LOCUS HSU94780 3676 bp mRNA linear HUM 20-NOV-1997
DEFINITION Human meningioma-expressed antigen 6 (MEA6) mRNA, complete cds.
ACCESSION U94780
VERSION U94780.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3676)
AUTHORS Heckel,D., Brass,N., Fischer,U., Blin,N., Steudel,I., Tureci,O.,
Fackler,O., Zang,K.D. and Meese,E.
TITLE cDNA cloning and chromosomal mapping of a predicted coiled-coil
proline-rich protein immunogenic in meningioma patients
JOURNAL Hum. Mol. Genet. 6 (12), 2031-2041 (1997)
PUBMED 9356211
REFERENCE 2 (bases 1 to 3676)
AUTHORS Heckel,D., Brass,N. and Meese,E.U.
TITLE Direct Submission
JOURNAL Submitted (20-MAR-1997) Inst. for Human Genetics, University of
Saarland; Medical School, Oskar-Orth-Strasse, Homburg, Saarland
66421, Germany
FEATURES Location/Qualifiers
source 1..3676
/db_xref="H-InvDB:HIT000222735"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="meningioma"
/note="PCR and in-situ hybridization mapping locate the
gene to chromosomes 2,3,6,7,9,13,14"
gene 1..3676
/gene="MEA6"
CDS 315..2729
/gene="MEA6"
/note="meningioma-expressed antigen 6; this sequence is
similar to MEA11, GenBank Accession Number U73682, but is
longer; it may be an alternate splice variant or it may be
from a separate gene"
/codon_start=1
/product="MEA6"
/protein_id="AAB86593.1"
/translation="MEEPGATPQPYLGLLLEELRRVVAALPEGMRPDSNLYGFPWELV
ICAAVVGFFAVLFFLWRSFRSVRSRLYVGREKKLALMLSGLIEEKSKLLEKFSLVQKE
YEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCLEKELKEEKSKHS
EQDELMADISKRIQSLEDESKSLKSQVAEAKMTFQIFPMNEERLKIAIKDALNENSQL
QESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTERLLKMKD
WAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTLEGERN
QIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELYQEN
EMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSYQ
GQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEKDPYALDVP
NTAFGREHSPYGPSPLGWPSSETRAFLSPPTLLEGPLTLSPLLPGGGGRGSRGPGNPL
DHQITNERGESSCDRLTDPHRALSDTGFLSPPWDQDRRMMFPPPGQSYPDSALPPQRQ
DRFCSNSGRLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDDLGNLNVPDSSLPA
ENEATGPGFVPPPLAPVRGPLFPVDARGPFLRRGPPFPPPPPGAMFGASRDYFPPGDF
PGPPPAPFAMRNVYPPRGFPPYLPPRPGFFPPPPHSEGRSEFPSGLIPPSNEPATEHP
EPQQET"
misc_feature 1854..1982
/gene="MEA6"
/note="possible alternatively spliced exon"
regulatory 3135..3140
/regulatory_class="polyA_signal_sequence"
/gene="MEA6"
/note="first polyA_signal"
regulatory 3640..3645
/regulatory_class="polyA_signal_sequence"
/gene="MEA6"
/note="second polyA_signal"
BASE COUNT 1148 a 689 c 794 g 1045 t
ORIGIN
1 tgcccggcgg aaaccaaacc gagggatggg gtggcgagga cagggtacgt cgcaggcttg
61 tgcgggtcgg gttcggacct gcgctgcctc gggatgtaaa gtataacaag agggtcggga
121 tgggcagcgt aggcctgtga ggcctgcggg tgcccctgtc ccccagctcc ccccgcagcc
181 ggctccgcag tggtccactc cggttgccgg gtgcggattc gggttccgga ccgaaggctg
241 tgtgttctcc gccgttcatt gtggccccga caggccgggg ttactgtggc gaccacgaga
301 gcagctttgg cgctatggag gagcccgggg ctacccctca accgtatttg gggctgctcc
361 tggaggagct acgcagggtt gtggcagcac tgcctgaagg tatgagacca gattctaatc
421 tttatggttt tccatgggaa ttggtgatat gtgcagctgt tgttggattt tttgctgttc
481 tctttttttt gtggagaagt tttagatcgg ttaggagtcg gctttatgtg ggacgagaga
541 aaaagcttgc tctaatgctt tctggactaa ttgaagaaaa aagtaaacta cttgaaaaat
601 ttagccttgt tcaaaaagag tatgaaggct atgaagtaga gtcatcttta aaggatgcca
661 gctttgagaa ggaggcaaca gaagcacaaa gtttggaggc aacctgtgaa aagctgaaca
721 ggtccaattc tgaacttgag gatgaaatac tctgtctaga aaaagagtta aaagaagaga
