LOCUS       X01683                  1371 bp    mRNA    linear   HUM 05-MAR-2002
DEFINITION  Human mRNA for alpha 1-antitrypsin.
ACCESSION   X01683
VERSION     X01683.1
KEYWORDS    antitrypsin; signal peptide.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1371)
  AUTHORS   Bollen A., Herzog A., Cravador A., Herion P., Chuchana P.,
            Straten A., Loriau R., Jacobs P., Van Elsen A.
  TITLE     Cloning and expression in Escherichia coli of full-length
            complementary DNA coding for human alpha 1-antitrypsin
  JOURNAL   DNA 2(4), 255-264(1983).
   PUBMED   6319097
REFERENCE   2  (bases 1 to 274)
  AUTHORS   Kurachi K., Chandra T., Degen S.J., White T.T., Marchioro T.L.,
            Woo S.L., Davie E.W.
  TITLE     Cloning and sequence of cDNA coding for alpha 1-antitrypsin
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 78(11), 6826-6830(1981).
   PUBMED   7031661
REFERENCE   3
  AUTHORS   Rosenberg S., Barr P.J., Najarian R.C., Hallewell R.A.
  TITLE     Synthesis in yeast of a functional oxidation-resistant mutant of
            human alpha-antitrypsin
  JOURNAL   Nature 312(5989), 77-80(1984).
   PUBMED   6387509
REFERENCE   4  (bases 1 to 1352)
  AUTHORS   Colau B., Chuchana P., Bollen A.
  TITLE     Revised sequence of full-length complementary DNA coding for human
            alpha 1-antitrypsin
  JOURNAL   DNA 3(4), 327-330(1984).
   PUBMED   6333329
COMMENT     Revised sequence in Colan B., Chuchana P., Bollen A.;
            DNA 3:327-330(1984).
            
            Data kindly reviewed (11-FEB-1986) by A. Bollen
FEATURES             Location/Qualifiers
     source          1..1371
                     /db_xref="H-InvDB:HIT000320905"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     sig_peptide     39..110
     CDS             39..1295
                     /product="alpha 1-antitrypsin"
                     /db_xref="GOA:P01009"
                     /db_xref="H-InvDB:HIT000320905.12"
                     /db_xref="HGNC:HGNC:8941"
                     /db_xref="InterPro:IPR000215"
                     /db_xref="InterPro:IPR023795"
                     /db_xref="InterPro:IPR023796"
                     /db_xref="InterPro:IPR036186"
                     /db_xref="InterPro:IPR042178"
                     /db_xref="InterPro:IPR042185"
                     /db_xref="PDB:1ATU"
                     /db_xref="PDB:1D5S"
                     /db_xref="PDB:1EZX"
                     /db_xref="PDB:1HP7"
                     /db_xref="PDB:1IZ2"
                     /db_xref="PDB:1KCT"
                     /db_xref="PDB:1OO8"
                     /db_xref="PDB:1OPH"
                     /db_xref="PDB:1PSI"
                     /db_xref="PDB:1QLP"
                     /db_xref="PDB:1QMB"
                     /db_xref="PDB:2D26"
                     /db_xref="PDB:2QUG"
                     /db_xref="PDB:3CWL"
                     /db_xref="PDB:3CWM"
                     /db_xref="PDB:3DRM"
                     /db_xref="PDB:3DRU"
                     /db_xref="PDB:3NDD"
                     /db_xref="PDB:3NDF"
                     /db_xref="PDB:3NE4"
                     /db_xref="PDB:3T1P"
                     /db_xref="PDB:4PYW"
                     /db_xref="PDB:5IO1"
                     /db_xref="PDB:5NBU"
                     /db_xref="PDB:5NBV"
                     /db_xref="PDB:7API"
                     /db_xref="PDB:8API"
                     /db_xref="PDB:9API"
                     /db_xref="UniProtKB/Swiss-Prot:P01009"
                     /protein_id="CAA25838.1"
                     /translation="MPSSVSWGILLLAGLCCLVPVSLAEDPQGDAAQKTDTSHHDQDH
                     PTFNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILE
                     GLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKK
                     LYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKW
                     ERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIF
                     FLPDEGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITK
                     VFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLEAIPMSIPPEVKFNK
                     PFVFLMIEQNTKSPLFMGKVVNPTQK"
     mat_peptide     111..1292
     polyA_site      1371..1371
BASE COUNT          350 a          388 c          340 g          293 t
ORIGIN      
        1 ctgcaggggg gggggggggc tgggacagtg aatcgacaat gccgtcttct gtctcgtggg
       61 gcatcctcct gctggcaggc ctgtgctgcc tggtccctgt ctccctggct gaggatcccc
      121 agggagatgc tgcccagaag acagatacat cccaccatga tcaggatcac ccaaccttca
      181 acaagatcac ccccaacctg gctgagttcg ccttcagcct ataccgccag ctggcacacc
      241 agtccaacag caccaatatc ttcttctccc cagtgagcat cgctacagcc tttgcaatgc
      301 tctccctggg gaccaaggct gacactcacg atgaaatcct ggagggcctg aatttcaacc
      361 tcacggagat tccggaggct cagatccatg aaggcttcca ggaactcctc cgtaccctca
      421 accagccaga cagccagctc cagctgacca ccggcaatgg cctgttcctc agcgagggcc
      481 tgaagctagt ggataagttt ttggaggatg ttaaaaagtt gtaccactca gaagccttca
      541 ctgtcaactt cggggacacc gaagaggcca agaaacagat caacgattac gtggagaagg
      601 gtactcaagg gaaaattgtg gatttggtca aggagcttga cagagacaca gtttttgctc
      661 tggtgaatta catcttcttt aaaggcaaat gggagagacc ctttgaagtc aaggacaccg
      721 aggaagagga cttccacgtg gaccaggtga ccaccgtgaa ggtgcctatg atgaagcgtt
      781 taggcatgtt taacatccag cactgtaaga agctgtccag ctgggtgctg ctgatgaaat
      841 acctgggcaa tgccaccgcc atcttcttcc tgcctgatga ggggaaacta cagcacctgg
      901 aaaatgaact cacccacgat atcatcacca agttcctgga aaatgaagac agaaggtctg
      961 ccagcttaca tttacccaaa ctgtccatta ctggaaccta tgatctgaag agcgtcctgg
     1021 gtcaactggg catcactaag gtcttcagca atggggctga cctctccggg gtcacagagg
     1081 aggcacccct gaagctctcc aaggccgtgc ataaggctgt gctgaccatc gacgagaaag
     1141 ggactgaagc tgctggggcc atgtttttag aggccatacc catgtctatc ccccccgagg
     1201 tcaagttcaa caaacccttt gtcttcttaa tgattgaaca aaataccaag tctcccctct
     1261 tcatgggaaa agtggtgaat cccacccaaa aataactgcc tctcgctcct caacccctcc
     1321 cctccatccc tggccccctc cctggatgac attaaagaag ggttgagctg g
//