LOCUS HSU97669 8091 bp mRNA linear HUM 17-DEC-1997
DEFINITION Homo sapiens Notch3 (NOTCH3) mRNA, complete cds.
ACCESSION U97669
VERSION U97669.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8091)
AUTHORS Joutel,A., Corpechot,C., Ducros,A., Vahedi,K., Chabriat,H.,
Mouton,P., Alamowitch,S., Domenga,V., Cecillion,M., Marechal,E.,
Maciazek,J., Vayssiere,C., Cruaud,C., Cabanis,E.A., Ruchoux,M.M.,
Weissenbach,J., Bach,J.F., Bousser,M.G. and Tournier-Lasserve,E.
TITLE Notch3 mutations in CADASIL, a hereditary adult-onset condition
causing stroke and dementia
JOURNAL Nature 383 (6602), 707-710 (1996)
PUBMED 8878478
REFERENCE 2 (bases 1 to 8091)
AUTHORS Joutel,A., Vahedi,K., Corpechot,C., Troesch,A., Chabriat,H.,
Vayssiere,C., Cruaud,C., Maciazek,J., Weissenbach,J., Bousser,M.G.,
Bach,J.F. and Tournier-Lasserve,E.
TITLE Strong clustering and stereotyped nature of Notch3 mutations in
CADASIL patients
JOURNAL Lancet 350 (9090), 1511-1515 (1997)
PUBMED 9388399
REFERENCE 3 (bases 1 to 8091)
AUTHORS Joutel,A. and Tournier-Lasserve,E.
TITLE Direct Submission
JOURNAL Submitted (15-APR-1997) INSERM U25, Faculte de Medecine
Necker-Enfants Malades, 156 rue de Vaugirard, Paris 75015, France
FEATURES Location/Qualifiers
source 1..8091
/db_xref="H-InvDB:HIT000222884"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19p13.1"
gene 1..8091
/gene="NOTCH3"
CDS 79..7044
/gene="NOTCH3"
/codon_start=1
/product="Notch3"
/protein_id="AAB91371.1"
/translation="MGPGARGRRRRRRPMSPPPPPPPVRALPLLLLLAGPGAAAPPCL
DGSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTA
RFSCRCPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVD
ECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDL
TYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVD
ECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVA
SFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDV
DECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRI
GQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDV
DECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASF
SCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDC
ASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCL
CPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACES
QPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSC
PQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPN
PCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPP
GYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCL
HGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSG
RLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPC
LAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLC
SCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEA
DINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCR
PSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLS
GPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAA
PEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRL
FNNSRCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQGCNTEECG
WDGLDCASEVPALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDAHGQ
AMVFPYHRPSPGSEPRARRELAPEVIGSVVMLEIDNRLCLQSPENDHCFPDAQSAADY
LGALSAVERLDFPYPLRDVRGEPLEPPEPSVPLLPLLVAGAVLLLVILVLGVMVARRK
REHSTLWFPEGFSLHKDVASGHKGRREPVGQDALGMKNMAKGESLMGEVATDWMDTEC
PEAKRLKVEEPGMGAEEAVDCRQWTQHHLVAADIRVAPAMALTPPQGDADADGMDVNV
RGPDGFTPLMLASFCGGALEPMPTEEDEADDTSASIISDLICQGAQLGARTDRTGETA
LHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTDLD
ARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLAL
LKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERL
HQDIVRLLDQPSGPRSPPGPHGLGPLLCPPGAFLPGLKAAQSGSKKSRRPPGKAGLGP
QGPRGRGKKLTLACPGPLADSSVTLSPVDSLDSPRPFGGPPASPGGFPLEGPYAAATA
TAVSLAQLGGPGRAGLGRQPPGGCVLSLGLLNPVAVPLDWARLPPPAPPGPSFLLPLA
PGPQLLNPGTPVSPQERPPPYLAVPGHGEEYPVAGAHSSPPKARFLRVPSEHPYLTPS
PESPEHWASPSPPSLSDWSESTPSPATATGAMATTTGALPAQPLPLSVPSSLAQAQTQ
LGPQPEVTPKRQVLA"
BASE COUNT 1311 a 2716 c 2488 g 1576 t
ORIGIN
1 acgcggcgcg gaggctggcc cgggacgcgc ccggagccca gggaaggagg gaggagggga
61 gggtcgcggc cggccgccat ggggccgggg gcccgtggcc gccgccgccg ccgtcgcccg
121 atgtcgccgc caccgccacc gccacccgtg cgggcgctgc ccctgctgct gctgctagcg
181 gggccggggg ctgcagcccc cccttgcctg gacggaagcc cgtgtgcaaa tggaggtcgt
241 tgcacccagc tgccctcccg ggaggctgcc tgcctgtgcc cgcctggctg ggtgggtgag
301 cggtgtcagc tggaggaccc ctgtcactca ggcccctgtg ctggccgtgg tgtctgccag
361 agttcagtgg tggctggcac cgcccgattc tcatgccggt gcccccgtgg cttccgaggc
421 cctgactgct ccctgccaga tccctgcctc agcagccctt gtgcccacgg tgcccgctgc
481 tcagtggggc ccgatggacg cttcctctgc tcctgcccac ctggctacca gggccgcagc
541 tgccgaagcg acgtggatga gtgccgggtg ggtgagccct gccgccatgg tggcacctgc
601 ctcaacacac ctggctcctt ccgctgccag tgtccagctg gctacacagg gccactatgt
661 gagaaccccg cggtgccctg tgcgccctca ccatgccgta acgggggcac ctgcaggcag
721 agtggcgacc tcacttacga ctgtgcctgt cttcctgggt ttgagggtca gaattgtgaa
781 gtgaacgtgg acgactgtcc aggacaccga tgtctcaatg gggggacatg cgtggatggc
841 gtcaacacct ataactgcca gtgccctcct gagtggacag gccagttctg cacggaggac
901 gtggatgagt gtcagctgca gcccaacgcc tgccacaatg ggggtacctg cttcaacacg
961 ctgggtggcc acagctgcgt gtgtgtcaat ggctggacag gtgagagctg cagtcagaat
1021 atcgatgact gtgccacagc cgtgtgcttc catggggcca cctgccatga ccgcgtggct
1081 tctttctact gtgcctgccc catgggcaag actggcctcc tgtgtcacct ggatgacgcc
1141 tgtgtcagca acccctgcca cgaggatgct atctgtgaca caaatccggt gaacggccgg
1201 gccatttgca cctgtcctcc cggcttcacg ggtggggcat gtgaccagga tgtggacgag
