LOCUS HSU93091 4868 bp mRNA linear HUM 30-NOV-1998
DEFINITION Human Toll protein homolog mRNA, complete cds and LINE-1 reverse
transcriptase homolog, pseudogene.
ACCESSION U93091
VERSION U93091.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4868)
AUTHORS Medzhitov,R., Preston-Hurlburt,P. and Janeway,C.A. Jr.
TITLE A human homologue of the Drosophila Toll protein signals activation
of adaptive immunity
JOURNAL Nature 388 (6640), 394-397 (1997)
PUBMED 9237759
REFERENCE 2 (bases 1 to 4868)
AUTHORS Medzhitov,R.M., Waterbury,P.G. and Janeway,C.A.
TITLE Direct Submission
JOURNAL Submitted (12-MAR-1997) Immunobiology, HHMI, Yale University
Medical School, 310 Cedar St., New Haven, CT 06510, USA
REFERENCE 3 (bases 1 to 4868)
AUTHORS Medzhitov,R.M., Waterbury,P.G. and Janeway,C.A.
TITLE Direct Submission
JOURNAL Submitted (22-SEP-1997) Immunobiology, HHMI, Yale University
Medical School, 310 Cedar St., New Haven, CT 06510, USA
REMARK Sequence update by submitter
COMMENT On Sep 22, 1997 this sequence version replaced gi:1930089.
FEATURES Location/Qualifiers
source 1..4868
/db_xref="H-InvDB:HIT000222659"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 104..2623
/note="similar to the Drosophila Toll protein; LRR motif;
similar to the cytoplasmic domain of IL-1 receptor"
/codon_start=1
/product="Toll protein homolog"
/protein_id="AAC80227.1"
/translation="MMSASRLAGTLIPAMAFLSCVRPESWEPCVEVVPNITYQCMELN
FYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLS
HLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHN
LIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFI
QPGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSA
LEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQH
LELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCS
QSDFGTTSLKYLDLSFNGVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLI
YLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQL
EQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQH
FPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVEVERMECATPSDKQGMPVLSLN
ITCQMNKTIIGVSVLSVLVVSVVAVLVYKFYFHLMLLAGCIKYGRGENIYDAFVIYSS
QDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIIHEGFHKSRKVIVVVSQH
FIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLRQQVELYRLLSRNTYLEWE
DSVLGRHIFWRRLRKALLDGKSWNPEGTVGTGCNWQEATSI"
CDS <3964..4485
/note="LINE-1 reverse transcriptase homolog"
/pseudo
/codon_start=2
BASE COUNT 1475 a 963 c 1000 g 1430 t
ORIGIN
1 aaaatactcc cttgcctcaa aaactgctcg gtcaaacggt gatagcaaac cacgcattca
61 cagggccact gctgctcaca aaaccagtga ggatgatgcc aggatgatgt ctgcctcgcg
121 cctggctggg actctgatcc cagccatggc cttcctctcc tgcgtgagac cagaaagctg
181 ggagccctgc gtggaggtgg ttcctaatat tacttatcaa tgcatggagc tgaatttcta
