LOCUS X02330 1836 bp mRNA linear HUM 14-NOV-2006 DEFINITION Homo sapiens mRNA for calcitonin and calcitonin gene related peptide (CGRP). ACCESSION X02330 VERSION X02330.1 KEYWORDS calcitonin; calcitonin gene related peptide; preprohormone. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1836) AUTHORS Edbrooke M.R., Parker D., McVey J.H., Riley J.H., Sorenson G.D., Pettengill O.S., Craig R.K. TITLE Expression of the human calcitonin/CGRP gene in lung and thyroid carcinoma JOURNAL EMBO J. 4(3), 715-724(1985). PUBMED 2408883 COMMENT Calcitonin and Calcitonin gene related peptide are transcribed from the same gene; differential splicing after transcription yields the different mRNAs for calcitonin and calcitonin gene related peptide FEATURES Location/Qualifiers source 1..1836 /db_xref="H-InvDB:HIT000320917" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" exon <1..577 /gene="CALC" /number=3 CDS <1..282 /codon_start=1 /gene="CALC" /product="calcitonin" /db_xref="GOA:P01258" /db_xref="H-InvDB:HIT000320917.13" /db_xref="HGNC:HGNC:1437" /db_xref="InterPro:IPR001693" /db_xref="InterPro:IPR018360" /db_xref="InterPro:IPR021116" /db_xref="InterPro:IPR021117" /db_xref="InterPro:IPR021118" /db_xref="PDB:2JXZ" /db_xref="UniProtKB/Swiss-Prot:P01258" /protein_id="CAA26189.1" /translation="VLLAALVQDYVQMKASELEQEQEREGSSLDSPRSKRCGNLSTCM LGTYTQDFNKFHTFPQTAIGVGAPGKKRDMSSDLERDHRPHVSMPQNAN" exon <1..1836 /gene="CGRP" /number=3 /note="alternative" 3'UTR 283..577 /gene="CALC" regulatory 559..564 /gene="CALC" /regulatory_class="polyA_signal_sequence" polyA_site 577 /gene="CALC" CDS <1224..1385 /gene="CGRP" /product="prepro calcitonin gene related peptide" /db_xref="GOA:P06881" /db_xref="HGNC:HGNC:1437" /db_xref="InterPro:IPR001693" /db_xref="InterPro:IPR015476" /db_xref="InterPro:IPR018360" /db_xref="InterPro:IPR021116" /db_xref="InterPro:IPR021117" /db_xref="PDB:1LS7" /db_xref="PDB:6E3Y" /db_xref="UniProtKB/Swiss-Prot:P06881" /protein_id="CAA26190.1" /translation="RIIAQKRACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF GRRRRDLQA" sig_peptide 1224..1244 /gene="CGRP" mat_peptide 1245..1355 /product="calcitonin gene related peptide" 3'UTR 1383..1836 /gene="CGRP" regulatory 1412..1417 /gene="CGRP" /note="putative" /regulatory_class="polyA_signal_sequence" regulatory 1810..1816 /gene="CGRP" /note="putative" /regulatory_class="polyA_signal_sequence" polyA_site 1836 /gene="CGRP" BASE COUNT 467 a 417 c 440 g 512 t ORIGIN 1 gtcctgctgg ctgcactggt gcaggactat gtgcagatga aggccagtga gctggagcag 61 gagcaagaga gagagggctc cagcctggac agccccagat ctaagcggtg cggtaatctg 121 agtacttgca tgctgggcac atacacgcag gacttcaaca agtttcacac gttcccccaa 181 actgcaattg gggttggagc acctggaaag aaaagggata tgtccagcga cttggagaga 241 gaccatcgcc ctcatgttag catgccccag aatgccaact aaactcctcc ctttccttcc 301 taatttccct tcttgcatcc ttcctataac ttgatgcatg tggtttggtt cctctctggt 361 ggctctttgg gctggtattg gtggctttcc ttgtggcaga ggatgtctca aacttcagat 421 gggaggaaag agagcaggac tcacaggttg gaagagaatc acctgggaaa ataccagaaa 481 atgagggccg ctttgagtcc cccagagatg tcatcagagc tcctctgtcc tgcttctgaa 541 tgtgctgatc atttgaggaa taaaattatt tttccccaaa gatctgagct gtggtggtca 601 ttgctctgat ctatgtccca ggcttcatag tgtctaagac ctatgcttag aaatagcctt 661 aaccctaggc tagctggaca gaggatatgg tgggtggtcc ctttgaccaa gctcaagcag 721 gaagaacagg ggtcctaagg agcaggtaag cacctctagg acttgatgct gcaaactccg 781 ctcctcttcc aggtaagact gaggaatttt ttattttcct aagaaagggt atttggtgcc 841 cgtgactggg gtgtagattt tatagtcctt tgtgaatggg gctgggtgtg ggaccataat 901 tcactccagt gtcataaacc tccgctttga tttttagtta atttatacag gaaagattgg 961 ctgttactgc tccacattcc atagccagtc atccagagtc accttgggtt tctgacaccc 1021 ctgggaatat ctatggggag tgatcatggc attttcccta atggccttgt gattttctgc 1081 tctgataatt gtgtttagga gaaacactta aagttaattg gtgcctttca gcacagcaac 1141 tttaccatga aggtcccatg gggctgacct ctctcccagc ctctcactca cagatcttct 1201 cttctttctc catcctgcaa atcagaatca ttgcccagaa gagagcctgt gacactgcca 1261 cctgtgtgac tcatcggctg gcaggcttgc tgagcagatc agggggtgtg gtgaagaaca 1321 actttgtgcc caccaatgtg ggttccaaag cctttggcag gcgccgcagg gaccttcaag 1381 cctgagcagc tgaatgactc aagaaggtca caataaagct gaactccttt taatgtgtaa 1441 tgaaagcaat ttgtaggaaa ggctccatgg aagacataca tataggcatc cttcttgata 1501 ctgaaaacaa tcttcttgtt tgaaaggaac tattgctaaa tgcagaacaa gctcattgca 1561 gttacctatt gtgcatcttt ttaaatactt gattatgtaa ccataaatct gacagcatgt 1621 ctcattggct tatctggtag caaatctagg ccccgtcagc caccctattg acattggtgg 1681 ctctgctaaa cctcaggggg acatgaaatc actgcctctt gggcatctgg ggacacatgg 1741 taatgctgtg ccttgacaga agtatttgtt taaagaaatg tcaatgctgt catttgtgaa 1801 ctctatcaaa attaaaaatg tattttatct accctt //