LOCUS       HSU97276                3314 bp    mRNA    linear   HUM 08-MAR-2001
DEFINITION  Homo sapiens quiescin (Q6) mRNA, complete cds, alternatively
            spliced.
ACCESSION   U97276
VERSION     U97276.2
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3314)
  AUTHORS   Coppock,D.L., Cina-Poppe,D.A. and Gilleran,S.
  TITLE     Quiescin Q6: a new member of an ancient gene family with a
            potential role in human cancer
  JOURNAL   (in) ? (Ed.);
            PROC. AMER. ASSOC. CAN. RES. 39: 471;
            (1998)
REFERENCE   2  (bases 1 to 3314)
  AUTHORS   Coppock,D.L., Cina-Poppe,D. and Gilleran,S.
  TITLE     The quiescin Q6 gene (QSCN6) is a fusion of two ancient gene
            families: thioredoxin and ERV1
  JOURNAL   Genomics 54 (3), 460-468 (1998)
   PUBMED   9878249
REFERENCE   3  (bases 1 to 3314)
  AUTHORS   Hoober,K.L., Glynn,N.M., Burnside,J., Coppock,D.L. and Thorpe,C.
  TITLE     Homology between egg white sulfhydryl oxidase and quiescin Q6
            defines a new class of flavin-linked sulfhydryl oxidases
  JOURNAL   J. Biol. Chem. 274 (45), 31759-31762 (1999)
   PUBMED   10542195
REFERENCE   4  (bases 1 to 3314)
  AUTHORS   Coppock,D., Kopman,C., Gudas,J. and Cina-Poppe,D.A.
  TITLE     Regulation of the quiescence-induced genes: quiescin Q6, decorin,
            and ribosomal protein S29
  JOURNAL   Biochem. Biophys. Res. Commun. 269 (2), 604-610 (2000)
   PUBMED   10708601
REFERENCE   5  (bases 1 to 3314)
  AUTHORS   Turi,G.K.
  TITLE     The Distribution and Specificity of Expression of Quiescin Q6 (Q6)
            in Human Tissues is Associated with Both Endocrine and
            Non-Endocrine Protein Secretion (Abstract #397)
  JOURNAL   Proc. Annu. Meet. Am. Assoc. Cancer Res. 42 (2001) In press
REFERENCE   6  (bases 1 to 3314)
  AUTHORS   Coppock,D.L., Cina,D., Gilleran,S. and Scandalis,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-APR-1997) Oncology Research Lab, Winthrop University
            Hospital, 222 Station Plaza North #300, Mineola, NY 11501, USA
REFERENCE   7  (bases 1 to 3314)
  AUTHORS   Coppock,D.L., Cina,D., Gilleran,S. and Scandalis,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-APR-1998) Oncology Research Lab, Winthrop University
            Hospital, 222 Station Plaza North #300, Mineola, NY 11501, USA
  REMARK    Sequence update by submitter
REFERENCE   8  (bases 1 to 3314)
  AUTHORS   Coppock,D.L., Kopman,C., Scandalis,S., Gilleran,S. and Singh,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-MAR-2001) Oncology Research Lab, Winthrop University
            Hospital, 222 Station Plaza North #300, Mineola, NY 11501, USA
  REMARK    Sequence update by submitter
COMMENT     On Mar 8, 2001 this sequence version replaced U97276.1.
