LOCUS HSU95825 5253 bp mRNA linear HUM 05-APR-1999
DEFINITION Human androgen-induced prostate proliferative shutoff associated
protein (AS3) mRNA, complete cds.
ACCESSION U95825
VERSION U95825.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5253)
AUTHORS Geck,P., Szelei,J., Jimenez,J., Soto,A.M. and Sonnenschein,C.
TITLE Androgen-induced proliferative shutoff in prostate cancer cells
JOURNAL Proc. Annu. Meet. Am. Assoc. Cancer Res. 37, 223-223 (1996)
REFERENCE 2 (bases 1 to 5253)
AUTHORS Geck,P., Szelei,J., Jimenez,J., Sonnenschein,C. and Soto,A.M.
TITLE Early gene expression during androgen-induced inhibition of
proliferation of prostate cancer cells: a new suppressor candidate
on chromosome 13, in the BRCA2-Rb1 locus
JOURNAL J. Steroid Biochem. Mol. Biol. 68 (1-2), 41-50 (1999)
PUBMED 10215036
REFERENCE 3 (bases 1 to 5253)
AUTHORS Geck,P., Szelei,J., Jimenez,J., Sonnenschein,C. and Soto,A.M.
TITLE Direct Submission
JOURNAL Submitted (28-MAR-1997) Anatomy and Cell Biology, Tufts University
Medical School, 136 Harrison Avenue, Boston, MA 02111, USA
REFERENCE 4 (bases 1 to 5253)
AUTHORS Geck,P., Szelei,J., Jimenez,J., Sonnenschein,C. and Soto,A.M.
TITLE Direct Submission
JOURNAL Submitted (05-APR-1999) Anatomy and Cell Biology, Tufts University
Medical School, 136 Harrison Avenue, Boston, MA 02111, USA
REMARK Sequence update by submitter
COMMENT On Apr 5, 1999 this sequence version replaced U95825.1.
FEATURES Location/Qualifiers
source 1..5253
/db_xref="H-InvDB:HIT000222793"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="13"
/map="13q12-q13"
/cell_line="LNCaP"
/cell_type="cancer cells"
/tissue_type="prostate"
/note="exon 1 maps to P1 Artificial Chromosome PAC26H23;
exons 2-24 map to cosmid 267p19; exons 25-34 map to P1
Artificial Chromosome PAC 49J10"
gene 1..5253
/gene="AS3"
exon 1..46
/gene="AS3"
/number=1
exon 47..173
/gene="AS3"
/number=2
CDS 66..4241
/gene="AS3"
/codon_start=1
/product="androgen-induced prostate proliferative shutoff
associated protein"
/protein_id="AAD22134.2"
/translation="MAHSKTRTNDGKITYPPGVKEISDKISKEEMVRRLKMVVKTFMD
MDQDSEEEKELYLNLALHLASDFFLKHPDKDVRLLVACCLADIFRIYAPEAPYTSPDK
LKDIFMFITRQLKGLEDTKSPQFNRYFYLLENIAWVKSYNICFELEDSNEIFTQLYRT
LFSVINNGHNQKVHMHMVDLMSSIICEGDTVSQELLDTVLVNLVPAHKNLNKQAYDLA
KALLKRTAQAIEPYITNFFNQVLMLGKTSISDLSEHVSDLILELYNIDSHLLLSVLPQ
LEFKLKSNDNEERLQVVKLLAKMFGAKDSELASQNKPLWQCYLGRFNDIHVPIRLECV
KFASHCLMNHPDLAKDLTEYLKVRSHDPEEAIRHDVIVSIVTAAKKDILLVNDHLLNF
VGERTLDKRWRVRKEAMMGLAQIYKKYALQSAAGKDAAKQIAWIKDKLLHIYYQNSID
DRLLVERIFAQYMVPHNLETTERMKCLYYLYATLDLNAVKALNEMWKCQNLLRHQVKD
LLDLIKQPKTDASVKAIFSKVMVITRSLPDPGKAQDFMKKFTQVLEDDEKIRKQLEVL
VSPTCSCKQAEGCVREITKKLGNPKQPTNPFLEMIKFLLERIAPVHIDTESISALIKQ
VNKSIDGTADDEDEGVPTDQAIRAGLELLKVLSFTHPISFHSAETFESLLACLKMDDE