241 caaaatcccc gacaacctcc ccttctcaac caagaacctg gacctgagct ttaatcccct
301 gaggcattta ggcagctata gcttcttcag tttcccagaa ctgcaggtgc tggatttatc
361 caggtgtgaa atccagacaa ttgaagatgg ggcatatcag agcctaagcc acctctctac
421 cttaatattg acaggaaacc ccatccagag tttagccctg ggagcctttt ctggactatc
481 aagtttacag aagctggtgg ctgtggagac aaatctagca tctctagaga acttccccat
541 tggacatctc aaaactttga aagaacttaa tgtggctcac aatcttatcc aatctttcaa
601 attacctgag tatttttcta atctgaccaa tctagagcac ttggaccttt ccagcaacaa
661 gattcaaagt atttattgca cagacttgcg ggttctacat caaatgcccc tactcaatct
721 ctctttagac ctgtccctga atcctatgaa ctttatccaa ccaggtgcat ttaaagaaat
781 taggcttcat aagctgactt taagaaataa ttttgatagt ttaaatgtaa tgaaaacttg
841 tattcaaggt ctggctggtt tagaagtcca tcgtttggtt ctgggagaat ttagaaatga
901 aggaaacttg gaaaagtttg acaaatctgc tctagagggc ctgtgcaatt tgaccattga
961 agaattccga ttagcatact tagactacta cctcgatgat attattgact tatttaattg
1021 tttgacaaat gtttcttcat tttccctggt gagtgtgact attgaaaggg taaaagactt
1081 ttcttataat ttcggatggc aacatttaga attagttaac tgtaaatttg gacagtttcc
1141 cacattgaaa ctcaaatctc tcaaaaggct tactttcact tccaacaaag gtgggaatgc
1201 tttttcagaa gttgatctac caagccttga gtttctagat ctcagtagaa atggcttgag
1261 tttcaaaggt tgctgttctc aaagtgattt tgggacaacc agcctaaagt atttagatct
1321 gagcttcaat ggtgttatta ccatgagttc aaacttcttg ggcttagaac aactagaaca
1381 tctggatttc cagcattcca atttgaaaca aatgagtgag ttttcagtat tcctatcact
1441 cagaaacctc atttaccttg acatttctca tactcacacc agagttgctt tcaatggcat
1501 cttcaatggc ttgtccagtc tcgaagtctt gaaaatggct ggcaattctt tccaggaaaa
1561 cttccttcca gatatcttca cagagctgag aaacttgacc ttcctggacc tctctcagtg
1621 tcaactggag cagttgtctc caacagcatt taactcactc tccagtcttc aggtactaaa
1681 tatgagccac aacaacttct tttcattgga tacgtttcct tataagtgtc tgaactccct
1741 ccaggttctt gattacagtc tcaatcacat aatgacttcc aaaaaacagg aactacagca
1801 ttttccaagt agtctagctt tcttaaatct tactcagaat gactttgctt gtacttgtga
1861 acaccagagt ttcctgcaat ggatcaagga ccagaggcag ctcttggtgg aagttgaacg
1921 aatggaatgt gcaacacctt cagataagca gggcatgcct gtgctgagtt tgaatatcac
1981 ctgtcagatg aataagacca tcattggtgt gtcggtcctc agtgtgcttg tagtatctgt
2041 tgtagcagtt ctggtctata agttctattt tcacctgatg cttcttgctg gctgcataaa
2101 gtatggtaga ggtgaaaaca tctatgatgc ctttgttatc tactcaagcc aggatgagga
2161 ctgggtaagg aatgagctag taaagaattt agaagaaggg gtgcctccat ttcagctctg
2221 ccttcactac agagacttta ttcccggtgt ggccattgct gccaacatca tccatgaagg
2281 tttccataaa agccgaaagg tgattgttgt ggtgtcccag cacttcatcc agagccgctg
2341 gtgtatcttt gaatatgaga ttgctcagac ctggcagttt ctgagcagtc gtgctggtat
2401 catcttcatt gtcctgcaga aggtggagaa gaccctgctc aggcagcagg tggagctgta
2461 ccgccttctc agcaggaaca cttacctgga gtgggaggac agtgtcctgg ggcggcacat
2521 cttctggaga cgactcagaa aagccctgct ggatggtaaa tcatggaatc cagaaggaac
