LOCUS V00531 9937 bp DNA linear HUM 18-APR-2005
DEFINITION Human interferon genes LeIF-L and LeIF-J and pseudogene LeIF-M with
intergenic regions. These genes are located on chromosome 9.
ACCESSION V00531 J00217
VERSION V00531.1
KEYWORDS interferon; pseudogene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 9937)
AUTHORS Ullrich A., Gray A., Goeddel D.V., Dull T.J.
TITLE Nucleotide sequence of a portion of human chromosome 9 containing a
leukocyte interferon gene cluster
JOURNAL J. Mol. Biol. 156(3), 467-486(1982).
PUBMED 6181262
COMMENT Interferons are a family of proteins that confer viral resistance
to many types of mammalian cells. There are at least thirteen
distinct but extremely homologous human leukocyte interferons
(leifn or ifn-alpha), all of which have been localized to human
chromosome 9. [1] proposes that leif-m may be a pseudogene, and
because the l gene has a termination codon within the signal
peptide coding sequence, it is potentially a pseudogene. The coding
regions of the l and j genes are separated by 4262 nucleotides, are
96% homologous, and are each surrounded by about 3500 nucleotides
of flanking sequences, which are also highly homologous. The l and
j genes and their respective flanking sequences constitute a 4000
nucleotide leukocyte interferon gene repeat unit; the l gene repeat
unit contains two major insertions (705-743; 3823-4361) not present
in the j gene repeat unit (5672-9635). The j gene repeat unit is
flanked by sequence features reminiscent of those found surrounding
transposable elements. Both the l and j gene repeat units are
embedded within sequences that are highly repeated in the human
genome. Additional poly-a sites for both j and l are conceivable.
See other <humifn> loci.
FEATURES Location/Qualifiers
source 1..9937
/organism="Homo sapiens"
/mol_type="genomic DNA"
/dev_stage="foetus"
/clone="lambda-hleif-1"
/tissue_type="liver"
/db_xref="taxon:9606"
CDS <1..153
/map="9p22"
/pseudo
/codon_start=1
/gene="IFNA"
/note="pseudo-IFN-alpha-m"
mRNA <1..>425
/note="pseudo-IFN-alpha-m processed pseudogene"
repeat_region 704..5233
/note="whole repeat unit of IFNA-L"
mRNA 2194..3178
/map="9p22"
/gene="IFNA"
/note="putative"
CDS 2262..2831
/map="9p22"
/pseudo
/gene="IFNA"
repeat_region 5672..9634
/note="whole repeat unit of IFNA-J"
mRNA 7128..8127
/gene="9p22"
/note="mRNA of IFNA-J"
CDS 7195..7764
/map="9p22"
/gene="IFNA"
/product="interferon alpha-j"
/note="precursor from leukocyte; NCBI gi: 386797"
/db_xref="GOA:P01567"
/db_xref="HGNC:HGNC:5428"
/db_xref="InterPro:IPR000471"
/db_xref="InterPro:IPR009079"
/db_xref="UniProtKB/Swiss-Prot:P01567"
/protein_id="CAA23792.1"
/translation="MARSFSLLMVVLVLSYKSICSLGCDLPQTHSLRNRRALILLAQM
GRISPFSCLKDRHEFRFPEEEFDGHQFQKTQAISVLHEMIQQTFNLFSTEDSSAAWEQ
SLLEKFSTELYQQLNDLEACVIQEVGVEETPLMNEDFILAVRKYFQRITLYLMEKKYS
PCAWEVVRAEIMRSFSFSTNLKKGLRRKD"
BASE COUNT 3489 a 1637 c 1732 g 3077 t
ORIGIN