FEATURES             Location/Qualifiers
     source          1..3314
                     /db_xref="H-InvDB:HIT000222878"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /cell_line="WI38"
                     /cell_type="fibroblasts"
                     /tissue_type="lung"
                     /dev_stage="embryo"
                     /note="cloned from quiescence specific cDNA library; cDNA
                     used in Coppock,D.L., et al., Cell Growth Differ., 4 (6),
                     483-493 (1993)"
     gene            1..3314
                     /gene="Q6"
     misc_feature    70..3314
                     /gene="Q6"
                     /note="expression is induced by reversible growth arrest,
                     trypsinization and serum starvation, and is blocked by
                     SV40 transformation; expressed in heart, placenta, lung,
                     liver, skeletal muscle and pancreas, and in fibroblasts,
                     endothelial cells, breast epithelial cells and
                     melanocytes"
     CDS             76..2319
                     /gene="Q6"
                     /note="alternatively spliced; probable sulfhydryl oxidase;
                     thioredoxin superfamily member"
                     /codon_start=1
                     /product="quiescin"
                     /protein_id="AAC09010.2"
                     /translation="MRRCNSGSGPPPSLLLLLLWLLAVPGANAAPRSALYSPSDPLTL
                     LQADTVRGAVLGSRSAWAVEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCA
                     EETNSAVCRDFNIPGFPTVRFFKAFTKNGSGAVFPVAGADVQTLRERLIDALESHHDT
                     WPPACPPLEPAKLEEIDGFFARNNEEYLALIFEKGGSYLGREVALDLSQHKGVAVRRV
                     LNTEANVVRKFGVTDFPSCYLLFRNGSVSRVPVLMESRSFYTAYLQRLSGLTREAAQT
                     TVAPTTANKIAPTVWKLADRSKIYMADLESALHYILRIEVGRFPVLEGQRLVALKKFV
                     AVLAKYFPGRPLVQNFLHSVNEWLKRQKRNKIPYSFFKTALDDRKEGAVLAKKVNWIG
                     CQGSEPHFRGFPCSLWVLFHFLTVQAARQNVDHSQEAAKAKEVLPAIRGYVHYFFGCR
                     DCASHFEQMAAASMHRVGSPNAAVLWLWSSHNRVNARLAGAPSEDPQFPKVQWPPREL
                     CSACHNERLDVPVWDVEATLNFLKAHFSPSNIILDFPAAGSAARRDVQNVAAAPELAM
                     GALELESRNSTLDPGKPEMMKSPTNTTPHVPAEGPEASRPPKLHPGLRAAPGQEPPEH
                     MAELQRNEQEQPLGQWHLSKRDTGAALLAESRAEKNRLWGPLEVRRVGRSSKQLVDIP
                     EGQLEARAGRGRGQWLQVLGGGFSYLDISLCVGLYSLSFMGLLAMYTYFQAKIRALKG
                     HAGHPAA"
     variation       510
                     /gene="Q6"
                     /replace="a"
     misc_feature    1881
                     /gene="Q6"
                     /note="cryptic splice donor site"
     misc_feature    2615
                     /gene="Q6"
                     /note="cryptic splice acceptor site"
BASE COUNT          609 a          987 c         1022 g          696 t
ORIGIN      
        1 ggaggcaggc ggtgccgcgg cgccgggacc cgactcatcc ggtgcttgcg tgtggtggtg
       61 agcgcagcgc cgaggatgag gaggtgcaac agcggctccg ggccgccgcc gtcgctgctg
      121 ctgctgctgc tgtggctgct cgcggttccc ggcgctaacg cggccccgcg gtcggcgctc
      181 tattcgcctt ccgacccgct gacgctgctg caggcggaca cggtgcgcgg cgcggtgctg
      241 ggctcccgca gcgcctgggc cgtggagttc ttcgcctcct ggtgcggcca ctgcatcgcc
      301 ttcgccccga cgtggaaggc gctggccgaa gacgtcaaag cctggaggcc ggccctgtat
      361 ctcgccgccc tggactgtgc tgaggagacc aacagtgcag tctgcagaga cttcaacatc
      421 cctggcttcc cgactgtgag gttcttcaag gcctttacca agaacggctc gggagcagta
      481 tttccagtgg ctggtgctga cgtgcagacg ctgcgggaga ggctcattga cgccctggag