1261 tgctctatcg gcgccaaccc ctgcgagcac ttgggcaggt gcgtgaacac gcagggctcc
1321 ttcctgtgcc agtgcggtcg tggctacact ggacctcgct gtgagaccga tgtcaacgag
1381 tgtctgtcgg ggccctgccg aaaccaggcc acgtgcctcg accgcatagg ccagttcacc
1441 tgtatctgta tggcaggctt cacaggaacc tattgcgagg tggacattga cgagtgtcag
1501 agtagcccct gtgtcaacgg tggggtctgc aaggaccgag tcaatggctt cagctgcacc
1561 tgcccctcgg gcttcagcgg ctccacgtgt cagctggacg tggacgaatg cgccagcacg
1621 ccctgcagga atggcgccaa atgcgtggac cagcccgatg gctacgagtg ccgctgtgcc
1681 gagggctttg agggcacgct gtgtgatcgc aacgtggacg actgctcccc tgacccatgc
1741 caccatggtc gctgcgtgga tggcatcgcc agcttctcat gtgcctgtgc tcctggctac
1801 acgggcacac gctgcgagag ccaggtggac gaatgccgca gccagccctg ccgccatggc
1861 ggcaaatgcc tagacctggt ggacaagtac ctctgccgct gcccttctgg gaccacaggt
1921 gtgaactgcg aagtgaacat tgacgactgt gccagcaacc cctgcacctt tggagtctgc
1981 cgtgatggca tcaaccgcta cgactgtgtc tgccaacctg gcttcacagg gcccctttgt
2041 aacgtggaga tcaatgagtg tgcttccagc ccatgcggcg agggaggttc ctgtgtggat
2101 ggggaaaatg gcttccgctg cctctgcccg cctggctcct tgcccccact ctgcctcccc
2161 ccgagccatc cctgtgccca tgagccctgc agtcacggca tctgctatga tgcacctggc
2221 gggttccgct gtgtgtgtga gcctggctgg agtggccccc gctgcagcca gagcctggcc
2281 cgagacgcct gtgagtccca gccgtgcagg gccggtggga catgcagcag cgatggaatg
2341 ggtttccact gcacctgccc gcctggtgtc cagggacgtc agtgtgaact cctctccccc
2401 tgcaccccga acccctgtga gcatgggggc cgctgcgagt ctgcccctgg ccagctgcct
2461 gtctgctcct gcccccaggg ctggcaaggc ccacgatgcc agcaggatgt ggacgagtgt
2521 gctggccccg caccctgtgg ccctcatggt atctgcacca acctggcagg gagtttcagc
2581 tgcacctgcc atggagggta cactggccct tcctgtgatc aggacatcaa tgactgtgac
2641 cccaacccat gcctgaacgg tggctcgtgc caagacggcg tgggctcctt ttcctgctcc
2701 tgcctccctg gtttcgccgg cccacgatgc gcccgcgatg tggatgagtg cctgagcaac
2761 ccctgcggcc cgggcacctg taccgaccac gtggcctcct tcacctgcac ctgcccgccg
2821 ggctacggag gcttccactg cgaacaggac ctgcccgact gcagccccag ctcctgcttc
2881 aatggcggga cctgtgtgga cggcgtgaac tcgttcagct gcctgtgccg tcccggctac
2941 acaggagccc actgccaaca tgaggcagac ccctgcctct cgcggccctg cctacacggg
3001 ggcgtctgca gcgccgccca ccctggcttc cgctgcacct gcctcgagag cttcacgggc
3061 ccgcagtgcc agacgctggt ggattggtgc agccgccagc cttgtcaaaa cgggggtcgc
3121 tgcgtccaga ctggggccta ttgcctttgt ccccctggat ggagcggacg cctctgtgac
3181 atccgaagct tgccctgcag ggaggccgca gcccagatcg gggtgcggct ggagcagctg
3241 tgtcaggcgg gtgggcagtg tgtggatgaa gacagctccc actactgcgt gtgcccagag
3301 ggccgtactg gtagccactg tgagcaggag gtggacccct gcttggccca gccctgccag
3361 catgggggga cctgccgtgg ctatatgggg ggctacatgt gtgagtgtct tcctggctac
3421 aatggtgata actgtgagga cgacgtggac gagtgtgcct cccagccctg ccagcacggg
3481 ggttcatgca ttgacctcgt ggcccgctat ctctgctcct gtcccccagg aacgctgggg
