LOCUS X02157 1342 bp mRNA linear HUM 21-OCT-2008
DEFINITION Human mRNA for fetal erythropoietin.
ACCESSION X02157
VERSION X02157.1
KEYWORDS erythropoietin; glycoprotein hormone; hormone; signal peptide.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1342)
AUTHORS Jacobs K., Shoemaker C., Rudersdorf R., Neill S.D., Kaufman R.J.,
Mufson A., Seehra J., Jones S.S., Hewick R., Fritsch E.F.,
Kawakita M., Shimizu T., Miyake T.
TITLE Isolation and characterization of genomic and cDNA clones of human
erythropoietin
JOURNAL Nature 313(6005), 806-810(1985).
PUBMED 3838366
COMMENT Data kindly reviewed (24-FEB-1986) by K. Jacobs
FEATURES Location/Qualifiers
source 1..1342
/db_xref="H-InvDB:HIT000320911"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 182..763
/note="erythropoietin precursor"
/db_xref="GOA:P01588"
/db_xref="H-InvDB:HIT000320911.13"
/db_xref="HGNC:HGNC:3415"
/db_xref="InterPro:IPR001323"
/db_xref="InterPro:IPR003013"
/db_xref="InterPro:IPR009079"
/db_xref="InterPro:IPR019767"
/db_xref="PDB:1BUY"
/db_xref="PDB:1CN4"
/db_xref="PDB:1EER"
/db_xref="UniProtKB/Swiss-Prot:P01588"
/protein_id="CAA26094.1"
/translation="MGVHECPAWLWLLLSLLSLPLGLPVLGAPPRLICDSRVLERYLL
EAKEAENITTGCAEHCSLNENITVPDTKVNFYAWKRMEVGQQAVEVWQGLALLSEAVL
RGQALLVNSSQPWEPLQLHVDKAVSGLRSLTTLLRALRAQKEAISPPDAASAAPLRTI
TADTFRKLFRVYSNFLRGKLKLYTGEACRTGDR"
sig_peptide 182..262
/note="signal peptide (aa -27 to -1)"
mat_peptide 263..760
/note="erythropoietin (aa 1-166)"
misc_feature 332..334
/note="glycosylation site"
misc_feature 374..376
/note="glycosylation site"
misc_feature 509..511
/note="glycosylation site"
BASE COUNT 276 a 434 c 385 g 247 t
ORIGIN
1 cccggagccg gaccggggcc accgcgcccg ctctgctccg acaccgcgcc ccctggacag
61 ccgccctctc ctccaggccc gtggggctgg ccctgcaccg ccgagcttcc cgggatgagg
121 gcccccggtg tggtcacccg gcgcgcccca ggtcgctgag ggaccccggc caggcgcgga
181 gatgggggtg cacgaatgtc ctgcctggct gtggcttctc ctgtccctgc tgtcgctccc
241 tctgggcctc ccagtcctgg gcgccccacc acgcctcatc tgtgacagcc gagtcctgga
301 gaggtacctc ttggaggcca aggaggccga gaatatcacg acgggctgtg ctgaacactg
361 cagcttgaat gagaatatca ctgtcccaga caccaaagtt aatttctatg cctggaagag
421 gatggaggtc gggcagcagg ccgtagaagt ctggcagggc ctggccctgc tgtcggaagc
481 tgtcctgcgg ggccaggccc tgttggtcaa ctcttcccag ccgtgggagc ccctgcagct
541 gcatgtggat aaagccgtca gtggccttcg cagcctcacc actctgcttc gggctctgcg
601 agcccagaag gaagccatct cccctccaga tgcggcctca gctgctccac tccgaacaat
661 cactgctgac actttccgca aactcttccg agtctactcc aatttcctcc ggggaaagct
721 gaagctgtac acaggggagg cctgcaggac aggggacaga tgaccaggtg tgtccacctg
781 ggcatatcca ccacctccct caccaacatt gcttgtgcca caccctcccc cgccactcct
841 gaaccccgtc gaggggctct cagctcagcg ccagcctgtc ccatggacac tccagtgcca
901 gcaatgacat ctcaggggcc agaggaactg tccagagagc aactctgaga tctaaggatg
961 tcacagggcc aacttgaggg cccagagcag gaagcattca gagagcagct ttaaactcag
1021 ggacagagcc atgctgggaa gacgcctgag ctcactcggc accctgcaaa atttgatgcc
1081 aggacacgct ttggaggcga tttacctgtt ttcgcaccta ccatcaggga caggatgacc
1141 tggagaactt aggtggcaag ctgtgacttc tccaggtctc acgggcatgg gcactccctt
1201 ggtggcaaga gcccccttga caccggggtg gtgggaacca tgaagacagg atgggggctg
1261 gcctctggct ctcatggggt ccaagttttg tgtattcttc aacctcattg acaagaactg
1321 aaaccaccaa aaaaaaaaaa aa
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