LOCUS HSU97276 3314 bp mRNA linear HUM 08-MAR-2001 DEFINITION Homo sapiens quiescin (Q6) mRNA, complete cds, alternatively spliced. ACCESSION U97276 VERSION U97276.2 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3314) AUTHORS Coppock,D.L., Cina-Poppe,D.A. and Gilleran,S. TITLE Quiescin Q6: a new member of an ancient gene family with a potential role in human cancer JOURNAL (in) ? (Ed.); PROC. AMER. ASSOC. CAN. RES. 39: 471; (1998) REFERENCE 2 (bases 1 to 3314) AUTHORS Coppock,D.L., Cina-Poppe,D. and Gilleran,S. TITLE The quiescin Q6 gene (QSCN6) is a fusion of two ancient gene families: thioredoxin and ERV1 JOURNAL Genomics 54 (3), 460-468 (1998) PUBMED 9878249 REFERENCE 3 (bases 1 to 3314) AUTHORS Hoober,K.L., Glynn,N.M., Burnside,J., Coppock,D.L. and Thorpe,C. TITLE Homology between egg white sulfhydryl oxidase and quiescin Q6 defines a new class of flavin-linked sulfhydryl oxidases JOURNAL J. Biol. Chem. 274 (45), 31759-31762 (1999) PUBMED 10542195 REFERENCE 4 (bases 1 to 3314) AUTHORS Coppock,D., Kopman,C., Gudas,J. and Cina-Poppe,D.A. TITLE Regulation of the quiescence-induced genes: quiescin Q6, decorin, and ribosomal protein S29 JOURNAL Biochem. Biophys. Res. Commun. 269 (2), 604-610 (2000) PUBMED 10708601 REFERENCE 5 (bases 1 to 3314) AUTHORS Turi,G.K. TITLE The Distribution and Specificity of Expression of Quiescin Q6 (Q6) in Human Tissues is Associated with Both Endocrine and Non-Endocrine Protein Secretion (Abstract #397) JOURNAL Proc. Annu. Meet. Am. Assoc. Cancer Res. 42 (2001) In press REFERENCE 6 (bases 1 to 3314) AUTHORS Coppock,D.L., Cina,D., Gilleran,S. and Scandalis,S. TITLE Direct Submission JOURNAL Submitted (11-APR-1997) Oncology Research Lab, Winthrop University Hospital, 222 Station Plaza North #300, Mineola, NY 11501, USA REFERENCE 7 (bases 1 to 3314) AUTHORS Coppock,D.L., Cina,D., Gilleran,S. and Scandalis,S. TITLE Direct Submission JOURNAL Submitted (01-APR-1998) Oncology Research Lab, Winthrop University Hospital, 222 Station Plaza North #300, Mineola, NY 11501, USA REMARK Sequence update by submitter REFERENCE 8 (bases 1 to 3314) AUTHORS Coppock,D.L., Kopman,C., Scandalis,S., Gilleran,S. and Singh,S. TITLE Direct Submission JOURNAL Submitted (08-MAR-2001) Oncology Research Lab, Winthrop University Hospital, 222 Station Plaza North #300, Mineola, NY 11501, USA REMARK Sequence update by submitter COMMENT On Mar 8, 2001 this sequence version replaced U97276.1. FEATURES Location/Qualifiers source 1..3314 /db_xref="H-InvDB:HIT000222878" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /cell_line="WI38" /cell_type="fibroblasts" /tissue_type="lung" /dev_stage="embryo" /note="cloned from quiescence specific cDNA library; cDNA used in Coppock,D.L., et al., Cell