KVAEAALQIFKNTGSKIEEDFPHIRSALLPVLHHKSKKGPPRQAKYAIHCIHAIFSSK
EAQFAQIFEPLHKSLDPSNLEHLITPLVTIGHIALLAPDQFAAPLKSLVATFIVKDLL
MNDRLPGKKTTKLWVPDEEVSPETMVKIQAIKMMVRWLLGMKNNHSKSGTSTLRLLTT
ILHSDGDLTEQGKISKPDMSRLRLAAGSAIVKLAQEPCYHEIITLEQYQLCALAINDE
CYQVRQVFAQKLHKGLSRLRLPLEYMAICALCAKDPVKERRAHARQCLVKNINVRREY
LKQHAAVSEKLLSLLPEYVVPYTIHLLAHDPDYVKVQDIEQLKDVKECLWFVLEILMA
KNENNSHAFIRKMVENIKQTKDAQGPDDAKMNEKLYTVCDVAMNIIMSKSTTYSLESP
KDPVLPARFFTQPDKNFSNTKNYLPPGMKSFFTPGKPKTTNVLGAVNKPLSSAGKQSQ
TKSSRMETVGNASSSSNPSSPGRIKGRLDSSEMDHSENEDYTMSSPLPGKRSDKRDDS
DLVRSELEKPRGRKKTPVTEREEKLGMDDLTKLVQEQRPKGSQRSRKRGHTASESDEQ
QWPEEKRLKEDILENEDEQNSPPKKGKRGRPPKPLGGGTPKEEPTMKTSKKGSKKKSG
PPAPEEEEEEERQSGNTEQKSKSKQHRVSRRAQQRAESSESSAIESTQSTPQKGRGRP
SKTPSPSQPKKNV"
exon 174..377
/gene="AS3"
/number=3
exon 378..464
/gene="AS3"
/number=4
exon 465..562
/gene="AS3"
/number=5
exon 563..689
/gene="AS3"
/number=6
exon 690..770
/gene="AS3"
/number=7
exon 771..911
/gene="AS3"
/number=8
exon 912..1027
/gene="AS3"
/number=9
exon 1028..1122
/gene="AS3"
/number=10
exon 1123..1268
/gene="AS3"
/number=11
exon 1269..1420
/gene="AS3"
/number=12
exon 1421..1534
/gene="AS3"
/number=13
exon 1535..1616
/gene="AS3"
/number=14
exon 1617..1665
/gene="AS3"
/number=15
exon 1666..1805
/gene="AS3"
/number=16
exon 1806..1921
/gene="AS3"
/number=17
exon 1922..2027
/gene="AS3"
/number=18
exon 2028..2188
/gene="AS3"
/number=19
exon 2189..2312
/gene="AS3"
/number=20
exon 2313..2471
/gene="AS3"
/number=21
exon 2472..2540
/gene="AS3"
/number=22
exon 2541..2677
/gene="AS3"
/number=23
exon 2678..2801
/gene="AS3"
/number=24
exon 2802..3006
/gene="AS3"
/number=25
exon 3007..3121
/gene="AS3"
/number=26
exon 3122..3254
/gene="AS3"
/number=27
exon 3255..3374
/gene="AS3"
/number=28
exon 3375..3437
/gene="AS3"
/number=29
exon 3438..3583
/gene="AS3"
/number=30
exon 3584..3689
/gene="AS3"
/number=31
exon 3690..4129
/gene="AS3"
/number=32
exon 4130..4354
/gene="AS3"
/number=33
exon 4355..4810
/gene="AS3"
/number=34
BASE COUNT 1755 a 944 c 1074 g 1480 t
ORIGIN
1 ccggagagcc ccggagtgag cggagtagcg agtcggcaac ccggaggggt agaaatattt
61 ctgtcatggc tcattcaaag actaggacca atgatggaaa aattacatat ccgcctgggg
121 tcaaggaaat atcagataaa atatctaaag aggagatggt gagacgatta aagatggttg
181 tgaaaacttt tatggatatg gaccaggact ctgaagaaga aaaggagctt tatttaaacc
241 tagctttaca tcttgcttca gatttttttc tcaagcatcc tgataaagat gttcgcttac
301 tggtagcctg ctgccttgct gatattttca ggatttatgc tcctgaagct ccttacacat
361 cccctgataa actaaaggat atatttatgt ttataacaag acagttgaag gggctagagg
421 atacaaagag cccacagttc aataggtatt tttatttgct tgagaacatt gcttgggtca
481 agtcatataa catatgcttt gagttagaag atagcaatga aattttcacc cagctataca
541 gaaccttatt ttcagttata aacaatggcc acaatcagaa agtccatatg cacatggtag
601 accttatgag ctctattatt tgtgaaggtg atacagtgtc tcaggagctt ttggatacgg
