LOCUS U94190 6469 bp mRNA linear HUM 04-MAY-1998
DEFINITION Homo sapiens Duo mRNA, complete cds.
ACCESSION U94190
VERSION U94190.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6469)
AUTHORS Colomer,V., Engelender,S., Sharp,A.H., Duan,K., Cooper,J.K.,
Lanahan,A., Lyford,G., Worley,P. and Ross,C.A.
TITLE Huntingtin-associated protein 1 (HAP1) binds to a Trio-like
polypeptide, with a rac1 guanine nucleotide exchange factor domain
JOURNAL Hum. Mol. Genet. 6 (9), 1519-1525 (1997)
PUBMED 9285789
REFERENCE 2 (bases 1 to 6469)
AUTHORS Engelender,S. and Colomer,V.
TITLE Direct Submission
JOURNAL Submitted (18-MAR-1997) Psychiatry, JHU, 720 Rutland Avenue,
Baltimore, MD 21205-2196, USA
FEATURES Location/Qualifiers
source 1..6469
/db_xref="H-InvDB:HIT000222684"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="frontal cortex"
CDS 101..5092
/note="encodes spectrin-like domain, coiled coil,
guanosine exchange factor domain and pleckstrin homology
domain"
/codon_start=1
/product="Duo"
/protein_id="AAC15791.1"
/translation="MTDRFWDQWYLWYLRLLRLLDRGSFRNDGLKASDVLPILKEKVA
FVSGGRDKRGGPILTFPARSNHDRIRQEDLRKLVTYLASVPSEDVCKRGFTVIIDMRG
SKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNFGSSKFIFETSMVSVEGLT
KLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPV
DVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQS
LVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFL
QSHTEIGVSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQI
STQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDL
ELAIHHHQTLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQVL
DVVHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGV
GKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEV
RIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELIKQ
FQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHI
ESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMND
FNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYITEVQASGIELICEKDID
LAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLN
ASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQAGHY
DADAIRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYRRDE
DWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYIHRNNVSMP
SVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAKQALDWI
QETGEFYLSTHTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGHI
HATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKALGVNTEDNKDLELDIIPASLSDREV
KLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPP
GILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKN
KPDSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGK
GELKDGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGR
ERHLFLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTP
SSDNKTVLKASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRD
GVEDIDSQGDGSSQPDTISIASRTSQNTVDSDKDGNLVPRWHLGPGDPFSTYV"
BASE COUNT 1681 a 1656 c 1728 g 1404 t
ORIGIN
1 tgcgagccca gcgtcaagtg attccggcct cctcgagaca gcggtggtgg gatgaggctc
61 tgccgagggg actggctgtg aaggatgagt tcagggtggg atgacggacc gcttctggga
121 ccagtggtat ctctggtatc tccgcttgct ccggctgctg gatcgagggt cttttcggaa
181 tgatggtttg aaagcttctg atgtccttcc tatcctaaag gaaaaggtgg ccttcgtgtc
241 tgggggtcgt gataagcgag gcggacccat cctgaccttc cctgctcgca gcaatcatga
301 cagaataaga caggaagacc tgcggaaact cgtgacgtat ttggccagcg tgccaagtga
361 ggacgtgtgc aaacgtggct tcactgtcat catcgacatg cggggctcca agtgggacct
421 catcaagccc ctcctcaaaa cgctgcagga agcctttcca gctgagatcc atgtggccct
481 catcattaaa cccgacaact tctggcagaa acagaagacc aactttggca gctccaaatt