Growth Differ., 4 (6), 483-493 (1993)" gene 1..3314 /gene="Q6" misc_feature 70..3314 /gene="Q6" /note="expression is induced by reversible growth arrest, trypsinization and serum starvation, and is blocked by SV40 transformation; expressed in heart, placenta, lung, liver, skeletal muscle and pancreas, and in fibroblasts, endothelial cells, breast epithelial cells and melanocytes" CDS 76..2319 /gene="Q6" /note="alternatively spliced; probable sulfhydryl oxidase; thioredoxin superfamily member" /codon_start=1 /product="quiescin" /protein_id="AAC09010.2" /translation="MRRCNSGSGPPPSLLLLLLWLLAVPGANAAPRSALYSPSDPLTL LQADTVRGAVLGSRSAWAVEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCA EETNSAVCRDFNIPGFPTVRFFKAFTKNGSGAVFPVAGADVQTLRERLIDALESHHDT WPPACPPLEPAKLEEIDGFFARNNEEYLALIFEKGGSYLGREVALDLSQHKGVAVRRV LNTEANVVRKFGVTDFPSCYLLFRNGSVSRVPVLMESRSFYTAYLQRLSGLTREAAQT TVAPTTANKIAPTVWKLADRSKIYMADLESALHYILRIEVGRFPVLEGQRLVALKKFV AVLAKYFPGRPLVQNFLHSVNEWLKRQKRNKIPYSFFKTALDDRKEGAVLAKKVNWIG CQGSEPHFRGFPCSLWVLFHFLTVQAARQNVDHSQEAAKAKEVLPAIRGYVHYFFGCR DCASHFEQMAAASMHRVGSPNAAVLWLWSSHNRVNARLAGAPSEDPQFPKVQWPPREL CSACHNERLDVPVWDVEATLNFLKAHFSPSNIILDFPAAGSAARRDVQNVAAAPELAM GALELESRNSTLDPGKPEMMKSPTNTTPHVPAEGPEASRPPKLHPGLRAAPGQEPPEH MAELQRNEQEQPLGQWHLSKRDTGAALLAESRAEKNRLWGPLEVRRVGRSSKQLVDIP EGQLEARAGRGRGQWLQVLGGGFSYLDISLCVGLYSLSFMGLLAMYTYFQAKIRALKG HAGHPAA" variation 510 /gene="Q6" /replace="a" misc_feature 1881 /gene="Q6" /note="cryptic splice donor site" misc_feature 2615 /gene="Q6" /note="cryptic splice acceptor site" BASE COUNT 609 a 987 c 1022 g 696 t ORIGIN 1 ggaggcaggc ggtgccgcgg cgccgggacc cgactcatcc ggtgcttgcg tgtggtggtg 61 agcgcagcgc cgaggatgag gaggtgcaac agcggctccg ggccgccgcc gtcgctgctg 121 ctgctgctgc tgtggctgct cgcggttccc ggcgctaacg cggccccgcg gtcggcgctc 181 tattcgcctt ccgacccgct gacgctgctg caggcggaca cggtgcgcgg cgcggtgctg 241 ggctcccgca gcgcctgggc cgtggagttc ttcgcctcct ggtgcggcca ctgcatcgcc 301 ttcgccccga cgtggaaggc gctggccgaa gacgtcaaag cctggaggcc ggccctgtat 361 ctcgccgccc tggactgtgc tgaggagacc aacagtgcag tctgcagaga cttcaacatc 421 cctggcttcc cgactgtgag gttcttcaag gcctttacca agaacggctc gggagcagta 481 tttccagtgg ctggtgctga cgtgcagacg ctgcgggaga ggctcattga cgccctggag 541 tcccatcatg acacgtggcc cccagcctgt cccccactgg agcctgccaa gctggaggag 601 attgatggat tctttgcgag aaataacgaa gagtacctgg ctctgatctt tgaaaaggga 661 ggctcctacc tgggtagaga ggtggctctg gacctgtccc agcacaaagg cgtggcggtg 721 cgcagggtgc tgaacacaga ggccaatgtg gtgagaaagt ttggtgtcac cgacttcccc 781 tcttgctacc tgctgttccg gaatggctct gtctcccgag tccccgtgct catggaatcc 841 aggtccttct ataccgctta cctgcagaga ctctctgggc tcaccaggga ggctgcccag 901 accacagttg caccaaccac tgctaacaag atagctccca ctgtttggaa attggcagat 961 cgctccaaga tctacatggc tgacctggaa tctgcactgc actacatcct