661 ttttagtaaa tctggtacct gctcataaga atttaaacaa gcaagcatat gatttggcaa
721 aggctttact gaagaggaca gctcaagcta ttgagccata tattaccaat ttttttaatc
781 aggttctgat gcttgggaaa acatctatca gcgatttgtc agagcatgtc tctgacttaa
841 ttttggagct ctacaatatt gatagtcatt tgctgctctc tgttttaccc cagcttgaat
901 ttaaattaaa gagcaatgat aatgaggagc gcctacaagt tgttaaacta ctggcgaaaa
961 tgtttggggc aaaggattca gaattggctt ctcaaaacaa gccactttgg cagtgctact
1021 tgggcaggtt taatgatatc catgtaccaa tccgcctgga atgtgtgaaa tttgctagcc
1081 attgtctcat gaaccatcct gatttagcaa aagacttaac agagtatctt aaagtgaggt
1141 cacatgaccc tgaggaagct attagacatg atgttattgt gtcaatagtt acagctgcta
1201 aaaaggatat tcttctggtc aatgatcact tacttaattt tgtgggagag agaacattag
1261 acaaacgatg gagagtacgc aaagaagcca tgatgggact tgcccaaatt tataagaaat
1321 atgctttaca gtcagcagct ggaaaagatg ctgcaaaaca gatagcatgg atcaaagaca
1381 aattgctaca tatatattat caaaatagta ttgatgatcg actacttgtt gaacggatct
1441 ttgctcaata catggttcct cacaatttag aaactacaga acggatgaaa tgcttatatt
1501 acttgtatgc cacactggat ttaaatgctg tgaaagcatt gaatgaaatg tggaaatgtc
1561 aaaatctgct ccgacatcaa gtaaaggatt tgcttgactt gattaagcaa cccaaaacag
1621 atgccagtgt caaggccata ttttcaaaag tgatggttat tacaagaagt ttacctgatc
1681 ctggtaaggc tcaggatttc atgaagaaat tcacacaggt gttagaagat gatgagaaaa
1741 taagaaagca gttagaagta cttgttagtc caacatgctc ctgcaagcag gctgaaggtt
1801 gtgtgcgtga aataactaag aagttgggca accccaaaca gcctacaaat cctttcctgg
1861 aaatgatcaa gtttctcttg gagaggatag cacctgtgca catagatacc gaatctatca
1921 gtgctcttat taaacaagtg aacaaatcaa tagatggaac agcagatgat gaagatgagg
1981 gtgttccaac tgatcaagcc atcagagcag gtcttgaact gcttaaggta ctctcattta
2041 cacatcccat ctcatttcat tctgctgaaa catttgaatc attactggcc tgtctgaaaa
2101 tggatgatga aaaagtagca gaagctgcac tacaaatttt caaaaacaca ggaagcaaaa
2161 ttgaagagga ttttccacac atcagatcag ccttgcttcc tgttttacat cacaaatcta
2221 aaaaaggacc cccccgtcaa gccaaatatg ccattcattg tatccatgcg atattttcta
2281 gtaaagaggc ccagtttgca cagatatttg agcctctgca taagagccta gatccaagca
2341 acctggaaca tctcataaca ccattggtta ctattggtca tattgctctc cttgcacctg
2401 atcaatttgc tgctcctttg aaatctttgg tagctacttt cattgtgaaa gatcttctca
2461 tgaatgatcg gcttccaggg aaaaagacaa ctaaactttg ggttccagat gaagaagtat
2521 ctcctgagac aatggtcaaa attcaggcta ttaaaatgat ggttcgatgg ctacttggaa
2581 tgaaaaataa tcacagtaaa tcaggaactt ctaccttaag attgctaaca acaatattgc
2641 atagtgatgg agacttgaca gaacagggga aaattagtaa accagatatg tcacgtctga
2701 gacttgctgc tgggagtgct attgtgaagc tggcacaaga accctgttac catgaaatca
2761 tcacattaga acaatatcag ctatgtgcat tagctatcaa cgatgaatgc tatcaagtaa
2821 gacaagtgtt tgcccagaaa cttcacaaag gcctttcccg tttacggctt ccacttgagt
2881 atatggcaat ctgtgccctt tgtgcaaaag atcctgtaaa ggagagaaga gctcatgcta