1 ccttgaggag gtacttcnag ggntccatgg gaatccagag aatctacctg aaagagaaga
61 aatacagtga ctgtgcttgg gaggttgtca gagtggaatc atgaaatcct tctcttcatc
121 aacagacttg caaggactga gaagtaagga tgaagacctg gggtctgctt tagtctttct
181 tattttcttc ctcttcctag ctgtgtgttt atttcttctt ttctagttcc ttaacttgta
241 aagttagttc attggtttga ggtctttctt cttttttaat ataagctttt acagctttca
301 atttcccctt tagctctgtt ttcactgcat cacatacgtc ttggtatgtt gtgttttcat
361 tttcacctct ctcaagatat tttctaagtt cccctctggt catctttttt ttttttgtac
421 tatactttaa gttccaggtt aaatgtgctc aacgtgcaag tttgttacat aggtatacat
481 ttgccatgtt ggtttgctgc acccattaac ttgtcattta cattaggtat ttctcctctt
541 acatgtttat cacatttaga catacatttg ttttcttttt gttcccataa attaagatga
601 aaatcagacc acttttacct tctaggaaaa gtgaagtgag aaatataaat atatttgctg
661 ttgtgaatgc catatagaac cattgtatag tccatttaaa aatgagaata aatgagaaat
721 tagtaaaaac accacttact aaatagctga tttgctaaag cagacctcat tccatttaag
781 gactcagtat ctatagggcc tacttataca aaaaaaaact tcttacacaa aaaaaaaaaa
841 aaaaaaaagt tagagccaga gttcaggatc atgctgaaag ttatttcttt gcataataat
901 attcaatatt tataaattta tgaatttaga acaaagatgg tcttttttat ttgataagaa
961 ttgacttgga taggaacttc tgaaaacctt tagggaatat gaacttcaat gtaaaatgcc
1021 aaaaatgatt taaatcatac tattttctaa gtcatatatg tttattggat tgatacttct
1081 tttaagggta caaaaattag ttctcgtagt gtaaatgaat ctaacatatt acaatagttt
1141 ctgactttcc aacaactcta tccaacaaaa ttttattgct taatatacat atttctcatt
1201 gggttttttt gtgtatgata tgagaagcac tggtattgag ttcatgaaga taaacaaaat
1261 atttgtaaga ccaatgttac aaacctatag caaatagatg actgtgattg gaggactttt
1321 tgtccatttt ttgctggatc ttaaagtctt atcacagtat gtggctttaa cctgcatatc
1381 tttgggctgc cattgactat cttatagtta ttagttatgt ttgatcctca gttcttcagg
1441 atgtttggta gactttgaga attcaatcca aatagcttac attatatgtt ttatttctac
1501 taaagttatt caatacatca gtacttgtgt caagtgctga aaagaaaaaa gttttggcaa
1561 tatctggatg aatactgcag ctggtgaatt tacaaattat tttctcatat aaagcaaaat
1621 tcaaagcttc atacactaag agaaaaattt taaaaaatta ttgattcata tttttaggag
1681 ttttgaatga ttaggtaggt aactacattc atattattaa tgtgtattat atagattttt
1741 attttgcata tgtactttga tacaaaattt gcatgaacaa attatactaa aagttattcc
1801 acaaatatac ttatcaaatt aaaataaatg tcaatagctt ttaaacttag attttagttt
1861 aacttttctg tcattcttaa ctttactttg aataaaaaga gcaaactttg tagtttttat
1921 ctgtgaagta gaggtatacg taatatacat aaatagatat gccaaatctg tgttactaaa
1981 atttcatgaa gatttcaatt aaaaaaaaac cataaaaggc tttgagtgca ggtgaaaaat
2041 aggcaatgat gaaaaaaaac gaaaaacttt ttaaacacat ggagagagta cataaagaaa
2101 gcaaaaacag agatagaaag taaaactagg gcatttagaa aatggaaatt agtatgttca
2161 ctatttaaga cctatgcaca gagcaaagtc ttcagaaaac ctagaggccg aagttcaagg
2221 ttatccatct caagtagcct agcaatattt gcaacatccc aatggccctg tccttttctt
2281 tacttatggc cgtgctggtg ctcagctaca aatccatctg atctctgggc tgtgatctgc
2341 ctcagaccca caccctgcgt aataggaggg ccttgatact cctgggacaa atgggaagaa
2401 tctctccttt ctcctgcctg aaggacagac atgatttccg aatcccccag gaggagtttg
2461 atggcaacca gttccagaag gctcaagcca tctctgtcct ccatgagatg atccagcaga