541 catctttgag acgagcatgg tatctgtgga gggcctcaca aagctggtgg acccctccca
601 gctgacggag gagtttgatg gctccctgga ctacaaccat gaggagtgga tcgaactgcg
661 gctctccctg gaggagttct tcaacagcgc cgtgcacctg ctctcgcgcc tcgaggacct
721 ccaggagatg ctagcccgga aggagtttcc tgtggatgtg gagggctctc ggcggctcat
781 tgacgaacac acacagctca agaaaaaggt gctgaaggcc cctgtggagg agctggaccg
841 ggaggggcag cggctgctgc agtgcatccg ctgcagcgac ggcttctcag gacgcaactg
901 catcccgggc agtgctgact tccagagcct ggtgcccaag atcaccagtc tcctggacaa
961 gctgcactcc acccggcagc acctgcacca gatgtggcac gtgcgcaagc tcaagctgga
1021 ccagtgcttt cagctgcggc tcttcgagca ggatgctgag aagatgtttg actggataag
1081 ccacaacaag gagttattcc tccagagcca cacggagatc ggagtcagct accagtacgc
1141 ccttgacctc cagacgcagc acaatcactt tgccatgaac tccatgaatg cctatgtcaa
1201 catcaaccgc atcatgtccg tggcttcccg cctctctgag gccggtcatt atgcctcaca
1261 acaaatcaag cagatctcca cccagctgga ccaggagtgg aagagctttg ctgctgccct
1321 ggatgaacgc agcaccatcc tcgccatgtc tgctgtgttc caccagaagg ctgagcagtt
1381 cctgtcggga gtggatgcct ggtgcaagat gtgcagtgaa ggtggtctgc catccgagat
1441 gcaagaccta gagctggcaa tccaccacca ccagaccttg tatgagcagg tgacccaagc
1501 ctacacagag gtcagccagg atggcaaagc actacttgat gtgctgcagc ggcccctgag
1561 ccctgggaac tccgaatccc tcacggccac agccaactac tccaaggcag tgcaccaggt
1621 gctggacgtg gtgcatgagg tgttacatca ccagcgacgg ctggagagca tctggcagca
1681 ccgcaaggtg cggctccacc agcggctgca gctctgcgtc ttccagcagg atgtacagca
1741 ggtgttggac tggattgaaa accatggtga ggcctttctc agcaaacaca ctggagttgg
1801 gaagtcccta catcgagccc gggccctgca gaagaggcat gatgactttg aagaggtggc
1861 tcagaatacg tacaccaatg cggacaagct cctagaagca gcagagcagt tggctcagac
1921 gggggaatgt gaccccgagg agatctacaa ggcagctcga cacctggagg tgcgcatcca
1981 agacttcgtg cgcagggtgg agcagcggaa gcttctcctg gacatgtctg tttccttcca
2041 cacacacacc aaagagttgt ggacatggat ggaagacctt cagaaggaga tgttggagga
2101 tgtctgtgca gattctgtgg atgcagtcca ggaactgatc aaacagttcc agcagcagca
2161 gaccgccact ctagatgcca cactcaatgt catcaaggaa ggcgaagacc ttatccagca
2221 gctcaggtca gcgcctccct ccctcgggga gcccagcgag gccagggact cggctgtgtc
2281 caacaacaaa acaccccaca gcagctccat cagccacatc gagtcggtcc tgcagcagct
2341 tgatgatgcc caggtgcaga tggaggagct gttccacgag cggaagatca agctggacat
2401 cttcctgcaa ctgcgcatct ttgagcagta caccatcgag gtgacagcag agctagacgc
2461 ctggaatgaa gacttgcttc ggcagatgaa tgacttcaac acagaggacc taaccctggc
2521 agaacagcgg ctgcagcgcc acacagaacg gaagctagcc atgaacaaca tgacctttga
2581 ggttatccag cagggacagg atctgcacca gtacatcacg gaggtccagg catcaggaat
2641 tgagttgatc tgtgaaaaag acattgatct ggcagcccag gtgcaagagt tattggaatt
2701 tctccatgag aagcagcatg aattggagct caatgcagag cagactcata agcggctaga
2761 gcagtgcctc caattacgtc acctccaggc tgaagtcaaa caggttctgg gatggatccg
2821 caatggagag tcaatgctca acgccagcct ggtcaatgcc agctctttgt cggaagcaga
2881 gcagctgcag cgggagcacg agcagttcca actggccatc gagtccctct ttcatgccac
2941 ttccttgcag aagacgcacc agagtgccct gcaggtacag cagaaagccg aggtgctgct
3001 ccaggccggc cactacgatg ccgatgccat ccgggaatgt gctgagaagg tggccctcca
3061 ctggcagcag ctcatgctga agatggaaga ccggctaaaa ttggtcaatg cctctgtggc
3121 cttttacaaa acttctgaac aggtgtgtag tgtcctggag agcttagagc aagaataccg
3181 gagagatgag gactggtgtg gtggacgaga taagctgggg ccagcagcag agatcgacca
3241 tgtcattccc ctcatcagca aacatttgga acaaaaggag gcctttctta aggcctgcac
3301 cctggctcgg cggaatgctg aggtgtttct caagtacatc cacaggaaca acgtcagcat
3361 gcccagtgtc gccagccaca ctcggggacc cgagcaacaa gtgaaagcca tcctgagtga
3421 gctcctgcag agggagaatc gcgtgctgca tttctggacc ttgaagaagc ggcggttaga