2941 ggcaatgttt ggtgaaaaat ataaatgtaa ggcgggagta tctgaagcag catgcagctg
3001 ttagtgaaaa attattgtct cttctaccag agtatgttgt tccatataca attcaccttt
3061 tggcacatga cccagattat gtcaaagtac aggatattga acaacttaaa gatgttaaag
3121 aatgtctttg gtttgttctg gaaatattaa tggctaaaaa tgaaaataac agtcacgctt
3181 ttatcagaaa gatggtagaa aatattaagc aaacaaaaga tgcccaagga ccagatgatg
3241 caaaaatgaa tgaaaaactg tacactgtgt gtgatgttgc catgaatatc atcatgtcaa
3301 agagtactac atacagtttg gaatctccta aagacccggt actaccagct cgtttcttca
3361 ctcaacctga caagaatttc agtaacacca aaaattatct gcctcctgga atgaaatcat
3421 ttttcactcc tggaaaacct aaaacaacca atgttctagg agctgttaac aagccacttt
3481 catcagcagg caagcaatct cagaccaaat catcacgaat ggaaactgta ggcaatgcaa
3541 gcagcagctc aaatccaagc tctcctggaa gaataaaggg gaggcttgat agttctgaaa
3601 tggatcacag tgaaaatgaa gattacacaa tgtcttcacc tttgccgggg aaaagaagtg
3661 acaagagaga cgactctgat cttgtaaggt ctgaattgga gaagcctaga ggcagaaaaa
3721 aaacgcccgt cacagaacgg gaggagaaat taggtatgga tgacttgact aagttggtac
3781 aggaacagag acctaaaggc agtcagcgaa gtcggaaaag aggccatacg gcttcagaat
3841 ctgatgaaca gcagtggcct gaggaaaaga ggctcaaaga agatatatta gaaaatgaag
3901 atgaacagaa tagtccgcca aaaaagggta aaagaggccg accaccaaaa cctcttggtg
3961 gaggtacacc aaaagaagag ccaacaatga aaacttctaa aaaaggaagc aaaaaaaaat
4021 ctggacctcc agcaccagag gaggaggaag aagaagaaag acaaagtgga aatacggaac
4081 agaagtccaa aagcaaacag caccgagtgt caaggagagc acagcagaga gcagaatctt
4141 ctgaatctag tgcaattgaa tccacacagt ccacaccaca gaaaggacga ggaagaccat
4201 caaaaacgcc atcaccatca caaccaaaaa aaaatgtgta agttgtaaat attacatttc
4261 aaaccaattt caaattattt tgcaaaagtt cctaaatttg taaacataca tattgctgta
4321 tttaaattcc atatatttag ccccattaca ctaggtacgg cggcgaagtg ctaaaaggga
4381 acggcgatga acaaatgtaa ttaataactt tctctgtgaa agctttggaa aaatcttttt
4441 tttttttttt tttttttggt caagcttgag gctgaataaa gcctttgatg cacaaaatgg
4501 gactgctgaa gagtggacag ttggacctta ctttggtgac cccatacatt tgtggtcaca
4561 tgctttagcc atacacatgg taacattgac tatggagtct tgtgaaagtg taatgtgcga
4621 tggctatgta gacataaaga agaaacttgt aaatatcttt tttctttttt ttaatgtttc
4681 tgatttctga agtgcttgta tagcttttat ctgcggcttt aaactgacag tacccgactg
4741 tttattggat ctattgattt gaaaagaatt tgttaggata gatcttaagc agtaatctgt
4801 cagtgtttgt atttgtattt tctgcaattt tactgtgaaa aaaaatttgt tttcaacaat
4861 tggtgtcatt ttcttgatgt cactatttgt tggagagtta aatggtctct tccctttgtg
4921 tatcttacct agtgtttact cctgggcacc cttaatcttc agaggtgcta aattgtctgc
4981 cattacacca gaaggatgcc tctgatagga ggacaaccat gcaaattgtg aaatagtcct
5041 gaagttcttg gattacttta cacctcagta ttgatttgtc ccagaatttt ctggcctttc
5101 atggcaatga aaattttaag aagaaagatt taaagtattt taattttaaa gagtgtgtta
5161 taaaataatg tactgaattc tttatcccat tttatcatcc tttcagtttt tattaatcta
5221 ctgtatcaat aaaattctgt aatttgaatg agt
//