      541 tcccatcatg acacgtggcc cccagcctgt cccccactgg agcctgccaa gctggaggag
      601 attgatggat tctttgcgag aaataacgaa gagtacctgg ctctgatctt tgaaaaggga
      661 ggctcctacc tgggtagaga ggtggctctg gacctgtccc agcacaaagg cgtggcggtg
      721 cgcagggtgc tgaacacaga ggccaatgtg gtgagaaagt ttggtgtcac cgacttcccc
      781 tcttgctacc tgctgttccg gaatggctct gtctcccgag tccccgtgct catggaatcc
      841 aggtccttct ataccgctta cctgcagaga ctctctgggc tcaccaggga ggctgcccag
      901 accacagttg caccaaccac tgctaacaag atagctccca ctgtttggaa attggcagat
      961 cgctccaaga tctacatggc tgacctggaa tctgcactgc actacatcct gcggatagaa
     1021 gtgggcaggt tcccggtcct ggaagggcag cgcctggtgg ccctgaaaaa gtttgtggca
     1081 gtgctggcca agtatttccc tggccggccc ttagtccaga acttcctgca ctccgtgaat
     1141 gaatggctca agaggcagaa gagaaataaa attccctaca gtttctttaa aactgccctg
     1201 gacgacagga aagagggtgc cgttcttgcc aagaaggtga actggattgg ctgccagggg
     1261 agtgagccgc atttccgggg ctttccctgc tccctgtggg tcctcttcca cttcttgact
     1321 gtgcaggcag ctcggcaaaa tgtagaccac tcacaggaag cagccaaggc caaggaggtc
     1381 ctcccagcca tccgaggcta cgtgcactac ttcttcggct gccgagactg cgctagccac
     1441 ttcgagcaga tggctgctgc ctccatgcac cgggtgggga gtcccaacgc cgctgtcctc
     1501 tggctctggt ctagccacaa cagggtcaat gctcgccttg caggtgcccc cagcgaggac
     1561 ccccagttcc ccaaggtgca gtggccaccc cgtgaacttt gttctgcctg ccacaatgaa
     1621 cgcctggatg tgcccgtgtg ggacgtggaa gccaccctca acttcctcaa ggcccacttc
     1681 tccccaagca acatcatcct ggacttccct gcagctgggt cagctgcccg gagggatgtg
     1741 cagaatgtgg cagccgcccc agagctggcg atgggagccc tggagctgga aagccggaat
     1801 tcaactctgg accctgggaa gcctgagatg atgaagtccc ccacaaacac caccccacat
     1861 gtgccggctg agggacctga ggcaagtcga cccccgaagc tgcaccctgg cctcagagct
     1921 gcaccaggcc aggagcctcc tgagcacatg gcagagcttc agaggaatga gcaggagcag
     1981 ccgcttgggc agtggcactt gagcaagcga gacacagggg ctgcattgct ggctgagtcc
     2041 agggctgaga agaaccgcct ctggggccct ttggaggtca ggcgcgtggg ccgcagctcc
     2101 aagcagctgg tcgacatccc tgagggccag ctggaggccc gagctggacg gggccgaggc
     2161 cagtggctgc aggtgctggg agggggcttc tcttacctgg acatcagcct ctgtgtgggg
     2221 ctctattccc tgtccttcat gggcctgctg gccatgtaca cctacttcca ggccaagata
     2281 agggccctga agggccatgc tggccaccct gcagcctgaa ccacctgggg aggaggcggg
     2341 agagggagct gccatctcta ggcacctcaa gccccctgac cccattccct cccctcccac
     2401 cccttgctcc ttgtctggcc tagaagtgtg ggaaattcag gaaaacgagt tgctccagtg
     2461 aagcttcttg gggttgctag gacagagagc tcctttgaca caaaagacag gagcagggtc
     2521 caggttcccc tgctgtgcag ggagggcagc cccgggcagt gggcataggg cagctcagtc
     2581 cctggcctct tagcaccaca ttcctgtttt tcagcttatt tgaagtcctg cctcattctc
     2641 actggagcct cagtctctcc tgcttggtct tggccctcaa ctggggcaag tgaagccaga
     2701 ggagggtccc ccagctgggt gggctggaat ggaactcctc actagctgct ggggctccgc
     2761 ccaccctgct cccttccgga caatgaagaa gcctttgcac cctgggagga aggaccaccc
     2821 cgggccctct atgcctggcc agcctccagc tcctcagacc tcctgggtgg ggtttggctt
     2881 cagggtgggg tttggaagct tctggaagtc gtgctggtct cccaggtgag gcaagccatg
     2941 gttgctgggc tgtagggtga gtggcttgct tggtgggacc tgacgagttg gtggcatggg
     3001 aaggatgtgg gtctctagtg ccttgccctg gcttagctgc aggagaagat ggctgctttc
     3061 acttcccccc attgagctct gctccctctg agcctggtct tttgtccttt tttattttgg
     3121 tctccaagat gaatgctcat ctttggaggg tgccaggtag aagctaggga ggggagtgtc
     3181 ttctctctcc aggtttcacc ttccagtgtg cagaagttag aagggtctgg cgggggcagt
     3241 gccttacaca tgcttgattc ccacgctacc ccctgccttg ggaggtgtgt ggaataaatt
     3301 atttttgtta aggc
//