LOCUS X02308 1536 bp mRNA linear HUM 23-OCT-2008 DEFINITION Human mRNA for thymidylate synthase (EC 2.1.1.45). ACCESSION X02308 VERSION X02308.1 KEYWORDS inverted repeat; synthetase; tandem repeat. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1536) AUTHORS Takeishi K., Kaneda S., Ayusawa D., Shimizu K., Gotoh O., Seno T. TITLE Nucleotide sequence of a functional cDNA for human thymidylate synthase JOURNAL Nucleic Acids Res. 13(6), 2035-2043(1985). PUBMED 2987839 COMMENT Data kindly reviewed (22-OCT-1985) by Seno T. FEATURES Location/Qualifiers source 1..1536 /db_xref="H-InvDB:HIT000320915" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" misc_feature 14..103 /note="triple tandemly repeated elements" repeat_region 14..16 /note="direct repeat 1" misc_feature 35..103 /note="pot. stem-loop structure" misc_feature 35..69 /note="pot. stem-loop structure" repeat_region 35..41 /note="inverted repeat A" repeat_region 42..44 /note="direct repeat 1" misc_feature 63..103 /note="pot. stem-loop structure" repeat_region 63..69 /note="inverted repeat A'" repeat_region 70..72 /note="direct repeat 1" repeat_region 97..103 /note="inverted repeat A''" repeat_region 104..106 /note="direct repeat 1" CDS 106..1047 /note="thymidylate synthase (aa 1-313)" /db_xref="GOA:P04818" /db_xref="H-InvDB:HIT000320915.12" /db_xref="HGNC:HGNC:12441" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="PDB:1HVY" /db_xref="PDB:1HW3" /db_xref="PDB:1HW4" /db_xref="PDB:1HZW" /db_xref="PDB:1I00" /db_xref="PDB:1JU6" /db_xref="PDB:1JUJ" /db_xref="PDB:1YPV" /db_xref="PDB:2ONB" /db_xref="PDB:2RD8" /db_xref="PDB:2RDA" /db_xref="PDB:3EAW" /db_xref="PDB:3EBU" /db_xref="PDB:3ED7" /db_xref="PDB:3EDW" /db_xref="PDB:3EF9" /db_xref="PDB:3EGY" /db_xref="PDB:3EHI" /db_xref="PDB:3EJL" /db_xref="PDB:3GG5" /db_xref="PDB:3GH0" /db_xref="PDB:3GH2" /db_xref="PDB:3H9K" /db_xref="PDB:3HB8" /db_xref="PDB:3N5E" /db_xref="PDB:3N5G" /db_xref="PDB:3OB7" /db_xref="PDB:4E28" /db_xref="PDB:4FGT" /db_xref="PDB:4G2O" /db_xref="PDB:4G6W" /db_xref="PDB:4GD7" /db_xref="PDB:4GYH" /db_xref="PDB:4H1I" /db_xref="PDB:4JEF" /db_xref="PDB:4KPW" /db_xref="PDB:4O1U" /db_xref="PDB:4O1X" /db_xref="PDB:4UP1" /db_xref="PDB:5HS3" /db_xref="PDB:5WRN" /db_xref="PDB:5X4W" /db_xref="PDB:5X4X" /db_xref="PDB:5X4Y" /db_xref="PDB:5X5A" /db_xref="PDB:5X5D" /db_xref="PDB:5X5Q" /db_xref="PDB:5X66" /db_xref="PDB:5X67" /db_xref="PDB:5X69" /db_xref="PDB:6OJU" /db_xref="PDB:6OJV" /db_xref="PDB:6QXG" /db_xref="PDB:6QXH" /db_xref="PDB:6QYQ" /db_xref="PDB:6R2E" /db_xref="UniProtKB/Swiss-Prot:P04818" /protein_id="CAA26178.1" /translation="MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCG VRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELS SKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQ LQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGD MGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPF PKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV" misc_feature 1231..1236 /note="pot. polyadenylation signal" misc_feature 1519..1524 /note="pot. polyadenylation signal" polyA_site 1536..1536 /note="polyadenylation site" BASE COUNT 390 a 369 c 399 g 378 t ORIGIN 1 gggggggggg ggaccacttg gcctgcctcc gtcccgccgc gccacttggc ctgcctccgt 61 cccgccgcgc cacttcgcct gcctccgtcc cccgcccgcc gcgccatgcc tgtggccggc 121 tcggagctgc cgcgccggcc cttgcccccc gccgcacagg agcgggacgc cgagccgcgt 181 ccgccgcacg gggagctgca gtacctgggg cagatccaac acatcctccg ctgcggcgtc 241 aggaaggacg accgcacggg caccggcacc ctgtcggtat tcggcatgca ggcgcgctac 301 agcctgagag atgaattccc tctgctgaca accaaacgtg tgttctggaa gggtgttttg 361 gaggagttgc tgtggtttat caagggatcc acaaatgcta aagagctgtc ttccaaggga 421 gtgaaaatct gggatgccaa tggatcccga gactttttgg acagcctggg attctccacc 481 agagaagaag gggacttggg cccagtttat ggcttccagt ggaggcattt tggggcagaa 541 tacagagata tggaatcaga ttattcagga cagggagttg accaactgca aagagtgatt 601 gacaccatca aaaccaaccc tgacgacaga agaatcatca tgtgcgcttg gaatccaaga 661 gatcttcctc tgatggcgct gcctccatgc catgccctct gccagttcta tgtggtgaac 721 agtgagctgt cctgccagct gtaccagaga tcgggagaca tgggcctcgg tgtgcctttc 781 aacatcgcca gctacgccct gctcacgtac atgattgcgc acatcacggg cctgaagcca 841 ggtgacttta tacacacttt gggagatgca catatttacc tgaatcacat cgagccactg 901 aaaattcagc ttcagcgaga acccagacct ttcccaaagc tcaggattct tcgaaaagtt 961 gagaaaattg atgacttcaa agctgaagac tttcagattg aagggtacaa tccgcatcca 1021 actattaaaa tggaaatggc tgtttagggt gctttcaaag gagcttgaag gatattgtca 1081 gtctttaggg gttgggctgg atgccgaggt aaaagttctt tttgctctaa aagaaaaagg 1141 aactaggtca aaaatctgtc cgtgacctat cagttattaa tttttaagga tgttgccact 1201 ggcaaatgta actgtgccag ttctttccat aataaaaggc tttgagttaa ctcactgagg 1261 gtatctgaca atgctgaggt tatgaacaaa gtgaggagaa tgaaatgtat gtgctcttag 1321 caaaaacatg tatgtgcatt tcaatcccac gtacttataa agaaggttgg tgaatttcac 1381 aagctatttt tggaatattt ttagaatatt ttaagaattt cacaagctat tccctcaaat 1441 ctgagggagc tgagtaacac catcgatcat gatgtagagt gtggttatga actttatagt 1501 tgttttatat gttgctataa taaagaagtg ttctgc //