781 aatccaaaca ttctgaacaa gatgaattga tggcggatat ttcaaaaagg atacagtctc
841 tagaagatga gtcaaaatcc ctcaaatcac aagtagctga agccaaaatg accttccaga
901 tatttccaat gaatgaagaa cgactgaaga tagcaataaa agatgctttg aatgaaaatt
961 ctcaacttca ggaaagccag aaacagcttt tgcaagaagc tgaagtatgg aaagaacaag
1021 tgagtgaact taataaacag aaagtaacat ttgaagactc caaagtacat gcagaacaag
1081 ttctaaatga taaagaaagt cacatcaaga ctctgactga acgcttgtta aagatgaaag
1141 attgggctgc tatgcttgga gaagacataa cggatgatga taacttggaa ttagaaatga
1201 acagtgaatc ggaaaatggt gcttacttag ataatcctcc aaaaggagct ttgaagaaac
1261 tgattcatgc tgctaagtta aatgcttctt taaaaacctt agaaggagaa agaaaccaaa
1321 tttatattca gttgtctgaa gttgataaaa caaaggaaga gcttacagag catattaaaa
1381 atcttcagac tgaacaagca tctttgcagt cagaaaacac acattttgaa aatgagaatc
1441 agaagcttca acagaaactt aaagtaatga ctgaattata tcaagaaaat gaaatgaaac
1501 tccacaggaa attaacagta gaggaaaatt atcggttaga gaaagaagag aaactttcta
1561 aagtagatga aaagatcagc catgccactg aagagctgga gacctataga aagcgagcca
1621 aagatcttga agaagaattg gagagaacta ttcattctta tcaagggcag attatttccc
1681 atgagaaaaa agcacatgat aattggttgg cagctcggaa tgctgaaaga aacctcaatg
1741 atttaaggaa agaaaatgct cacaacagac aaaaattaac tgaaacagag cttaaatttg
1801 aacttttaga aaaagatcct tatgcactcg atgttccaaa tacagcattt ggcagagagc
1861 attccccata tggtccctca ccattgggtt ggccttcatc tgaaacaaga gcttttctct
1921 ctcctccaac tttgttggag ggtccactca cactctcacc tttgcttcca gggggaggag
1981 gaagaggctc acgaggccca gggaatcctt tggaccatca gattaccaat gaaagaggag
2041 aatcaagctg tgataggtta accgatcctc atagggctct ctctgacact gggtttctgt
2101 cacctccatg ggaccaggac cgtaggatga tgtttcctcc gccaggacaa tcatatcctg
2161 attcagccct tcctccacaa aggcaagaca gattttgttc taattctggt agactgtctg
2221 gaccagcaga actcagaagt tttaatatgc cttctttgga taaaatggat gggtcaatgc
2281 cttcagaaat ggaatccagt agaaatgata ccaaagatga tcttggtaat ttaaatgtgc
2341 ctgattcatc tctccctgct gaaaatgaag ccactggccc tggctttgtt cctccacctc
2401 ttgctccagt cagaggtcca ttgtttccag tggatgcaag aggcccattc ttgagaagag
2461 gacctccttt ccccccacct cctccaggag ccatgtttgg agcttctcga gattattttc
2521 caccagggga tttcccaggt ccaccacctg ctccatttgc aatgagaaat gtctatccac
2581 cgaggggttt tcctccttac cttcccccaa gacctggatt tttcccccca cccccacatt
2641 ctgaaggtag aagtgagttc ccctcaggtt tgattccacc ttcaaatgag cctgctactg
2701 aacatccaga accacagcaa gaaacctgac aatatttttg ctctcttcaa aagtaatttt
2761 gactgatctc attttcagtt taagtaactg ctgttactta agtgattaca cttttgctca
2821 aattgaagct taatggaatt ataattctca ggatagtatt ttgtaaataa agatgattta
2881 aatatgaatc ttatgagtaa attatttcaa ttttatttta gacggtataa ctatttcaat
2941 ttgattaatc cactattata taaacaatag tgggagtttt atatatgtaa tcttgcaggt
3001 ggggaggctt taaattctga agtctgtgtc tttatgccaa gaactgtatt tactgtggtt
3061 gtggacaaat gtgaaagtaa ctttatgctt aaataaatta tagttgattt aaagatttgt
3121 ttggcattga taataataaa atcagtagtt tttctataac tatggctcta ttaattaact
3181 tttttccttt taccaataac tttgaggtgc aaaactcaaa cttatgtggg tcttttgtgt
3241 tcaattatgt tatgacaaat gtgctctctt tcttgtaaat agacatgagt ggcccaaagc
3301 aacaaattaa tacactttta aaagtcaaaa ttgattatat tttaaagata accaggatat
3361 tatctaatgg tgaattgtag aattttgatc ttcttattca ctgagtttct tgcacggttt
3421 ctttattgct ttttttcccg cctgttcttt tgtaaggtat ttactatttt ctgtggagga
3481 tattgagatg tactacagga taactgtagt gaatgatgtg tcatcatttt gagctttgga
3541 ctcaatatct ttagtgtttc cctaaatcag atttgtaggt catgttaagc ttcttgcaca
3601 ttaatatgat tatggaagga aaggcagtga agcataacta ataaacatca taatacttaa
3661 aaaaaaaaaa aaaaaa
//