2521 ccttcaatct cttcagcaca gaggactcat ctgctgcttg ggaacagagc ctcctagaaa
2581 aattttccac tgaaatttac cagcaactga atgacctgga agcatgtgtg atacaggagg
2641 ttggggtgga agagactccc ctgatgaatg aggactccat cctggctgtg aggaaatact
2701 tccaaagaat cactctttat ctaatagaga ggaaatacag cccttgtgcc tgggaggttg
2761 tcagagcaga aatcatgaga tccctctcgt tttcaacaaa cttgcaaaaa agattaagga
2821 ggaaggattg aaaactggtt caacatggca atgatcctga ttgactaata cattatctca
2881 cactttcatg agttcttcca tttcaaagac tcacttctat aaccacgacg tgttgaatca
2941 aaattttcaa atgttttcag cagtgtaaag aagtgtcgtg tatacctgtg caggcactag
3001 tcctttacag atgaccattc tgatgtctct gttcatcttt tgtttaaata tttatttaat
3061 tatttttaaa atttatgtaa tatcatgagt cgctttacat tgtggttaat gtaacaatat
3121 atgttcttca tatttagcca atatattaat ttcctttttc attaaatttt tactatacaa
3181 aatttcttgt gtttgtttat tctttaagat aaaatgccaa ggctgacttt acaacctgac
3241 ttaaaaatag atgatttaat tatgttacct atcataattt tattcaagtt ataaaaatat
3301 atttttttct gtacctggtt atatgttgcc ttcaggatat aaacgtgaac ataaaatata
3361 cagtccctgt tctcttgtat ctttgatttt ttcaggaaag aaatctaaaa acaataataa
3421 tgctgaatta atatcagtga tgctaactgc tataatgtga ggaagtaaaa aaacaatgaa
3481 ttcctcttag cagaatgtag attgagacat atctggaaat aaaagcagag atattctctg
3541 taaactgact tcaacatgta attgaaaatg tacattgcaa gtcagatatg tgaatttgca
3601 gtttccaagg aatacgatat ctggaagttc ataactggca atggaaagga cgcaaatgaa
3661 ggctgtcata tggggagcaa gtggagaggg aaaaaaagac ttaaactgga ttctgaggat
3721 cttccaccat taaagtgtgg gaacagaaga gacacaaagg aaacagaggt ggaatacctt
3781 aacattagaa ggacaagagg gaatggtgat aaaagtgtat ttagaaaata aatgtgctta
3841 gaaaaggaat caataaactt atggaaaatg tgaattaaaa ctgagcacta cagcaagaaa
3901 atagatggca atgcagagct tactgagagc tggattcata gaattaatca gcagaagcca
3961 tactggggta gacagaagag tgactcagaa aagagaaatc aagataacac atacagaaaa
4021 tgtgagaaaa ctgcctttgc aatggtggca agtaataagt ttggaccccc caaaaatgtg
4081 gattatcttt tatctgcata gtgtttcctt tttgaaaata tgtcactgaa taaatttcat
4141 aattgtgatg cattggtgaa tcatattaat acatttaata atttatatat ttaaagcata
4201 aaatgtaaaa ttatttacaa tagtaattga tcattatttt gattaatact ctgttaaatg
4261 tcagtaaaaa ctgacacatt ttttcataaa ataaaattgg aaactggaaa agataatctc
4321 tttctgagta ctttaggaat ggggaaagga ttccctcttt aataaatggt gctgggaaaa
4381 ctggatagcc atatgcagag aactgaaact ggaccccttc cttacacctt atacaaaaat
4441 taatgcaaga tggattaaac gcttaaatgt aaaacccaaa accataaaaa ccctagaaga
4501 aaacgtaggc aatagcattc aggacatcgg catgggcaaa gattttatga tgaaatcgcc
4561 aaaagcaact gcaaccaaag ctaaaattga caaatggcat ctaattaaag agattctgca
4621 cagcaaaaga aactgtcaat catcacggtg aacaggcaac ttacagaatg ggagaaaatt
4681 tttacagcct acccaattga cagaggtcta atatccagaa tggacaaaga acttaaacaa
4741 attcacaaaa aaaaaaaaaa gccccatcga aaagtgggca aaggacatga acagacactt
4801 ctcaaaagta gacatttatg tggccaataa acatgaaaaa agctcaacat cactgatcat
4861 tagagaaatg aaaatcaaaa ctgcaatgag atgccatctc atgtcactca gaatggcaat
4921 tactaaaaag tcaggaaaca acagatgctg gtgaagctgt ggaaaaatag gaaagctttt