gcggatagaa 1021 gtgggcaggt tcccggtcct ggaagggcag cgcctggtgg ccctgaaaaa gtttgtggca 1081 gtgctggcca agtatttccc tggccggccc ttagtccaga acttcctgca ctccgtgaat 1141 gaatggctca agaggcagaa gagaaataaa attccctaca gtttctttaa aactgccctg 1201 gacgacagga aagagggtgc cgttcttgcc aagaaggtga actggattgg ctgccagggg 1261 agtgagccgc atttccgggg ctttccctgc tccctgtggg tcctcttcca cttcttgact 1321 gtgcaggcag ctcggcaaaa tgtagaccac tcacaggaag cagccaaggc caaggaggtc 1381 ctcccagcca tccgaggcta cgtgcactac ttcttcggct gccgagactg cgctagccac 1441 ttcgagcaga tggctgctgc ctccatgcac cgggtgggga gtcccaacgc cgctgtcctc 1501 tggctctggt ctagccacaa cagggtcaat gctcgccttg caggtgcccc cagcgaggac 1561 ccccagttcc ccaaggtgca gtggccaccc cgtgaacttt gttctgcctg ccacaatgaa 1621 cgcctggatg tgcccgtgtg ggacgtggaa gccaccctca acttcctcaa ggcccacttc 1681 tccccaagca acatcatcct ggacttccct gcagctgggt cagctgcccg gagggatgtg 1741 cagaatgtgg cagccgcccc agagctggcg atgggagccc tggagctgga aagccggaat 1801 tcaactctgg accctgggaa gcctgagatg atgaagtccc ccacaaacac caccccacat 1861 gtgccggctg agggacctga ggcaagtcga cccccgaagc tgcaccctgg cctcagagct 1921 gcaccaggcc aggagcctcc tgagcacatg gcagagcttc agaggaatga gcaggagcag 1981 ccgcttgggc agtggcactt gagcaagcga gacacagggg ctgcattgct ggctgagtcc 2041 agggctgaga agaaccgcct ctggggccct ttggaggtca ggcgcgtggg ccgcagctcc 2101 aagcagctgg tcgacatccc tgagggccag ctggaggccc gagctggacg gggccgaggc 2161 cagtggctgc aggtgctggg agggggcttc tcttacctgg acatcagcct ctgtgtgggg 2221 ctctattccc tgtccttcat gggcctgctg gccatgtaca cctacttcca ggccaagata 2281 agggccctga agggccatgc tggccaccct gcagcctgaa ccacctgggg aggaggcggg 2341 agagggagct gccatctcta ggcacctcaa gccccctgac cccattccct cccctcccac 2401 cccttgctcc ttgtctggcc tagaagtgtg ggaaattcag gaaaacgagt tgctccagtg 2461 aagcttcttg gggttgctag gacagagagc tcctttgaca caaaagacag gagcagggtc 2521 caggttcccc tgctgtgcag ggagggcagc cccgggcagt gggcataggg cagctcagtc 2581 cctggcctct tagcaccaca ttcctgtttt tcagcttatt tgaagtcctg cctcattctc 2641 actggagcct cagtctctcc tgcttggtct tggccctcaa ctggggcaag tgaagccaga 2701 ggagggtccc ccagctgggt gggctggaat ggaactcctc actagctgct ggggctccgc 2761 ccaccctgct cccttccgga caatgaagaa gcctttgcac cctgggagga aggaccaccc 2821 cgggccctct atgcctggcc agcctccagc tcctcagacc tcctgggtgg ggtttggctt 2881 cagggtgggg tttggaagct tctggaagtc gtgctggtct cccaggtgag gcaagccatg 2941 gttgctgggc tgtagggtga gtggcttgct tggtgggacc tgacgagttg gtggcatggg 3001 aaggatgtgg gtctctagtg ccttgccctg gcttagctgc aggagaagat ggctgctttc 3061 acttcccccc attgagctct gctccctctg agcctggtct tttgtccttt tttattttgg 3121 tctccaagat gaatgctcat ctttggaggg tgccaggtag aagctaggga ggggagtgtc 3181 ttctctctcc aggtttcacc ttccagtgtg cagaagttag aagggtctgg cgggggcagt 3241 gccttacaca tgcttgattc ccacgctacc ccctgccttg ggaggtgtgt ggaataaatt 3301 atttttgtta aggc //