2581 agtgggtaca ggatgcaatt ggcaggaagc aacatctatc tgaagaggaa aaataaaaac
2641 ctcctgaggc atttcttgcc cagctgggtc caacacttgt tcagttaata agtattaaat
2701 gctgccacat gtcaggcctt atgctaaggg tgagtaattc catggtgcac tagatatgca
2761 gggctgctaa tctcaaggag cttccagtgc agagggaata aatgctagac taaaatacag
2821 agtcttccag gtgggcattt caaccaactc agtcaaggaa cccatgacaa agaaagtcat
2881 ttcaactctt acctcatcaa gttgaataaa gacagagaaa acagaaagag acattgttct
2941 tttcctgagt cttttgaatg gaaattgtat tatgttatag ccatcataaa accattttgg
3001 tagttttgac tgaactgggt gttcactttt tcctttttga ttgaatacaa tttaaattct
3061 acttgatgac tgcagtcgtc aaggggctcc tgatgcaaga tgccccttcc attttaagtc
3121 tgtctcctta cagatgttaa agtctagtgg ctaattccta aggaaacctg attaacacat
3181 gctcacaacc atcctggtca ttctcgagca tgttctattt tttaactaat cacccctgat
3241 atatttttat ttttatatat ccagttttca tttttttacg tcttgcctat aagctaatat
3301 cataaataag gttgtttaag acgtgcttca aatatccata ttaaccacta tttttcaagg
3361 aagtatggaa aagtacactc tgtcactttg tcactcgatg tcattccaaa gttattgcct
3421 actaagtaat gactgtcatg aaagcagcat tgaaataatt tgtttaaagg gggcactctt
3481 ttaaacggga agaaaatttc cgcttcctgg tcttatcatg gacaatttgg gctagaggca
3541 ggaaggaagt gggatgacct caggaggtca ccttttcttg attccagaaa catatgggct
3601 gataaacccg gggtgacctc atgaaatgag ttgcagcaga agtttatttt tttcagaaca
3661 agtgatgttt gatggacctc tgaatctctt tagggagaca cagatggctg ggatccctcc
3721 cctgtaccct tctcactgcc aggagaacta cgtgtgaagg tattcaaggc agggagtata
3781 cattgctgtt tcctgttggg caatgctcct tgaccacatt ttgggaagag tggatgttat
3841 cattgagaaa acaatgtgtc tggaattaat ggggttctta taaagaaggt tcccagaaaa
3901 gaatgttcat tccagcttct tcaggaaaca ggaacattca aggaaaagga caatcaggat
3961 gtcatcaggg aaatgaaaat aaaaaccaca atgagatatc accttatacc aggtagatgg
4021 ctactataaa aaaatgaagt gtcatcaagg atatagagaa attggaaccc ttcttcactg
4081 ctggagggaa tggaaaatgg tgtagccgtt atgaaaaaca gtacggaggt ttctcaaaaa
4141 ttaaaaatag aactgctata tgatccagca atctcacttc tgtatatata cccaaaataa
4201 ttgaaatcag aatttcaaga aaatatttac actcccatgt tcattgtggc actcttcaca
4261 atcactgttt ccaaagttat ggaaacaacc caaatttcca ttggaaaata aatggacaaa
4321 ggaaatgtgc atataacgta caatggggat attattcagc ctaaaaaaag gggggatcct
4381 gttatttatg acaacatgaa taaacccgga ggccattatg ctatgtaaaa tgagcaagta
4441 acagaaagac aaatactgcc tgatttcatt tatatgaggt tctaaaatag tcaaactcat
4501 agaagcagag aatagaacag tggttcctag ggaaaaggag gaagggagaa atgaggaaat
4561 agggagttgt ctaattggta taaaattata gtatgcaaga tgaattagct ctaaagatca
4621 gctgtatagc agagttcgta taatgaacaa tactgtatta tgcacttaac attttgttaa
4681 gagggtacct ctcatgttaa gtgttcttac catatacata tacacaagga agcttttgga
4741 ggtgatggat atatttatta ccttgattgt ggtgatggtt tgacaggtat gtgactatgt
4801 ctaaactcat caaattgtat acattaaata tatgcagttt tataatatca aaaaaaaaaa
4861 aaaaaaaa
//