4981 acactgttgg taggaatgta aattacttca accattgtgg aagacagtgt ggcgattcat
5041 caaggattta gaaccagaaa taccattaga cccagcaatc ctattcctga gtatataccc
5101 aaaggaatac aaataattct attataaaaa tacatgcacg tgtatgttta ttgcaacact
5161 atttacaata gcaaagacag gaaaccaacc caaatgccca tcaatgatag aatggattaa
5221 aaaaattgtg cttcaatttt tttaatccta ctgaagctgt aggattattt gggggacaga
5281 gactattatt ccctactttt gggaatagta aattgtctga ttcctacaaa ctgtgtgaat
5341 tggagagttt gaatttcaat atgtgactct gtatttgaca ccaggctatt tattttctat
5401 tataacaaag tagagggagg attagagatg aagtcataaa tagttaatat agtgccaggc
5461 aaaggatgat attatgctgc tcttgcaact tgaatcccca gatctacatg caccttaaaa
5521 aactagaacc ccagtggttt tagcagtaaa ctaaatgggc attactgatt ttcactaaaa
5581 gctgaatgga aatttttgtc attgtctatt acaatcccaa atatggccat gatgaagaaa
5641 aacagcttca ttcttgaaca ccttccatta gaagaaaaaa tgagaaacta ggaaaaactc
5701 cacctactaa atagctgatt tgctaaaaca gacctcattc catttaagga ctcagtatct
5761 atagggccga ggcaaactaa ctttgccaga gttcaggacc actctgaaag ttaattcctt
5821 acataataat attcaatatt tataaattta tgaatttaga acaaagatgg tcttttatat
5881 ttgataagaa ttgacttgga taggaacttc tgaaaacctt tagggaatat gaacttcaat
5941 gaaaaatgcc aaaaatgatt taattgataa tattttctaa gtcacatatg tttattggaa
6001 tgatacttct tctaagggta caaaaattag ttctcgtagt gtaaacaaat ctgacatatt
6061 gcaaaagttt gtaactctcc aagaactcta tccaacaaaa tttcattgct taatatacat
6121 ctttctcgtt gggttttctt gtgtatgata tgagaagcac tggtattgag ttcatgatga
6181 taaacaaaat atttgcaaga tcaacgttac aaacctatgg caaatagatg actgtgattg
6241 gaggactttt tgtcaatttt tttgctggat cttgaagtct taccacaata tgtggcttta
6301 acctgcctac ctttgtgctg ccattgacca tcttatggtt attagttatg attgatcctc
6361 agttcttcag gatgttttgt acactttgag aattcaatgc aaatagccta tattatatga
6421 tttatttcta caaaagttat tcaacacatc agtacttatg tcaagtgctg aaaagaaaaa
6481 agtgttggca atatctggat gaatactgca gctagtgaag tttacaaatt attttctcat
6541 ataaagcaaa attcaaagct tcatatacta tgagaaaatt tttttaaaat tgattcatat
6601 ttctagcagt tttgaatgat taggtatgta attacattca tattaatgtg tattatacag
6661 atttttattt tgcatatgta atttgaaaca acaaaattta catgaacaaa ttacattaaa
6721 agttattcca caaatatact tatctaatta aacttagatt ttaatagctt ttaaacttag
6781 attttagttt aacttttctg tcattcttaa cttactttga ataaaaagag caaacttcat
6841 actttttatc tgtgaagtag aggtatatgt agaataccta aatagatatg ccaaatctgt
6901 gttattaaaa tttcatgaac atttcaatta gaaaaaaata ccataaaagg ctttgagtgc
6961 aggggaaaaa caggcaatga tgaaaaaaaa aatgaaaaac gtatttaaac acatggagag
7021 agtgcataaa gaaagcaaaa acagagatag aaagtaaaac tagggcattt agaaaatgga
7081 aattagtatg ttcactattt aagacctatg cacagagcaa agtctccaga aaacctagag
7141 gccacggttc aagttaccca cctcaggtag cctagtgata tttgcaaaat cccaatggcc
7201 cggtcctttt ctttactgat ggtcgtgctg gtactcagct acaaatccat ctgctctctg
7261 ggctgtgatc tgcctcagac ccacagcctg cgtaatagga gggccttgat actcctggca
7321 caaatgggaa gaatctctcc tttctcctgc ttgaaggaca gacatgaatt cagattccca
7381 gaggaggagt ttgatggcca ccagttccag aagactcaag ccatctctgt cctccatgag
