgg
4201 aggtcatgtc ccaggtccag gtgctgctgt acttcctgca gctggaggcc atccctgccc
4261 cggacagcaa gagacagagc atcctgttct ccaccgaagt ctaaaggtcc cagtccatct
4321 cctggaggca gacagatggc ctggaaacct ctggctaatc gggccatccg tagagcggga
4381 accttcctga ggtgtccttg ggccaccccc aagtgttggg ccatctgcca agagacagcg
4441 acccaaagcc gaaggacagg tggcctgggc agatctcgcc caggtctggg agccccaggc
4501 tggcctcaga ctgtggtttt ttatgtggcc acccgagggc gccccaagcc agttcatctc
4561 agagtccagg cctgaccctg ggagacaggg tgaagggagt gatttttatg aacttaactt
4621 agagtctaaa agatttctac tggatcactt gtcaagatgc gccctctctg gggagaaggg
4681 aacgtgaccg gattccctca ctgttgtatc ttgaataaac gctgctgctt catcctgtg
//