3481 ccaatgccag caatatgtgg tgttcgagcg cagcgctaag caggcgcttg actggatcca
3541 agaaacaggt gaattttacc tctcaacaca tacctccact ggagagacca cagaggagac
3601 tcaggaactg ctgaaagaat atggggaatt cagggtgcct gccaagcaaa caaaggagaa
3661 ggtgaagctt ctgattcagc tggccgatag ctttgtggaa aaaggccaca ttcatgccac
3721 ggagataagg aaatgggtga ccacggtgga caagcactac agagatttct ccctgaggat
3781 gggaaagtac cgatactcac tggagaaagc cctaggagtc aacacagagg ataataagga
3841 cctggagctg gatattatcc cagcaagcct ttcggatcgg gaggtcaagc tgcgggacgc
3901 caaccacgaa gtcaatgaag agaagcggaa gtcagcccgg aagaaagaat ttattatggc
3961 tgaactactc cagacagaga aggcttatgt aagggatttg catgagtgct tagagaccta
4021 cctgtgggaa atgaccagtg gtgtggagga gatcccccct gggatcctca ataaagagca
4081 tatcatcttt ggcaacatcc aagagatcta cgatttccat aacaacatct tcctcaaaga
4141 gctggagaag tacgagcaac tgcctgagga tgtgggacac tgctttgtta cctgggcaga
4201 caaatttcag atgtatgtca cctactgtaa aaacaagcct gattccaacc agcttatcct
4261 ggagcatgcg ggcaccttct ttgatgagat acaacagcgg catggtctgg ccaactccat
4321 ctcttcctac ctaattaagc ctgtccaaag gatcaccaaa tatcaactgc tcctgaagga
4381 acttttaact tgctgtgaag aagggaaagg ggagctcaag gatggcctgg aggtgatgct
4441 cagtgtccca aagaaagcca atgatgccat gcatgtcagc atgctggaag ggttcgacga
4501 gaacctggat gtgcaggggg agttgattct ccaggatgcc tttcaagtgt gggacccgaa
4561 gtcgctgatc cggaaggggc gggagcggca cttgttcctc tttgagatct ccttggtttt
4621 tagcaaggag atcaaagatt cttcaggaca cacgaaatat gtttacaaga acaagctact
4681 gacctcagag ctgggtgtga ccgagcacgt ggagggcgat ccctgcaaat tcgccttgtg
4741 gtctgggcgc accccatcct cagacaataa aacagtgctg aaagcctcca acattgaaac
4801 caagcaggag tggatcaaga acattcgaga agtgattcaa gaaaggatca ttcacctgaa
4861 aggagcttta aaggagccac ttcagctccc caaaacacca gccaaacaga ggaacaatag
4921 taagagggat ggagtggagg atattgacag ccagggggat gggagcagcc aaccagacac
4981 catctccatt gcttctagga cctctcagaa cacagtggac agtgacaagg atggcaacct
5041 tgttcctcgg tggcacctgg gacctggaga tcctttctcc acttacgttt agcgcgcatc
5101 ctgggacttg tccctgcagc tcaccgggtt agccgtggca ccgttgggac ctcccaccag
5161 gactccaatc acccacctct cttgagactt ctctggcagg gctggtgtgg ggtgcagcct
5221 ttgctcagag ggcaacatgt tccaagcaaa atctccccgc ctgggccatg ggctcaccct
5281 cggggctccc ttcttctcta ctgggtgcaa ttcgaggttg ctgagcttct ctccaaagtc
5341 taaaatggtg gggcagtagg gacctgtgag aggcccaatg gcccaatgta cttcccccag
5401 atcccactca gaacagcagg tacgcccagg ctcctgctgc cctagaggtc tgcaacatga
5461 gtgaagaggt taattagagg gacacactta tctctgaagt ttttctccag gctgaacatt
5521 tctattatca gtggccccta atctggaaaa acccatcatt ctaatctagc ttgtatcccc
5581 acatcatgag aaagagggaa gaagaagaag ggatgatgtg tggtagagaa gatgagggtt
5641 aactttagcc tttcccaaac actggcaaca accacttcct caacaatttt tctatttgct
5701 tcagcctact cagatttttt caggtttttc tagctcctcc ataacctcac tccctcccga
5761 ggtctctggt tcaaagacca ccctaccagc ccctatttgc ttcaggttat cctgttgagg
5821 gtgggtggga agagtgagaa gatataaatg aaaaactggc cacatgttga taattgttga
5881 aactagatga tggtacgtgg acattcatta taccattctc cccacttctg tatttgtttg
5941 caatttttca taataaaaaa gttttaaaag tcctccagtt tccaacacac tcaagagaga
6001 gccccaaccc caaacacaga gtttcatgga aaccccacac caaggcaaga ggcagagatg
6061 atgattccat ttcatatata cactcatttt ctaacttttt ttaaaggccc actgctttat
6121 tttcaataga ttaaacctga tttctgagag gtcctgaagt tgggcttatt tccctggctg
6181 ggttatgggg gagggcaggg taaagggatc cttaaaaaag tttacacttc tatgtatctc
6241 acaatcttat tgtgaggatg tgacttgttc agtgttctga acttttcgaa ggaatcgtgc
6301 tctcaatgca aagtgtcatt ctctggaatt gcacctggct caggaaagga ctgtctttgt
6361 acttgaattt aaatccaatg gagaacttta acacgggcat ttgcatgact gagaattgct
6421 gctgtctttt ttccgtatgt cactttcttg aatgtgttct aataaaatg
//