7441 atgatccagc agaccttcaa tctcttcagc acagaggact catctgctgc ttgggaacag
7501 agcctcctag aaaaattttc cactgaactt taccagcaac tgaatgacct ggaagcatgt
7561 gtgatacagg aggttggggt ggaagagact cccctgatga atgaggactt catcctggct
7621 gtgaggaaat acttccaaag aatcactctt tatctaatgg agaagaaata cagcccttgt
7681 gcctgggagg ttgtcagagc agaaatcatg agatccttct ctttttcaac aaacttgaaa
7741 aaaggattaa ggaggaagga ttgaaaactg gttcatcatg gaaatgattc tcattgacta
7801 atgcatcatc tcacactttc atgagttctt ccatttcaaa gactcacttc tataaccacc
7861 acaagttgaa tcaaaatttc caaatgtttt caggagtgtt aagaagcatc gtgtttacct
7921 gtgcaggcac tagtccttta cagatgacca ttctgatgtc tcctttcatc tatttattta
7981 aatatttatt tatttaacta tttttattat ttaaattatt ttttatgtaa tatcatatgt
8041 acctttacat tgtggttaat gtaacaaata tgttcttcat atttagccaa tatattaatt
8101 tcctttttca ttaaattttt actatacaaa atttcttgtg tttgtttatt ttttaagatt
8161 aaatgccaag cctgactgta taacctgact taaaaataga tgatttaagt aagttaccta
8221 tcataatttt attcaagtta tagaaaaata tatttttcta taccaggtta tctgttgcct
8281 tcatgatata aacgtgaaca taaaaaatac agttcttgtt ctcttgtatc tttgattttt
8341 gtcaggaaag aaatctaaaa acaataataa tgctgaatta atatcggtta tactaactgc
8401 tgtaatgtga ggaagtaaaa aaaaatgaat tcctcttagc agaacataga ttaagaaatg
8461 tctgcaaata aaagtagagg tactctctat aaactgactt tcaacatgta attgaaaatg
8521 tacattgcaa gtcagatata tgagtttgca gtttccaagg aatatgatat ctggaagttc
8581 ataactaagc aatggaaacg ccaaaaatga aggctgtcat gtggggagca agcagagagg
8641 gaaaaaagac ttaaactgga ttctgaggaa cttccactat taaagtgggg gaacagaaga
8701 cacacaaaga aaacagaggt ggaatacctt atcattagaa ggacgagagg gaatgatgat
8761 aaaagtgtat ttggagggaa tgatgataaa tggtgctggg aaaactggat agccataggc
8821 agaaaattga acctggacca cttccttaca ccttatacaa aaattaactc aagatggatt
8881 aaagacttaa atgtaaaacc aaaaaccata aaaaccctag aagaaaacat aggacacagg
8941 atgggcaaag attttatgaa gaaatcgcca aaagcaactg caacaaaagt taaattgaca
9001 aatggcattt aattagagaa cttctgcaca gcaaaagaaa ctacctatca tcagagtgaa
9061 caggcaaccc atagaatggg agaaaatttt tgcagtctac ccaactcaca caggtctaat
9121 atccagaatg tacaaagaac ttaaacaaat ttacaaaaac aaaaagcccc atcaaaaagt
9181 gggtgaagga tatgaacaga atcttctcga aagtagacat ttatgcgacc aataatcatt
9241 aaaaaactca acatcactga tcattagaga aatgcaaatc aaaaccacaa tgaaatacca
9301 tctcatgcca ctcagaatgg caattattaa agagtcaaaa tcaacagatg ctggtgaagc
9361 tgtggaaaaa taggaaatct tttacactgt ttgtgggaat gtaaattact tcaaccattg
9421 tggaagacag tgtggcgatt catcaaggtt ctagaaccag aaataccatt tgacccagca
9481 atctcattac tgagtatata cccaaaggaa tataaatcgt tctgttataa aatacacgca
9541 cgtgtatgtt tattgcagca tgtttacaat agcaaagaca caaaaccaac ccaagtgccc
9601 atcaatgata gactggatta aaaaaaattg tacttaaaac ctaggtgacg gatgagagtg
9661 accttgaact ggcaagacca ggtcagtgca agtgacattg gtttcttaga tactcctcag
9721 ctccgtgtgg gtctcccgat tctcagttct gcctgctgac ttgttcattc atttccatgg
9781 cagggctgca gttgggtcgt gcctggtttt ttggcctccc aatgtctctt aattaactta
9841 atattacttg gtaatactaa agcaatgatg aattatgtgc atggagtcat taatcttctg
9901 tgtaaatatc tcaaacactg tgtcttaatt atagact
//