LOCUS HSU97584 1965 bp mRNA linear HUM 07-JUL-1998
DEFINITION Homo sapiens cyclic AMP-specific phosphodiesterase HSPDE4A1A
(PDE4A) mRNA, complete cds.
ACCESSION U97584
VERSION U97584.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1965)
AUTHORS Sullivan,M., Rena,G., Begg,F., Gordon,L., Olsen,A.S. and
Houslay,M.D.
TITLE Identification and characterization of the human homologue of the
short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by
analysis of the human HSPDE4A gene locus located at chromosome
19p13.2
JOURNAL Biochem. J. 333 (Pt 3), 693-703 (1998)
PUBMED 9677330
REFERENCE 2 (bases 1 to 1965)
AUTHORS Rena,G. and Houslay,M.D.
TITLE Direct Submission
JOURNAL Submitted (15-APR-1997) Biochemistry & Molecular Biology,
University of Glasgow, University Avenue, Glasgow, Scotland G12
8QQ, UK
FEATURES Location/Qualifiers
source 1..1965
/db_xref="H-InvDB:HIT000222883"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19p13.2"
/tissue_type="brain"
gene 1..1965
/gene="PDE4A"
CDS 22..1965
/gene="PDE4A"
/note="type-IV cyclic AMP phosphodiesterase; RD1 cyclic
AMP PDE4 phosphodiesterase"
/codon_start=1
/product="cyclic AMP-specific phosphodiesterase HSPDE4A1A"
/protein_id="AAC25679.1"
/translation="MPLVDFFCETCSKPWLVGWWDQFKRMLNRELTHLSEMSRSGNQV
SEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKL
MHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIF
QERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAV
FTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQ
EDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLL
DNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMC
DKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSP
PPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALD
ATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVA
VSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACA
GTFGEDTSALPAPGGGGSGGDPT"
BASE COUNT 458 a 593 c 558 g 356 t
ORIGIN
1 caggcgggct aagtctccaa gatgcccttg gtggatttct tctgcgagac ctgctctaag
61 ccttggctgg tgggctggtg ggaccagttc aaaaggatgt tgaaccgtga gctcacacac
121 ctgtcagaaa tgagcaggtc cggaaaccag gtctcagagt acatttccac aacattcctg
181 gacaaacaga atgaagtgga gatcccatca cccacgatga aggaacgaga aaaacagcaa
241 gcgccgcgac caagaccctc ccagccgccc ccgccccctg taccacactt acagcccatg
301 tcccaaatca cagggttgaa aaagttgatg catagtaaca gcctgaacaa ctctaacatt
361 ccccgatttg gggtgaagac cgatcaagaa gagctcctgg cccaagaact ggagaacctg
421 aacaagtggg gcctgaacat cttttgcgtg tcggattacg ctggaggccg ctcactcacc
481 tgcatcatgt acatgatatt ccaggagcgg gacctgctga agaaattccg catcccggtg
541 gacacgatgg tgacatacat gctgacgctg gaggatcact accacgctga cgtggcctac
601 cataacagcc tgcacgcagc tgacgtgctg cagtccaccc acgtactgct ggccacgcct
661 gcactagatg cagtgttcac ggacctggag attctcgccg ccctcttcgc ggctgccatc
721 cacgatgtgg atcaccctgg ggtctccaac cagttcctca tcaacaccaa ttcggagctg
781 gcgctcatgt acaacgatga gtcggtgctc gagaatcacc acctggccgt gggcttcaag
841 ctgctgcagg aggacaactg cgacatcttc cagaacctca gcaagcgcca gcggcagagc
901 ctacgcaaga tggtcatcga catggtgctg gccacggaca tgtccaagca catgaccctc
961 ctggctgacc tgaagaccat ggtggagacc aagaaagtga ccagctcagg ggtcctcctg
1021 ctagataact actccgaccg catccaggtc ctccggaaca tggtgcactg tgccgacctc
1081 agcaacccca ccaagccgct ggagctgtac cgccagtgga cagaccgcat catggccgag
1141 ttcttccagc agggtgaccg agagcgcgag cgtggcatgg aaatcagccc catgtgtgac
1201 aagcacactg cctccgtgga gaagtctcag gtgggtttta ttgactacat tgtgcaccca
1261 ttgtgggaga cctgggcgga ccttgtccac ccagatgccc aggagatctt ggacactttg
1321 gaggacaacc gggactggta ctacagcgcc atccggcaga gcccatctcc gccacccgag
1381 gaggagtcaa gggggccagg ccacccaccc ctgcctgaca agttccagtt tgagctgacg
1441 ctggaggagg aagaggagga agaaatatca atggcccaga taccgtgcac agcccaagag
1501 gcattgactg cgcagggatt gtcaggagtc gaggaagctc tggatgcaac catagcctgg
1561 gaggcatccc cggcccagga gtcgttggaa gttatggcac aggaagcatc cctggaggcc
1621 gagctggagg cagtgtattt gacacagcag gcacagtcca caggcagtgc acctgtggct
1681 ccggatgagt tctcgtcccg ggaggaattc gtggttgctg taagccacag cagcccctct
1741 gccctggctc ttcaaagccc ccttctccct gcttggagga ccctgtctgt ttcagagcat
1801 gccccgggcc tcccgggcct cccctccacg gcggccgagg tggaggccca acgagagcac
1861 caggctgcca agagggcttg cagtgcctgc gcagggacat ttggggagga cacatccgca
1921 ctcccagctc ctggtggcgg ggggtcaggt ggagacccta cctga
//