LOCUS V01514 2029 bp mRNA linear HUM 07-OCT-2008
DEFINITION Human mRNA encoding alpha-fetoprotein (AFP). AFP is a major serum
protein (MG: 70000) synthesized during fetal life.
ACCESSION V01514 J00077
VERSION V01514.1
KEYWORDS complementary DNA; fetoprotein; signal peptide.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2029)
AUTHORS Morinaga T., Sakai M., Wegmann T.G., Tamaoki T.
TITLE Primary structures of human alpha-fetoprotein and its mRNA
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 80(15), 4604-4608(1983).
PUBMED 6192439
COMMENT Data kindly reviewed (13-SEP-1983) by T. Tamaoki
FEATURES Location/Qualifiers
source 1..2029
/db_xref="H-InvDB:HIT000320846"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
mRNA 1..2029
/note="messenger RNA"
CDS 45..1874
/note="reading frame AFP"
/db_xref="GOA:P02771"
/db_xref="H-InvDB:HIT000320846.14"
/db_xref="HGNC:HGNC:317"
/db_xref="InterPro:IPR000264"
/db_xref="InterPro:IPR014760"
/db_xref="InterPro:IPR020857"
/db_xref="InterPro:IPR020858"
/db_xref="InterPro:IPR021177"
/db_xref="PDB:3MRK"
/db_xref="UniProtKB/Swiss-Prot:P02771"
/protein_id="CAA24758.1"
/translation="MKWVESIFLIFLLNFTESRTLHRNEYGIASILDSYQCTAEISLA
DLATIFFAQFVQEATYKEVSKMVKDALTAIEKPTGDEQSSGCLENQLPAFLEELCHEK
EILEKYGHSDCCSQSEEGRHNCFLAHKKPTPASIPLFQVPEPVTSCEAYEEDRETFMN
KFIYEIARRHPFLYAPTILLWAARYDKIIPSCCKAENAVECFQTKAATVTKELRESSL
LNQHACAVMKNFGTRTFQAITVTKLSQKFTKVNFTEIQKLVLDVAHVHEHCCRGDVLD
CLQDGEKIMSYICSQQDTLSNKITECCKLTTLERGQCIIHAENDEKPEGLSPNLNRFL
GDRDFNQFSSGEKNIFLASFVHEYSRRHPQLAVSVILRVAKGYQELLEKCFQTENPLE
CQDKGEEELQKYIQESQALAKRSCGLFQKLGEYYLQNAFLVAYTKKAPQLTSSELMAI
TRKMAATAATCCQLSEDKLLACGEGAADIIIGHLCIRHEMTPVNPGVGQCCTSSYANR
RPCFSSLVVDETYVPPAFSDDKFIFHKDLCQAQGVALQTMKQEFLINLVKQKPQITEE
QLEAVIADFSGLLEKCCQGQEQEVCFAEEGQKLISKTRAALGV"
sig_peptide 45..101
/note="signal peptide"
polyA_site 2029..2029
/note="polyA addition site"
BASE COUNT 667 a 406 c 425 g 531 t
ORIGIN
1 atattgtgct tccaccactg ccaataacaa aataactagc aaccatgaag tgggtggaat
61 caattttttt aattttccta ctaaatttta ctgaatccag aacactgcat agaaatgaat
121 atggaatagc ttccatattg gattcttacc aatgtactgc agagataagt ttagctgacc
181 tggctaccat attttttgcc cagtttgttc aagaagccac ttacaaggaa gtaagcaaaa
241 tggtgaaaga tgcattgact gcaattgaga aacccactgg agatgaacag tcttcagggt
301 gtttagaaaa ccagctacct gcctttctgg aagaactttg ccatgagaaa gaaattttgg
361 agaagtacgg acattcagac tgctgcagcc aaagtgaaga gggaagacat aactgttttc
421 ttgcacacaa aaagcccact ccagcatcga tcccactttt ccaagttcca gaacctgtca
481 caagctgtga agcatatgaa gaagacaggg agacattcat gaacaaattc atttatgaga
541 tagcaagaag gcatcccttc ctgtatgcac ctacaattct tctttgggct gctcgctatg
601 acaaaataat tccatcttgc tgcaaagctg aaaatgcagt tgaatgcttc caaacaaagg
661 cagcaacagt tacaaaagaa ttaagagaaa gcagcttgtt aaatcaacat gcatgtgcag
721 taatgaaaaa ttttgggacc cgaactttcc aagccataac tgttactaaa ctgagtcaga
781 agtttaccaa agttaatttt actgaaatcc agaaactagt cctggatgtg gcccatgtac
841 atgagcactg ttgcagagga gatgtgctgg attgtctgca ggatggggaa aaaatcatgt
901 cctacatatg ttctcaacaa gacactctgt caaacaaaat aacagaatgc tgcaaactga
961 ccacgctgga acgtggtcaa tgtataattc atgcagaaaa tgatgaaaaa cctgaaggtc
1021 tatctccaaa tctaaacagg tttttaggag atagagattt taaccaattt tcttcagggg
1081 aaaaaaatat cttcttggca agttttgttc atgaatattc aagaagacat cctcagcttg
1141 ctgtctcagt aattctaaga gttgctaaag gataccagga gttattggag aagtgtttcc
1201 agactgaaaa ccctcttgaa tgccaagata aaggagaaga agaattacag aaatacatcc
1261 aggagagcca agcattggca aagcgaagct gcggcctctt ccagaaacta ggagaatatt
1321 acttacaaaa tgcgtttctc gttgcttaca caaagaaagc cccccagctg acctcgtcgg
1381 agctgatggc catcaccaga aaaatggcag ccacagcagc cacttgttgc caactcagtg
1441 aggacaaact attggcctgt ggcgagggag cggctgacat tattatcgga cacttatgta
1501 tcagacatga aatgactcca gtaaaccctg gtgttggcca gtgctgcact tcttcatatg
1561 ccaacaggag gccatgcttc agcagcttgg tggtggatga aacatatgtc cctcctgcat
1621 tctctgatga caagttcatt ttccataagg atctgtgcca agctcagggt gtagcgctgc
1681 aaacgatgaa gcaagagttt ctcattaacc ttgtgaagca aaagccacaa ataacagagg
1741 aacaacttga ggctgtcatt gcagatttct caggcctgtt ggagaaatgc tgccaaggcc
1801 aggaacagga agtctgcttt gctgaagagg gacaaaaact gatttcaaaa actcgtgctg
1861 ctttgggagt ttaaattact tcaggggaag agaagacaaa acgagtcttt cattcggtgt
1921 gaacttttct ctttaatttt aactgattta acactttttg tgaattaatg aaatgataaa
1981 gacttttatg tgagatttcc ttatcacaga aataaaatat ctccaaatg
//