LOCUS       HSU94332                1356 bp    mRNA    linear   HUM 05-MAY-1997
DEFINITION  Human osteoprotegerin (OPG) mRNA, complete cds.
ACCESSION   U94332
VERSION     U94332.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1356)
  AUTHORS   Simonet,W.S., Lacey,D.L., Dunstan,C.R., Kelley,M., Chang,M.S.,
            Luthy,R., Nguyen,H.Q., Wooden,S., Bennett,L., Boone,T.,
            Shimamoto,G., DeRose,M., Elliott,R., Colombero,A., Tan,H.L.,
            Trail,G., Sullivan,J., Davy,E., Bucay,N., Renshaw-Gegg,L.,
            Hughes,T.M., Hill,D., Pattison,W., Campbell,P., Sander,S., Van,G.,
            Tarpley,J., Derby,P., Lee,R., Amgen EST Program and Boyle,W.J.
  TITLE     Osteoprotegerin: a novel secreted protein involved in the
            regulation of bone density
  JOURNAL   Cell 89 (2), 309-319 (1997)
   PUBMED   9108485
REFERENCE   2  (bases 1 to 1356)
  AUTHORS   Boyle,W.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-MAR-1997) Department of Cell Biology, Amgen, Inc.,
            1840 Dehavilland Drive, Thousand Oaks, CA 91320, USA
FEATURES             Location/Qualifiers
     source          1..1356
                     /db_xref="H-InvDB:HIT000222688"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     gene            1..1356
                     /gene="OPG"
     CDS             95..1300
                     /gene="OPG"
                     /codon_start=1
                     /product="osteoprotegerin"
                     /protein_id="AAB53709.1"
                     /translation="MNKLLCCALVFLDISIKWTTQETFPPKYLHYDEETSHQLLCDKC
                     PPGTYLKQHCTAKWKTVCAPCPDHYYTDSWHTSDECLYCSPVCKELQYVKQECNRTHN
                     RVCECKEGRYLEIEFCLKHRSCPPGFGVVQAGTPERNTVCKRCPDGFFSNETSSKAPC
                     RKHTNCSVFGLLLTQKGNATHDNICSGNSESTQKCGIDVTLCEEAFFRFAVPTKFTPN
                     WLSVLVDNLPGTKVNAESVERIKRQHSSQEQTFQLLKLWKHQNKAQDIVKKIIQDIDL
                     CENSVQRHIGHANLTFEQLRSLMESLPGKKVGAEDIEKTIKACKPSDQILKLLSLWRI
                     KNGDQDTLKGLMHALKHSKTYHFPKTVTQSLKKTIRFLHSFTMYKLYQKLFLEMIGNQ
                     VQSVKISCL"
BASE COUNT          421 a          326 c          314 g          294 t
ORIGIN      
        1 gtatatataa cgtgatgagc gtacgggtgc ggagacgcac cggagcgctc gcccagccgc
       61 cgyctccaag cccctgaggt ttccggggac cacaatgaac aagttgctgt gctgcgcgct
      121 cgtgtttctg gacatctcca ttaagtggac cacccaggaa acgtttcctc caaagtacct
      181 tcattatgac gaagaaacct ctcatcagct gttgtgtgac aaatgtcctc ctggtaccta
      241 cctaaaacaa cactgtacag caaagtggaa gaccgtgtgc gccccttgcc ctgaccacta
      301 ctacacagac agctggcaca ccagtgacga gtgtctatac tgcagccccg tgtgcaagga
      361 gctgcagtac gtcaagcagg agtgcaatcg cacccacaac cgcgtgtgcg aatgcaagga
      421 agggcgctac cttgagatag agttctgctt gaaacatagg agctgccctc ctggatttgg
      481 agtggtgcaa gctggaaccc cagagcgaaa tacagtttgc aaaagatgtc cagatgggtt
      541 cttctcaaat gagacgtcat ctaaagcacc ctgtagaaaa cacacaaatt gcagtgtctt
      601 tggtctcctg ctaactcaga aaggaaatgc aacacacgac aacatatgtt ccggaaacag
      661 tgaatcaact caaaaatgtg gaatagatgt taccctgtgt gaggaggcat tcttcaggtt
      721 tgctgttcct acaaagttta cgcctaactg gcttagtgtc ttggtagaca atttgcctgg
      781 caccaaagta aacgcagaga gtgtagagag gataaaacgg caacacagct cacaagaaca
      841 gactttccag ctgctgaagt tatggaaaca tcaaaacaaa gcccaagata tagtcaagaa
      901 gatcatccaa gatattgacc tctgtgaaaa cagcgtgcag cggcacattg gacatgctaa
      961 cctcaccttc gagcagcttc gtagcttgat ggaaagctta ccgggaaaga aagtgggagc
     1021 agaagacatt gaaaaaacaa taaaggcatg caaacccagt gaccagatcc tgaagctgct
     1081 cagtttgtgg cgaataaaaa atggcgacca agacaccttg aagggcctaa tgcacgcact
     1141 aaagcactca aagacgtacc actttcccaa aactgtcact cagagtctaa agaagaccat
     1201 caggttcctt cacagcttca caatgtacaa attgtatcag aagttatttt tagaaatgat
     1261 aggtaaccag gtccaatcag taaaaataag ctgcttataa ctggaaatgg ccattgagct
     1321 gtttcctcac aattggcgag atcccatgga tgataa
//