LOCUS       X02330                  1836 bp    mRNA    linear   HUM 14-NOV-2006
DEFINITION  Homo sapiens mRNA for calcitonin and calcitonin gene related
            peptide (CGRP).
ACCESSION   X02330
VERSION     X02330.1
KEYWORDS    calcitonin; calcitonin gene related peptide; preprohormone.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1836)
  AUTHORS   Edbrooke M.R., Parker D., McVey J.H., Riley J.H., Sorenson G.D.,
            Pettengill O.S., Craig R.K.
  TITLE     Expression of the human calcitonin/CGRP gene in lung and thyroid
            carcinoma
  JOURNAL   EMBO J. 4(3), 715-724(1985).
   PUBMED   2408883
COMMENT     Calcitonin and Calcitonin gene related peptide are transcribed from
            the same gene; differential splicing after transcription yields
            the different mRNAs for calcitonin and calcitonin gene related
            peptide
FEATURES             Location/Qualifiers
     source          1..1836
                     /db_xref="H-InvDB:HIT000320917"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     exon            <1..577
                     /gene="CALC"
                     /number=3
     CDS             <1..282
                     /codon_start=1
                     /gene="CALC"
                     /product="calcitonin"
                     /db_xref="GOA:P01258"
                     /db_xref="H-InvDB:HIT000320917.13"
                     /db_xref="HGNC:HGNC:1437"
                     /db_xref="InterPro:IPR001693"
                     /db_xref="InterPro:IPR018360"
                     /db_xref="InterPro:IPR021116"
                     /db_xref="InterPro:IPR021117"
                     /db_xref="InterPro:IPR021118"
                     /db_xref="PDB:2JXZ"
                     /db_xref="UniProtKB/Swiss-Prot:P01258"
                     /protein_id="CAA26189.1"
                     /translation="VLLAALVQDYVQMKASELEQEQEREGSSLDSPRSKRCGNLSTCM
                     LGTYTQDFNKFHTFPQTAIGVGAPGKKRDMSSDLERDHRPHVSMPQNAN"
     exon            <1..1836
                     /gene="CGRP"
                     /number=3
                     /note="alternative"
     3'UTR           283..577
                     /gene="CALC"
     regulatory      559..564
                     /gene="CALC"
                     /regulatory_class="polyA_signal_sequence"
     polyA_site      577
                     /gene="CALC"
     CDS             <1224..1385
                     /gene="CGRP"
                     /product="prepro calcitonin gene related peptide"
                     /db_xref="GOA:P06881"
                     /db_xref="HGNC:HGNC:1437"
                     /db_xref="InterPro:IPR001693"
                     /db_xref="InterPro:IPR015476"
                     /db_xref="InterPro:IPR018360"
                     /db_xref="InterPro:IPR021116"
                     /db_xref="InterPro:IPR021117"
                     /db_xref="PDB:1LS7"
                     /db_xref="PDB:6E3Y"
                     /db_xref="UniProtKB/Swiss-Prot:P06881"
                     /protein_id="CAA26190.1"
                     /translation="RIIAQKRACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF
                     GRRRRDLQA"
     sig_peptide     1224..1244
                     /gene="CGRP"
     mat_peptide     1245..1355
                     /product="calcitonin gene related peptide"
     3'UTR           1383..1836
                     /gene="CGRP"
     regulatory      1412..1417
                     /gene="CGRP"
                     /note="putative"
                     /regulatory_class="polyA_signal_sequence"
     regulatory      1810..1816
                     /gene="CGRP"
                     /note="putative"
                     /regulatory_class="polyA_signal_sequence"
     polyA_site      1836
                     /gene="CGRP"
BASE COUNT          467 a          417 c          440 g          512 t
ORIGIN      
        1 gtcctgctgg ctgcactggt gcaggactat gtgcagatga aggccagtga gctggagcag
       61 gagcaagaga gagagggctc cagcctggac agccccagat ctaagcggtg cggtaatctg
      121 agtacttgca tgctgggcac atacacgcag gacttcaaca agtttcacac gttcccccaa
      181 actgcaattg gggttggagc acctggaaag aaaagggata tgtccagcga cttggagaga
      241 gaccatcgcc ctcatgttag catgccccag aatgccaact aaactcctcc ctttccttcc
      301 taatttccct tcttgcatcc ttcctataac ttgatgcatg tggtttggtt cctctctggt
      361 ggctctttgg gctggtattg gtggctttcc ttgtggcaga ggatgtctca aacttcagat
      421 gggaggaaag agagcaggac tcacaggttg gaagagaatc acctgggaaa ataccagaaa
      481 atgagggccg ctttgagtcc cccagagatg tcatcagagc tcctctgtcc tgcttctgaa
      541 tgtgctgatc atttgaggaa taaaattatt tttccccaaa gatctgagct gtggtggtca
      601 ttgctctgat ctatgtccca ggcttcatag tgtctaagac ctatgcttag aaatagcctt
      661 aaccctaggc tagctggaca gaggatatgg tgggtggtcc ctttgaccaa gctcaagcag
      721 gaagaacagg ggtcctaagg agcaggtaag cacctctagg acttgatgct gcaaactccg
      781 ctcctcttcc aggtaagact gaggaatttt ttattttcct aagaaagggt atttggtgcc
      841 cgtgactggg gtgtagattt tatagtcctt tgtgaatggg gctgggtgtg ggaccataat
      901 tcactccagt gtcataaacc tccgctttga tttttagtta atttatacag gaaagattgg
      961 ctgttactgc tccacattcc atagccagtc atccagagtc accttgggtt tctgacaccc
     1021 ctgggaatat ctatggggag tgatcatggc attttcccta atggccttgt gattttctgc
     1081 tctgataatt gtgtttagga gaaacactta aagttaattg gtgcctttca gcacagcaac
     1141 tttaccatga aggtcccatg gggctgacct ctctcccagc ctctcactca cagatcttct
     1201 cttctttctc catcctgcaa atcagaatca ttgcccagaa gagagcctgt gacactgcca
     1261 cctgtgtgac tcatcggctg gcaggcttgc tgagcagatc agggggtgtg gtgaagaaca
     1321 actttgtgcc caccaatgtg ggttccaaag cctttggcag gcgccgcagg gaccttcaag
     1381 cctgagcagc tgaatgactc aagaaggtca caataaagct gaactccttt taatgtgtaa
     1441 tgaaagcaat ttgtaggaaa ggctccatgg aagacataca tataggcatc cttcttgata
     1501 ctgaaaacaa tcttcttgtt tgaaaggaac tattgctaaa tgcagaacaa gctcattgca
     1561 gttacctatt gtgcatcttt ttaaatactt gattatgtaa ccataaatct gacagcatgt
     1621 ctcattggct tatctggtag caaatctagg ccccgtcagc caccctattg acattggtgg
     1681 ctctgctaaa cctcaggggg acatgaaatc actgcctctt gggcatctgg ggacacatgg
     1741 taatgctgtg ccttgacaga agtatttgtt taaagaaatg tcaatgctgt catttgtgaa
     1801 ctctatcaaa attaaaaatg tattttatct accctt
//