3541 gtgctctgcg agattaatga ggatgactgc ggcccaggcc caccgctgga ctcagggccc
3601 cggtgcctac acaatggcac ctgcgtggac ctggtgggtg gtttccgctg cacctgtccc
3661 ccaggataca ctggtttgcg ctgcgaggca gacatcaatg agtgtcgctc aggtgcctgc
3721 cacgcggcac acacccggga ctgcctgcag gacccaggcg gaggtttccg ttgcctttgt
3781 catgctggct tctcaggtcc tcgctgtcag actgtcctgt ctccctgcga gtcccagcca
3841 tgccagcatg gaggccagtg ccgtcctagc ccgggtcctg ggggtgggct gaccttcacc
3901 tgtcactgtg cccagccgtt ctggggtccg cgttgcgagc gggtggcgcg ctcctgccgg
3961 gagctgcagt gcccggtggg cgtcccatgc cagcagacgc cccgcgggcc gcgctgcgcc
4021 tgccccccag ggttgtcggg accctcctgc cgcagcttcc cggggtcgcc gccgggggcc
4081 agcaacgcca gctgcgcggc cgccccctgt ctccacgggg gctcctgccg ccccgcgccg
4141 ctcgcgccct tcttccgctg cgcttgcgcg cagggctgga ccgggccgcg ctgcgaggcg
4201 cccgccgcgg cacccgaggt ctcggaggag ccgcggtgcc cgcgcgccgc ctgccaggcc
4261 aagcgcgggg accagcgctg cgaccgcgag tgcaacagcc caggctgcgg ctgggacggc
4321 ggcgactgct cgctgagcgt gggcgacccc tggcggcaat gcgaggcgct gcagtgctgg
4381 cgcctcttca acaacagccg ctgcgacccc gcctgcagct cgcccgcctg cctctacgac
4441 aacttcgact gccacgccgg tggccgcgag cgcacttgca acccggtgta cgagaagtac
4501 tgcgccgacc actttgccga cggccgctgc gaccagggct gcaacacgga ggagtgcggc
4561 tgggatgggc tggattgtgc cagcgaggtg ccggccctgc tggcccgcgg cgtgctggtg
4621 ctcacagtgc tgctgccgcc ggaggagcta ctgcgttcca gcgccgactt tctgcagcgg
4681 ctcagcgcca tcctgcgcac ctcgctgcgc ttccgcctgg acgcgcacgg ccaggccatg
4741 gtcttccctt accaccggcc tagtcctggc tccgaacccc gggcccgtcg ggagctggcc
4801 cccgaggtga tcggctcggt agtaatgctg gagattgaca accggctctg cctgcagtcg
4861 cctgagaatg atcactgctt ccccgatgcc cagagcgccg ctgactacct gggagcgttg
4921 tcagcggtgg agcgcctgga cttcccgtac ccactgcggg acgtgcgggg ggagccgctg
4981 gagcctccag aacccagcgt cccgctgctg ccactgctag tggcgggcgc tgtcttgctg
5041 ctggtcattc tcgtcctggg tgtcatggtg gcccggcgca agcgcgagca cagcaccctc
5101 tggttccctg agggcttctc actgcacaag gacgtggcct ctggtcacaa gggccggcgg
5161 gaacccgtgg gccaggacgc gctgggcatg aagaacatgg ccaagggtga gagcctgatg
5221 ggggaggtgg ccacagactg gatggacaca gagtgcccag aggccaagcg gctaaaggta
5281 gaggagccag gcatgggggc tgaggaggct gtggattgcc gtcagtggac tcaacaccat
5341 ctggttgctg ctgacatccg cgtggcacca gccatggcac tgacaccacc acagggcgac
5401 gcagatgctg atggcatgga tgtcaatgtg cgtggcccag atggcttcac cccgctaatg
5461 ctggcttcct tctgtggggg ggctctggag ccaatgccaa ctgaagagga tgaggcagat
5521 gacacatcag ctagcatcat ctccgacctg atctgccagg gggctcagct tggggcacgg
5581 actgaccgta ctggcgagac tgctttgcac ctggctgccc gttatgcccg tgctgatgca
5641 gccaagcggc tgctggatgc tggggcagac accaatgccc aggaccactc aggccgcact
5701 cccctgcaca cagctgtcac agccgatgcc cagggtgtct tccagattct catccgaaac
5761 cgctctacag acttggatgc ccgcatggca gatggctcaa cggcactgat cctggcggcc
5821 cgcctggcag tagagggcat ggtggaagag ctcatcgcca gccatgctga tgtcaatgct
5881 gtggatgagc ttgggaaatc agccttacac tgggctgcgg ctgtgaacaa cgtggaagcc
5941 actttggccc tgctcaaaaa tggagccaat aaggacatgc aggatagcaa ggaggagacc
6001 cccctattcc tggccgcccg cgagggcagc tatgaggctg ccaagctgct gttggaccac
6061 tttgccaacc gtgagatcac cgaccacctg gacaggctgc cgcgggacgt agcccaggag
6121 agactgcacc aggacatcgt gcgcttgctg gatcaaccca gtgggccccg cagccccccc
6181 ggtccccacg gcctggggcc tctgctctgt cctccagggg ccttcctccc tggcctcaaa
6241 gcggcacagt cggggtccaa gaagagcagg aggccccccg ggaaggcggg gctggggccg
6301 caggggcccc gggggcgggg caagaagctg acgctggcct gcccgggccc cctggctgac
6361 agctcggtca cgctgtcgcc cgtggactcg ctggactccc cgcggccttt cggtgggccc
6421 cctgcttccc ctggtggctt cccccttgag gggccctatg cagctgccac tgccactgca
6481 gtgtctctgg cacagcttgg tggcccaggc cgggcaggtc tagggcgcca gccccctgga
6541 ggatgtgtac tcagcctggg cctgctgaac cctgtggctg tgcccctcga ttgggcccgg
6601 ctgcccccac ctgcccctcc aggcccctcg ttcctgctgc cactggcgcc gggaccccag
6661 ctgctcaacc cagggacccc cgtctccccg caggagcggc ccccgcctta cctggcagtc
6721 ccaggacatg gcgaggagta cccggtggct ggggcacaca gcagcccccc aaaggcccgc
6781 ttcctgcggg ttcccagtga gcacccttac ctgaccccat cccccgaatc ccctgagcac
6841 tgggccagcc cctcacctcc ctccctctca gactggtccg aatccacgcc tagcccagcc
6901 actgccactg gggccatggc caccaccact ggggcactgc ctgcccagcc acttcccttg
6961 tctgttccca gctcccttgc tcaggcccag acccagctgg ggccccagcc ggaagttacc
7021 cccaagaggc aagtgttggc ctgagacgct cgtcagttct tagatcttgg gggcctaaag
7081 agacccccgt cctgcctcct ttctttctct gtctcttcct tccttttagt ctttttcatc
7141 ctcttctctt tccaccaacc ctcctgcatc cttgccttgc agcgtgaccg agataggtca
7201 tcagcccagg gcttcagtct tcctttattt ataatgggtg ggggctacca cccaccctct
7261 cagtcttgtg aagagtctgg gacctccttc ttccccactt ctctcttccc tcattccttt
7321 ctctctcctt ctggcctctc atttccttac actctgacat gaatgaatta ttattatttt
7381 tctttttctt ttttttttta cattttgtat agaaacaaat tcatttaaac aaacttatta
7441 ttattatttt ttacaaaata tatatatgga gatgctccct ccccctgtga accccccagt
7501 gcccccgtgg ggctgagtct gtgggcccat tcggccaagc tggattctgt gtacctagta
7561 cacaggcatg actgggatcc cgtgtaccga gtacacgacc caggtatgta ccaagtaggc
7621 acccttgggc gcacccactg gggccagggg tcgggggagt gttgggagcc tcctccccac
7681 cccacctccc tcacttcact gcattccaga ttggacatgt tccatagcct tgctggggaa
7741 gggcccactg ccaactccct ctgccccagc cccacccttg gccatctccc tttgggaact
7801 agggggctgc tggtgggaaa tgggagccag ggcagatgta tgcattcctt tatgtccctg
7861 taaatgtggg actacaagaa gaggagctgc ctgagtggta ctttctcttc ctggtaatcc
7921 tctggcccag ccttatggca gaatagaggt atttttaggc tatttttgta atatggcttc
7981 tggtcaaaat ccctgtgtag ctgaattccc aagccctgca ttgtacagcc ccccactccc
8041 ctcaccacct aataaaggaa tagttaacac tcaaaaaaaa aaaaaaaaaa a
//